Dr Russ Morphew

PhD

Dr Russ Morphew

Senior Lecturer

Institute Director of Marketing and Recruitment

Contact Details

Teaching

Research

Current research is aimed at utilising modern high resolution proteomic technologies and mass spectrometry to investigate protein function and interactions. This work has focussed upon microbial-host interactions and the proteins that act upon this interface. In particular, how proteins can facilitate the invasion, establishment or colonisation of an organism within a host. Present research focuses upon the interaction of ruminant bacteria upon ingested forage using proteomics to uncover proteins involved in bacterial colonisation, plant protein degradation and the metabolic pathways involved. Also of interest are parasitic helminths of economic importance including the liver flukes Fasciola hepatica and F. gigantica, nematodes Haemonchus contortus and Teladorsagia circumcincta and the model nematode Caenorhabditis elegans. Recent research using high resolution proteomics has focussed upon vaccine discovery and the development and response to anthelmintic stress and metabolism. The main driver of future research is to increase our understanding of how proteins interact with other proteins within the same organism, between organisms, within a host or with a forage. How proteins interact with ligands such as anthelmintics and metabolites are also of interest, including how proteins function in the metabolism and action of anthelmintics and ultimately anthelmintic resistance.

Publications

Morphew, RM, Barrett, J & Brophy, PM 2006, Flatworm parasite proteomics. in J N (ed.), in. CABI Publishing, pp. 327-.
Tyson, F, Allen, T, Pennington, C, Brophy, P, Thomas, E & Morphew, R 2017, 'Worms at the Royal Welsh Show' Veterinary Record, vol 181, no. 14, pp. 376-377. DOI: 10.1136/vr.j4548
Pierre, S, Griffith, G, Morphew, R, Mur, L & Scott, I 2017, 'Saprotrophic proteomes of biotypes of the witches’ broom pathogen Moniliophthora perniciosa' Fungal Biology, vol 121, no. 9, pp. 743-753. DOI: 10.1016/j.funbio.2017.05.004
Livingstone, P, Morphew, R & Whitworth, D 2017, 'Myxobacteria are able to prey broadly upon clinically-relevant pathogens, exhibiting a prey range which cannot be explained by phylogeny' Frontiers in Microbiology, vol 8, 1593. DOI: 10.3389/fmicb.2017.01593
Morphew, R, Wilkinson, T, MacKintosh, N, Jahndel, V, Paterson, S, McVeigh, P, Abbas Abidi, SM, Saifullah, K, Raman, M, Ravikumar , G, LaCourse, EJ, Maule, AG & Brophy, P 2016, 'Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species' Journal of Proteome Research, vol 15, no. 9, pp. 3308-3321. DOI: 10.1021/acs.jproteome.6b00331
Hart, E, Onime, LA, Davies, T, Morphew, R & Kingston-Smith, A 2016, 'The effects of PPO activity on the proteome of ingested red clover and implications for improving the nutrition of grazing cattle' Journal of Proteomics, vol 141, pp. 67-76. DOI: 10.1016/j.jprot.2016.04.023
McCammick, E, McVeigh, P, McCusker, P, Timson, D, Morphew, R, Brophy, P, Marks, N, Mousley, A & Maule, A 2016, 'Calmodulin disruption impacts growth and motility in juvenile liver fluke' Parasites & Vectors, vol 9, 46. DOI: 10.1186/s13071-016-1324-9
Huson, KM, Brophy, P, Morphew, R & MacKintosh, N 2015, 'Identification of the rumen fluke Calicophoron daubneyi infecting cattle in Wales' Advances in Animal Biosciences, vol 6, no. Special Issue 02, pp. 183.
Ahammed Shareef, PA, Brennan, GP, McVeigh, P, Hannan Khan, MA, Morphew, RM, Mousley, A, Marks, NJ, Khalid Saifullah, MK, Brophy, PM, Maule, AG & Abidi, SMA 2014, 'Time-dependent tegumental surface changes in juvenile Fasciola gigantica in response to triclabendazole treatment in goat' Acta Tropica, vol 136, pp. 108-117. DOI: 10.1016/j.actatropica.2014.04.011
