Dr Matthew Hegarty PhD, PGCTHE
My research is focused on understanding how changes in the genome or transcriptome of an individual affects its phenotype, and also how genetic diversity affects populations. This research is based in a broad range of biological systems but always with a key theme of identifying genes underpinning physical traits. This is of particular relevance to the plant breeding and animal research programmes at IBERS, where my research brings a genomics aspect to these systems. I have a particular interest in the genetics of hybridisation and polyploidy, as many of the world's major crops are either polyploids or utilise hybrid vigour in their breeding.In addition to my own research interests, which heavily utilise the technology, I also oversee the IBERS Translational Genomics Facility, which supplies access to next-generation DNA sequencing and high-throughput genotyping for projects across IBERS and with collaborative partners.
A novel multivariate approach to phenotyping and association mapping of multi-locus gametophytic self-incompatibility reveals S, Z and other loci in a perennial ryegrass (Poaceae) population: Identifying Multi-Locus Gametophytic Self-Incompatibility Genes. Frontiers in Plant Science 8 1331 10.3389/fpls.2017.013312017.
Metagenomic Sequencing of the Chronic Obstructive Pulmonary Disease Upper Bronchial Tract Microbiome Reveals Functional Changes Associated with Disease Severity. PLoS One 11 (2) 0149095 10.1371/journal.pone.0149095 Cadair2016.
Red clover (Trifolium pratense L.) draft genome provides a platform for trait improvement. Scientific Reports 5 17394 10.1038/srep173942015.
Epigenetic regulation of sex ratios may explain natural variation in self-fertilization rates. Proceedings of the Royal Society B: Biological Sciences 282 (1819) pp. 1900. 10.1098/rspb.2015.1900 Cadair2015.
Genetic-geographic correlation revealed across a broad European ecotypic sample of perennial ryegrass (Lolium perenne) using array-based SNP genotyping. Theoretical and Applied Genetics 128 (10) pp. 1917-1932. 10.1007/s00122-015-2556-3 Cadair2015.
Genetic Analysis of Pedigree Welsh Pigs and British Landrace Pigs in relation to discriminating between pork products from these two breeds. Prifysgol Aberystwyth | Aberystwyth University, Aberystwyth Cadair2015.
Comparative genetic diversity in a sample of pony breeds from the UK and North America: A case study in the conservation of global genetic resources. Ecology and Evolution 5 (16) pp. 3507-3522. 10.1002/ece3.1562 Cadair2015.
Draft Genomes, Phylogenetic Reconstruction, and Comparative Genomics of Two Novel Cohabiting Bacterial Symbionts Isolated from Frankliniella occidentalis. Genome Biology and Evolution 7 (8) pp. 2188-2202. 10.1093/gbe/evv136 Cadair2015.
Developing low GI pearl millet and its potential in combatting diabetes. UK PlantSci. Cadair2015.
Progress in Oat FISHIS and Chromosome Specific Sequencing. Plant and Animal Genome XXIII. Cadair2015.
Comparitive population genomics of red clover domestication and improvement. Proceedings of the 12th British Grassland Society Research Conference. BGS 12th Research Conference. British Grassland Society pp. 59-60. Cadair2015.
Transcriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate pancreas function. BMC Genomics 15 1074 10.1186/1471-2164-15-1074 Cadair2014.
Metaphylogenomic and Potential Functionality of the Limpet Patella pellucida’s Gastrointestinal Tract Microbiome. International Journal of Molecular Sciences 15 (10) pp. 18819-18839. 10.3390/ijms151018819 Cadair2014.
A genetic association between leaf elongation rate and flowering time in perennial ryegrass. In (eds) Quantitative Traits Breeding for Multifunctional Grasslands and Turf. Springer Nature pp. 267-271. Cadair2014.
De novo assembly of red clover transcriptome based on RNA-Seq data provides insight into drought response, gene discovery and marker identification. BMC Genomics 15 pp. 453. 10.1186/1471-2164-15-453 Cadair2014.
Red Kite Genetics – The Research. Cadair2013.
A metagenomic snapshot of taxonomic and functional diversity in an Alpine glacier cryoconite ecosystem: Alpine cryoconite metagenome. Environmental Research Letters 8 (3) 035003 10.1088/1748-9326/8/3/035003 Cadair2013.
Phylogeographic relationships between native pony populations of Britain and Ireland. Cadair2012.
An investigation of the role of Insulin-Like Growth Factor 1 (IGF-1) in determining adult height of the horse. BSAS. Cadair2011.
Nonadditive changes to cytosine methylation as a consequence of hybridization and genome duplication in Senecio (Asteraceae). Molecular Ecology 20 (1) pp. 105-113. 10.1111/j.1365-294X.2010.04926.x Cadair2011.
Characterisation of phylogeographic relationships between native pony populations of Britain and Ireland. Ecological Genetics Group. Cadair2011.
Recent hybrid origin and invasion of the British Isles by a self-incompatible species, Oxford ragwort (Senecio squalidus L., Asteraceae). Biological Invasions 11 (5) pp. 1145-1158. 10.1007/s10530-008-9382-3 Cadair2009.