Dr Manfred Beckmann


Dr Manfred Beckmann


Contact Details


Dr Beckmann obtained his doctorate in analytical chemistry at the C.v.O. University Oldenburg, Germany, on the identification of pheromones in marine polychaetes. Since then he has contributed as a marine chemical ecologist to the understanding of chemical communication and antifouling (HKUST, Hongkong), to measure and estimate production of green house gases in wetlands (Cardiff University) and to the investigatigation of metabolic changes in GM-crops, during host-pathogen interactions and dietary effects on mammalian biofluids (Aberystwyth).

He is now a research lecturer and Metabolomics Champion in the High Resolution Metabolomics Laboratory at Aberystwyth University. His research interests are in high through-put ultra-high resolution Metabolomics of difficult matrices and 'real world samples'.



Current research activities focus on Metabolomics: the non-targeted and comprehensive analysis of all metabolites in biological material detecting unforeseen metabolic changes.

Metabolomics is the sum of a well designed and performed experiment, sampling strategies, sample preparation, instrumental analysis, raw data conversion, signal processing, data analysis, and data interpretation.
The outcome of a Metabolomics experiment and interpretability of data very much depend on all members of a skilled team and their tools. In order to minimize sources of variability and bias, robust methods and protocols have been developed in a team effort orchestrated by Prof. John Draper at IBERS over the last 15 years, and are the subject of future activities.

As an analytical chemist I am interested in maximising the information content of Metabolomics data through signal processing and data mining, metabolite identification and characterisation of unknown signals. I am responsible for the functionality of the IBERS High Resolution Metabolomics Laboratory and concerned with method development and optimisation of the following Metabolomics techniques:

  • High through-put ultra-high resolution Flow Infusion Electrospray Mass Spectrometry (FIE-MS)
  • High through-put ultra-high resolution LC-MS
  • High through-put GC-tof-MS
  • Metabolite targeted analysis and quantification.

I am particularly interested in applying Metabolomics methodologies to study the effect of diet on urinary and plasma metabolome and resulting changes in physiology. In collaboration with clinical/veterinary institutions in academia and industry, we are currently determining dietary exposure and individual responses to diet constituents in humans and domesticated animals. A key mission is the search for biomarkers of 'health and wellbeing'.


Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824)Baptista, R., Fazakerley, D. M., Beckmann, M., Baillie, L. & Mur, L. A. J. 2018 In : Scientific Reports.8, 1, p. 50841 p., 5084
Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell lineWonfor, R., Natoli, M., Shah, I., Beckmann, M., Nash, R. J. & Nash, D. 2017 In : Journal of Ethnopharmacology.209, p. 283-2875 p.
Diversity and association of phenotypic and metabolomic traits in the close model grasses Brachypodium distachyon, B. stacei and B. hybridumLópez-Álvarez, D., Zubair, H., Beckmann, M., Draper, J. & Catalán, P. 2017 In : Annals of Botany.119, 4, p. 545-561
Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trialGarcia-Perez, I., Posma, J. M., Gibson, R., Chambers, E. S., Hanson, T. H., Vestergaard, H., Hansen, T., Beckmann, M., Pedersen, O., Elliott, P., Stamler, J., Nicholson, J. K., Draper, J., Mathers, J. C., Holmes, E. & Frost, G. 2017 In : Lancet Diabetes and Endocrinology.5, 3, p. 184-195
Ultra High Performance Liquid Chromatography-High Resolution Mass Spectrometry plasma lipidomics can distinguish between canine breeds despite uncontrolled environmental variability and non-standardized diets: Plasma lipidome of dog breeds using UHPLC-HRMLloyd, A., Beckmann, M., Wilson, T., Tailliart, K., Allaway, D. & Draper, J. 2017 In : Metabolomics.13, 15
Developing community-based urine sampling methods to facilitate dietary exposure biomarker technology for population assessmentWilson, T., Willis, N. D., Zubair, H., Beckmann, M., Xie, L., Tailliart, K., Lloyd, A., Mathers, J. C. & Draper, J. 2016 In : Proceedings of the Nutrition Society.75, OCE3, E240
Quantification of dietary biomarkers in spot urine samples reflects the intake of foods of UK high public health importanceLloyd, A. J., Zubair, H., Willis, N. D., Wilson, T., Xie, L., Tailliart, K., Chambers, E. S., Garcia-Perez, I., Holmes, E., Frost, G., Mathers, J. C., Beckmann, M. & Draper, J. 2016 In : Proceedings of the Nutrition Society.75, OCE3, E248
The metabolomic detection of lung cancer biomarkers in sputumCameron, S., Lewis, K. E., Beckmann, M., Allison, G., Ghosal, R., Lewis, P. D. & Mur, L. 2016 In : Lung Cancer.94, p. 88-958 p.
Characterisation of the main drivers of intra- and inter- breed variability in the plasma metabolome of dogsLloyd, A., Beckmann, M., Tailliart, K., Brown, W. Y., Draper, J. & Allaway, D. 2016 In : Metabolomics.12, 4, 72
An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape IntakeGarcia-Perez, I., Posma, J. M., Chambers, E. S., Nicholson, J. K., Mathers, J. C., Beckmann, M., Draper, J., Holmes, E. & Frost, G. 2016 In : Journal of Agricultural and Food Chemistry.64, 11, p. 2423-24319 p.
Changes in the human plasma and urinary metabolome associated with acute dietary exposure to sucrose and the identification of potential biomarkers of sucrose intakeBeckmann, M., Joosen, A. M., Clarke, M. M., Mugridge, O., Frost, G., Engel, B., Tailliart, K., Lloyd, A., Draper, J. & Lodge, J. K. 2016 In : Molecular Nutrition and Food Research.60, 2, p. 444-457
Dietary compliance in a human intervention study investigating the impact of specific foods on urinary metabolitesWillis, N. D., Dodds, S. E., Lloyd, A. J., Xie, L., Chambers, E. S., Garcia-Perez, I., Frost, G., Beckmann, M., Draper, J. & Mathers, J. C. 2015 In : Proceedings of the Nutrition Society.74, OCE1, 1 p., E127
No effect of oral tyrosine administration on mood and motivation or heart rate variability during endurance performance in the heatTumilty, L., Thatcher, R., Beckmann, M. & Davison, G. 2015
Failure of oral tyrosine supplementation to improve exercise performance in the heatTumilty, L., Davison, G., Beckmann, M. & Thatcher, R. 2014 In : Medicine and Science in Sports and Exercise.46, 7, p. 1417-259 p.
Acute oral tyrosine supplementation does not prevent the decline in maximal handgrip force in hyperthermic subjectsTumilty, L., Thatcher, R., Beckmann, M. & Davison, G. 2014
Hydroxylated phenylacetamides derived from bioactive benzoxazinoids are bioavailable in humans after habitual consumption of whole grain sourdough rye breadBeckmann, M., Lloyd, A. J., Halder, S., Seal, C., Brandt, K. & Draper, J. 2013 In : Molecular Nutrition and Food Research.57, 10, p. 1859-187315 p.
Dietary exposure biomarker-lead discovery based on Metabolomics analysis of urine samplesBeckmann, M., Lloyd, A., Halder, S., Fave, G., Seal, C., Brandt, K., Mathers, J. C. & Draper, J. 2013 In : Proceedings of the Nutrition Society.72, 3, p. 352-36110 p.
Acute oral administration of a tyrosine and phenylalanine-free amino acid mixture reduces exercise capacity in the heatTumilty, L., Davison, G., Beckmann, M. & Thatcher, R. 2013 In : European Journal of Applied Physiology.113, 6, p. 1511-152212 p.
