Dr Manfred Beckmann PhD

Dr Manfred Beckmann

Lecturer

Contact Details

Profile

Dr Beckmann obtained his doctorate in analytical chemistry at the C.v.O. University Oldenburg, Germany, on the identification of pheromones in marine polychaetes. Since then he has contributed as a marine chemical ecologist to the understanding of chemical communication and antifouling (HKUST, Hongkong), to measure and estimate production of green house gases in wetlands (Cardiff University) and to the investigatigation of metabolic changes in GM-crops, during host-pathogen interactions and dietary effects on mammalian biofluids (Aberystwyth).

He is now a research lecturer and Metabolomics Champion in the High Resolution Metabolomics Laboratory at Aberystwyth University. His research interests are in high through-put ultra-high resolution Metabolomics of difficult matrices and 'real world samples'.

Teaching

Research

Current research activities focus on Metabolomics: the non-targeted and comprehensive analysis of all metabolites in biological material detecting unforeseen metabolic changes.

Metabolomics is the sum of a well designed and performed experiment, sampling strategies, sample preparation, instrumental analysis, raw data conversion, signal processing, data analysis, and data interpretation.
The outcome of a Metabolomics experiment and interpretability of data very much depend on all members of a skilled team and their tools. In order to minimize sources of variability and bias, robust methods and protocols have been developed in a team effort orchestrated by Prof. John Draper at IBERS over the last 15 years, and are the subject of future activities.

As an analytical chemist I am interested in maximising the information content of Metabolomics data through signal processing and data mining, metabolite identification and characterisation of unknown signals. I am responsible for the functionality of the IBERS High Resolution Metabolomics Laboratory and concerned with method development and optimisation of the following Metabolomics techniques:

  • High through-put ultra-high resolution Flow Infusion Electrospray Mass Spectrometry (FIE-MS)
  • High through-put ultra-high resolution LC-MS
  • High through-put GC-tof-MS
  • Metabolite targeted analysis and quantification.

I am particularly interested in applying Metabolomics methodologies to study the effect of diet on urinary and plasma metabolome and resulting changes in physiology. In collaboration with clinical/veterinary institutions in academia and industry, we are currently determining dietary exposure and individual responses to diet constituents in humans and domesticated animals. A key mission is the search for biomarkers of 'health and wellbeing'.

Publications

2017

Wonfor, R., Natoli, M., Shah, I., Beckmann, M., Nash, R.J., Nash, D. 2017. Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell line. Journal of Ethnopharmacology

López-Álvarez, D., Zubair, H., Beckmann, M., Draper, J., Catalán, P. 2017. Diversity and association of phenotypic and metabolomic traits in the close model grasses Brachypodium distachyon, B. stacei and B. hybridum. Annals of Botany 119 (4) pp. 545-561. Cadair

Garcia-Perez, I., Posma, J.M., Gibson, R., Chambers, E.S., Hanson, T.H., Vestergaard, H., Hansen, T., Beckmann, M., Pedersen, O., Elliott, P., Stamler, J., Nicholson, J.K., Draper, J., Mathers, J.C., Holmes, E., Frost, G. 2017. Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial. Lancet Diabetes and Endocrinology 5 (3) pp. 184-195. Cadair

Lloyd, A., Beckmann, M., Wilson, T., Tailliart, K., Allaway, D., Draper, J. 2017. Ultra High Performance Liquid Chromatography-High Resolution Mass Spectrometry plasma lipidomics can distinguish between canine breeds despite uncontrolled environmental variability and non-standardized diets: Plasma lipidome of dog breeds using UHPLC-HRM. Metabolomics 13 15 Cadair

2016

Wilson, T., Willis, N.D., Zubair, H., Beckmann, M., Xie, L., Tailliart, K., Lloyd, A., Mathers, J.C., Draper, J. 2016. Developing community-based urine sampling methods to facilitate dietary exposure biomarker technology for population assessment. Proceedings of the Nutrition Society 75 (OCE3) E240 Nutrition Society Summer Meeting. Cadair

Lloyd, A.J., Zubair, H., Willis, N.D., Wilson, T., Xie, L., Tailliart, K., Chambers, E.S., Garcia-Perez, I., Holmes, E., Frost, G., Mathers, J.C., Beckmann, M., Draper, J. 2016. Quantification of dietary biomarkers in spot urine samples reflects the intake of foods of UK high public health importance. Proceedings of the Nutrition Society 75 (OCE3) E248 Nutrition Society Summer Meeting. Cadair

Cameron, S., Lewis, K.E., Beckmann, M., Allison, G., Ghosal, R., Lewis, P.D., Mur, L. 2016. The metabolomic detection of lung cancer biomarkers in sputum. Lung Cancer 94 pp. 88-95. Cadair

