Dr Ifat Parveen Shah

BSc, PhD, PGCTHE, MRSC

Dr Ifat Parveen Shah

Senior Lecturer

Institute Director of International Teaching

Contact Details

Profile

I received my PhD at the University of Bath (England, UK), in 2001 on a thesis entitled "Novel Hypoxia-Selective Prodrugs of Radiosensitisers and Chemosensitisers" under the supervision of Professor Mike D. Threadgill (Department of Pharmacy and Pharmacology) and Dr. William J. D. Whish (Department of Biology and Biochemistry). I joined IGER in 2002 as the post-doctoral researcher on a BBSRC-LINK project (Phytochemical library from British plants 2002-2004) with a pharmaceutical industrial partner (Molecular Nature Ltd.) on the isolation and identification of natural plant products. This enabled me to expand my skills into natural product chemistry, following my PhD studies in which I trained as a synthetic medicinal chemist focusing on design, synthesis and evaluation of drugs for cancer therapy. In 2004, I was made principal investigator on a metabolomics project to develop a pre-mortem diagnostic test for transmissible spongiform encepathalopathy (TSE) diseases in sheep and cattle.I have since also worked on a project concerned with utilising a metabolomics approach to improve animal health and performance. In April 2008, I joined the Biorenewables and Environmental Change division at IBERS.

Additional Information

  • KESS PhD Studentship (07/15) - Developing oats as a source of pharmaceutical, nutraceutical and cosmetic ingredients. Ifat Parveen Shah, Kevin Shingfield, Catherine Howarth, Cark Mansell (Industrial partner)
  • Life Science Research Network Wales - National Research Network (NRN) (10/15-09/19; ?60,000): PhD Studentship: Exploiting natural products from Hops (Humulus lupulus) to suppress tuberculosis. Luis Mur, Ifat Parveen, Prof. Les Baillie.
  • Newton-Bhabha Fund, 6-month Fellowship (2015; ?5,000): Comparative metabolic profiling of Phyllanthus emblica and transgenic Arabidopsis thaliana over expressing type III Polyketide synthase. Luis Mur, Ifat Parveen Shah.
  • TETFUND Split-Site PhD (Nigeria-UK; 2015-2017; ?40,000) - The targeting and identifying clinically active natural products from Moringa. Luis Mur, Ifat Parveen.
  • BBSRC ICASE (10/15-09/19; ?90,000): Endophytic Bacteria: Co-existence and Chemical Warfare. Kerrie Farrar, Ifat Parveen.
  • HVCfP Network Fund (06/15-12/16; ?50,000) - Exploiting Oat Genetic Resources to Elevate Bioactive Avenanthramide Content. Luis Mur and Ifat Parveen, Cathy Howarth
  • Access to Masters (ATM) European Social Fund (?13,400) (10/14-10/15) - Isolation, purification and structure elucidation of antimicrobial compounds from Japanese Knotweed. Ifat Parveen Shah and Luis Mur
  • Life Science Research Network Wales - National Research Network (NRN) (10/15-09/19; ?60,000): PhD Studentship: Identifying new antimicrobial drugs in microorganisms from extreme environments. Luis Mur, Ifat Parveen Shah, Arwyn Edwards.
  • Life Science Research Network Wales - National Research Network (NRN) (10/14-09/19; ?60,000): PhD Studentships: Targeting natural products to counter the challenge of MRSA. Luis Mur and Ifat Parveen Shah
  • BBSRC Sparking Impact Award (2014; ?16,000): Maximizing t

Teaching

Research

My research focusses on the following areas:

Green Biotechnology: High value chemicals to improve plant and human health. Antimicrobials from extremophiles. Rhizosphere and endophytic microbes to identify metabolites that promote plant growth or trigger plant defence.

Identification of chemical markers linked to key traits relevant for the biorefining industry: Chemicals in Miscanthus and oats, which are active against pests such as nematodes and pathogens and link these to specific QTLs.

Characterisation of cell wall chemistry: Synthesis of diferulates using novel synthetic routes in order to develop monoclonal antibodies characterisation of cell walls and synthesis of chromogenic substrates for identification and quantification of cell-wall enzymes.

Professional Memberships:

Secretary of the Royal Society Chemistry Mid-Wales Local Section Committee.

