Dr Manfred Beckmann

PhD

Dr Manfred Beckmann

Lecturer

Contact Details

Profile

Dr Beckmann obtained his doctorate in analytical chemistry at the C.v.O. University Oldenburg, Germany, on the identification of pheromones in marine polychaetes. Since then he has contributed as a marine chemical ecologist to the understanding of chemical communication and antifouling (HKUST, Hongkong), to measure and estimate production of green house gases in wetlands (Cardiff University) and to the investigatigation of metabolic changes in GM-crops, during host-pathogen interactions and dietary effects on mammalian biofluids (Aberystwyth).

He is now a research lecturer and Metabolomics Champion in the High Resolution Metabolomics Laboratory at Aberystwyth University. His research interests are in high through-put ultra-high resolution Metabolomics of difficult matrices and 'real world samples'.

Teaching

Research

Current research activities focus on Metabolomics: the non-targeted and comprehensive analysis of all metabolites in biological material detecting unforeseen metabolic changes.

Metabolomics is the sum of a well designed and performed experiment, sampling strategies, sample preparation, instrumental analysis, raw data conversion, signal processing, data analysis, and data interpretation.
The outcome of a Metabolomics experiment and interpretability of data very much depend on all members of a skilled team and their tools. In order to minimize sources of variability and bias, robust methods and protocols have been developed in a team effort orchestrated by Prof. John Draper at IBERS over the last 15 years, and are the subject of future activities.

As an analytical chemist I am interested in maximising the information content of Metabolomics data through signal processing and data mining, metabolite identification and characterisation of unknown signals. I am responsible for the functionality of the IBERS High Resolution Metabolomics Laboratory and concerned with method development and optimisation of the following Metabolomics techniques:

  • High through-put ultra-high resolution Flow Infusion Electrospray Mass Spectrometry (FIE-MS)
  • High through-put ultra-high resolution LC-MS
  • High through-put GC-tof-MS
  • Metabolite targeted analysis and quantification.

I am particularly interested in applying Metabolomics methodologies to study the effect of diet on urinary and plasma metabolome and resulting changes in physiology. In collaboration with clinical/veterinary institutions in academia and industry, we are currently determining dietary exposure and individual responses to diet constituents in humans and domesticated animals. A key mission is the search for biomarkers of 'health and wellbeing'.

