YLR017W

2.12.08

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SGD

MEU1

“Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression”

go molecular function : S-methyl-5-thioadenosine phosphorylase activity (IDA, IMP) (GO:0017061)

go biological process : glutamate biosynthetic process (IMP)

go biological process : methionine salvage (IDA, IMP)

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MIPS

(2.12.08 – not working)

(4.12.08)

similarity to human 5^-methylthioadenosine phosphorylase

purin nucleotide/nucleoside/nucleobase metabolism

biosynthesis of glutamate

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KEGG

Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step
in the methionine salvage pathway; affects polyamine biosynthesis
through regulation of ornithine decarboxylase (Spe1p) activity;
regulates ADH2 gene expression

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Literature examined:

Subhi AL, et al. (2003) Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. J Biol Chem 278(50):49868-73

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literature_function(ylr017w, 'E.C.2.4.2.1').

2.4.2.1
purine-nucleoside phosphorylase
purine nucleoside + phosphate = purine + α-D-ribose 1-phosphate