Dr Ifat Shah BSc, PhD, PGCTHE, MRSC

Dr Ifat Shah

Senior Lecturer

Contact Details

Profile

I received my PhD at the University of Bath (England, UK), in 2001 on a thesis entitled "Novel Hypoxia-Selective Prodrugs of Radiosensitisers and Chemosensitisers" under the supervision of Professor Mike D. Threadgill (Department of Pharmacy and Pharmacology) and Dr. William J. D. Whish (Department of Biology and Biochemistry). I joined IGER in 2002 as the post-doctoral researcher on a BBSRC-LINK project (Phytochemical library from British plants 2002-2004) with a pharmaceutical industrial partner (Molecular Nature Ltd.) on the isolation and identification of natural plant products. This enabled me to expand my skills into natural product chemistry, following my PhD studies in which I trained as a synthetic medicinal chemist focusing on design, synthesis and evaluation of drugs for cancer therapy. In 2004, I was made principal investigator on a metabolomics project to develop a pre-mortem diagnostic test for transmissible spongiform encepathalopathy (TSE) diseases in sheep and cattle.I have since also worked on a project concerned with utilising a metabolomics approach to improve animal health and performance. In April 2008, I joined the Biorenewables and Environmental Change division at IBERS.

Additional Information

  • KESS PhD Studentship (07/15) - Developing oats as a source of pharmaceutical, nutraceutical and cosmetic ingredients. Ifat Parveen Shah, Kevin Shingfield, Catherine Howarth, Cark Mansell (Industrial partner)
  • Life Science Research Network Wales - National Research Network (NRN) (10/15-09/19; ?60,000): PhD Studentship: Exploiting natural products from Hops (Humulus lupulus) to suppress tuberculosis. Luis Mur, Ifat Parveen, Prof. Les Baillie.
  • Newton-Bhabha Fund, 6-month Fellowship (2015; ?5,000): Comparative metabolic profiling of Phyllanthus emblica and transgenic Arabidopsis thaliana over expressing type III Polyketide synthase. Luis Mur, Ifat Parveen Shah.
  • TETFUND Split-Site PhD (Nigeria-UK; 2015-2017; ?40,000) - The targeting and identifying clinically active natural products from Moringa. Luis Mur, Ifat Parveen.
  • BBSRC ICASE (10/15-09/19; ?90,000): Endophytic Bacteria: Co-existence and Chemical Warfare. Kerrie Farrar, Ifat Parveen.
  • HVCfP Network Fund (06/15-12/16; ?50,000) - Exploiting Oat Genetic Resources to Elevate Bioactive Avenanthramide Content. Luis Mur and Ifat Parveen, Cathy Howarth
  • Access to Masters (ATM) European Social Fund (?13,400) (10/14-10/15) - Isolation, purification and structure elucidation of antimicrobial compounds from Japanese Knotweed. Ifat Parveen Shah and Luis Mur
  • Life Science Research Network Wales - National Research Network (NRN) (10/15-09/19; ?60,000): PhD Studentship: Identifying new antimicrobial drugs in microorganisms from extreme environments. Luis Mur, Ifat Parveen Shah, Arwyn Edwards.
  • Life Science Research Network Wales - National Research Network (NRN) (10/14-09/19; ?60,000): PhD Studentships: Targeting natural products to counter the challenge of MRSA. Luis Mur and Ifat Parveen Shah
  • BBSRC Sparking Impact Award (2014; ?16,000): Maximizing the commercial opportunities of natural product-based drug discovery at Aberystwyth. Luis Mur and Ifat Parveen Shah

Teaching

Research

My research focusses on the following areas:

Green Biotechnology: High value chemicals to improve plant and human health. Antimicrobials from extremophiles. Rhizosphere and endophytic microbes to identify metabolites that promote plant growth or trigger plant defence.

Identification of chemical markers linked to key traits relevant for the biorefining industry: Chemicals in Miscanthus and oats, which are active against pests such as nematodes and pathogens and link these to specific QTLs.

Characterisation of cell wall chemistry: Synthesis of diferulates using novel synthetic routes in order to develop monoclonal antibodies characterisation of cell walls and synthesis of chromogenic substrates for identification and quantification of cell-wall enzymes.

Professional Memberships:

Secretary of the Royal Society Chemistry Mid-Wales Local Section Committee.

Collaborations:

  • Professor Michael D. Threadgill (Department of Pharmacy and Pharmacology, University of Bath).
  • Professor Mark Baird (School of Chemistry, Bangor University)
  • Dr. Mark Elliott (Cardiff School of Chemistry, Cardiff University)
  • Professor John Ralph (Department of Biochemistry, University of Wisconsin-Madison)

Publications

2017

Wonfor, R., Natoli, M., Shah, I., Beckmann, M., Nash, R.J., Nash, D. 2017. Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell line. Journal of Ethnopharmacology 10.1016/j.jep.2017.08.006

Nur-e-Alam, M., Yousaf, M., Ahmed, S., Al-Sheddi, E.S., Shah, I., Fazakerley, D., Bari, A., Ghabbour, H.A., Threadgill, M.D., Whatley, K., Hoffmann, K., Al-Rehaily, A.J. 2017. Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense. Journal of Natural Products 10.1021/acs.jnatprod.7b00188 Cadair