Collaborations:

  • Professor Michael D. Threadgill (Department of Pharmacy and Pharmacology, University of Bath).
  • Professor Mark Baird (School of Chemistry, Bangor University)
  • Dr. Mark Elliott (Cardiff School of Chemistry, Cardiff University)
  • Professor John Ralph (Department of Biochemistry, University of Wisconsin-Madison)

Publications

Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell lineWonfor, R., Natoli, M., Shah, I., Beckmann, M., Nash, R. J. & Nash, D. 2017 In : Journal of Ethnopharmacology.209, p. 283-2875 p.
Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemenseNur-e-Alam, M., Yousaf, M., Ahmed, S., Al-Sheddi, E. S., Shah, I., Fazakerley, D., Bari, A., Ghabbour, H. A., Threadgill, M. D., Whatley, K., Hoffmann, K. & Al-Rehaily, A. J. 2017 In : Journal of Natural Products.
An efficient assay for ferulic acid esterase and para-coumaric acid esterases in plants at physiologically relevant activitiesShah, I., Donnison, I., Insole, J., Winters, A., Dalton, S., Woodman, T., Bosch, M. & Threadgill, M. D. 2016 (Accepted/In press) In : Cell Chemistry and Biology.6, 5, p. 300-31111 p.
Isolation and characterisation of 13 pterosins and pterosides from bracken (Pteridium aquilinum (L.) Kuhn) rhizomeMohammad, R. H., Nur e-Alam, M., Lahman, M., Shah, I., Tizzard, G. J., Coles, S. J., Fowler, M., Drake, A. F., Heyes, D. & Thoss, V. 2016 In : Phytochemistry.128, p. 82-94
A metagenomics approach to evaluate the impact of dietary supplementation with Ascophyllum nodosum or Laminaria digitata on rumen function in Rusitec fermentersBelanche Gracia, A., Jones, E. L., Shah, I. & Newbold, C. 2016 In : Frontiers in Microbiology.7, 299
Screening for potential co-products in a Miscanthus sinensis mapping family by liquid chromatography with mass spectrometry detectionParveen, I., Wilson, T., Threadgill, M. D., Luyten, J., Roberts, R. E., Robson, P. R., Hauck, B. D., Donnison, I. S. & Winters, A. L. 2014 In : Phytochemistry.105, p. 186-19610 p.
Potential sources of high value chemicals from leaves, stems and flowers of Miscanthus sinensis 'Goliath' and Miscanthus sacchariflorusParveen Shah, I., Wilson, T., Donnison, I. S., Cookson, A. R., Hauck, B. D. & Threadgill, M. D. 2013 In : Phytochemistry.92, p. 160-1677 p.
Isolation, identification and quantitation of hydroxycinnamic acid conjugates, potential platform chemicals, in the leaves and stems of Miscanthus x giganteus using LC-ESI-MS(n)Parveen, I., Threadgill, M. D., Hauck, B. D., Donnison, I. S. & Winters, A. L. 2011 In : Phytochemistry.72, 18, p. 2376-23849 p.
Isolation, identification and quantitation of hydroxycinnamic acid conjugates, potential platform chemicals, in the leaves and stems of Miscanthus × giganteus using LC–ESI-MSnParveen, I., Threadgill, M. D., Hauck, B. D., Donnison, I. & Winters, A. L. 2011 In : Phytochemistry.72, 18, p. 2376-23849 p.
Comparison of 2 high-throughput spectral techniques to predict differences in diet composition of grazing sheep and cattleMoorby, J. M., Fraser, M. D., Parveen, I., Lee, M. R. F. & Wold, J. -P. 2010 In : Journal of Animal Science.88, 5, p. 1905-19139 p.
Relationship between grazing lamb growth rate and blood plasma analytes as profiled by gas chromatography with time-of-flight mass spectrometry (GC-TOF/MS)Parveen, I., Moorby, J. M., Fraser, M. D., Erban, A. & Kopka, J. 2010 In : Journal of Agricultural and Food Chemistry.58, 2, p. 913-9175 p.
Oxidative phenols in forage crops containing polyphenol oxidase enzymesParveen, I., Threadgill, M. D., Moorby, J. M. & Winters, A. L. 2010 In : Journal of Agricultural and Food Chemistry.58, 3, p. 1371-138212 p.
Accumulation of soluble phenolic compounds in the forage grass species, cocksfoot (Dactylis glomerata L).Hauck, B. D., Parveen, I., Gallagher, J. A., Donnison, I. S. & Winters, A. 2010 p. T2.03
Isolation, identification and quantification of hydroxycinnamic acid conjugates in leaf and stem tissue of Miscanthus sacchariflorus and sinensis and their potential as platform chemicalsParveen, I., Donnison, I. S., Threadgill, M. D., Hauck, B. D. & Winters, A. L. 2010
