Dr Iain Chalmers

PhD

Dr Iain Chalmers

Lecturer in Veterinary Biosciences

Contact Details

Profile

2013-present
Lecturer in Veterinary Biosciences, IBERS, Aberstwyth University, UK
2010-2013
EU-funded Post-Doctoral Research Associate, IBERS, Aberystwyth University, UK
2008-2009
Research Technician, IBERS, Aberystwyth University, UK
2002-2009
Wellcome Trust PhD programme, under supervision of Dr. Karl Hoffmann, Department of Pathology, University of Cambridge, UK
1998-2002
BSc (Hons.) Degree in Immunology, Edinburgh University, UK

Teaching

Research

My research focuses on the identification and characterisation of helminth proteins essential to the parasites survival in the host. The aim of this research is to discover novel vaccine candidates/drug targets and to also gain a deeper understanding of host/parasite interactions. Using bioinformatic approaches, my research also examines the evolution of gene families (such as the SmVAL family) across parasitic and non-parasitic species.

Publications

Adema, CM, Hillier, LW, Jones, CS, Loker, ES, Knight, M, Minx, P, Oliveira, G, Raghavan, N, Shedlock, A, do Amaral, LR, Arican-Goktas, HD, Assis, JG, Baba, EH, Baron, OL, Bayne, CJ, Bickham-Wright, U, Biggar, KK, Blouin, M, Bonning, BC, Botka, C, Bridger, JM, Buckley, KM, Buddenborg, SK, Lima Caldeira, R, Carleton, J, Carvalho, OS, Castillo, MG, Chalmers, IW, Christensens, M, Clifton, S, Cosseau, C, Coustau, C, Cripps, RM, Cuesta-Astroz, Y, Cummins, SF, Di Stephano, L, Dinguirard, N, Duval, D, Emrich, S, Feschotte, C, Feyereisen, R, Fitzgerald, P, Fronick, C, Fulton, L, Galinier, R, Gava, SG, Geusz, M, Geyer, KK, Giraldo-Calderón, GI, de Souza Gomes, M, Gordy, MA, Gourbal, B, Grunau, C, Hanington, PC, Hoffmann, KF, Hughes, D, Humphries, J, Jackson, DJ, Jannotti-Passos, LK, De Jesus Jeremias, W, Jobling, S, Kamel, B, Kapusta, A, Kaur, S, Koene, JM, Kohn, AB, Lawson, D, Lawton, SP, Liang, D, Limpanont, Y, Liu, S, Lockyer, AE, Lovato, TL, Ludolf, F, Magrini, V, Mcmanus, DP, Medina, M, Misra, M, Mitta, G, Mkoji, GM, Montague, MJ, Montelongo, C, Moroz, LL, Munoz-Torres, MC, Niazi, U, Noble, LR, Oliveira, FS, Pais, FS, Papenfuss, AT, Peace, R, Pena, JJ, Pila, EA, Quelais, T, Raney, BJ, Rast, JP, Rollinson, D, Rosse, IC, Rotgans, B, Routledge, EJ, Ryan, KM, Scholte, LLS, Storey, KB, Swain, M, Tennessen, JA, Tomlinson, C, Trujillo, DL, Volpi, EV, Walker, AJ, Wang, T, Wannaporn, I, Warren, WC, Wu, X-J, Yoshino, TP, Yusuf, M, Zhang, S-M, Zhao, M & Wilson, RK 2017, 'Whole genome analysis of a schistosomiasis-transmitting freshwater snail' Nature Communications, vol 8, 15451 (2017), pp. 15451. DOI: 10.1038/ncomms15451
Geyer, K, Niazi, U, Duval, D, Cosseau, C, Tomlinson, C, Chalmers, I, Swain, M, Cutress, D, Bickham-Wright, U, Munshi, SE, Grunau, C, Yoshino, TP & Hoffmann, K 2017, 'The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni' PLoS Neglected Tropical Diseases, vol 11, no. 5, e0005246. DOI: 10.1371/journal.pntd.0005246
Chalmers, IW, Fitzsimmons, CM, Brown, M, Pierrot, C, Jones, FM, Wawrzyniak, JM, Fernandez-Fuentes, N, Tukahebwa, EM, Dunne, DW, Khalife, J & Hoffmann, KF 2015, 'Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment' PLoS Neglected Tropical Diseases, vol 9, no. 7, pp. e0003920. DOI: 10.1371/journal.pntd.0003920
