Dr Michael Rose

PhD

Dr Michael Rose

Reader

Institute Director of Learning and Teaching

Contact Details

Profile

I am an animal scientist with a particular interest in dairy cows. I graduated in 1989 with a degree in Animal Science and followed this with a PhD in 1993, where I investigated the extent of the milk yield response of dairy cows to bovine somatotropin. Following this I worked in the National Institute of Grassland and Livestock Research, Tsukuba, Japan, for several years as a research officer, where I studied the metabolic endocrinology of dairy cows. I moved to Aberystwyth University in 2000. From 2015, I have acted as Director of Learning and Teaching for IBERS.

Additional Information

I have two dogs.

Teaching

Research

I am interested in the physiology of ruminants, but especially dairy cows. With colleagues, I have a project to investigate the immunity of the endometrium and the response to endometritis in dairy cows. Additionally, with other colleagues, I have a project to identify immune markers of mastitis susceptibility in early lactation in dairy cows. Thirdly, I am working with others to model the behaviour of dairy cows using GPS and other forms of precision agriculture.

Publications

Fixed-time data segmentation and behaviour classification of pasture-based cattle: Enhancing performance using a hidden Markov modelWilliams, M. L., James, W. & Rose, M. 2017 In : Computers and Electronics in Agriculture.142, Part B, p. 585-59612 p.
Effects of preimplantation factor on interleukin-6 and prostaglandin F2a and E2 in the bovine endometriumWonfor, R., Natoli, M., Rose, M. & Nash, D. 2017 In : Theriogenology.102, p. 174-1829 p.
Energy Homeostasis by the Peripheral Serotonergic SystemWatanabe, H., Rose, M., Kanayama, Y., Shirakawa, H. & Aso, H. 2017 Seratonin - A Chemical Messenger Between All Types of Living Cells. Shad, K. F. (ed.). InTechOpen
Comparison of the microbial population in rabbits and guinea pigs by next generation sequencingCrowley, E. J., King, J. J., Wilkinson, T., Worgan, H., Huson, K. M., Rose, M. & McEwan, N. 2017 In : PLoS One.12, 2, e0165779
Cyclophilin A is a new M cell marker of bovine intestinal epitheliumHondo, T., Someya, S., Nagasawa, Y., Terada, S., Watanabe, H., Chen, X., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M., Nochi, T. & Aso, H. 2016 In : Cell and Tissue Research.364, 3, p. 585-59713 p.
A novel behavioral model of the pasture-based dairy cow from GPS data using data mining and machine learning techniquesWilliams, M., MacParthalain, N., Brewer, P., James, P. & Rose, M. 2016 In : Journal of Dairy Science.99, 3, p. 2063-2075
Serotonin Improves High Fat Diet Induced Obesity in MiceWatanabe, H., Nakano, T., Saito, R., Aksaka, D., Saito, K., Ogasawara, H., Minashima, T., Miyazawa, K., Kanaya, T., Takakura, I., Inoue, N., Ikeda, I., Chen, X., Miyake, M., kitazawa, H., Shirakawa, H., Sato, K., Tahara, K., Nagasawa, Y., Watanabe, K., Rose, M. & Aso, H. 2016 In : PLoS One.11, 1, e0147143
Interaction of preimplantation factor with the bovine global endometrial transcriptome.Clamp, R., Creevey, C., Natoli, M., Barnea, E. R., Nash, D. & Rose, M. 2016
Life Sciences Aberystwyth University: A Blended Higher Education Environment for Raising Ambition, Aspirations and driving Social Mobility. Response to Welsh Government’s Consultation on Foundation Degrees in Wales.Hamilton, J., Davey, H. & Rose, M. 2016
