|Delivery Type||Delivery length / details|
|Lecture||5 x 1 hour lectures per week|
|Practical||2 x 3 hour practicals|
|Other||2 x 3 hour revision sessions|
|Assessment Type||Assessment length / details||Proportion|
|Semester Assessment||2 x workshop reports||25%|
|Semester Assessment||Group work||25%|
|Semester Exam||2 Hours Written examination||50%|
|Supplementary Assessment||2 Hours Students must take elements of assessment equivalent to those that led to failure of the module.||100%|
On successful completion of this module students should be able to:
1. Describe key signaling pathways and gene expression regulatory mechanisms and discuss the impact of the former on the latter
2. Describe the regulation of adhesion and migration and its role in development and cancer
3. Describe the impact of cancer molecular biology on treatment and outcomes
4. Discuss the mechanisms underpinning the ageing process
5. Discuss the importance of stem cells and the regulation of pluripotency v. differentiation
6. Compare and contrast the processes involved in cancer progression and development
7. Analyse raw developmental data and produce a summary and draw conclusions
8. Critically interpret published data and analyse key published experiments
The importance of cell signaling and its impact on differential gene expression will serve as an introduction to the module (building on the material in BR10310). This introductory section will also examine the regulation of cell migration and programmed cell death. These basic principles will then be put into context by examining the role they play in early embryo development, aging and cancer formation and treatment and plant cell biology.
In the section on the development of the early embryo we will examine how signals and differential gene expression are important for determining the basic body pattern of embryos as diverse as those of a fly and a human, determining the fates of individual cells in the embryo, and regulating the movements of cells required to form a complex organism.
Cell fate (differentiation) and movement are two key factors in the development of cancer and, in the final part of the module, we will examine how problems with signaling and differential gene expression can lead to cancer and show how many of the process that are features of early development are also crucial for the growth and spread of cancer. How this understanding impacts on treatments and outcomes will also be discussed.
Plant molecular cell biology will also be discussed focusing on special aspects of signaling and gene expression. The experimental and commercial manipulation of these will be addressed.
Two lectures will be set aside to allow staff to discuss relevant topical subjects. This will vary from year to year depending on recent research. It may involve IBERS staff talking about their own research work or be based on events in the media.
Workshops will use a variety of video, virtual and data interpretation exercises to reinforce and expand on the taught material. In addition students will work in groups to develop websites based on cancer molecular biology topics.
The module will also feature a 2 hour session involving an invited speaker who will talk about her or his work in a field related to the topic and discuss career paths with students.
|Skills Type||Skills details|
|Application of Number||Analysis of data, calculation of basic descriptive stats and production of appropriate graphical representations|
|Communication||Production of succinct and professional reports within strict word limits and to a pre-set format. Production of professional, accessible web resources.|
|Improving own Learning and Performance|
|Information Technology||Production of a professional and accessible cancer topic website.|
|Personal Development and Career planning||Opportunity to hear about a career related to the topic and question an invited speaker about career paths|
|Problem solving||Critical analysis of published data and approaches to resolution of conflicts in the literature. Developing and testing hypotheses.|
|Subject Specific Skills|
|Team work||Working together as a team, keeping minutes, organizing regular meetings, identifying and using the strengths of each member|
Reading ListEssential Reading
Lodish, Harvey et. al. (2007) Molecular Cell Biology 6th Edition W. H. Freeman Primo search Neal, Anthony J. et al. (2008) Clinical Oncology, Basic Principles and Practice 4th Edition Hodder Arnold Primo search
This module is at CQFW Level 5