Reyer Zwiggelaar Ir (Groningen), PhD (University College London)


Head of the Graduate School

Director of Research (IMPACS)

Contact Details

Room Number..........:  B61
Building....................:  Llandinam
Phone.......................:   +44 (0)1970 628691
E-Mail........................:   rrz
External Publication Websites:
Google Scholar


Reyer Zwiggelaar received the Ir. Degree in Applied Physics from the State University Groningen, Groningen, The Netherlands, in 1989, and the Ph.D. Degree in Electronic and Electrical Engineering from the University College London, London, UK, in 1993. He is currently a Professor at the Department of Computer Science, Aberystwyth University, UK. He is the author or co-author of more than 180 conference and journal papers. His current research interests include Medical Image Understanding, especially Focusing on Mammographic and Prostate Data, Pattern Recognition, Statistical Methods, Texture-Based Segmentation, and Feature-Detection Techniques.

Research Groups

Teaching Areas

Modules Taught

  • MAM5120: Statistical Concepts, Methods and Tools
  • MOR0510: Dulliau Darllen
  • MOR9005: Moeseg, Llenladrata ac Ymarfer Academaidd ar gyfer Myfyrwyr Ymchwil
  • PGM1010: Quantitative Data Collection and Analysis
  • PGM2210: Research Skills and Personal Development (Arts and Humanities) (2210)
  • PGM2310: Research Skills and Personal Development (Science) (2310)
  • PGM2400: Research Seminar Skills in the Life Sciences
  • PGM2410: Research Seminar Skills in the Life Sciences
  • PGM2510: Grants Development Workshops
  • PGM2600: Reading and Writing Development Group
  • PGM2610: Reading and Writing Development Group
  • PGM2910: Research Writing Programme
  • PGM3310: Entrepreneurship for Research Students
  • PGM4005: Ethics, Plagiarism and Academic Practice for Research Students
  • PGM4710: Research Skills and Personal Development (Arts and Humanities) (2210)
  • PGM9005: Ethics, Plagiarism and Academic Practice for Research Students



Wang, L., Labrosse, F., Zwiggelaar, R. 2017 (In press). Comparison of Image Intensity, Local and Multi-Atlas Priors in Brain Tissue Classication. Medical Physics

Hoon Yap, M., Pons, G., Marti, J., Ganau, S., Sentís, M., Zwiggelaar, R., Davison, A., Martí, R. 2017 (In press). Automated breast ultrasound lesions detection using convolutional neural networks. IEEE Journal of Biomedical and Health Informatics

Suhail, Z., Denton, E.R.E., Zwiggelaar, R. 2017. Tree-based modelling for the classification of mammographic benign and malignant micro-calcification clusters. Multimedia Tools and Applications 10.1007/s11042-017-4522-3 Cadair

Surajudeen, A., Zwiggelaar, R. 2017. Breast density segmentation based on fusion of super pixels and watershed transform. International Journal of Computer Applications 161 (12) pp. 1-7. 10.5120/ijca2017913208

Ashiru, O., Zwiggelaar, R. 2017. Classification of mammorgraphic microcalcification clusters using a combination of topological and location modelling. In M. Pietikainen., A. Hadid., M. B. Lopez. (eds) 6th International Conference on Image Processing Theory: Tools and Applications. 6th International Conference on Image Processing Theory . IEEE Press 10.1109/IPTA.2016.7820986 Cadair


González-Villà, S., Oliver, A., Valverde, S., Wang, L., Zwiggelaar, R., Lladó, X. 2016. A review on brain structures segmentation in magnetic resonance imaging. Artificial Intelligence in Medicine 73 pp. 45-69. 10.1016/j.artmed.2016.09.001 Cadair

Rampun, Y.A., Tiddeman, B., Zwiggelaar, R., Malcolm, P. 2016. Computer aided diagnosis of prostate cancer: A texton based approach. Medical Physics 43 (10) 5412 10.1118/1.4962031 Cadair

Daubney, B., Xie, X., Deng, J., MacParthalain, N., Zwiggelaar, R. 2016. Fixing the root node: Efficient tracking and detection of 3D human pose through local solutions. Image and Vision Computing 52 pp. 73-87. 10.1016/j.imavis.2016.05.010 Cadair