Morphew, RM, MacKintosh, ND, Hart, EH, Prescott, M, LaCourse, EJ & Brophy, PM 2014, 'In vitro biomarker discovery in the parasitic flatworm Fasciola hepatica for monitoring chemotherapeutic treatment' EuPA Open Proteomics, vol 3, pp. 85-99. DOI: 10.1016/j.euprot.2014.02.013
McVeigh, P, McCammick, E, McCusker, P, Morphew, RM, Mousley, A, Abidi, A, Saifullah, KM, Muthusamy, R, Gopalakrishnan, R, Spithill, TW, Dalton, JP, Brophy, PM, Marks, NJ & Maule, AG 2014, 'RNAi dynamics in juvenile Fasciola spp. liver flukes reveals the persistence of gene silencing in vitro' PLoS Neglected Tropical Diseases, vol 8, no. 9, 0003185.
Morphew, RM, Hamilton, CM, Wright, HA, Dowling, DJ, O'Neill, SM & Brophy, PM 2013, 'Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica resleased by Nonident P40' Veterinary Parasitology, vol 191, no. 3-4, pp. 379–385. DOI: 10.1016/j.vetpar.2012.08.029
Hart, EH, Morphew, RM, Bartley, DJ, Millares, P, Wolf, BT, Brophy, PM & Hamilton, JV 2012, 'The soluble proteome phenotypes of ivermectin resistant and ivermectin susceptible Haemonchus contortus females compared' Veterinary Parasitology, vol 190, no. 1-2, pp. 104-113. DOI: 10.1016/j.vetpar.2012.06.009
Brophy, PM, Mackintosh, N & Morphew, RM 2012, 'Anthelmintic metabolism in parasitic helminths: proteomic insights' Parasitology, vol 139, no. 9, pp. 1205-1217. DOI: 10.1017/S003118201200087X
LaCourse, EJ, Perally, S, Morphew, RM, Moxon, JV, Prescott, MC, Dowling, DJ, O'Neill, SM, Kipar, A, Hetzel, U, Hoey, E, Zafra, R, Buffoni, L, Arévalo, JP & Brophy, PM 2012, 'The Sigma Class glutathione transferase from the liver fluke Fasciola hepatica' PLoS Neglected Tropical Diseases, vol 6, no. 5, e1666, pp. n/a. DOI: 10.1371/journal.pntd.0001666
Morphew, RM, Eccleston, N, Wilkinson, TJ, McGarry, J, Perally, S, Prescott, M, Ward, D, Williams, D, Paterson, S, Raman, M, Ravikumar, G, Khalid Saifullah, M, Abbas Abidi, SM, McVeigh, P, Maule, AG, Brophy, PM & LaCourse, EJ 2012, 'Proteomics and in silico approaches to extend understanding of the glutathione transferase superfamily of the tropical liver fluke Fasciola gigantica' Journal of Proteome Research, vol 11, no. 12, pp. 5876–5889. DOI: 10.1021/pr300654w
Morphew, RM, Wright, HA, LaCourse, EJ, Porter, J, Barrett, J, Woods, DJ & Brophy, PM 2011, 'Towards delineating functions within the fasciola secreted cathepsin L protease family by integrating in vivo based sub-proteomics and phylogenetics' PLoS Neglected Tropical Diseases, vol 5, no. 1, e-937. DOI: 10.1371/journal.pntd.0000937
Pierre, S, Mur, LAJ, Morphew, R, Hamilton, J, Scott, IM & Griffith, GW 2009, 'Proteomic analysis of the cacao pathogen Moniliophthora perniciosa' 16th International Cocoa Research Conference, Bali, Indonesia, 2009 - 2009, .
Hamilton, CM, Dowling, DJ, Loscher, CE, Morphew, RM, Brophy, PM & O'Neill, SM 2009, 'The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function' Infection and Immunity, vol 77, no. 6, pp. 2488-2498. DOI: 10.1128/IAI.00919-08
Morphew, RM, Wright, HA, LaCourse, EJ, Woods, DJ & Brophy, PM 2007, 'Comparative proteomics of excretory-secretory proteins released by the liver fluke Fasciola hepatica in sheep host bile and during in vitro culture ex host' Molecular and Cellular Proteomics, vol 6, pp. 963-972. DOI: 10.1074/mcp.M600375-MCP200
Chemale, G, Morphew, RM, Moxon, JV, Morassuti, AL, LaCourse, EJ, Barrett, J, Johnston, DA & Brophy, PM 2006, 'Proteomic analysis of glutathione transferases from the liver fluke parasite, Fasciola hepatica' Proteomics, vol 6, no. 23, pp. 6263-6273. DOI: 10.1002/pmic.200600499