Publications

Rodriguez Lopez, CM, Morán, P, Lago, F, Espiñeira, M, Beckmann, M & Olmo, SCD 2012, 'Detection and quantification of tissue of origin in salmon and veal products using methylation sensitive AFLPs' Food Chemistry, vol 131, no. 4, pp. 1493-1498. DOI: 10.1016/j.foodchem.2011.09.120
Allwood, JW, Parker, D, Beckmann, M, Draper, J & Goodacre, R 2012, Fourier transform ion cyclotron resonance mass spectrometry for plant metabolite profiling and metabolite identification. in Methods in Molecular Biology. Springer Nature, pp. 157-176. DOI: 10.1007/978-1-61779-594-7_11
Belanche Gracia, A, Beckmann, M, Moorby, JM, De La Fuente Oliver, G & Newbold, CJ 2012, 'Effects of changing rumen protozoa populations in sheep on plasma metabolomic profiles' 8th INRA-RRI International Symposium on Gut Microbiology, Clermont Ferrand, France, 2012 - 2012, .
Tumilty, L, Davison, G, Beckmann, M & Thatcher, R 2012, 'Acute oral tyrosine administration does not improve exercise performance in the heat in man' The Biomedical Basis of Elite Performance, London, United Kingdom of Great Britain and Northern Ireland, 2012 - 2012, pp. 93.
Favé, G, Beckmann, M, Lloyd, A, Zhou, S, Harold, G, Lin, W, Tailliart, K, Xie, L, Draper, J & Mathers, JC 2011, 'Development and validation of a standardized protocol to monitor human dietary exposure by metabolite fingerprinting of urine samples' Metabolomics, vol 7, no. 4, pp. 469-484. DOI: 10.1007/s11306-011-0289-0
Tumilty, L, Davison, G, Beckmann, M & Thatcher, R 2011, 'Oral tyrosine supplementation improves exercise capacity in the heat' European Journal of Applied Physiology, vol 111, no. 12, pp. 2941-2950. DOI: 10.1007/s00421-011-1921-4
Lloyd, AJ, Beckmann, M, Favé, G, Mathers, JC & Draper, J 2011, 'Proline betaine and its biotransformation products in fasting urine samples are potential biomarkers of habitual citrus fruit consumption' British Journal of Nutrition, vol 106, no. 6, pp. 812-824. DOI: 10.1017/S0007114511001164
Lloyd, AJ, Favé, G, Beckmann, M, Lin, W, Tailliart, K, Xie, L, Mathers, JC & Draper, J 2011, 'Use of mass spectrometry fingerprinting to identify urinary metabolites after consumption of specific foods' American Journal of Clinical Nutrition, vol 94, no. 4, pp. 981-991. DOI: 10.3945/ajcn.111.017921
Primrose, S, Draper, J, Elsom, R, Kirkpatrick, V, Mathers, JC, Seal, C, Beckmann, M, Haldar, S, Beattie, JH, Lodge, JK, Jenab, M, Keun, H & Scalbert, A 2011, 'Workshop Report Metabolomics and human nutrition' British Journal of Nutrition, vol 105, no. 8, pp. 1277-1283. DOI: 10.1017/S0007114510004812
Tumilty, L, Davison, G, Beckmann, M & Thatcher, R 2011, 'A tyrosine and phenylalanine-free amino acid mixture decreases exercise capacity in the heat' The British Association of Sport and Exercise Sciences Conference 2011, Colchester, United Kingdom of Great Britain and Northern Ireland, 2011 - 2011, .
Ward, JL, Forcat, S, Beckmann, M, Bennett, M, Miller, SJ, Baker, JM, Hawkins, ND, Vermeer, CP, Lu, C, Lin, W, Truman, WM, Beale, MH, Draper, J, Mansfield, JW & Grant, M 2010, 'The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato.' Plant Journal, vol 63, no. 3, pp. 443-457. DOI: 10.1111/j.1365-313X.2010.04254.x
Beckmann, M, Enot, DPL, Overy, DP, Scott, IM, Jones, PG, Allaway, D & Draper, J 2010, 'Metabolite fingerprinting of urine suggests breed-specific dietary metabolism differences in domestic dogs' British Journal of Nutrition, vol 103, no. 8, pp. 1127-1138. DOI: 10.1017/S000711450999300X
Tumilty, L, Davison, G, Beckmann, M & Thatcher, R 2010, 'Oral tyrosine supplementation improves exercise capacity in the heat' BASES 2010 Annual Student Conference, Aberystwyth, United Kingdom of Great Britain and Northern Ireland, 2010 - 2010, pp. 181.