Rampun, A., Wang, L., Malcolm, P., Zwiggelaar, R. 2016. A Quantatiitive Study of Texture Features across Different Window Sizes in Prostate T2-weighted MRI. Procedia Computer Science 90 20th Conference on Medical Image Understanding and Analysis. pp. 74-79. 10.1016/j.procs.2016.07.026 Cadair

George, M., Denton, E., Zwiggelaar, R. 2016. Mammographic Ellispe Modelling for Risk Estimation. Procedia Computer Science 90 20th Conference on Medical Image Understanding and Analysis. pp. 163-168. 10.1016/j.procs.2016.07.020 Cadair

He, W., Harvey, S., Juette, A., Denton, E.R.E., Zwiggelaar, R. 2016. Mammographic Segmentation and Density Classification: A Fractal Inspired Approach. In A. Tingberg., K. Lång., P. Timberg. (eds) Breast Imaging: 13th International Workshop, IWDM 2016. Lecture Notes in Computer Science, vol. 9699 Proceedings 13th International Workshop, IWDM 2016. Springer Nature pp. 359-366. 10.1007/978-3-319-41546-8_45 Cadair

Rampun, A., Zheng, L., Malcolm, P., Tiddeman, B., Zwiggelaar, R. 2016. Computer-aided detection of prostate cancer in T2-weighted MRI within the peripheral zone. Physics in Medicine and Biology 61 (3) pp. 4796-4825. 10.1088/0031-9155/61/13/4796 Cadair

Rampun, Y.A., Chen, Z., Malcolm, P., Tiddeman, B., Zwiggelaar, R. 2016. Computer-aided diagnosis: Detection and localization of prostate cancer within the peripheral zone. International Journal for Numerical Methods in Biomedical Engineering 32 (5) 10.1002/cnm.2745 Cadair

Doonan, J., Boyle, R., Han, J., Williams, K.S., Alcalde Barrios, A., Strange, H., Corke, F., Nibau, C., Scotson, C.P., Camargo-Rodriguez, A., Zwiggelaar, R., Sturrock, C., Mooney, S. 2016. Image-based phenotyping to measure plant diversity and performance. Plant and Animal Genome Conference XXIV. Cadair


He, W., Hogg, P., Juette, A., Denton, E.R.E., Zwiggelaar, R. 2015. Breast Image Pre-processing For Mammographic Tissue Segmentation. Computers in Biology and Medicine 67 pp. 61-73. 10.1016/j.compbiomed.2015.10.002 Cadair

Strange, H., Zwiggelaar, R. 2015. Piecewise-Linear Manifold Learning: A Heuristic Approach to Nonlinear Dimensionality Reduction. Intelligent Data Analysis 19 (6) pp. 1213-1232. 10.3233/IDA-150779 Cadair

He, W., Juette, A., Denton, E.R.E., Oliver, A., Marti, R., Zwiggelaar, R. 2015. A review on automatic mammographic density and parenchymal segmentation. International Journal of Breast Cancer 2015 276217 pp. 1-31. 10.1155/2015/276217 Cadair

Chen, Z., Strange, H., Oliver, A., Denton, E.R.E., Boggis, C.R.M., Zwiggelaar, R. 2015. Topological Modelling and Classification of Mammographic Microcalcification Clusters. IEEE Transactions on Biomedical Engineering 62 (4) pp. 1203-1214. 10.1109/TBME.2014.2385102 Cadair

Strange, H., Zwiggelaar, R., Sturrock, C., Mooney, S., Doonan, J. 2015. Automatic Estimation of Wheat Grain Morphometry from CT Data. Functional Plant Biology 42 pp. 452-459. 10.1071/FP14068 Cadair

Zeng, Z., Chen, S., Yin, L., Zwiggelaar, R. 2015. Unsupervised segmentation for multiple sclerosis lesions in multimodality Magnetic Resonance images. 2015 8th International Conference on BioMedical Engineering and Informatics (BMEI 2015). IEEE Press pp. 126-130. 10.1109/BMEI.2015.7401486 Cadair