Extracellular cyclophilin A possesses chemotaxic activity in cattleTakanashi, S., Nochi, T., Abe, M., Itaya, N., Urakawa, M., Sato, K., Tao, Z., Uemura, S., Hayashi, T., Kiku, Y., kitazawa, H., Rose, M., Watanabe, K. & Aso, H. 2015 In : Veterinary Research.46, 80, 10 p.
Stimulatory effect of plasma samples from fattening cattle on adipogenesis-related gene expression in preadipocyte cellsWatanabe, H., Chen, X., Shoji, N., Saito, R., Nakano, T., Saito, K., Sumiyoshi, K., Rose, M., Okada, N., Watanabe, K. & Aso, H. 2015 In : Animal Science Journal.86, 7, p. 698-706
Effect of preimplantation factor in an in vitro model of bovine E. coli endometritis.Clamp, R., Natoli, M., Barnea, E. R., Nash, D. & Rose, M. 2015
Effect of preimplantation factor in response to a LPS challenge on bovine endometrial IL-6 secretion and expressionClamp, R., Natoli, M., Barnea, E. R., Rose, M. & Nash, D. 2015
Myostatin alters glucose transporter-4 (GLUT4) expression in bovine skeletal muscles and myoblasts isolated from. double-muscled (DM) and normal-muscled (NM) Japanese Shorthorn cattle.Takahashi, H., Sato, K., Yamaguchi, T., Miyake, M., Watanabe, H., Nagasawa, Y., Kitagawa, E., Terada, S., Urakawa, M., Rose, M. T., McMahon, C. D., Watanabe, K., Ohwada, S., Gotoh, T. & Aso, H. 2014 In : Domestic Animal Endocrinology.48, p. 62-688 p.
Effect of Peripheral 5-HT on Glucose and Lipid Metabolism in Wether SheepWatanabe, H., Saito, R., Nakano, T., Takahashi, H., Takahashi, Y., Sumiyoshi, K., Sato, K., Chen, X., Okada, N., Iwasaki, S., Harjanti, D. W., Sekiguchi, N., Sano, H., Kitazawa, H., Rose, M. T., Ohwada, S., Watanabe, K., Aso, H. & Vaudry, H. (ed.) 2014 In : PLoS One.9, 2, e88058
Effect of pre-implantation factor on the secretion of prostaglandin F2α and prostaglandin E2 from bovine endometrial tissue following a lipopolysaccharide challenge in vitro.Clamp, R. E., Paddison, J. S., Nash, D. M., Rose, M. T. & Barnea, E. 2014 p. 2071 p.
Dexamethasone and Acetate Modulate Cytoplasmic Leptin in Bovine PreadipocytesYonekura, S., Hirota, S., Tokutake, Y., Rose, M. T., Katoh, K. & Aso, H. 2014 In : Asian-Australasian Journal of Animal Sciences.27, 4, p. 567-5737 p.
Proliferating bovine intramuscular preadipocyte cells synthesize leptinYonekura, S., Tokutake, Y., Hirota, T., Rose, M. T., Katoh, K. & Aso, H. 2013 In : Domestic Animal Endocrinology.45, 1, p. 33-375 p.
Expression of Myostatin in Neural Cells of the Olfactory SystemIwasaki, S., Miyake, M., Watanabe, H., Kitagawa, E., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M. T. & Aso, H. 2013 In : Molecular Neurobiology.47, 1, p. 1-88 p.
Effect of pre-implantation factor on the secretion of prostaglandins from bovine endometrial tissue following a lipopolysaccharide challenge in vitroClamp, R., Paddison, J., Rose, M., Nash, D. & Barnea, E. R. 2013
Effect of growth factors on the migration of equine oral and limb fibroblasts using an in vitro scratch assayRose, M. T. 2012 In : Veterinary Journal.193, 2, p. 539-5446 p.
Effect of iodine, selenium and cobalt rumen boluses given to dry dairy cows on the immunoglobulin and thyroid hormone status of calvesRose, M. T., Pearson, S. & Cratchley, T. 2012 In : Animal Science Journal.83, 7, p. 543-5486 p.
Orally administered prion protein is incorporated by M cells and spreads into lymphoid tissues with macrophages in prion protein knockout miceTakakura, I., Miyazawa, K., Kanaya, T., Itani, W., Watanabe, K., Ohwada, S., Watanabe, H., Hondo, T., Rose, M. T., Mori, T., Sakaguchi, S., Nishida, N., Katamine, S., Yamaguchi, T. & Aso, H. 2011 In : American Journal of Pathology.179, 3, p. 1301-13099 p.