Lloyd, A., Beckmann, M., Tailliart, K., Brown, W.Y., Draper, J., Allaway, D. 2016. Characterisation of the main drivers of intra- and inter- breed variability in the plasma metabolome of dogs. Metabolomics 12 (4) 72 Cadair

Garcia-Perez, I., Posma, J.M., Chambers, E.S., Nicholson, J.K., Mathers, J.C., Beckmann, M., Draper, J., Holmes, E., Frost, G. 2016. An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake. Journal of Agricultural and Food Chemistry 64 (11) pp. 2423-2431. Cadair

Beckmann, M., Joosen, A.M., Clarke, M.M., Mugridge, O., Frost, G., Engel, B., Tailliart, K., Lloyd, A., Draper, J., Lodge, J.K. 2016. Changes in the human plasma and urinary metabolome associated with acute dietary exposure to sucrose and the identification of potential biomarkers of sucrose intake. Molecular Nutrition and Food Research 60 (2) pp. 444-457. Cadair

2015

Tumilty, L., Thatcher, R., Beckmann, M., Davison, G. 2015. No effect of oral tyrosine administration on mood and motivation or heart rate variability during endurance performance in the heat. 19th Annual Congress of the European College of Sport Science. Cadair

2014

Tumilty, L., Davison, G., Beckmann, M., Thatcher, R. 2014. Failure of oral tyrosine supplementation to improve exercise performance in the heat. Medicine and Science in Sports and Exercise 46 (7) pp. 1417-25. Cadair

Tumilty, L., Thatcher, R., Beckmann, M., Davison, G. 2014. Acute oral tyrosine supplementation does not prevent the decline in maximal handgrip force in hyperthermic subjects. 19th Annual Congress of the European College of Sport Science. Cadair

2013

Beckmann, M., Lloyd, A.J., Halder, S., Seal, C., Brandt, K., Draper, J. 2013. Hydroxylated phenylacetamides derived from bioactive benzoxazinoids are bioavailable in humans after habitual consumption of whole grain sourdough rye bread. Molecular Nutrition and Food Research 57 (10) pp. 1859-1873. Cadair

Beckmann, M., Lloyd, A., Halder, S., Fave, G., Seal, C., Brandt, K., Mathers, J.C., Draper, J. 2013. Dietary exposure biomarker-lead discovery based on Metabolomics analysis of urine samples. Proceedings of the Nutrition Society 72 (3) pp. 352-361. Cadair

Tumilty, L., Davison, G., Beckmann, M., Thatcher, R. 2013. Acute oral administration of a tyrosine and phenylalanine-free amino acid mixture reduces exercise capacity in the heat. European Journal of Applied Physiology European Journal of Applied Physiology and Occupational Physiology 113 (6) pp. 1511-1522. Cadair

Draper, J., Lloyd, A.J., Goodacre, R., Beckmann, M. 2013. Flow infusion electrospray ionisation mass spectrometry for high throughput, non-targeted metabolite fingerprinting: A Review. Metabolomics 9 (1 Supplement) pp. S4–S29. Cadair

Lloyd, A.J., Beckmann, M., Haldar, S., Seal, C., Brandt, K., Draper, J. 2013. Data-driven strategy for the discovery of potential urinary biomarkers of habitual dietary exposure. American Journal of Clinical Nutrition 97 (2 ) pp. 377-389. Cadair

2012

Allwood, J.W., Parker, D., Beckmann, M., Draper, J., Goodacre, R. 2012. Fourier transform ion cyclotron resonance mass spectrometry for plant metabolite profiling and metabolite identification. Methods in Molecular Biology. Springer Nature pp. 157-176. Cadair

Belanche Gracia, A., Beckmann, M., Moorby, J.M., De La Fuente Oliver, G., Newbold, C.J. 2012. Effects of changing rumen protozoa populations in sheep on plasma metabolomic profiles. 8th INRA-RRI International Symposium on Gut Microbiology, Clermont Ferrand, France. Cadair

Tumilty, L., Davison, G., Beckmann, M., Thatcher, R. 2012. Acute oral tyrosine administration does not improve exercise performance in the heat in man. The Biomedical Basis of Elite Performance. Cadair

Graupels, F., Sarioglu, H., Beckmann, M., Hause, B., Spannagl, M., Draper, J., Lindermayr, C., Durner, J. 2012. Deciphering systemic wound responses of the pumpkin extrafascicular phloem by metabolomics and stable isotope-coded protein labeling (ICPL). Plant Physiology 160 (4) pp. 2285-99. Cadair

Rodriguez Lopez, C.M., Morán, P., Lago, F., Espiñeira, M., Beckmann, M., Olmo, S.C.D. 2012. Detection and quantification of tissue of origin in salmon and veal products using methylation sensitive AFLPs. Food Chemistry 131 (4) pp. 1493-1498. Cadair

2011

Favé, G., Beckmann, M., Lloyd, A., Zhou, S., Harold, G., Lin, W., Tailliart, K., Xie, L., Draper, J., Mathers, J.C. 2011. Development and validation of a standardized protocol to monitor human dietary exposure by metabolite fingerprinting of urine samples. Metabolomics 7 (4) pp. 469-484.

