Research Publications

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2019

2018

  • Whiteland, H., Chakroborty, A., Forde-Thomas, J., Crusco, A., Cookson, A., Hollinshead, J., ... Hoffmann, K. (2018). An Abeis procera - Derived tetracyclic triterpene containing a steroid-like core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni. International Journal for Parasitology: Drugs and Drug Resistance, 8(3), 465-474. DOI: 10.1016/j.ijpddr.2018.10.009
  • Padalino, G., Ferla, S., Brancale, A., Chalmers, I., & Hoffmann, K. (2018). Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni. International Journal for Parasitology: Drugs and Drug Resistance. DOI: 10.1016/j.ijpddr.2018.10.005
  • Egesa, M., Lubyayi, L., Jones, F. M., van Diepen, A., Chalmers, I., Tukahebwa, E. M., ... Cose, S. (2018). Antibody Responses to Schistosoma mansoni Schistosomula Antigens. Parasite Immunology, [e12591]. DOI: 10.1111/pim.12591
  • Egesa, M., Lubyayi, L., Tukahebwa, E. M., Bagaya, B. S., Chalmers, I., Wilson, S., ... Cose, S. (2018). S. mansoni Schistosomula Antigens Induce Th1/Proinflammatory Cytokine Responses. Parasite Immunology, [e12592]. DOI: 10.1111/pim.12592
  • Geyer, K., Munshi, S. E., Vickers, M., Squance, M., Wilkinson, T., Berrar, D., ... Hoffmann, K. (2018). The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulation transcription, translation and stem cell activities. International Journal for Parasitology: Drugs and Drug Resistance, 8(2), 213-222. DOI: 10.1016/j.ijpddr.2018.03.006
  • Geyer, K. K., Munshi, S. E., Vickers, M., Squance, M., Wilkinson, T., Berrar, D., ... Hoffmann, K. (2018). The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities. International Journal for Parasitology: Drugs and Drug Resistance, 8(2018), 213-222. DOI: 10.1016/j.ijpddr.2018.07.002
  • Geyer, K., Munshi, S. E., Whiteland, H., Fernandez-Fuentes, N., Phillips, D., & Hoffmann, K. (2018). Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni. PLOS Pathogens. DOI: 10.1371/journal.ppat.1007107
  • Crusco, A., Bordoni, C., Chakroborty, A., Whatley, K. C. L., Whiteland, H., Westwell, A. D., & Hoffmann, K. (2018). Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues. European Journal of Medicinal Chemistry, 152, 87-100. DOI: 10.1016/j.ejmech.2018.04.032
  • Roquis, D., Taudt, A., Geyer, K., Padalino, G., Hoffmann, K., Holroyd, N., ... de Carvalho Augusto, R. (2018). Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni. PLOS Pathogens, 14(5), [1007066]. DOI: 10.1371/journal.ppat.1007066

 2017 

  • Egesa, M., Hoffmann, K., Hokke, C. H., Yazdanbakhsh, M., & Cose, S. (2017). Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles. Trends in Parasitology, 1671. DOI: 10.1016/j.pt.2017.07.007
  • Nur-e-Alam, M., Yousaf, M., Ahmed, S., Al-Sheddi, E. S., Shah, I., Fazakerley, D., ... Al-Rehaily, A. J. (2017). Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense. Journal of Natural Products, 80(6), 1900-1908. DOI: 10.1021/acs.jnatprod.7b00188
  • Geyer, K., Niazi, U., Duval, D., Cosseau, C., Tomlinson, C., Chalmers, I., ... Hoffmann, K. (2017). The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni. PLoS Neglected Tropical Diseases, 11(5), [e0005246]. DOI: 10.1371/journal.pntd.0005246
  • Adema, C. M., Hillier, L. W., Jones, C. S., Loker, E. S., Knight, M., Minx, P., ... Wilson, R. K. (2017). Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications, 8, 15451. [15451 (2017)]. DOI: 10.1038/ncomms1545
  • Cosseau, C., Wolkenhauer, O., Padalino, G., Geyer, K., Hoffmann, K., & Grunau, C. (2017). (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach. Trends in Parasitology, 33(4), 285-294. DOI: 10.1016/j.pt.2016.12.002