Role of peripheral serotonin in glucose and lipid metabolismWatanabe, H., Rose, M. T. & Aso, H. 2011 In : Current Opinion in Lipidology.22, 3, p. 186-1916 p.
Extracellular matrix expression by equine oral and limb fibroblasts in in vitro cultureWatts, E. J. & Rose, M. T. 2011 In : Research in Veterinary Science.92, 2, p. 213-2186 p.
Cytokeratin 18 is a specific marker of bovine intestinal M cellHondo, T., Kanaya, T., Takakura, I., Watanabe, H., Takahashi, Y., Nagasawa, Y., Terada, S., Ohwada, S., Watanabe, K., Kitazawa, H., Rose, M. T., Yamaguchi, T. & Aso, H. 2011 In : American Journal of Physiology - Gastrointestinal and Liver Physiology.300, 3, p. G442-G453
Transcytosis of murine-adapted Bovine Spongiform Encephalopathy agents in an in vitro bovine M cell modelMiyazawa, K., Kanaya, T., Takakura, I., Tanaka, S., Hondo, T., Watanabe, H., Rose, M. T., Kitazawa, H., Yamaguchi, T., Katamine, S., Nishida, N. & Aso, H. 2010 In : Journal of Virology.84, 23, p. 12285-122917 p.
Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnoverWatanabe, H., Akasaka, D., Ogasawara, H., Sato, K., Miyake, M., Saito, K., Takahashi, Y., Kanaya, T., Takakura, I., Hondo, T., Chao, G., Rose, M. T., Ohwada, S., Watanabe, K., Yamaguchi, T. & Aso, H. 2010 In : Endocrinology.151, 10, p. 4776-478611 p.
Platelet-derived growth factor acts via both the Rho-kinase and p38 signaling enzymes to stimulate contraction in an in vitro model of equine wound healingWatts, E. J. & Rose, M. T. 2010 In : Domestic Animal Endocrinology.38, 4, p. 253-2597 p.
Behaviour of growing lambs housed on straw or woodchip bedding materials and their preference for floor typeWolf, B. T., Molloy, H. R. B., Trayte, M. J. & Rose, M. T. 2010 In : Applied Animal Behaviour Science.124, 1-2, p. 45-506 p.
Characterization of newly established bovine intestinal epithelial cell lineMiyazawa, K., Hondo, T., Kanaya, T., Tanaka, S., Takakura, I., Itani, W., Rose, M. T., Kitazawa, H., Yamaguchi, T. & Aso, H. 2010 In : Histochemistry and Cell Biology.133, 1, p. 125-13410 p.
Comparison of extracellular matric production in equine oral mucosal and dermal limb fibroblastsWatts, E. J. & Rose, M. T. 2009
Relationship between the milk yield response to short-term bovine somatotropin treatment and the lipolytic response to adrenaline in dairy cowsRose, M. T., Weekes, T. E. C. & Rowlinson, P. 2009 In : Domestic Animal Endocrinology.36, 1, p. 24-318 p.
Equine limb and oral fibroblasts in in vitro models of cell proliferation and wound contractionWatts, E. & Rose, M. 2009 p. 1919 p.
Anterior Pituitary Progenitor Cells Express Costimulatory Molecule 4Ig-B7-H31Nagai, Y., Aso, H., Ogasawara, H., Tanaka, S., Taketa, Y., Watanabe, K., Ohwada, S., Rose, M. T., Kitazawa, H. & Yamaguchi, T. 2008 In : Journal of Immunology.181, 9, p. 6073–60819 p.
Differentiation of a murine intestinal epithelial cell line (MIE) towards the M cell lineageKanaya, T., Miyazawa, K., Takakura, I., Itani, W., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M. T., McConochie, H. R., Okano, H., Yamaguchi, T. & Aso, H. 2008 In : American Journal of Physiology - Gastrointestinal and Liver Physiology.295, 2, p. G273-G28412 p.
Development of a laboratory model to test natural products for wound healing properties in horsesRose, M. T., Van Houten, B. H. G. W. & Watts, E. J. 2008 IBERS Knowledge-based Innovations, 1, 8, p. 39-413 p.
The effects of the use of straw or woodchip bedding materials on the behaviour of lambsWolf, B. T. & Rose, M. T. 2008 Unknown Publisher. (Report to Hybu Cig Cymru)