Tumilty, L., Davison, G., Beckmann, M., Thatcher, R. 2011. Oral tyrosine supplementation improves exercise capacity in the heat. European Journal of Applied Physiology European Journal of Applied Physiology and Occupational Physiology 111 (12) pp. 2941-2950. Cadair

Lloyd, A.J., Beckmann, M., Favé, G., Mathers, J.C., Draper, J. 2011. Proline betaine and its biotransformation products in fasting urine samples are potential biomarkers of habitual citrus fruit consumption. British Journal of Nutrition 106 (6) pp. 812-824.

Lloyd, A.J., Favé, G., Beckmann, M., Lin, W., Tailliart, K., Xie, L., Mathers, J.C., Draper, J. 2011. Use of mass spectrometry fingerprinting to identify urinary metabolites after consumption of specific foods. American Journal of Clinical Nutrition 94 (4) pp. 981-991. Cadair

Primrose, S., Draper, J., Elsom, R., Kirkpatrick, V., Mathers, J.C., Seal, C., Beckmann, M., Haldar, S., Beattie, J.H., Lodge, J.K., Jenab, M., Keun, H., Scalbert, A. 2011. Workshop Report Metabolomics and human nutrition. British Journal of Nutrition 105 (8) pp. 1277-1283. Cadair

Tumilty, L., Davison, G., Beckmann, M., Thatcher, R. 2011. A tyrosine and phenylalanine-free amino acid mixture decreases exercise capacity in the heat. The British Association of Sport and Exercise Sciences Conference 2011. Cadair

2010

Ward, J.L., Forcat, S., Beckmann, M., Bennett, M., Miller, S.J., Baker, J.M., Hawkins, N.D., Vermeer, C.P., Lu, C., Lin, W., Truman, W.M., Beale, M.H., Draper, J., Mansfield, J.W., Grant, M. 2010. The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato. Plant Journal 63 (3) pp. 443-457.

Beckmann, M., Enot, D.P.L., Overy, D.P., Scott, I.M., Jones, P.G., Allaway, D., Draper, J. 2010. Metabolite fingerprinting of urine suggests breed-specific dietary metabolism differences in domestic dogs. British Journal of Nutrition 103 (8) pp. 1127-1138.

Tumilty, L., Davison, G., Beckmann, M., Thatcher, R. 2010. Oral tyrosine supplementation improves exercise capacity in the heat. BASES 2010 Annual Student Conference. Cadair

2009

Parker, D.A., Beckmann, M., Zubair, H., Enot, D.P.L., Caracuel-Rios, Z., Overy, D.P., Snowdon, S., Talbot, N.J., Draper, J. 2009. Metabolomic analysis reveals a common pattern of metabolic re-programming during invasion of three host plant species by Magnaporthe grisea. Plant Journal 59 (5) pp. 723-737.

Draper, J., Enot, D.P.L., Parker, D.A., Beckmann, M., Snowdon, S., Lin, W., Zubair, H. 2009. Metabolite signal identification in accurate mass metabolomics data with MZedDB, an interactive m/z annotation tool utilising predicted ionisation behaviour 'rules'. BMC Bioinformatics 10 (227) 227

Favé, G., Beckmann, M., Draper, J., Mathers, J.C. 2009. Measurement of dietary exposure: a challenging problem which may be overcome thanks to metabolomics? Genes and Nutrition 4 (2) pp. 135-141.

Tumilty, L., Davison, G., Beckmann, M., Thatcher, R. 2009. Oral tyrosine supplementation improves exercise capacity in the heat. 6th Wales Institute of Sport, Health and Exercise Science Conference. Cadair

2008

Aon, M.A., Roussel, M.R., Cortassa, S., O'Rourke, B., Murray, D.B., Beckmann, M., Lloyd, D. 2008. The Scale-Free Dynamics of Eukaryotic Cells. PLoS One 3 (11) e3624 Cadair

Overy, D.P., Enot, D.P.L., Tailliart, K., Jenkins, H.A., Parker, D.A., Beckmann, M., Draper, J. 2008. Explanatory signal interpretation and metabolite identification strategies for nominal mass FIE-MS metabolite fingerprints. Nature Protocols 3 pp. 471-485.

Parker, D., Beckmann, M., Enot, D.P., Overy, D.P., Rios, Z.C., Gilbert, M., Talbot, N., Draper, J. 2008. Rice blast infection of Brachypodium distachyon as a model system to study dynamic host/pathogen interactions. Nature Protocols 3 pp. 435-445.

