Prof Joanne Hamilton

PhD

Prof Joanne Hamilton

Professor

Institute Director of Student Experience

Contact Details

Teaching

Module Coordinator
Tutor
Lecturer

PhD Students

Miss Rebekah Stuart (second Supervisor). IBERS funded.

Example of PhD Project

Arthropods as environmental reservoirs of potential human pathogens
Cronobacter sakazakii (formerly known as Enterobacter sakazakii) is a foodborne pathogen that causes meningitis, sepsis, or necrotizing enterocolitis in newborns, particularly affecting premature or other immunocompromised infants. Morbidity&mortality associated with C. sakazakii infection in neonates varies considerably, & mortality rates as high as 80% have been recorded. Although most documented cases involve infants, reports also describe adult infections. Whilst this organism has been susceptible to antibiotics in the past, there is concern regarding antibiotic resistance in C. sakazakii. C. sakazakii was isolated from the guts of larvae of the stable fly, Stomoxys calcitrans, demonstrating, for the first time, an environmental reservoir for C. sakazakii & raising the possibility that environmental contamination by insects may be important in the spread of this opportunistic organism (Hamilton, Lehane & Braig, 2003). This PhD project will investigate the role of arthropods as environmental reservoirs of human pathogens using a combination of entomological, molecular & bioinformatics approaches.

Joanne V. Hamilton, Michael J. Lehane, & Henk R. Braig. Isolation of Enterobacter sakazakii from Midgut of Stomoxys calcitrans. Emerg Infect Dis. 2003 Oct.

If you are interested in pursuing postgraduate research with me please contact me .

Research

My research focuses on the use of proteomic and molecular technologies to explore host- parasite interactions. My current interests are unravelling the complexities of innate immunity in a range of invertebrates and in exploring the mechanisms used by parasites to overcome the host immune system. Current projects include drug resistance mechanisms in model and parasitic nematodes; liver fluke biology; tsetse fly-trypanosome interactions; immunity in Giant African land snails; immunity in Biomphalaria sp. (an intermediate snail host involved in the transmission of schistosomiasis); schistosome biology and the role of the arthropod gut in the transmission of human pathogens.
I also have a major role in ensuring that University research becomes part of the school curriculum as Principal Investigator on the RCUK funded Schools University Partnership Initiative: SusNet Wales (Sustainability Network Wales).

SusNet Wales is a collaborative multi-disciplinary approach to delivering a "Module" in Sustainability and Social Responsibility developed, led and delivered by practising researchers within Aberystwyth University. It provides exposure to world class research to encourage young people to pursue relevant post-16 studies, establish research careers and become better informed global citizens.

Awards

  • Commendation Award House of Commons, Science Engineering and Technology for Britain.
  • BBSRC Schools Regional Champion (2011-2013)