A combination of octanoate and oleate promotes in vitro differentiation of porcine intramuscular adipocytesSanosaka, M., Minashima, T., Suzuki, K., Watanabe, K., Ohwada, S., Hagino, A., Rose, M. T., Yamaguchi, T. & Aso, H. 2008 In : Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology.149, 2, p. 285-2928 p.
Cell signalling pathways controlling contraction of platelet-derived growth factor stimulated fibroblast populated collagen matrices as a model of wound contractionRose, M. T., Van Houten, B. H. G. W. & Watts, E. J. 2008 In : Equine Veterinary Journal.
Staining patterns for actin and villin distinguish M cells in bovine follicle-associated epitheliumKanaya, T., Aso, H., Miyazawa, K., Kido, T., Minashima, T., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M. T. & Yamaguchi, T. 2007 In : Research in Veterinary Science.82, 2, p. 141-1499 p.
Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and miceMiyazawa, K., Kanaya, T., Tanaka, S., Takakura, I., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M. T., Sakaguchi, S., Katamine, S., Yamaguchi, T. & Aso, H. 2007 In : Histochemistry and Cell Biology.127, 3, p. 291-30111 p.
Effect of the level of iodine in the diet of pregnant ewes on the concentration of immunoglobulin G in the plasma of neonatal lambs following the consumption of colostrumRose, M. T., Wolf, B. T. & Haresign, W. 2007 In : British Journal of Nutrition.97, 2, p. 315-3206 p.
Mechanism of plasma glutathione peroxidase production in bovine adipocytesYamasaki, T., Tahara, K., Takano, S., Inoue-Murayama, M., Rose, M. T., Minashima, T., Aso, H. & Ito, S. 2006 In : Cell and Tissue Research.326, 1, p. 139-1479 p.
Identification of bovine dendritic cell phenotype from bovine peripheral bloodMiyazawa, K., Aso, H., Honda, M., Kido, T., Minashima, T., Kanaya, T., Watanabe, K., Ohwada, S., Rose, M. T. & Yamaguchi, T. 2006 In : Research in Veterinary Science.81, 1, p. 40-456 p.
Apoptotic process of porcine intestinal M cellsMiyazawa, K., Aso, H., Kanaya, T., Kido, T., Minashima, T., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M. T., Tahara, K., Yamasaki, T. & Yamaguchi, T. 2006 In : Cell and Tissue Research.323, 3, p. 425-4328 p.
The long road to a representative model of bovine lactation in dairy cowsMcConochie, H. R. & Rose, M. T. 2006 In : Journal of Integrated Field Science.3, p. 67-726 p.
Growth hormone acts on the synthesis and secretion of alpha-casein in bovine mammary epithelial cellsSakamoto, K., Komatsu, T., Kobayashi, T., Rose, M. T., Aso, H., Hagino, A. & Obara, Y. 2005 In : Journal of Dairy Research.72, 3, p. 264-2707 p.
Correlation of blood and milk components with the milk yield response to bovine somatotropin in dairy cowsRose, M. T., Weekes, T. E. C. & Rowlinson, P. 2005 In : Domestic Animal Endocrinology.28, 3, p. 296-30712 p.
Individual variation in the milk yield response to bovine somatotropin in dairy cowsRose, M. T., Weekes, T. E. C. & Rowlinson, P. 2004 In : Journal of Dairy Science.87, 7, p. 2024-20318 p.
Cloning and expression of type XII collagen isoforms during bovine adipogenesisTahara, K., Aso, H., Yamasaki, T., Rose, M. T., Takasuga, A., Sugimoto, Y., Yamaguchi, T. & Takano, S. 2004 In : Differentiation.72, 4, p. 113-12210 p.
Mammary specific function of a bovine mammary epithelial cell clone cultured on collagen I coated insertsMcConochie, H. R., Rose, M. T., Haresign, W. & Davies, B. 2004 In : Journal of Animal and Feed Sciences.13, Supplement 1, p. 523-5264 p.