2016

Shah, I., Donnison, I., Insole, J., Winters, A., Dalton, S., Woodman, T., Bosch, M., Threadgill, M.D. 2016 (In press). An efficient assay for ferulic acid esterase and para-coumaric acid esterases in plants at physiologically relevant activities. Cell Chemistry and Biology 6 (5) pp. 300-311. Cadair

Mohammad, R.H., Nur e-Alam, M., Lahman, M., Shah, I., Tizzard, G.J., Coles, S.J., Fowler, M., Drake, A.F., Heyes, D., Thoss, V. 2016. Isolation and characterisation of 13 pterosins and pterosides from bracken (Pteridium aquilinum (L.) Kuhn) rhizome. Phytochemistry 128 pp. 82-94. 10.1016/j.phytochem.2016.05.001 Cadair

Belanche Gracia, A., Jones, E.L., Shah, I., Newbold, C. 2016. A metagenomics approach to evaluate the impact of dietary supplementation with Ascophyllum nodosum or Laminaria digitata on rumen function in Rusitec fermenters. Frontiers in Microbiology 7 299 10.3389/fmicb.2016.00299 Cadair

2014

Parveen, I., Wilson, T., Threadgill, M.D., Luyten, J., Roberts, R.E., Robson, P.R., Hauck, B.D., Donnison, I.S., Winters, A.L. 2014. Screening for potential co-products in a Miscanthus sinensis mapping family by liquid chromatography with mass spectrometry detection. Phytochemistry 105 pp. 186-196. 10.1016/j.phytochem.2014.05.003 Cadair

2013

Parveen Shah, I., Wilson, T., Donnison, I.S., Cookson, A.R., Hauck, B.D., Threadgill, M.D. 2013. Potential sources of high value chemicals from leaves, stems and flowers of Miscanthus sinensis 'Goliath' and Miscanthus sacchariflorus. Phytochemistry 92 pp. 160-167. 10.1016/j.phytochem.2013.04.004 Cadair

2011

Parveen, I., Threadgill, M.D., Hauck, B.D., Donnison, I.S., Winters, A.L. 2011. Isolation, identification and quantitation of hydroxycinnamic acid conjugates, potential platform chemicals, in the leaves and stems of Miscanthus x giganteus using LC-ESI-MS(n). Phytochemistry 72 (18) pp. 2376-2384. 10.1016/j.phytochem.2011.08.015 Cadair

Parveen, I., Threadgill, M.D., Hauck, B.D., Donnison, I., Winters, A.L. 2011. Isolation, identification and quantitation of hydroxycinnamic acid conjugates, potential platform chemicals, in the leaves and stems of Miscanthus × giganteus using LC–ESI-MSn. Phytochemistry 72 (18) pp. 2376-2384. 10.1016/j.phytochem.2011.08.015, Cadair

2010

Moorby, J.M., Fraser, M.D., Parveen, I., Lee, M.R.F., Wold, J.-. 2010. Comparison of 2 high-throughput spectral techniques to predict differences in diet composition of grazing sheep and cattle. Journal of Animal Science 88 (5) pp. 1905-1913. 10.2527/jas.2009-1944 Cadair

Parveen, I., Moorby, J.M., Fraser, M.D., Erban, A., Kopka, J. 2010. Relationship between grazing lamb growth rate and blood plasma analytes as profiled by gas chromatography with time-of-flight mass spectrometry (GC-TOF/MS). Journal of Agricultural and Food Chemistry 58 (2) pp. 913-917. 10.1021/jf902116m Cadair

Parveen, I., Threadgill, M.D., Moorby, J.M., Winters, A.L. 2010. Oxidative phenols in forage crops containing polyphenol oxidase enzymes. Journal of Agricultural and Food Chemistry 58 (3) pp. 1371-1382. 10.1021/jf9024294 Cadair

Hauck, B.D., Parveen, I., Gallagher, J.A., Donnison, I.S., Winters, A. 2010. Accumulation of soluble phenolic compounds in the forage grass species, cocksfoot (Dactylis glomerata L). XXVth International Conference on Polyphenols. Cadair

Parveen, I., Donnison, I.S., Threadgill, M.D., Hauck, B.D., Winters, A.L. 2010. Isolation, identification and quantification of hydroxycinnamic acid conjugates in leaf and stem tissue of Miscanthus sacchariflorus and sinensis and their potential as platform chemicals. Gordon Research Conference, 'Green Chemistry', Davidson College, Davison, North Carolina. Cadair

Parveen, I., Threadgill, M.D., Hauck, B.D., Donnison, I.S., Winters, A.L. 2010. Isolation, identification and quantification of hydroxycinnamic acid conjugates in leaf and stem tissue of Miscanthus x giganteus and their potential as platform chemicals. XXVth International Conference on Polyphenols. Cadair

