Dr Debbie Nash

PhD, PGCtHE, Senior Fellow of Higher Education Academy, Registered Animal Scientist

Dr Debbie Nash

Senior Lecturer

Contact Details

Profile

I gained my Ph.D. at The Royal Veterinary College, University of London in 2007. My research developed in vivo and in vitro models to enhance the study of the innate immune response to breeding-induced endometritis in mares which is a significant cause of infertility. During this time I gained a range of laboratory skills and was involved in four animal trials including taking sole lead of one. Consequently I am a personal Home Office licence holder and am competent in a range of reproductive and clinical procedures such as ultrasound of the reproductive tract, blood sampling and uterine biopsy.

I joined Aberystwyth University as a Lecturer in Equine and Animal Science in 2007. I lead undergraduate to MSc modulesI also supervise PhD and MPhil students. The projects I supervise tend to include developing an ex vivo tissue culture technique as a potential anti-inflammatory screening test, testing potential anti-inflammatory compounds. I've also dabbled in population genetics with collaboration of colleagues in our state-of-the-art genomics facility.

I am an active member of the British Society for Animal Science Programme Committee, taking responsibility for arranging the equine sessions on several occasions, as well as chairing sessions each year. In 2011 I was invited onto the consultative committee for setting up the Register of Animal Scientists and in 2012 was invited and elected to the BSAS Council. In addition, I am the founder, organiser and chair of the Colloquium for Equine Reproduction (http://users.aber.ac.uk/dmn/cfer/Homepage.html), which since its inaugural event in 2010, goes from strength to strength. A further event was held in 2011 and CFER was hosted within the BSAS annual conference in 2013 and in 2015.

Teaching

Research

Reproductive physiology (specifically uterine inflammatory disease of horses and cattle); native pony population genetics.