Zwiggelaar, R., Denton, E.R.E., Strange, H. 2014. Modelling cancer risk. International Innovation 165 pp. 73-75. Other Cadair

Strange, H.G., Chen, Z., Denton, E.R.E., Zwiggelaar, R. 2014. Modelling mammographic microcalcification clusters using persistent mereotopology. Pattern Recognition Letters 47 pp. 157-163. 10.1016/j.patrec.2014.04.008 Cadair

Tortajada, M., Oliver, A., Martí, R., Ganau, S., Tortajada, L., Sentís, M., Freixenet, J., Zwiggelaar, R. 2014. Breast peripheral area correction in digital mammograms. Computers in Biology and Medicine 50 pp. 32-40. 10.1016/j.compbiomed.2014.03.010 Cadair

Al-Rjoub, B.A., Zwiggelaar, R. 2014. Thermal Facial Analysis for Deception Detection. IEEE Transactions on Information Forensics and Security 9 (6) pp. 1015-1023. 10.1109/TIFS.2014.2317309 Cadair

Rampun, Y.A., Malcolm, P., Zwiggelaar, R. 2014. Detection of Prostate Abnormality within the Peripheral Zone Using Grey Level Distribution. International Journal of Image and Graphics 2 (1) pp. 15-21. 10.12720/joig.2.1.15-21 Cadair

Hoon Yap, M., Ugail, H., Zwiggelaar, R. 2014. Facial Behavioral Analysis: A Case Study in Deception Detection. British Journal of Applied Science and Technology 4 (10) pp. 1485-1496. 10.9734/BJAST/2014/6369 Cadair

Zwiggelaar, R., Strange, H.G., He, W., Chen, Z., Kshirasagar, A., Denton, E.R. 2014. Image Based Tissue Segmentation: Towards the Automation of Mammographic Risk Assessment. Other Cadair

Strange, H.G., Zwiggelaar, R. 2014. Open Problems in Spectral Dimensionality Reduction. Springer Nature 10.1007/978-3-319-03943-5 Cadair

Strange, H., Scott, I., Zwiggelaar, R. 2014. Myofibre Segmentation in H&E Stained Adult Skeletal Muscle Images using Coherence-Enhancing Diffusion Filtering. BMC Medical Imaging 14 38 10.1186/1471-2342-14-38 Cadair


Zeng, Z., Wang, J., Tiddeman, B., Zwiggelaar, R. 2013. Unsupervised Tumour Segmentation in PET using Local and Global Intensity-Fitting Active Surface and Alpha Matting. Computers in Biology and Medicine 43 (10) pp. 1530-1544. 10.1016/j.compbiomed.2013.07.027 Other Cadair

Malone, T.S., Hubbard, B.P., Merton-Lyn, D., Worthington, P., Zwiggelaar, R. 2013. Borehole and Ice Feature Annotation Tool (BIFAT): A program for the automatic and manual annotation of glacier borehole images. Computers and Geosciences 51 pp. 381-389. 10.1016/j.cageo.2012.09.002 Cadair


Zwiggelaar, R., Ugail, H., Yap, M.H. 2012. Intensity Score for Facial Actions Detection in Near-Frontal-View Face Sequences. Cadair

Phillips, C.O., Syed, Y., MacParthaláin, N.S., Zwiggelaar, R., Claypole, T.C., Lewis, K.E. 2012. Machine learning methods on exhaled volatile organic compounds for distinguishing COPD patients from healthy controls. Journal of Breath Research 6 (3) 036003 pp. -. 10.1088/1752-7155/6/3/036003 Cadair

Ugail, H., Doherty, V., Zwiggelaar, R., Appleyard, S., Huddy, G., Rajoub, B., Yap, M.H. 2012. A Short Review of Methods for Face Detection and Multifractal Analysis. International Conference on Cyberworlds, 7-11 September, University of Bradford, UK (2009). IEEE Press pp. 7-11. 10.1109/CW.2009.47 Cadair

Rajoub, B., Yap, M.H., Ugail, H., Zwiggelaar, R. 2012. Visual Cues for Facial Behaviour in Deception Detection. Cadair

