One Health recognises the inter-dependence of human, animal and environmental health and emphasizes the multidisciplinary nature of collaboration needed to secure that health. According to the One Health Global Network, the aim of One Health is “to improve health and well-being through the prevention of risks and the mitigation of effects of crises that originate at the interface between humans, animals and their various environments”.
Historically, the health of people or animals was defined as the absence of disease, but this developed into concepts of well-being and then, more recently, as the ability to manage change and be sustainable. This more holistic approach is reflected in One Health, not only in regard to the factors that affect health but how research, policy formulation or interventions are implemented. Over seventy percent of emerging human diseases are zoonotic in origin, illustrating the importance of addressing both human and animal risks.
- Arwain Vet Cymru – A national network of Veterinary Prescribing Champions for Wales
- Assessing the antimicrobial potencies of novel chemical entities (Technology Transfer Grant Development Award – AU).
- Optimising health advice in resource-constrained communities (CIDRA).
- Sêr Cymru Centre of Excellence for Bovine Tuberculosis (EDRF/Welsh Government) link to Bovine Tuberculosis
Clinical Science Projects
- Rapid diagnostic approaches for thoracic disease based on pleural effusions EU KESS Programme (PI)
- Identification and Validation of Low-Cost, High-Throughput Microbial and Metabolite Biomarker Assay for Lung Cancer Status, Stage and Type Tenovus Cancer Care (PI)
- Towards a saliva-based screen for the early detection of lung cancer Tenovus Cancer Care (PI)
- Novel Approaches for the detection of prostate cancer EU KESS Programme (PI)
- Microbiomic changes in respiratory disease EU KESS Programme (PI)
- Development of LImBuS, an open source, standards compliant Biobank Information Management System : Hywel Dda University Health Board (CoI)
- Cigarettes compared with varenicline for smoking cessation in patients with COPD and effect on the Lungs (EME-ECAL study) NIHR131600 Efficacy and Mechanism Evaluation - Effectiveness of Electronic (CoI) with University of Birmingham.
- Application of microbiomic approaches for the detection of TB São Paulo Research Foundation (FAPESP) (São Paulo State University (UNESP) and University of Stellenbosch (South Africa) Col
- Tuberculosis variant identification: evaluation of variation graphs for bioinformatics sequence analysis techniques for impact on highly infectious African disease CIDRA (CoI)
Veterinary Science projects
- Using omic approaches to improve the detection of paratuberculosis in cattle EU KESS Programme (PI)
- Metabolomic and proteomic approaches to identify target biomarkers as analystes for the development of improved diagnostic tests for Bovine TB EU KESS Programme (PI)
- Improving the detection of bovine tuberculosis in badgers EU KESS Programme (PI)
Anto-microbial Resistance Projects
- Natural products to counter the challenge of MRSA. The Life Science Research Network Wales (PI)
- Identifying new antimicrobial drugs leads from extremophile microbes The Life Science Research Network Wales (PI)
Intellectual property protection – current patent filed by AU involves chemical matter (PF36021GB1) for treating infections caused by bacteria, protozoan and metazoan pathogens.
Roadmap for Zoonotic TB
This multisectoral roadmap details ten priorities for addressing zoonotic tuberculosis in people and bovine tuberculosis in animals. It calls for concerted action through broad engagement across political, financial and technical levels, including government agencies, donors, academia, non-governmental organizations and private stakeholders.