Reimers, N, Homann, A, Höschler, B, Langhans, K, Wilson, RA, Pierrot, C, Khalife, J, Grevelding, CG, Chalmers, IW, Yazdanbakhsh, M, Hoffmann, KF, Hokke, CH, Haas, H & Schramm, G 2015, 'Drug-Induced Exposure of Schistosoma mansoni Antigens SmCD59a and SmKK7' PLoS Neglected Tropical Diseases, vol 9, no. 3, e0003593. DOI: 10.1371/journal.pntd.0003593
Farnell, EJ, Tyagi, N, Ryan, S, Chalmers, IW, Pinot de Moira, A, Jones, FM, Wawrzyniak, J, Fitzsimmons, CM, Tukahebwa, EM, Furnham, N, Maizels, RM & Dunne, DW 2015, 'Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection' Frontiers in Immunology, vol 6, pp. 26. DOI: 10.3389/fimmu.2015.00026
Yoshino, TP, Brown, M, Wu, X-J, Jackson, CJ, Ocadiz-Ruiz, R, Chalmers, IW, Kolb, M, Hokke, CH & Hoffmann, KF 2014, 'Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression' International Journal for Parasitology, vol 44, no. 8, pp. 551-563. DOI: 10.1016/j.ijpara.2014.04.002
Geyer, KK, Chalmers, IW, MacKintosh, ND, Hirst, JE, Geoghegan, R, Badets, M, Brophy, PM, Brehm, K & Hoffmann, KF 2013, 'Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes' BMC Genomics, vol 14, 462. DOI: 10.1186/1471-2164-14-462
Chalmers, IW & Hoffmann, KF 2012, 'Platyhelminth venom allergen-like (VAL) proteins: revealing structural diversity, class specific features and biological associations across the phylum' Parasitology, vol 139, no. 10, pp. 1231-1245. DOI: 10.1017/S0031182012000704
Fitzsimmons, CM, Jones, FM, Stearn, A, Chalmers, IW, Hoffmann, KF, Wawrzyniak, J, Wilson, S, Kabatereine, NB & Dunne, DW 2012, 'The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses' PLoS Neglected Tropical Diseases, vol 6, no. 4, e1593. DOI: 10.1371/journal.pntd.0001593
Geyer, KK, Rodríguez-López, CM, Hoffmann, KF, Chalmers, IW, Munshi, SE, Truscott, M, Heald, JK, Wilkinson, MJ & Hoffmann, KF 2011, 'Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni' Nature Communications, vol 2, 424. DOI: 10.1038/ncomms1433
Peak, E, Chalmers, IW & Hoffmann, KF 2010, 'Development and Validation of a Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability' PLoS Neglected Tropical Diseases, vol 4, no. 7, e759. DOI: 10.1371/journal.pntd.0000759
Fitzpatrick, JM, Peak, E, Perally, S, Chalmers, IW, Barrett, J, Yoshino, TP, Ivens, AC & Hoffmann, KF 2009, 'Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses' PLoS Neglected Tropical Diseases, vol 3, no. 11, e543.. DOI: 10.1371/journal.pntd.0000543
Fitzpatrick, JM, Fuentes, JM, Chalmers, IW, Wynn, TA, Modolell, M, Hoffmann, KF & Hesse, M 2009, 'Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity' International Journal for Parasitology, vol 39, no. 3, pp. 267-279. DOI: 10.1016/j.ijpara.2008.06.015
Peak, E, Chalmers, IW & Hoffmann, KF 2009, 'Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect Schistosoma viability' The Schistosome Molecular Toolbox Workshop, University of California, 2009 - 2009, .
Chalmers, IW, McArdle, AJ, Coulson, RMR, Wagner, MA, Schmid, R, Hirai, H & Hoffmann, KF 2008, 'Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family' BMC Genomics, vol 9, no. 89, 89. DOI: 10.1186/1471-2164-9-89
Fitzsimmons, CM, Schramm, G, Jones, FM, Chalmers, IW, Hoffmann, KF, Grevelding, CG, Wuhrer, M, Hokke, CH, Haas, H, Doenhoff, MJ & Dunne, DW 2005, 'Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs' Molecular and Biochemical Parasitology, vol 144, no. 1, pp. 123-127. DOI: 10.1016/j.molbiopara.2005.08.003