Dr Helen Whiteland

Dr Helen Whiteland

PDRA - Hit Discovery for Schistosomiasis


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Crusco, A, Whiteland, H, Baptista, R, Forde-Thomas, JE, Beckmann, M, Mur, LAJ, Nash, RJ, Westwell, AD & Hoffmann, KF 2019, 'Antischistosomal Properties of Sclareol and Its Heck-Coupled Derivatives: Design, Synthesis, Biological Evaluation and Untargeted Metabolomics' ACS Infectious Diseases. https://doi.org/10.1021/acsinfecdis.9b00034
Whatley, K, Padalino, G, Whiteland, H, Geyer, KK, Hulme, BJ, Chalmers, I, Forde-Thomas, J, Ferla, S, Brancale, A & Hoffmann, K 2019, 'The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets' PLoS Neglected Tropical Diseases, vol. 13, no. 11, e0007693. https://doi.org/10.1371/journal.pntd.0007693
Whiteland, H, Chakroborty, A, Forde-Thomas, J, Crusco, A, Cookson, A, Hollinshead, J, Fenn, C, Bartholomew, B, Holdsworth, PA, Fisher, M, Nash, RJ & Hoffmann, K 2018, 'An Abeis procera - Derived tetracyclic triterpene containing a steroid-like core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni' International Journal for Parasitology: Drugs and Drug Resistance, vol. 8, no. 3, pp. 465-474. https://doi.org/10.1016/j.ijpddr.2018.10.009
Crusco, A, Bordoni, C, Chakroborty, A, Whatley, KCL, Whiteland, H, Westwell, AD & Hoffmann, K 2018, 'Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues' European Journal of Medicinal Chemistry, vol. 152, pp. 87-100. https://doi.org/10.1016/j.ejmech.2018.04.032
Geyer, K, Munshi, SE, Whiteland, H, Fernandez-Fuentes, N, Phillips, D & Hoffmann, K 2018, 'Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni' PLOS Pathogens, vol. 14, no. 6, e1007107. https://doi.org/10.1371/journal.ppat.1007107
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