Module Identifier BS33720  
Module Title GENOMICS AND BIOINFORMATICS  
Academic Year 2002/2003  
Co-ordinator Dr Michael K Winson  
Semester Semester 1  
Other staff Dr Gerard J Bishop, Dr Hywel D Griffiths, Dr James R Jefferies, Dr Leighton Pritchard, Professor Michael Young, Dr Roy Goodacre  
Pre-Requisite BS10910 or external equivalent, BS22520 , BS22720  
Course delivery Lecture   24 Hours  
  Seminars / Tutorials   6 Hours  
  Other   10 Hours Workshop. 5 x 2hours workshops  
Assessment Semester Exam   2 Hours Essays and data interpretation   60%  
  Semester Assessment   Poster presentation and Essay Poster presentation during the 8th week of Semester 1, and essay to be submitted during 12th week of Semester 1.   40%  
  Supplementary Exam   2 Hours    
  Supplementary Assessment   Essays and data interpretation (plus resubmission of failed coursework or an alternative)    

Learning outcomes

On completion of this applied module, students

? will appreciate current research strategies for gene discovery and determining gene function (genomics) and biological data analysis and interpretation (bioinformatics)
? will have practical experience and knowledge of the concepts underlying database access, sequence analysis, protein classification and functional assignment
?   will be able to utilise bioinformatics resources, including websites and software tools, to analyse gene and protein sequences
?   will have experience of presenting the results of bioinformatic analysis of gene and protein sequences in a research poster format to a mixed audience
?   will appreciate the range of computational methods being used to interpret functional genomics data
?   will appreciate the role that genomics and bioinformatics has to play in modern medicine
?   will be aware of the current status of the human genome project and its context in society.

Aims

This module is an integrated series of lectures, seminars and workshops covering the key expanding disciplines of genomics and bioinformatics. Genomics is a family of 'information technologies' for biology that are being used to obtain interpret and exploit the complete sequences of the chromosomes and genomes of organisms ranging from bacteria to man.
Bioinformatics encompasses the methodologies (particularly computational) enabling the analysis and integration of information made available by structural, physiological taxonomic and genomic studies with the ultimate goal of assigning functions to genes. The results emerging from these two disciplines will inform new predictive strategies to identify new and useful genes and potential drug targets, understand gene behaviour, and develop novel therapeutic products. The module will provide both theoretical and practical training in laboratory-based genomics and computational biology.

Content

The lectures cover the following topics:

Reading Lists

Books
** Recommended Text
Trends Supplement. (1998) Trends guide to bioinformatics. Elsevier Science.
Attwood, T.K. & Parry-Smith, D.J.. Introdution to Bioinformatics. Addison Wesley Longman Higher Education. 0582327881
Baxevanis, A.d. & Ouelletee, B.F. eds. (1998) A practical guide to the analysis of genes and proteins. Wiley.
Lewin, B.. (1999) Genes VII. Oxford University Press. 0198792778
Brown, T.A. (1999) Genomes. Bio Scientific Publishers Ltd.