Ugail, H., Yap, M.H., Rajoub, B., Zwiggelaar, R., Doherty, V., Appleyard, S., Huddy, G. 2012. Facial Image Processing in Facial Analysis for Real-Time Profiling. Cadair

Crocker, M., Saadoun, S., Jury, A., Jones, C., Zacharoulis, S., Zwiggelaar, R., Bridges, L.R., Bell, B.A., Papadopoulos, M.C. 2012. Glioblastoma blood flow measured with stable xenon CT indicates tumor necrosis, vascularity, and brain invasion. Neuro-Oncology 14 (5) pp. 641-648. 10.1093/neuonc/nos063 Cadair

Oliver, A., Torrent, A., Lladó, X., Tortajada, M., Tortajada, L., Sentís, M., Freixenet, J., Zwiggelaar, R. 2012. Automatic microcalcification and cluster detection for digital and digitised mammograms. Knowledge-Based Systems 28 pp. 68-75. 10.1016/j.knosys.2011.11.021 Cadair

Zwiggelaar, R., Roscoe, J.F., Dee, H. 2012. Coping with Noise in Ultrasound Images: A review. Cadair


He, W., Denton, E.R., Stafford, K., Zwiggelaar, R. 2011. Mammographic image segmentation and risk classification based on mammographic parenchymal patterns and geometric moments. Biomedical Signal Processing and Control 6 (3) pp. 321-329. 10.1016/j.bspc.2011.03.008 Cadair


Strange, H., Zwiggelaar, R. 2010. Iterative Hyperplane Merging: A Framework for Manfiold Learning. 10.5244/C.24.18 Cadair

MacParthaláin, N.S., Jensen, R., Shen, Q., Zwiggelaar, R. 2010. Fuzzy-rough approaches for mammographic risk analysis. Intelligent Data Analysis 14 (2) pp. 225-244. 10.3233/IDA-2010-0418 Cadair

Oliver, A., Freixenet, J., Marti, J., Denton, E.R.E., Zwiggelaar, R., Pérez, E., Pont, J. 2010. A review of automatic mass detection and segmentation in mammographic images. Medical Image Analysis 14 (2) pp. 87-110. 10.1016/ Cadair

Strange, H., Zwiggelaar, R. 2010. Parallel Projections for Manifold Learning. Cadair


Bunting, P.J., He, W., Zwiggelaar, R., Lucas, R.M. 2009. Combining textural and hyperspectral information for the classification of tree species in Australian savanna woodlands. In S. Jones., K. Reinke. (eds) Innovations in Remote Sensing and Photogrammetry. pp. 19-26. 10.1007/978-3-540-93962-7_2 Cadair Other

Strange, H.G., Zwiggelaar, R. 2009. Classification Performance related to Intrinsic Dimensionality in Mammographic Image Analysis. Proceedings of the Thirteenth Annual Conference on Medical Image Understanding and Analysis. pp. 219-223. Cadair Other

Hadley, E.M., Bakic, P.R., Maidment, A.D.A., Zwiggelaar, R. 2009. Detection of linear structures in 3D breast tomosynthesis images. Proceedings of Medical Image Understanding and Analysis 09, pp. 194-198 (2009). pp. 194-198. Cadair

He, W., Denton, E.R.E., Zwiggelaar, R. 2009. Mammographic segmentation based on mammographic parenchymal patterns and spatial moments. Proceedings of the 9th International Conference on Information Technology and Applications in Biomedicine, 5-7 November, Larnaca, Cyprus (2009). 9th International Conference on Information Technology and Applications in Biomedicine. 10.1109/ITAB.2009.5394451 Other Cadair


He, W., Denton, E.R.E., Zwiggelaar, R., Strange, H. 2008. Cancer Risk Assessment Related to Anatomical Tissue Types. Cadair Other

Martí, R., Martí, J., Freixenet, J., Zwiggelaar, R., Vilanova, J., Barceló, J. 2008. Optimally discriminant moments for speckle detection in real B-Scan images. Ultrasonics 48 (3) pp. 169-181. 10.1016/j.ultras.2007.11.010 Cadair

Zwiggelaar, R. 2008. Comparing the performance of a mass detection CAD system when using manual and automatic breast density information, 22nd International Congress and Exhibition. 10.1007/s11548-008-0207-8 Cadair

