Dr David Whitworth

PhD, FRSB, SFHEA

Dr David Whitworth

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My research focuses on the myxobacterial predator Myxococcus xanthus and how it preys upon other microbes. We are studying natural myxobacterial isolates using a variety of genomic, proteomic and phenotypic techniques to identify the genes conferring antimicrobial activity. Particular topics of interest include the predatory vesicles shed by myxobacteria, and myxobacterial signalling pathways and how they alter behaviour in response to a changing environment. In particular, I am interested in the social and predatory myxobacteria, and how they use two-component signalling pathways to co-ordinate group behaviour.

Publications

Stamou, GP, . Monokrousos, N, Gwynn-Jones, D, Whitworth, D & Paptheodorou, EM 2019, 'A polyphasic approach for assessing eco-system connectivity demonstrates that perturbation remodels network architecture in soil microcosms' Microbial Ecology. https://doi.org/10.1007/s00248-019-01367-x
Sengupta, K, Swain, M, Livingstone, P, Whitworth, D & Saha, P 2019, 'Genome Sequencing and Comparative Transcriptomics Provide a Holistic View of 4-Nitrophenol Degradation and Concurrent Fatty Acid Catabolism by Rhodococcus sp. Strain BUPNP1' Frontiers in Microbiology, vol. 9, 3209. https://doi.org/10.3389/fmicb.2018.03209
Sutton, D, Livingstone, P, Furness, E, Swain, M & Whitworth, D 2019, 'Genome-wide identification of myxobacterial predation genes and demonstration of formaldehyde secretion as a potentially predation-resistant trait of Pseudomonas aeruginosa' Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2019.02650
Marshall, R & Whitworth, D 2019, 'Is “Wolf‐Pack” Predation by Antimicrobial Bacteria Cooperative? Cell Behaviour and Predatory Mechanisms Indicate Profound Selfishness, Even when Working Alongside Kin' BioEssays, vol. 41, no. 4, 1800247. https://doi.org/10.1002/bies.201800247
Livingstone, P, Morphew, R, Cookson, A & Whitworth, D 2018, 'Genome Analysis, Metabolic Potential, and Predatory Capabilities of Herpetosiphon llansteffanense sp. nov.' Applied and Environmental Microbiology, vol. 84, no. 22, e01040-18. https://doi.org/10.1128/AEM.01040-18
More publications on the Research Portal