2016

  • Niazi, U. (Developer), Geyer, K. (Developer), Vickers, M. (Developer), Hoffmann, K. (Developer), & Swain, M. (Developer). (2016). DISMISS: MeDIP-seq: High-throughput sequencing. Software, OMICtools.
  • Niazi, U., Geyer, K. K., Vickers, M. J., Hoffmann, K., & Swain, M. (2016). DISMISS: detection of stranded methylation in MeDIP-Seq data. BMC Bioinformatics, 17, [295]. DOI: 10.1186/s12859-016-1158-7

 2015

  • Hoffmann, K. (2015). Sharing expertise/data/reagents. In Accelerating R&D for Neglected Diseases through Global Collaborations: WIPO Re:Search Partnership Stories 2013-2015 (2nd ed., pp. 23). Seattle, USA: BIO Ventures for Global Health.
  • Nowacki, F. C., Swain, M. T., Klychnikov, O. I., Niazi, U., Ivens, A., Quintana, J. F., ... Hoffmann, K. F. (2015). Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni. Journal of Extracellular Vesicles, 4, [28665]. DOI: 10.3402/jev.v4.28665
  • Chalmers, I. W., Fitzsimmons, C. M., Brown, M., Pierrot, C., Jones, F. M., Wawrzyniak, J. M., ... Hoffmann, K. F. (2015). Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment. PLoS Neglected Tropical Diseases, 9(7), e0003920. DOI: 10.1371/journal.pntd.0003920
  • Smit, C. H., van Diepen, A., Nguyen, D. L., Wuhrer, M., Hoffmann, K. F., Deelder, A. M., & Hokke, C. H. (2015). Glycomic analysis of life stages of the human parasite Schistosoma mansoni reveals developmental expression profiles of functional and antigenic glycan motifs. Molecular and Cellular Proteomics, 14(7), 1750-1769. DOI: 10.1074/mcp.M115.048280
  • Reimers, N., Homann, A., Höschler, B., Langhans, K., Wilson, R.A., Pierrot, C., Khalife, J., Grevelding, C.G., Chalmers, I.W.,Yazdanbakhsh, M., Hoffmann, K.F., Hokke, C.H., Haas, H., Schramm, G. 2015. Drug-Induced Exposure of Schistosoma mansoni Antigens SmCD59a and SmKK7. PLoS Neglected Tropical Diseases 9 (3) e0003593 10.1371/journal.pntd.0003593
  • Smit, C.H., van Diepen, A., Nguyen, D.L., Wuhrer, M., Hoffmann, K.F., Deelder, A.M., Hokke, C.H. 2015. Glycomic analysis of life stages of the human parasite Schistosoma mansoni reveals developmental expression profiles of functional and antigenic glycan motifs. Molecular and Cellular Proteomics 14 (7) pp. 1750-1769. 10.1074/mcp.M115.048280 Other
  • Chalmers, I.W., Fitzsimmons, C.M., Brown, M., Pierrot, C., Jones, F.M., Wawrzyniak, J.M., Fernandez-Fuentes, N., Tukahebwa, E.M., Dunne, D.W., Khalife, J., Hoffmann, K.F. 2015. Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment. PLoS Neglected Tropical Diseases 9 (7) pp. e0003920.10.1371/journal.pntd.0003920
  • Nowacki, F.C., Swain, M.T., Klychnikov, O.I., Niazi, U., Ivens, A., Quintana, J.F., Hensbergen, P.J., Hokke, C.H., Buck, A.H.,Hoffmann, K.F. 2015. Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni. Journal of Extracellular Vesicles 4 28665 10.3402/jev.v4.28665 Other
  • Hoffmann, K. 2015. Sharing expertise/data/reagents: Alnylam Pharmaceuticals & Aberystwyth University.
  • Edwards, J., Brown, M., Peak, E., Bartholomew, B., Nash, R.J., Hoffmann, K.F. 2015. The Diterpenoid 7-Keto-Sempervirol, Derived from Lycium chinense, Displays Anthelmintic Activity against both Schistosoma mansoni and Fasciola hepatica. PLoS Neglected Tropical Diseases 9 (3) e0003604 10.1371/journal.pntd.0003604