2009

Parveen, I., Threadgill, M.D., Hauck, B.D., Donnison, I.S., Winters, A.L. 2009. Rapid identification of hydroxycinnamate esters in Miscanthus giganteus and Miscanthus goliath as substrates for polyphenol oxidase using ESI-MS/MS. Planta Medica 75 (9) 55th International Congress and Annual Meeting of the Society for Medicinal Plant Research and Natural Product Research. pp. 900. 10.1055/s-0029-1234318 Cadair

2008

Parveen, I., Winters, A., Threadgill, M.D., Hauck, B.D., Morris, P. 2008. Extraction, structural characterisation and evaluation of hydroxycinnamate esters of orchard grass (Dactylis glomerata) as substrates for polyphenol oxidase. Phytochemistry 69 (16) pp. 2799-2806. 10.1016/j.phytochem.2008.08.019 Cadair

Parveen, I., Morris, P., Winters, A.L., Hauck, B.D., Threadgill, M.D. 2008. Extraction, structural characterisation and evaluation of hydroxycinnamate esters of orchard grass (Dactylis glomerata) as substrates for polyphonel oxidase. Planta Medica 74 Natural products with Pharmaceutical, Nutraceutical, Cosmetic and Agrochemical interest. Joint meeting of AFERP/ASP/GA/PSE/SIF. pp. T1.51. 10.1055/s-0028-1084432 Cadair

Parveen, I., Moorby, J.M., Hirst, W.M., Morris, S.M., Fraser, M.D. 2008. Profiling of plasma and faeces by FT-IR to differentiate between heathland plant diets offered to zero-grazed sheep. Animal Feed Science and Technology 144 (1-2) pp. 65-81. 10.1016/j.anifeedsci.2007.10.002 Cadair

Parveen, I., Winters, A.L., Hauck, B.D., Morris, P. 2008. Identification of substrates of polyphenol oxidase enzyme from cocksfoot species using NMR and LCMS techniques. A young scientists symposium, Garganano. Cadair

Winters, A.L., Gill, S., Parveen, I., Sullivan, M.L., Webb, K.J. 2008. Role of red clover polyphenol oxidase in pathogen resistance. 24th International Conference on Polyphenols. Cadair

2007

Parveen, I., Moorby, J., Fraser, M., Allison, G., Kopka, J. 2007. Application of gas chromatography-mass spectrometry metabolite profiling techniques to the analysis of heathland plant diets of sheep. Journal of Agricultural and Food Chemistry 55 (4) pp. 1129-1138. 10.1021/jf062995w Cadair

2006

Parveen, I., Moorby, J.M., Fraser, M.D., Allison, G.G., Kopka, J. 2006. Application of GCMS-TOF metabolite profiling techniques to the analysis of heathland plant diets of sheep. 8th British Grassland Society Research Conference. Cadair Other

Winters, A.L., Bryant, D.N., Gallagher, J.A., Lee, M.R.F., Minchin, F.R., Parveen, I., Theodorou, M.K., Morris, P. 2006. Biochemistry and molecular biology of polyphenol oxidases in grasses. XXIII International Conference on Polyphenols, Winnipeg. Cadair

Parveen, I., Moorby, J.M., Hirst, W.M., Morris, S.M., Fraser, M.D. 2006. Profiling of plasma and faeces by FT-IR to differentiate between heathland plant diets offered to zero-grazed sheep. 8th British Grassland Society Research Conference, 'Grassland as a Multifunctional Resource. 8th British Grassland Society Research Conference. British Grassland Society pp. 101-102. Cadair

2005

Parveen, I., Moorby, J.M., Allison, G.G., Jackman, R. 2005. The use of non-prion biomarkers for the diagnosis of bovine spongiform encephalopathy and scrapie in the live animal. Veterinary Research 36 (5-6) pp. 665-683. 10.1051/vetres:2005028 Cadair

2002

Hill, K., Gescher, A.J., Perkins, S., Parveen, I., Threadgill, M.D., Williams, M.L., Sharma, R.A., Verschoyle, R.D., Steward, W.P. 2002. Chemopreventive efficacy and pharmacokinetics of curcumin in the Min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiology, Biomarkers and Prevention 11 (6) pp. 535-540. Cadair Other

Threadgill, M.D., Ferrer, S., Naughton, D.P., Parveen, I. 2002. N- and O-alkylation of isoquinolin-1-ones in the Mitsunobu reaction: Development of potential drug delivery systems. Journal of the Chemical Society, Perkin Transactions 1 pp. 335-340. 10.1039/b109776h Cadair

2000

Shah, I., Threadgill, M.D. 2000. Labelled compounds of interest as antitumour agents-VII1. [2H]- and [14C]-curcumin. Journal of Labelled Compounds and Radiopharmaceuticals 43 (9) pp. 883-889. 10.1002/1099-1344(200008)43:9<883::AID-JLCR372>3.0.CO;2-4 Cadair

1999

Shah, I., Naughton, D.P., Whish, W.J.D., Threadgill, M.D. 1999. 2-Nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: reductively triggered release of the parp inhibitor 5-bromoisoquinolinone. Bioorganic and Medicinal Chemistry Letters 9 (14) pp. 2031-2036. 10.1016/S0960-894X(99)00306-6 Cadair