Dr Iain Chalmers

PhD

Dr Iain Chalmers

Lecturer in Veterinary Biosciences

Contact Details

Profile

2013-present
Lecturer in Veterinary Biosciences, IBERS, Aberstwyth University, UK
2010-2013
EU-funded Post-Doctoral Research Associate, IBERS, Aberystwyth University, UK
2008-2009
Research Technician, IBERS, Aberystwyth University, UK
2002-2009
Wellcome Trust PhD programme, under supervision of Dr. Karl Hoffmann, Department of Pathology, University of Cambridge, UK
1998-2002
BSc (Hons.) Degree in Immunology, Edinburgh University, UK

Teaching

Research

My research focuses on the identification and characterisation of helminth proteins essential to the parasites survival in the host. The aim of this research is to discover novel vaccine candidates/drug targets and to also gain a deeper understanding of host/parasite interactions. Using bioinformatic approaches, my research also examines the evolution of gene families (such as the SmVAL family) across parasitic and non-parasitic species.

Publications

Whole genome analysis of a schistosomiasis-transmitting freshwater snailAdema, C. M., Hillier, L. W., Jones, C. S., Loker, E. S., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., do Amaral, L. R., Arican-Goktas, H. D., Assis, J. G., Baba, E. H., Baron, O. L., Bayne, C. J., Bickham-Wright, U., Biggar, K. K., Blouin, M., Bonning, B. C., Botka, C., Bridger, J. M., Buckley, K. M., Buddenborg, S. K., Lima Caldeira, R., Carleton, J., Carvalho, O. S., Castillo, M. G., Chalmers, I. W., Christensens, M., Clifton, S., Cosseau, C., Coustau, C., Cripps, R. M., Cuesta-Astroz, Y., Cummins, S. F., Di Stephano, L., Dinguirard, N., Duval, D., Emrich, S., Feschotte, C., Feyereisen, R., Fitzgerald, P., Fronick, C., Fulton, L., Galinier, R., Gava, S. G., Geusz, M., Geyer, K. K., Giraldo-Calderón, G. I., de Souza Gomes, M., Gordy, M. A., Gourbal, B., Grunau, C., Hanington, P. C., Hoffmann, K. F., Hughes, D., Humphries, J., Jackson, D. J., Jannotti-Passos, L. K., De Jesus Jeremias, W., Jobling, S., Kamel, B., Kapusta, A., Kaur, S., Koene, J. M., Kohn, A. B., Lawson, D., Lawton, S. P., Liang, D., Limpanont, Y., Liu, S., Lockyer, A. E., Lovato, T. L., Ludolf, F., Magrini, V., Mcmanus, D. P., Medina, M., Misra, M., Mitta, G., Mkoji, G. M., Montague, M. J., Montelongo, C., Moroz, L. L., Munoz-Torres, M. C., Niazi, U., Noble, L. R., Oliveira, F. S., Pais, F. S., Papenfuss, A. T., Peace, R., Pena, J. J., Pila, E. A., Quelais, T., Raney, B. J., Rast, J. P., Rollinson, D., Rosse, I. C., Rotgans, B., Routledge, E. J., Ryan, K. M., Scholte, L. L. S., Storey, K. B., Swain, M., Tennessen, J. A., Tomlinson, C., Trujillo, D. L., Volpi, E. V., Walker, A. J., Wang, T., Wannaporn, I., Warren, W. C., Wu, X-J., Yoshino, T. P., Yusuf, M., Zhang, S-M., Zhao, M. & Wilson, R. K. 2017 In : Nature Communications.8, p. 15451 15451 (2017)
The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoniGeyer, K., Niazi, U., Duval, D., Cosseau, C., Tomlinson, C., Chalmers, I., Swain, M., Cutress, D., Bickham-Wright, U., Munshi, S. E., Grunau, C., Yoshino, T. P. & Hoffmann, K. 2017 In : PLoS Neglected Tropical Diseases.11, 5, e0005246
Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel TreatmentChalmers, I. W., Fitzsimmons, C. M., Brown, M., Pierrot, C., Jones, F. M., Wawrzyniak, J. M., Fernandez-Fuentes, N., Tukahebwa, E. M., Dunne, D. W., Khalife, J. & Hoffmann, K. F. 2015 In : PLoS Neglected Tropical Diseases.9, 7, p. e0003920