Isolation, identification and quantification of hydroxycinnamic acid conjugates in leaf and stem tissue of Miscanthus x giganteus and their potential as platform chemicalsParveen, I., Threadgill, M. D., Hauck, B. D., Donnison, I. S. & Winters, A. L. 2010 p. T5.62
Rapid identification of hydroxycinnamate esters in Miscanthus giganteus and Miscanthus goliath as substrates for polyphenol oxidase using ESI-MS/MSParveen, I., Threadgill, M. D., Hauck, B. D., Donnison, I. S. & Winters, A. L. 2009 In : Planta Medica.75, 9, p. 900
Role of red clover polyphenol oxidase in pathogen resistanceWinters, A. L., Gill, S., Parveen, I., Sullivan, M. L. & Webb, K. J. 2008 p. T3.28
Extraction, structural characterisation and evaluation of hydroxycinnamate esters of orchard grass (Dactylis glomerata) as substrates for polyphenol oxidaseParveen, I., Winters, A., Threadgill, M. D., Hauck, B. D. & Morris, P. 2008 In : Phytochemistry.69, 16, p. 2799-28068 p.
Extraction, structural characterisation and evaluation of hydroxycinnamate esters of orchard grass (Dactylis glomerata) as substrates for polyphonel oxidaseParveen, I., Morris, P., Winters, A. L., Hauck, B. D. & Threadgill, M. D. 2008 In : Planta Medica.74, p. T1.512 p.
Profiling of plasma and faeces by FT-IR to differentiate between heathland plant diets offered to zero-grazed sheepParveen, I., Moorby, J. M., Hirst, W. M., Morris, S. M. & Fraser, M. D. 2008 In : Animal Feed Science and Technology.144, 1-2, p. 65-8117 p.
Identification of substrates of polyphenol oxidase enzyme from cocksfoot species using NMR and LCMS techniquesParveen, I., Winters, A. L., Hauck, B. D. & Morris, P. 2008
Application of gas chromatography-mass spectrometry metabolite profiling techniques to the analysis of heathland plant diets of sheepParveen, I., Moorby, J., Fraser, M., Allison, G. & Kopka, J. 2007 In : Journal of Agricultural and Food Chemistry.55, 4, p. 1129-113810 p.
Application of GCMS-TOF metabolite profiling techniques to the analysis of heathland plant diets of sheepParveen, I., Moorby, J. M., Fraser, M. D., Allison, G. G. & Kopka, J. 2006 p. 103-1042 p.
Biochemistry and molecular biology of polyphenol oxidases in grassesWinters, A. L., Bryant, D. N., Gallagher, J. A., Lee, M. R. F., Minchin, F. R., Parveen, I., Theodorou, M. K. & Morris, P. 2006 p. 303-3042 p.
Profiling of plasma and faeces by FT-IR to differentiate between heathland plant diets offered to zero-grazed sheepParveen, I., Moorby, J. M., Hirst, W. M., Morris, S. M. & Fraser, M. D. 2006 8th British Grassland Society Research Conference, 'Grassland as a Multifunctional Resource.British Grassland Society, p. 101-1022 p.
The use of non-prion biomarkers for the diagnosis of bovine spongiform encephalopathy and scrapie in the live animalParveen, I., Moorby, J. M., Allison, G. G. & Jackman, R. 2005 In : Veterinary Research.36, 5-6, p. 665-683
Chemopreventive efficacy and pharmacokinetics of curcumin in the Min/+ mouse, a model of familial adenomatous polyposisHill, K., Gescher, A. J., Perkins, S., Parveen, I., Threadgill, M. D., Williams, M. L., Sharma, R. A., Verschoyle, R. D. & Steward, W. P. 2002 In : Cancer Epidemiology, Biomarkers and Prevention.11, 6, p. 535-5406 p.
N- and O-alkylation of isoquinolin-1-ones in the Mitsunobu reaction: Development of potential drug delivery systemsThreadgill, M. D., Ferrer, S., Naughton, D. P. & Parveen, I. 2002 In : Journal of the Chemical Society, Perkin Transactions 1.p. 335-3406 p.
Labelled compounds of interest as antitumour agents-VII1. [2H]- and [14C]-curcuminShah, I. & Threadgill, M. D. 2000 In : Journal of Labelled Compounds and Radiopharmaceuticals.43, 9, p. 883-889
2-Nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: reductively triggered release of the parp inhibitor 5-bromoisoquinolinoneShah, I., Naughton, D. P., Whish, W. J. D. & Threadgill, M. D. 1999 In : Bioorganic and Medicinal Chemistry Letters.9, 14, p. 2031-2036