Oliver, A., Freixenet, J., Marti, R., Pont, J., Perez, E., Denton, E.R.E., Zwiggelaar, R. 2008. A novel breast tissue density classification framework. IEEE Transactions on Information Technology in Biomedicine 12 (1) pp. 55-65. 10.1109/TITB.2007.903514 Cadair

Freixenet, J., Oliver, A., Martí, R., Lladó, X., Pont, J., Pérez, E., Denton, E.R.E., Zwiggelaar, R. 2008. Eigendetection of masses considering false positive reduction and breast density information. Medical Physics 35 (5) pp. 1840-1853. 10.1118/1.2897950 Cadair

Zwiggelaar, R. 2008. Mammographic risk assessment: does anatomical linear structure information improve the accuracy of a density-based classifier? Proceedings of the 12th Annual Conference on Medical Image Understanding and Analysis 2008. Medical Image Understanding and Analysis 2008. pp. 224-228. Other Cadair

He, W., Zwiggelaar, R., Denton, E.R.E., Muhimmah, I. 2008. Mammographic Segmentation Based on Texture Modelling of Tabár Mammographic Building Blocks. Digital Mammography: 9th International Workshop, IWDM 2008 Tucson, AZ, USA, July 20-23, 2008 Proceedings. Lecture Notes in Computer Science, vol. 5116 pp. 17-24. Cadair

Zwiggelaar, R. 2008. Analysis of using anatomical linear structure information in mammographic risk assessment. Proceeding IWDM '08 Proceedings of the 9th international workshop on Digital Mammography. Springer Nature pp. 483-490. 10.1007/978-3-540-70538-3_67 Cadair

Qi, D., Denton, E.R.E., Leason, J.M.E., Othman, D., Zwiggelaar, R. 2008. The evaluation of effects on breast cancer diagnoses using the mammographic semantic information. In E. A. Krupinski. (ed) Lecture Notes in Computer Science: Digital Mammography: 9th International Workshop, IWDM 2008 Tucson, AZ, USA, July 20-23, 2008 Proceedings. pp. 307-314. 10.1007/978-3-540-70538-3_43 Cadair


Zhu, Y., Williams, S., Zwiggelaar, R. 2007. A hybrid ASM approach for sparse volumetric data segmentation. Pattern Recognition and Image Analysis 17 (2) pp. 252-258. 10.1134/S1054661807020125 Cadair Other Other


Williams, S., Zhu, Y., Zwiggelaar, R. 2006. Computer technology in detection and staging of prostate carcinoma: a review. Medical Image Analysis 10 (2) pp. 178-199. 10.1016/ Cadair Other


Blot, L., Zwiggelaar, R. 2005. A volumetric approach to risk assessment in mammography: a feasibility study. Physics in Medicine and Biology 50 (4) pp. 695-708. 10.1088/0031-9155/50/4/009 Cadair Other

Ouyang, F., Blot, L., Zwiggelaar, R., Cherng, A.-.P. 2005. An estimation of firmness for solid ellipsoidal fruits. Biosystems Engineering 91 (2) pp. 257-259. 10.1016/j.biosystemseng.2005.02.011 Cadair


Rubin, C.M.E., Marti, R., Denton, E.R.E., Zwiggelaar, R. 2004. Two-Dimensional–Three-Dimensional Correspondence in Mammography. Cybernetics and Systems 35 (1) pp. 85-105. 10.1080/019697204902446858 Cadair

Boggis, C.R.M., Taylor, C.J., Astley, S.M., Zwiggelaar, R. 2004. Linear structures in mammographic images: detection and classification. IEEE Transactions on Medical Imaging 23 (9) pp. 1077-1086. 10.1109/TMI.2004.828675 Cadair Other


Blot, L., Davis, A., Holubinka, M., Martí, R., Zwiggelaar, R. 2002. Automated Quality Assurance Applied to Mammographic Imaging. EURASIP Journal of Applied Signal Processing 7 pp. 736-745. 10.1155/S1110865702203029 Cadair

