YMR020W

(FMS1)

27.2.08

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SGD

Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis

go molecular function : amine oxidase activity (IDA, IGI, ISS)

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MIPS

similarity to Candida corticosteroid binding protein Cbp1p,

weak similarity to monoamine oxidases

.degradation of polyamines

amine oxidase (flavin-containing)

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KEGG

FMS1; Fms1p;

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Literature examined:

Manas K. Chattopadhyay, Celia White Tabor, and Herbert Tabor*

Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: Spermine is converted to spermidine in vivo by the FMS1-amine oxidase

PNAS November 25, 2003 vol. 100 no. 24 13869–13874