Publications

SusNet Wales: Blended Learning Environments for Raising Ambition, Aspirations and driving Social Mobility. An invited case study for Universities UK and the UK Government’s Social Mobility Advisory Group (commissioned by RCUK and the National Coordinating Centre for Public Engagement).Hamilton, J., Grattan, J. & Hughes, P. 2016 9 p.
Life Sciences Aberystwyth University: A Blended Higher Education Environment for Raising Ambition, Aspirations and driving Social Mobility. Response to Welsh Government’s Consultation on Foundation Degrees in Wales.Hamilton, J., Davey, H. & Rose, M. 2016
A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: Case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortusHart, E., Brophy, P., Prescott, M., Bartley, D. J., Wolf, B. & Hamilton, J. V. 2015 In : Veterinary Parasitology.207, 3-4, p. 266-27510 p.
The soluble proteome phenotypes of ivermectin resistant and ivermectin susceptible Haemonchus contortus females comparedHart, E. H., Morphew, R. M., Bartley, D. J., Millares, P., Wolf, B. T., Brophy, P. M. & Hamilton, J. V. 2012 In : Veterinary Parasitology.190, 1-2, p. 104-11310 p.
Proteomic analysis of embryonic Fasciola hepatica: Characterization and antigenic potential of a developmentally regulated heat shock proteinMoxon, J. V., LaCourse, E. J., Wright, H. A., Perally, S., Prescott, M. C., Gillard, J. L., Barrett, J., Hamilton, J. V. & Brophy, P. M. 2010 In : Veterinary Parasitology.169, 1-2, p. 62-7514 p.
Proteomic analyses of Caenorhabditis elegans dauer larvae and long-lived daf-2 mutants implicates a shared detoxification system in longevity assuranceJones, L. M., Staffa, K., Perally, S., LaCourse, E. J., Brophy, P. M. & Hamilton, J. V. 2010 In : Journal of Proteome Research.9, 6, p. 2871-288111 p.
Immune responses directed at egg proteins during experimental infection with the liver fluke Fasciola hepaticaMoxon, J. V., Flynn, R., Golden, O., Hamilton, J. V., Mulcahy, G. & Brophy, P. M. 2010 In : Parasite Immunology.32, 2, p. 111-12414 p.
Proteomic analysis of the cacao pathogen Moniliophthora perniciosaPierre, S., Mur, L. A. J., Morphew, R., Hamilton, J., Scott, I. M. & Griffith, G. W. 2009
Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggsSchramm, G., Hamilton, J. V., Balog, C. I. A., Wuhrer, M., Gronow, A., Beckmann, S., Wippersteg, V., Grevelding, C. G., Goldmann, T., Weber, E., Brattig, N. W., Deelder, A. M., Dunne, D. W., Hokke, C. H., Haas, H. & Doenhoff, M. J. 2009 In : Molecular and Biochemical Parasitology.166, 1, p. 4-1411 p.
Plasticity demonstrated in the proteome of a parasitic nematode within the intestine of different host strainsMorgan, C. T., LaCourse, E. J., Rushbrook, B. J., Greetham, D., Hamilton, J. V., Barrett, J., Bailey, K. & Brophy, P. M. 2006 In : Proteomics.6, 16, p. 4633-464513 p.
Analysing proteomic dataBarrett, J., Brophy, P. M. & Hamilton, J. V. 2005 In : International Journal for Parasitology.35, 5, p. 543-55311 p.
Tsetse midgut immunity - DiGE-ESTing for clues into African sleeping sicknessHamilton, J. V. & Lehane, M. J. 2005 In : Outlooks on Pest Management.16, 1, p. 19-224 p.
Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies?Doenhoff, M. J., Chiodini, P. L. & Hamilton, J. V. 2004 In : Parasitology.20, 1, p. 35-395 p.
Adult midgut expressed sequence tags from the tsetse fly Glossina morsitans morsitans and expression analysis of putative immune response genesLehane, M. J., Aksoy, S., Gibson, W., Kerhornou, A., Berriman, M., Hamilton, J. V., Soares, M. B., Bonaldo, B. F., Lehane, S. & Hall, N. 2003 In : Genome Biology.4, R63, R63
Isolation of Enterobacter sakazakii from midgut of Stomoxys calcitransBraig, H. R., Lehane, M. J. & Hamilton, J. V. 2003 In : Emerging Infectious Diseases.9, 10, p. 1355-13562 p.
Epithelial innate immunity - A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect Stomoxys calcitransBoulanger, N., Munks, R. J. L., Hamilton, J. V., Vovelle, F., Brun, R., Lehane, M. J. & Bulet, P. 2002 In : Journal of Biological Chemistry.277, p. 49921-499266 p.
Association of midgut defensin with a novel serine protease in the blood-sucking fly Stomoxys calcitransHamilton, J. V., Munks, R. J. L., Lehane, S. M. & Lehane, M. J. 2002 In : Insect Molecular Biology.11, 3, p. 197-2059 p.