Parker, DA, Beckmann, M, Zubair, H, Enot, DPL, Caracuel-Rios, Z, Overy, DP, Snowdon, S, Talbot, NJ & Draper, J 2009, 'Metabolomic analysis reveals a common pattern of metabolic re-programming during invasion of three host plant species by Magnaporthe grisea' Plant Journal, vol 59, no. 5, pp. 723-737. DOI: 10.1111/j.1365-313X.2009.03912.x
Draper, J, Enot, DPL, Parker, DA, Beckmann, M, Snowdon, S, Lin, W & Zubair, H 2009, 'Metabolite signal identification in accurate mass metabolomics data with MZedDB, an interactive m/z annotation tool utilising predicted ionisation behaviour 'rules'' BMC Bioinformatics, vol 10, no. 227, 227. DOI: 10.1186/1471-2105-10-227
Favé, G, Beckmann, M, Draper, J & Mathers, JC 2009, 'Measurement of dietary exposure: a challenging problem which may be overcome thanks to metabolomics?' Genes and Nutrition, vol 4, no. 2, pp. 135-141. DOI: 10.1007/s12263-009-0120-y
Tumilty, L, Davison, G, Beckmann, M & Thatcher, R 2009, 'Oral tyrosine supplementation improves exercise capacity in the heat' 6th Wales Institute of Sport, Health and Exercise Science Conference, United Kingdom of Great Britain and Northern Ireland, 2009 - 2009, .
Aon, MA, Roussel, MR, Cortassa, S, O'Rourke, B, Murray, DB, Beckmann, M & Lloyd, D 2008, 'The Scale-Free Dynamics of Eukaryotic Cells' PLoS One, vol 3, no. 11, e3624, pp. n/a. DOI: 10.1371/journal.pone.0003624
Overy, DP, Enot, DPL, Tailliart, K, Jenkins, HA, Parker, DA, Beckmann, M & Draper, J 2008, 'Explanatory signal interpretation and metabolite identification strategies for nominal mass FIE-MS metabolite fingerprints' Nature Protocols, vol 3, pp. 471-485. DOI: 10.1038/nprot.2007.512
Parker, D, Beckmann, M, Enot, DP, Overy, DP, Rios, ZC, Gilbert, M, Talbot, N & Draper, J 2008, 'Rice blast infection of Brachypodium distachyon as a model system to study dynamic host/pathogen interactions' Nature Protocols, vol 3, pp. 435-445. DOI: 10.1038/nprot.2007.499
Beckmann, M, Parker, DA, Enot, DPL, Duval, E & Draper, J 2008, 'High throughput, non-targeted metabolite fingerprinting using nominal mass Flow Injection Electrospray Mass Spectrometry' Nature Protocols, vol 3, pp. 486-504. DOI: 10.1038/nprot.2007.500
Enot, DP, Lin, W, Beckmann, M, Parker, D, Overy, DP & Draper, J 2008, 'Preprocessing, classification modeling and feature selection using flow injection electrospray mass spectrometry metabolite fingerprint data' Nature Protocols, vol 3, pp. 446-470. DOI: 10.1038/nprot.2007.511
Enot, DP, Beckmann, M & Draper, J 2007, 'Detecting a difference - assessing generalisability when modelling metabolome fingerprint data in longer term studies of genetically modified plants' Metabolomics, vol 3, no. 3, pp. 335-347. DOI: 10.1007/s11306-007-0064-4
Beckmann, M, Enot, DP, Overy, DP & Draper, J 2007, 'Representation, comparison, and interpretation of metabolome fingerprint data for total composition analysis and quality trait investigation in potato cultivars' Journal of Agricultural and Food Chemistry, vol 55, no. 9, pp. 3444-3451. DOI: 10.1021/jf0701842
Murray, DB, Beckmann, M & Kitano, H 2007, 'Regulation of yeast oscillatory dynamics' Proceedings of the National Academy of Sciences of the United States of America, vol 104, no. 7, pp. 2241-2246. DOI: 10.1073/pnas.0606677104
Jenkins, HA, Beckmann, M, Draper, J & Hardy, NW 2007, GC-MS Peak Labeling Under ArMet. in BJ Nikolau & ES Wurtele (eds), Concepts in Plant Metabolomics. Springer Nature, Dordrecht, pp. 19-28. DOI: 10.1007/978-1-4020-5608-6_2