Drug-Induced Exposure of Schistosoma mansoni Antigens SmCD59a and SmKK7Reimers, N., Homann, A., Höschler, B., Langhans, K., Wilson, R. A., Pierrot, C., Khalife, J., Grevelding, C. G., Chalmers, I. W., Yazdanbakhsh, M., Hoffmann, K. F., Hokke, C. H., Haas, H. & Schramm, G. 2015 In : PLoS Neglected Tropical Diseases.9, 3, e0003593
Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human InfectionFarnell, E. J., Tyagi, N., Ryan, S., Chalmers, I. W., Pinot de Moira, A., Jones, F. M., Wawrzyniak, J., Fitzsimmons, C. M., Tukahebwa, E. M., Furnham, N., Maizels, R. M. & Dunne, D. W. 2015 In : Frontiers in Immunology.6, p. 26
Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expressionYoshino, T. P., Brown, M., Wu, X-J., Jackson, C. J., Ocadiz-Ruiz, R., Chalmers, I. W., Kolb, M., Hokke, C. H. & Hoffmann, K. F. 2014 In : International Journal for Parasitology.44, 8, p. 551-56313 p.
Cytosine methylation is a conserved epigenetic feature found throughout the phylum PlatyhelminthesGeyer, K. K., Chalmers, I. W., MacKintosh, N. D., Hirst, J. E., Geoghegan, R., Badets, M., Brophy, P. M., Brehm, K. & Hoffmann, K. F. 2013 In : BMC Genomics.14, 462
Platyhelminth venom allergen-like (VAL) proteins: revealing structural diversity, class specific features and biological associations across the phylumChalmers, I. W. & Hoffmann, K. F. 2012 In : Parasitology.139, 10, p. 1231-124515 p.
The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responsesFitzsimmons, C. M., Jones, F. M., Stearn, A., Chalmers, I. W., Hoffmann, K. F., Wawrzyniak, J., Wilson, S., Kabatereine, N. B. & Dunne, D. W. 2012 In : PLoS Neglected Tropical Diseases.6, 4, e1593
Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoniGeyer, K. K., Rodríguez-López, C. M., Hoffmann, K. F., Chalmers, I. W., Munshi, S. E., Truscott, M., Heald, J. K., Wilkinson, M. J. & Hoffmann, K. F. 2011 In : Nature Communications.2, 424
Development and Validation of a Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma ViabilityPeak, E., Chalmers, I. W. & Hoffmann, K. F. 2010 In : PLoS Neglected Tropical Diseases.4, 7, e759
Anti-schistosomal intervention targets identified by lifecycle transcriptomic analysesFitzpatrick, J. M., Peak, E., Perally, S., Chalmers, I. W., Barrett, J., Yoshino, T. P., Ivens, A. C. & Hoffmann, K. F. 2009 In : PLoS Neglected Tropical Diseases.3, 11, e543.
Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activityFitzpatrick, J. M., Fuentes, J. M., Chalmers, I. W., Wynn, T. A., Modolell, M., Hoffmann, K. F. & Hesse, M. 2009 In : International Journal for Parasitology.39, 3, p. 267-27913 p.
Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect Schistosoma viabilityPeak, E., Chalmers, I. W. & Hoffmann, K. F. 2009
Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene familyChalmers, I. W., McArdle, A. J., Coulson, R. M. R., Wagner, M. A., Schmid, R., Hirai, H. & Hoffmann, K. F. 2008 In : BMC Genomics.9, 89
Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggsFitzsimmons, C. M., Schramm, G., Jones, F. M., Chalmers, I. W., Hoffmann, K. F., Grevelding, C. G., Wuhrer, M., Hokke, C. H., Haas, H., Doenhoff, M. J. & Dunne, D. W. 2005 In : Molecular and Biochemical Parasitology.144, 1, p. 123-1275 p.