Rubin, C.M.E., Marti, R., Zwiggelaar, R. 2002. Automatic point correspondence and registration based on linear structures. International Journal of Pattern Recognition and Artificial Intelligence 16 (3) pp. 331-340. 10.1142/S021800140200171X Cadair Other


Zwiggelaar, R., Parr, T.C., Schumm, J.E., Hutt, I.W., Taylor, C.J., Astley, S.M., Boggis, C.R.M. 1999. Model-based detection of spiculated lesions in mammograms. Medical Image Analysis 3 (1) pp. 39-62. 10.1016/S1361-8415(01)80055-4 Cadair Other


Zwiggelaar, R. 1998. A review of spectral properties of plants and their potential use for crop/weed discrimination in row-crops. Crop Protection 17 (3) pp. 189-206. 10.1016/S0261-2194(98)00009-X Cadair Other


Bull, C.R., Zwiggelaar, R. 1997. Discrimination between low atomic number materials from their characteristic scattering of X-ray radiation. Journal of Agricultural Engineering Research 68 (2) pp. 77-87. 10.1006/jaer.1997.0181 Cadair

Onyango, C.M., Marchant, J.A., Zwiggelaar, R. 1997. Modelling uncertainty in agricultural image analysis. Computers and Electronics in Agriculture 17 (3) pp. 295-305. 10.1016/S0168-1699(97)01322-7 Cadair Other

Mooney, M.J., Bull, C.R., Zwiggelaar, R., Czarnes, S. 1997. The detection of 'soft' materials by selective energy xray transmission imaging and computer tomography. Journal of Agricultural Engineering Research 66 (3) pp. 203-212. 10.1006/jaer.1996.0134 Cadair

Zwiggelaar, R., Speller, R.D., Bull, C.R. 1997. Review of inspection techniques based on the elastic and inelastic scattering of X-rays and their potential in the food and agricultural industry. Journal of Food Engineering 33 (1-2) pp. 167-179. 10.1016/S0260-8774(97)88544-5 Cadair


Bull, C.R., McFarlane, N.J.B., Zwiggelaar, R., Allen, C.J., Mottram, T.T. 1996. Inspection of teats by colour image analysis for automatic milking systems. Computers and Electronics in Agriculture 15 (1) pp. 15-26. 10.1016/0168-1699(95)00054-2 Cadair

Bull, C.R., Mooney, M.J., Zwiggelaar, R. 1996. X-ray simulations for imaging applications in the agricultural and food industry. Journal of Agricultural Engineering Research 63 (2) pp. 161-170. 10.1006/jaer.1996.0018 Cadair

Garcia-Pardo, E., Yang, Q., Bull, C.R., Zwiggelaar, R. 1996. Using spectral information and machine vision for bruise detection on peaches and apricots. Journal of Agricultural Engineering Research 63 (4) pp. 323-332. 10.1006/jaer.1996.0035 Cadair

Zwiggelaar, R., Wilson, M.G.F. 1996. Propagation of the degree of polarisation in a few-mode optical fibre: Experimental results. International Journal of Optoelectronics 10 (4) pp. 295-297. Cadair


Zwiggelaar, R., Bull, C.R. 1995. Optical determination of fractal dimensions using Fourier transforms. Optical Engineering 34 (5) pp. 1325-1332. 10.1117/12.201665 Cadair

Zwiggelaar, R. 1995. 100 Jaar rontgen straling: wisselwerking tussen theorie, experiment en simulatie. Tijdschrift voor Natuurkunde 61 (12) pp. 207-209. Cadair

Stafford, J.V., Zwiggelaar, R., Bull, C.R. 1995. Imaging as a technique for assessment and control in the field. Aspects of Applied Biology 43 pp. 197-204. Cadair


Wilson, M.G.F., Zwiggelaar, R. 1994. Single Mueller matrix description of the propagation of degree of polarisation in a uniformly anisotropic single-mode optical fibre. IEE Proceedings - Optoelectronics 141 (6) pp. 367-372. 10.1049/ip-opt:19941471 Cadair Other


Zwiggelaar, R., Wilson, M.G.F. 1993. Spectral changes in inhomogeneous media: a quasi-optical approach. International Journal of Infrared and Millimeter Waves 14 (10) pp. 2253-2259. 10.1007/BF02096386 Cadair