Enot, DP, Beckmann, M, Overy, DP & Draper, J 2006, 'Predicting interpretability of metabolome models based on behavior, putative identity, and biological relevance of explanatory signals' Proceedings of the National Academy of Sciences of the United States of America, vol 103, no. 40, pp. 14865-14870. DOI: 10.1073/pnas.0605152103
Huang, W, Hopper, DJ, Goodacre, R, Beckmann, M, Singer, A & Draper, J 2006, 'Rapid characterization of microbial biodegradation pathways by FT-IR spectroscopy' Journal of Microbiological Methods, vol 67, no. 2, pp. 273-280. DOI: 10.1016/j.mimet.2006.04.009
Enot, DP, Beckmann, M & Draper, J 2006, On the interpretation of high throughput MS based metabolomics fingerprints with Random Forest. in Second International Symposium, CompLife 2006, Cambridge, UK, September 27-29, 2006. Proceedings. Springer Nature, pp. 226-235, International Symposium, CompLife, Cambridge, United Kingdom of Great Britain and Northern Ireland, 2006. DOI: 10.1007/11875741_22
Huang, W, Goodacre, R, Elliott, GN, Beckmann, M, Worgan, H, Bailey, MJ, Williams, PA, Scullion, J & Draper, J 2005, 'The use of chemical profiling for monitoring metabolic changes in artificial soil slurries caused by horizontal gene transfer' Metabolomics, pp. 305-315. DOI: 10.1007/s11306-005-0011-1
Catchpole, G, Beckmann, M, Enot, DPL, Mondhe, M, Zywicki, B, Taylor, J, Hardy, NW, Smith, AR, King, RD, Kell, DB, Fiehn, O & Draper, J 2005, 'Hierarchical metabolomics demonstrates substantial compositional similarity between genetically-modified and conventional potato crops' Proceedings of the National Academy of Sciences of the United States of America, vol 102, no. 40, pp. 14458-14462. DOI: 10.1073/pnas.0503955102
Muller, CT, Priesnitz, FM & Beckmann, M 2005, 'Pheromonal communication in nereids and the likely intervention by petroleum derived pollutants' Integrative and Comparative Biology, vol 45, no. 1, pp. 189-193. DOI: 10.1093/icb/45.1.189
Jenkins, HA, Hardy, NW, Beckmann, M, Draper, J, Smith, AR, Taylor, J, Fiehn, O, Goodacre, R, Bino, RJ, Hall, RD, Kopka, J, Lane, GA, Lange, M, Liu, JR, Mendes, P, Nikolau, BJ, Oliver, SG, Paton, NW, Rhee, S, Roessner-Tunali, U, Saito, K, Smedsgaard, J, Sumner, LW, Wang, T, Walsh, S, Wurtele, ES & Kell, DB 2004, 'A proposed framework for the description of plant metabolomics experiments and their results' Nature Biotechnology, vol 22, no. 12, pp. 1601-1606. DOI: 10.1038/nbt1041
Draper, J, Darby, RM, Beckmann, M, Maddison, AL, Mondhe, M, Sheldrick, C, Taylor, J, Goodacre, R & Kell, DB 2002, 'Metabolic Engineering, metabolite profiling and machine learning to investigate the phloem-mobile signal in systemic acquired resistance in tobacco'.
Beckmann, M & Lloyd, D 2001, 'Mass spectrometric monitoring of gases (CO2, CH4, O-2) in a mesotrophic peat core from Kopparas Mire, Sweden' Global Change Biology, vol 7, no. 2, pp. 171-180. DOI: 10.1046/j.1365-2486.2001.00396.x
Wonfor, R, Natoli, M, Shah, I, Beckmann, M, Nash, RJ & Nash, D 2017, 'Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell line' Journal of Ethnopharmacology, vol 209, pp. 283-287. DOI: 10.1016/j.jep.2017.08.006
López-Álvarez, D, Zubair, H, Beckmann, M, Draper, J & Catalán, P 2017, 'Diversity and association of phenotypic and metabolomic traits in the close model grasses Brachypodium distachyon, B. stacei and B. hybridum' Annals of Botany, vol 119, no. 4, pp. 545-561. DOI: 10.1093/aob/mcw239
Garcia-Perez, I, Posma, JM, Gibson, R, Chambers, ES, Hanson, TH, Vestergaard, H, Hansen, T, Beckmann, M, Pedersen, O, Elliott, P, Stamler, J, Nicholson, JK, Draper, J, Mathers, JC, Holmes, E & Frost, G 2017, 'Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial' Lancet Diabetes and Endocrinology, vol 5, no. 3, pp. 184-195. DOI: 10.1016/S2213-8587(16)30419-3
