Dr David Whitworth

PhD

Dr David Whitworth

Reader

Contact Details

Teaching

Research

My research focuses on the myxobacterial predator Myxococcus xanthus and how it preys upon other microbes. We are studying natural myxobacterial isolates using a variety of genomic, proteomic and phenotypic techniques to identify the genes conferring antimicrobial activity. Particular topics of interest include the predatory vesicles shed by myxobacteria, and myxobacterial signalling pathways and how they alter behaviour in response to a changing environment. In particular, I am interested in the social and predatory myxobacteria, and how they use two-component signalling pathways to co-ordinate group behaviour.

Publications

Interspecies conflict affects RNA expressionWhitworth, D. 2018 In : FEMS Microbiology Letters.365, 10, fny096
Transcriptional changes when Myxococcus xanthus preys on Escherichia coli suggest myxobacterial predators are consititutively toxic but regulate their feedingLivingstone, P., Millard, A., Swain, M. T. & Whitworth, D. E. 2018 In : Microbial Genomics.4, 2, 152
Group Therapy or Mass Suicide? The Sharing of Cellular Damage Between Members of a Bacterial CommunityWhitworth, D. 2017 In : BioEssays.
Myxobacteria are able to prey broadly upon clinically-relevant pathogens, exhibiting a prey range which cannot be explained by phylogenyLivingstone, P., Morphew, R. & Whitworth, D. 2017 In : Frontiers in Microbiology.8, 1593
The myxobacterium Myxococcus xanthus can sense and respond to the quorum signals secreted by potential prey organismsLloyd, D. & Whitworth, D. 2017 In : Frontiers in Microbiology.8, 439
More publications on the Research Portal