The profile of gene expression during bovine adipogenesis: Cloning and expression of type XII collagen isoformsAso, H., Tahara, K., Yamasaki, T., Rose, M. T., Kido, T., Minashima, T., Miyazawa, K., Hayashi, S., Sanosaka, M., Watanabe, K., Ohwada, S. & Yamaguchi, T. 2004 In : Journal of Animal and Feed Sciences.13, Supp. 1, p. 369-3724 p.
Role of caveolin-1 and cytoskeletal proteins, actin and vimentin, in adipogenesis of bovine intramuscular preadipocyte cellsTakenouchi, T., Miyashita, N., Ozutsumi, K., Rose, M. T. & Aso, H. 2004 In : Cell Biology International.28, 8-9, p. 615-239 p.
In vitro differentiation of a cloned bovine mammary epithelial cellRose, M. T., Aso, H., Yonekura, S., Komatsu, T., Hagino, A., Ozutsumi, K. & Obara, Y. 2002 In : Journal of Dairy Research.69, 3, p. 345-35511 p.
Effects of heat exposure on adrenergic modulation of insulin and glucagon secretion in sheepItoh, F., Hodate, K., Koyama, S., Rose, M. T., Matsumoto, M., Ozawa, A. & Obara, Y. 2001 In : Endocrine Journal.48, 2, p. 193-1986 p.
Sequence of IGF-I, IGF-II, and HGF expression in regenerating skeletal muscleHayashi, S., Aso, H., Watanabe, S., Nara, H., Rose, M. T., Ohwada, S. & Yamaguchi, T. 2000 In : Histochemistry and Cell Biology.122, 5, p. 427-4348 p.
Effect of alpha 1-acidic glycoprotein in the ascitic fluid of cancer patients on human NK cells: selective suppression of interferon-induced NK activationAso, H., Tamura, K., Rose, M. T., Tomioka, Y., Mizugaki, M. & Ishida, N. 1999 In : Inflammation.23, 2, p. 117-2913 p.
A 63 kDa tumor necrosis factor inhibitor released from a human monocytic leukemia cell line, THP-1Aso, H., Yoshite, O., Tomioka, Y., Rose, M. T. & Mizugaki, M. 1999 In : Microbiology and Immunology.43, 1, p. 53-597 p.
Heat influences on plasma insulin and glucagon in response to secretogogues in non-lactating dairy cowsItoh, F., Obara, Y., Rose, M. T. & Fuse, H. 1998 In : Domestic Animal Endocrinology.15, 6, p. 499-51012 p.
Insulin and glucagon secretion in lactating cows during heat exposureItoh, F., Obara, Y., Rose, M. T., Fuse, H. & Hashimoto, H. 1998 In : Journal of Animal Science.76, 8, p. 2182-21898 p.
Effects of heat exposure on plasma insulin, glucagon and metabolites in response to nutrient injection in heifersItoh, F., Obara, Y., Fuse, H., Rose, M. T., Osaka, I. & Takahashi, H. 1998 In : Comparative Biochemistry and Physiology - Part C: Pharmacology, Toxicology and Endocrinology.119, 2, p. 157-648 p.
Insulin-independent glucose uptake in growth hormone treated dairy cowsRose, M. T., Itoh, F., Matsumoto, M., Takahashi, Y. & Obara, Y. 1998 In : Journal of Dairy Research.65, 3, p. 423-319 p.
Effect of glucose-dependent insulinotropic polypeptide on whole-body glucose utilization in sheepRose, M. T., Itoh, F. & Takahashi, Y. 1998 In : Experimental Physiology.83, 6, p. 783-9210 p.
Non-insulin- and insulin-mediated glucose uptake in dairy cowsRose, M. T., Obara, Y., Itoh, F., Hashimoto, H. & Takahashi, Y. 1997 In : Journal of Dairy Research.64, 3, p. 341-35313 p.
Growth hormone does not affect non-insulin-mediated glucose uptake in sheepRose, M. T., Obara, Y., Itoh, F., Hashimoto, H. & Takahashi, Y. 1997 In : Experimental Physiology.82, 4, p. 749-76012 p.
Effect of growth hormone-releasing factor on the response to insulin of cows during early and late lactationRose, M. T., Obara, Y., Fuse, H., Itoh, F., Ozawa, A., Takahashi, Y., Hodate, K. & Ohashi, S. 1996 In : Journal of Dairy Science.79, 10, p. 1734-4512 p.