Flow infusion electrospray ionisation mass spectrometry for high throughput, non-targeted metabolite fingerprinting: A ReviewDraper, J., Lloyd, A. J., Goodacre, R. & Beckmann, M. 2013 In : Metabolomics.9, 1 Supplement, p. S4–S2926 p.
Data-driven strategy for the discovery of potential urinary biomarkers of habitual dietary exposureLloyd, A. J., Beckmann, M., Haldar, S., Seal, C., Brandt , K. & Draper, J. 2013 In : American Journal of Clinical Nutrition.97 , 2 , p. 377-38912 p.
Deciphering systemic wound responses of the pumpkin extrafascicular phloem by metabolomics and stable isotope-coded protein labeling (ICPL).Graupels, F., Sarioglu, H., Beckmann, M., Hause, B., Spannagl, M., Draper, J., Lindermayr, C. & Durner, J. 2012 In : Plant Physiology.160, 4, p. 2285-9915 p.
Detection and quantification of tissue of origin in salmon and veal products using methylation sensitive AFLPsRodriguez Lopez, C. M., Morán, P., Lago, F., Espiñeira, M., Beckmann, M. & Olmo, S. C. D. 2012 In : Food Chemistry.131, 4, p. 1493-14986 p.
Fourier transform ion cyclotron resonance mass spectrometry for plant metabolite profiling and metabolite identificationAllwood, J. W., Parker, D., Beckmann, M., Draper, J. & Goodacre, R. 2012 Methods in Molecular Biology.Springer Nature, p. 157-17620 p.
Effects of changing rumen protozoa populations in sheep on plasma metabolomic profilesBelanche Gracia, A., Beckmann, M., Moorby, J. M., De La Fuente Oliver, G. & Newbold, C. J. 2012
Acute oral tyrosine administration does not improve exercise performance in the heat in manTumilty, L., Davison, G., Beckmann, M. & Thatcher, R. 2012 p. 93
Development and validation of a standardized protocol to monitor human dietary exposure by metabolite fingerprinting of urine samplesFavé, G., Beckmann, M., Lloyd, A., Zhou, S., Harold, G., Lin, W., Tailliart, K., Xie, L., Draper, J. & Mathers, J. C. 2011 In : Metabolomics.7, 4, p. 469-48416 p.
Oral tyrosine supplementation improves exercise capacity in the heatTumilty, L., Davison, G., Beckmann, M. & Thatcher, R. 2011 In : European Journal of Applied Physiology.111, 12, p. 2941-295010 p.
Proline betaine and its biotransformation products in fasting urine samples are potential biomarkers of habitual citrus fruit consumptionLloyd, A. J., Beckmann, M., Favé, G., Mathers, J. C. & Draper, J. 2011 In : British Journal of Nutrition.106, 6, p. 812-82413 p.
Use of mass spectrometry fingerprinting to identify urinary metabolites after consumption of specific foodsLloyd, A. J., Favé, G., Beckmann, M., Lin, W., Tailliart, K., Xie, L., Mathers, J. C. & Draper, J. 2011 In : American Journal of Clinical Nutrition.94, 4, p. 981-99111 p.
Workshop Report Metabolomics and human nutritionPrimrose, S., Draper, J., Elsom, R., Kirkpatrick, V., Mathers, J. C., Seal, C., Beckmann, M., Haldar, S., Beattie, J. H., Lodge, J. K., Jenab, M., Keun, H. & Scalbert, A. 2011 In : British Journal of Nutrition.105, 8, p. 1277-12837 p.
A tyrosine and phenylalanine-free amino acid mixture decreases exercise capacity in the heatTumilty, L., Davison, G., Beckmann, M. & Thatcher, R. 2011
The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato.Ward, J. L., Forcat, S., Beckmann, M., Bennett, M., Miller, S. J., Baker, J. M., Hawkins, N. D., Vermeer, C. P., Lu, C., Lin, W., Truman, W. M., Beale, M. H., Draper, J., Mansfield, J. W. & Grant, M. 2010 In : Plant Journal.63, 3, p. 443-45715 p.
Metabolite fingerprinting of urine suggests breed-specific dietary metabolism differences in domestic dogsBeckmann, M., Enot, D. P. L., Overy, D. P., Scott, I. M., Jones, P. G., Allaway, D. & Draper, J. 2010 In : British Journal of Nutrition.103, 8, p. 1127-113812 p.
Oral tyrosine supplementation improves exercise capacity in the heatTumilty, L., Davison, G., Beckmann, M. & Thatcher, R. 2010 p. 181
Metabolomic analysis reveals a common pattern of metabolic re-programming during invasion of three host plant species by Magnaporthe griseaParker, D. A., Beckmann, M., Zubair, H., Enot, D. P. L., Caracuel-Rios, Z., Overy, D. P., Snowdon, S., Talbot, N. J. & Draper, J. 2009 In : Plant Journal.59, 5, p. 723-73715 p.
Metabolite signal identification in accurate mass metabolomics data with MZedDB, an interactive m/z annotation tool utilising predicted ionisation behaviour 'rules'Draper, J., Enot, D. P. L., Parker, D. A., Beckmann, M., Snowdon, S., Lin, W. & Zubair, H. 2009 In : BMC Bioinformatics.10, 227, 227
Measurement of dietary exposure: a challenging problem which may be overcome thanks to metabolomics?Favé, G., Beckmann, M., Draper, J. & Mathers, J. C. 2009 In : Genes and Nutrition.4, 2, p. 135-1417 p.
Oral tyrosine supplementation improves exercise capacity in the heatTumilty, L., Davison, G., Beckmann, M. & Thatcher, R. 2009