Beckmann, M., Parker, D.A., Enot, D.P.L., Duval, E., Draper, J. 2008. High throughput, non-targeted metabolite fingerprinting using nominal mass Flow Injection Electrospray Mass Spectrometry. Nature Protocols 3 pp. 486-504. Cadair

Enot, D.P., Lin, W., Beckmann, M., Parker, D., Overy, D.P., Draper, J. 2008. Preprocessing, classification modeling and feature selection using flow injection electrospray mass spectrometry metabolite fingerprint data. Nature Protocols 3 pp. 446-470.

2007

Enot, D.P., Beckmann, M., Draper, J. 2007. Detecting a difference - assessing generalisability when modelling metabolome fingerprint data in longer term studies of genetically modified plants. Metabolomics 3 (3) pp. 335-347.

Beckmann, M., Enot, D.P., Overy, D.P., Draper, J. 2007. Representation, comparison, and interpretation of metabolome fingerprint data for total composition analysis and quality trait investigation in potato cultivars. Journal of Agricultural and Food Chemistry 55 (9) pp. 3444-3451.

Murray, D.B., Beckmann, M., Kitano, H. 2007. Regulation of yeast oscillatory dynamics. Proceedings of the National Academy of Sciences of the United States of America 104 (7) pp. 2241-2246.

Jenkins, H.A., Beckmann, M., Draper, J., Hardy, N.W. 2007. GC-MS Peak Labeling Under ArMet. In B. J. Nikolau., E. S. Wurtele. (eds) Concepts in Plant Metabolomics. Springer Nature, Dordrecht pp. 19-28.

2006

Enot, D.P., Beckmann, M., Overy, D.P., Draper, J. 2006. Predicting interpretability of metabolome models based on behavior, putative identity, and biological relevance of explanatory signals. Proceedings of the National Academy of Sciences of the United States of America 103 (40) pp. 14865-14870.

Huang, W., Hopper, D.J., Goodacre, R., Beckmann, M., Singer, A., Draper, J. 2006. Rapid characterization of microbial biodegradation pathways by FT-IR spectroscopy. Journal of Microbiological Methods 67 (2) pp. 273-280.

Enot, D.P., Beckmann, M., Draper, J. 2006. On the interpretation of high throughput MS based metabolomics fingerprints with Random Forest. Second International Symposium, CompLife 2006, Cambridge, UK, September 27-29, 2006. Proceedings. International Symposium, CompLife. Springer Nature pp. 226-235.

2005

Huang, W., Goodacre, R., Elliott, G.N., Beckmann, M., Worgan, H., Bailey, M.J., Williams, P.A., Scullion, J., Draper, J. 2005. The use of chemical profiling for monitoring metabolic changes in artificial soil slurries caused by horizontal gene transfer. Metabolomics pp. 305-315.

Catchpole, G., Beckmann, M., Enot, D.P.L., Mondhe, M., Zywicki, B., Taylor, J., Hardy, N.W., Smith, A.R., King, R.D., Kell, D.B., Fiehn, O., Draper, J. 2005. Hierarchical metabolomics demonstrates substantial compositional similarity between genetically-modified and conventional potato crops. Proceedings of the National Academy of Sciences of the United States of America 102 (40) pp. 14458-14462.

Muller, C.T., Priesnitz, F.M., Beckmann, M. 2005. Pheromonal communication in nereids and the likely intervention by petroleum derived pollutants. Integrative and Comparative Biology 45 (1) pp. 189-193.

2004

Jenkins, H.A., Hardy, N.W., Beckmann, M., Draper, J., Smith, A.R., Taylor, J., Fiehn, O., Goodacre, R., Bino, R.J., Hall, R.D., Kopka, J., Lane, G.A., Lange, M., Liu, J.R., Mendes, P., Nikolau, B.J., Oliver, S.G., Paton, N.W., Rhee, S., Roessner-Tunali, U., Saito, K., Smedsgaard, J., Sumner, L.W., Wang, T., Walsh, S., Wurtele, E.S., Kell, D.B. 2004. A proposed framework for the description of plant metabolomics experiments and their results. Nature Biotechnology 22 (12) pp. 1601-1606.

2002

Draper, J., Darby, R.M., Beckmann, M., Maddison, A.L., Mondhe, M., Sheldrick, C., Taylor, J., Goodacre, R., Kell, D.B. 2002. Metabolic Engineering, metabolite profiling and machine learning to investigate the phloem-mobile signal in systemic acquired resistance in tobacco.

2001

Beckmann, M., Lloyd, D. 2001. Mass spectrometric monitoring of gases (CO2, CH4, O-2) in a mesotrophic peat core from Kopparas Mire, Sweden. Global Change Biology 7 (2) pp. 171-180.