 2014

  • Hai, Y., Edwards, J., Van Zandt, M.C., Hoffmann, K.F., Christianson, D.W. 2014. Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis. Biochemistry 53 (28) pp. 4671-4684. 10.1021/bi5004519
  • Yoshino, T.P., Brown, M., Wu, X., Jackson, C.J., Ocadiz-Ruiz, R., Chalmers, I.W., Kolb, M., Hokke, C.H., Hoffmann, K.F. 2014.Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression. International Journal for Parasitology 44 (8) pp. 551-563. 10.1016/j.ijpara.2014.04.002
  • Hoffmann, K.F., Brindley, P.J., Berriman, M. 2014. Halting harmful helminths: Vaccines and new drugs are needed to combat parasitic worm infections. Science 346 (168) pp. 168-169. 10.1126/science.1261139

2013

  • Geyer, K. K., Chalmers, I. W., MacKintosh, N. D., Hirst, J. E., Geoghegan, R., Badets, M., Brophy, P. M., Brehm, K. & Hoffmann, K. F. Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes. 9 Jul 2013. BMC Genomics. 14, 462.
  • Truscott, M., Evans, D.A., Gunn, M. and Hoffmann, K.F.  Schistosoma mansoni haemozoin modulates IL-4 induced alternative activation of macrophages via specific suppression of Retnla (Relma/Fizz1) expression and secretion.  Infect and Immun.  2013 81(1): 133-142.

2012

  • Chalmers, I.W. and Hoffmann, K.F.  Platyhelminth venom allergen-like (VAL) proteins: revealing structural diversity, class-specific features and biological associations across the phylum.  Parasitology.  2012 139(10): 1231-1245.
  • Geyer, K.K. and Hoffmann K.F.  Epigenetics: a key regulator of platyhelminth developmental biology?  Int. J. Parasitol.  2012 42(3): 221-224.

2011

  • Martin T. Swain, Denis M. Larkin, Conor R. Caffrey, Stephen J. Davies, Alex Loukas, Patrick J. Skelly, and Karl F. Hoffmann.  Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery.  2011  Dec., Trends Parasitol.  doi:10.1016/j.pt.2011.09.003.
  • Geyer, K.K., Rodriques, C.M., Chalmers, I.W., Munshi, S.E., Truscott, M., Heald, J., Wilkinson, M.J. and Hoffmann, K.F. Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni. 2011 August, Nat. Commun. 2:424.
  • Peak, E & Hoffman, K.F. Cross-disciplinary approaches for measuring parasitic helminth viability and phenotype. Anais da Academia Brasileira de Ciências (Annals of the Brazilian Academy of Sciences), 83(2): 1-14, 2011

2010

  • Peak, E., Chalmers, I.W. and Hoffmann, K.F.  Development and validation of a quantitative, high-throughout, fluorescent-based bioassay to detect Schistosoma viability. PLoS Negl Trop Dis. 2010 Jul 27;4(7):e759

2009

  • Fitzpatrick, J.M., Peak, E., Perally, S., Chalmers, I.W., Barrett, J., Yoshino, T.P., Ivens, A.C. and Hoffmann, K.F.  Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses.  PLoS Negl Trop Dis.  2009 Nov 3;3(11):e543.  
  • Fitzpatrick, J.M., Fuentes, J-M., Chalmers, I.W., Wynn, T.A., Modolell, M., Hoffmann, K.F. and Hesse, M. Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.   Int J Parasitol . 2009 Feb;39(3):267-79.