Publications

Effects of preimplantation factor on interleukin-6 and prostaglandin F2a and E2 in the bovine endometriumWonfor, R., Natoli, M., Rose, M. & Nash, D. 2017 In : Theriogenology.102, p. 174-1829 p.
Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell lineWonfor, R., Natoli, M., Shah, I., Beckmann, M., Nash, R. J. & Nash, D. 2017 In : Journal of Ethnopharmacology.209, p. 283-2875 p.
Interaction of preimplantation factor with the bovine global endometrial transcriptome.Clamp, R., Creevey, C., Natoli, M., Barnea, E. R., Nash, D. & Rose, M. 2016
Comparative genetic diversity in a sample of pony breeds from the UK and North America: A case study in the conservation of global genetic resourcesWinton, C. L., Plant, Y., Hind, P., McMahon, R., Hegarty, M., McEwan, N., Davies-Morel, M., Powell, W. & Nash, D. 2015 In : Ecology and Evolution.5, 16, p. 3507-352231 p.
Effect of preimplantation factor in an in vitro model of bovine E. coli endometritis.Clamp, R., Natoli, M., Barnea, E. R., Nash, D. & Rose, M. 2015
Effect of preimplantation factor in response to a LPS challenge on bovine endometrial IL-6 secretion and expressionClamp, R., Natoli, M., Barnea, E. R., Rose, M. & Nash, D. 2015
Effect of heterologous and homologous seminal plasma on stallion sperm quality.Morrell, J., Georgakas, A., Lundeheim, N., Nash, D. M., Davies-Morel, M. C. G. & Johannison, A. 2014 In : Theriogenology.82, p. 176-183
The validation of a novel protocol for the culture of equine endometrial epithelial and stromal cells.Ross, A., Nash, D. M. & Paddison, J. 2014 p. 58
Effect of pre-implantation factor on the secretion of prostaglandin F2α and prostaglandin E2 from bovine endometrial tissue following a lipopolysaccharide challenge in vitro.Clamp, R. E., Paddison, J. S., Nash, D. M., Rose, M. T. & Barnea, E. 2014 p. 2071 p.
Validation of a novel culture protocol for equine endometrial cells as a model to investigate uterine inflammation.Ross, A., Paddison, J. S. & Nash, D. M. 2014 p. 721 p.
Effect of Preimplanataion Factor (PIF) and lipopolysaccharide on inflammatory responses of equine endometrial explants in vitroPaddison, J. S., Nash, D. M. & Barnea, E. 2013
Equine endometrial cytology and bacteriology: Effectiveness for predicting live foaling ratesDavies-Morel, M. C. G., Lawlor, O. M. F. & Nash, D. M. 2013 In : Veterinary Journal.198, 1, p. 206-2116 p.
Genetic diversity and phylogenetic analysis of the native mountain ponies of Britain and Ireland reveal a novel rare populationWinton, C. L., Hegarty, M. J., McMahon, R., Slavov, G. T., McEwan, N. R., Davies-Morel, M. C. G., Morgan, C. T., Powell, W. & Nash, D. M. 2013 In : Ecology and Evolution.3, 4, p. 934–94714 p.
PreImplantation Factor (PIF) displays developmental-related evolving immune anti-inflammatory response of equine endometrial explants in vitroPaddison, J. S., Nash, D. M. & Barnea, E. 2013 p. 41 p.
Effect of pre-implantation factor on the secretion of prostaglandins from bovine endometrial tissue following a lipopolysaccharide challenge in vitroClamp, R., Paddison, J., Rose, M., Nash, D. & Barnea, E. R. 2013
Phylogeographic relationships between native pony populations of Britain and IrelandWinton, C. L., Hegarty, M. J., Slavov, G. T., McEwan, N. R., Davies-Morel, M. C. G., Potter, C., Powell, W. & Nash, D. M. 2012
An investigation of the role of Insulin-Like Growth Factor 1 (IGF-1) in determining adult height of the horseReader, R., Parrott, C., Hegarty, M., McEwan, N. R., Davies-Morel, M., Powell, W. & Nash, D. M. 2011 p. 175-1751 p.
A preliminary characterisation of the ecology of gut anaerobic fungal populations in horsesBirch, R., Edwards, J., Worgan, H. J., Macias, B., Stevens, P. R., Newbold, C. J. & Nash, D. M. 2011 p. 1761 p.
Characterisation of phylogeographic relationships between native pony populations of Britain and Ireland.Winton, C. L., Hegarty, M. J., McEwan, N. R., Davies-Morel, M. C. G., Powell, W. & Nash, D. M. 2011
Markers of the uterine innate immune response of the mareNash, D. M., Sheldon, I. M., Herath, S. & Lane, E. A. 2010 In : Animal Reproduction Science.119, 1-2, p. 31-399 p.
Quantitative comparison of pressure distribution exerted by different numnahs beneath the saddle of a ridden horseDickason, A., Nash, D. M., Chaffe, O. H. & McEwan, N. R. 2010 p. p106
Endometrial explant culture to study the response of equine endometrium to inseminationNash, D. M., Sheldon, I. M., Herath, S. & Lane, E. A. 2010 In : Reproduction in Domestic Animals.45, 4, p. 670-6767 p.
The effect of an endurance exercise upon kinematic parameters of the jump stride of the hind limb during take-off when jumping a cross country fenceRapkin, E. H., Guire, R., Davies-Morel, M. C. G. & Nash, D. M. 2009
The effect of Escherichia coli lipopolysaccharide and tumour necrosis factor alpha on ovarian functionWilliams, E. J., Sibley, K., Miller, A. N., Lane, E. A., Fishwick, J., Nash, D. M., Herath, S., England, G. C. W., Dobson, H. & Sheldon, I. M. 2008 In : American Journal of Reproductive Immunology.60, 5, p. 462-47312 p.
Optimisation of an Equine Endometrial Cell CulturePenaluna, L., Herath, S., Sheldon, I. M. & Nash, D. M. 2008 p. 821 p.
Endometrial Toll-like Receptor 4 (TLR4) and Interleukin-8 (IL-8) Expression in Mares Resistant (RM) or Susceptible (SM) to EndometritisCuervo-Arango, J., Worgan, H., Macías, B. & Nash, D. M. 2008 p. 751 p.
Uterine diseases in cattle after parturitionSheldon, I. M., Williams, E. J., Miller, A. N. A., Nash, D. M. & Herath, S. 2008 In : Veterinary Journal.176, 1, p. 115-1217 p.
Endometrial explant culture for characterizing equine endometritisNash, D. M., Lane, E. A., Herath, S. & Sheldon, I. M. 2008 In : American Journal of Reproductive Immunology.59, 2, p. 105-11713 p.
Characteristics of follicular development and oestrus following prostaglandin administration in maresLane, E. A. & Nash, D. M. 2008 p. 501 p.