Rice blast infection of Brachypodium distachyon as a model system to study dynamic host/pathogen interactionsParker, D., Beckmann, M., Enot, D. P., Overy, D. P., Rios, Z. C., Gilbert, M., Talbot, N. & Draper, J. 2008 In : Nature Protocols.3, p. 435-44511 p.
High throughput, non-targeted metabolite fingerprinting using nominal mass Flow Injection Electrospray Mass SpectrometryBeckmann, M., Parker, D. A., Enot, D. P. L., Duval, E. & Draper, J. 2008 In : Nature Protocols.3, p. 486-50419 p.
Preprocessing, classification modeling and feature selection using flow injection electrospray mass spectrometry metabolite fingerprint dataEnot, D. P., Lin, W., Beckmann, M., Parker, D., Overy, D. P. & Draper, J. 2008 In : Nature Protocols.3, p. 446-47025 p.
The Scale-Free Dynamics of Eukaryotic CellsAon, M. A., Roussel, M. R., Cortassa, S., O'Rourke, B., Murray, D. B., Beckmann, M. & Lloyd, D. 2008 In : PLoS One.3, 11, p. n/a e3624
Explanatory signal interpretation and metabolite identification strategies for nominal mass FIE-MS metabolite fingerprintsOvery, D. P., Enot, D. P. L., Tailliart, K., Jenkins, H. A., Parker, D. A., Beckmann, M. & Draper, J. 2008 In : Nature Protocols.3, p. 471-48515 p.
Detecting a difference - assessing generalisability when modelling metabolome fingerprint data in longer term studies of genetically modified plantsEnot, D. P., Beckmann, M. & Draper, J. 2007 In : Metabolomics.3, 3, p. 335-34713 p.
Representation, comparison, and interpretation of metabolome fingerprint data for total composition analysis and quality trait investigation in potato cultivarsBeckmann, M., Enot, D. P., Overy, D. P. & Draper, J. 2007 In : Journal of Agricultural and Food Chemistry.55, 9, p. 3444-34518 p.
Regulation of yeast oscillatory dynamicsMurray, D. B., Beckmann, M. & Kitano, H. 2007 In : Proceedings of the National Academy of Sciences of the United States of America.104, 7, p. 2241-22466 p.
GC-MS Peak Labeling Under ArMetJenkins, H. A., Beckmann, M., Draper, J. & Hardy, N. W. 2007 Concepts in Plant Metabolomics. Nikolau, B. J. & Wurtele, E. S. (eds.). Dordrecht: Springer Nature, p. 19-2810 p.
Predicting interpretability of metabolome models based on behavior, putative identity, and biological relevance of explanatory signalsEnot, D. P., Beckmann, M., Overy, D. P. & Draper, J. 2006 In : Proceedings of the National Academy of Sciences of the United States of America.103, 40, p. 14865-148706 p.
Rapid characterization of microbial biodegradation pathways by FT-IR spectroscopyHuang, W., Hopper, D. J., Goodacre, R., Beckmann, M., Singer, A. & Draper, J. 2006 In : Journal of Microbiological Methods.67, 2, p. 273-2808 p.
On the interpretation of high throughput MS based metabolomics fingerprints with Random ForestEnot, D. P., Beckmann, M. & Draper, J. 2006 Second International Symposium, CompLife 2006, Cambridge, UK, September 27-29, 2006. Proceedings.Springer Nature, p. 226-23510 p.
The use of chemical profiling for monitoring metabolic changes in artificial soil slurries caused by horizontal gene transferHuang, W., Goodacre, R., Elliott, G. N., Beckmann, M., Worgan, H., Bailey, M. J., Williams, P. A., Scullion, J. & Draper, J. 2005 In : Metabolomics.p. 305-31511 p.
Hierarchical metabolomics demonstrates substantial compositional similarity between genetically-modified and conventional potato cropsCatchpole, G., Beckmann, M., Enot, D. P. L., Mondhe, M., Zywicki, B., Taylor, J., Hardy, N. W., Smith, A. R., King, R. D., Kell, D. B., Fiehn, O. & Draper, J. 2005 In : Proceedings of the National Academy of Sciences of the United States of America.102, 40, p. 14458-144625 p.
Pheromonal communication in nereids and the likely intervention by petroleum derived pollutantsMuller, C. T., Priesnitz, F. M. & Beckmann, M. 2005 In : Integrative and Comparative Biology.45, 1, p. 189-1935 p.
A proposed framework for the description of plant metabolomics experiments and their resultsJenkins, H. A., Hardy, N. W., Beckmann, M., Draper, J., Smith, A. R., Taylor, J., Fiehn, O., Goodacre, R., Bino, R. J., Hall, R. D., Kopka, J., Lane, G. A., Lange, . M., Liu, J. R., Mendes, P., Nikolau, B. J., Oliver, S. G., Paton, N. W., Rhee, S., Roessner-Tunali, U., Saito, K., Smedsgaard, J., Sumner, L. W., Wang, T., Walsh, S., Wurtele, E. S. & Kell, D. B. 2004 In : Nature Biotechnology.22, 12, p. 1601-16066 p.
Metabolic Engineering, metabolite profiling and machine learning to investigate the phloem-mobile signal in systemic acquired resistance in tobaccoDraper, J., Darby, R. M., Beckmann, M., Maddison, A. L., Mondhe, M., Sheldrick, C., Taylor, J., Goodacre, R. & Kell, D. B. 2002
Mass spectrometric monitoring of gases (CO2, CH4, O-2) in a mesotrophic peat core from Kopparas Mire, SwedenBeckmann, M. & Lloyd, D. 2001 In : Global Change Biology.7, 2, p. 171-18010 p.