Lloyd, A, Beckmann, M, Wilson, T, Tailliart, K, Allaway, D & Draper, J 2017, 'Ultra High Performance Liquid Chromatography-High Resolution Mass Spectrometry plasma lipidomics can distinguish between canine breeds despite uncontrolled environmental variability and non-standardized diets: Plasma lipidome of dog breeds using UHPLC-HRM' Metabolomics, vol 13, 15. DOI: 10.1007/s11306-016-1152-0
Wilson, T, Willis, ND, Zubair, H, Beckmann, M, Xie, L, Tailliart, K, Lloyd, A, Mathers, JC & Draper, J 2016, 'Developing community-based urine sampling methods to facilitate dietary exposure biomarker technology for population assessment' Proceedings of the Nutrition Society, vol 75, no. OCE3, E240. DOI: 10.1017/S002966511600255X
Lloyd, AJ, Zubair, H, Willis, ND, Wilson, T, Xie, L, Tailliart, K, Chambers, ES, Garcia-Perez, I, Holmes, E, Frost, G, Mathers, JC, Beckmann, M & Draper, J 2016, 'Quantification of dietary biomarkers in spot urine samples reflects the intake of foods of UK high public health importance' Proceedings of the Nutrition Society, vol 75, no. OCE3, E248. DOI: 10.1017/S0029665116002639
Cameron, S, Lewis, KE, Beckmann, M, Allison, G, Ghosal, R, Lewis, PD & Mur, L 2016, 'The metabolomic detection of lung cancer biomarkers in sputum' Lung Cancer, vol 94, pp. 88-95. DOI: 10.1016/j.lungcan.2016.02.006
Lloyd, A, Beckmann, M, Tailliart, K, Brown, WY, Draper, J & Allaway, D 2016, 'Characterisation of the main drivers of intra- and inter- breed variability in the plasma metabolome of dogs' Metabolomics, vol 12, no. 4, 72. DOI: 10.1007/s11306-016-0997-6
Garcia-Perez, I, Posma, JM, Chambers, ES, Nicholson, JK, Mathers, JC, Beckmann, M, Draper, J, Holmes, E & Frost, G 2016, 'An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake' Journal of Agricultural and Food Chemistry, vol 64, no. 11, pp. 2423-2431. DOI: 10.1021/acs.jafc.5b05878
Beckmann, M, Joosen, AM, Clarke, MM, Mugridge, O, Frost, G, Engel, B, Tailliart, K, Lloyd, A, Draper, J & Lodge, JK 2016, 'Changes in the human plasma and urinary metabolome associated with acute dietary exposure to sucrose and the identification of potential biomarkers of sucrose intake' Molecular Nutrition and Food Research, vol 60, no. 2, pp. 444-457. DOI: 10.1002/mnfr.201500495
Willis, ND, Dodds, SE, Lloyd, AJ, Xie, L, Chambers, ES, Garcia-Perez, I, Frost, G, Beckmann, M, Draper, J & Mathers, JC 2015, 'Dietary compliance in a human intervention study investigating the impact of specific foods on urinary metabolites' Proceedings of the Nutrition Society, vol 74, no. OCE1, E127. DOI: 10.1017/S0029665115001421
Tumilty, L, Thatcher, R, Beckmann, M & Davison, G 2015, 'No effect of oral tyrosine administration on mood and motivation or heart rate variability during endurance performance in the heat' 19th Annual Congress of the European College of Sport Science, Amsterdam, Netherlands, 2014 - 2014, .
Tumilty, L, Davison, G, Beckmann, M & Thatcher, R 2014, 'Failure of oral tyrosine supplementation to improve exercise performance in the heat' Medicine and Science in Sports and Exercise, vol 46, no. 7, pp. 1417-25. DOI: 10.1249/MSS.0000000000000243
Tumilty, L, Thatcher, R, Beckmann, M & Davison, G 2014, 'Acute oral tyrosine supplementation does not prevent the decline in maximal handgrip force in hyperthermic subjects' 19th Annual Congress of the European College of Sport Science, Amsterdam, Netherlands, 2014 - 2014, .
Beckmann, M, Lloyd, AJ, Halder, S, Seal, C, Brandt, K & Draper, J 2013, 'Hydroxylated phenylacetamides derived from bioactive benzoxazinoids are bioavailable in humans after habitual consumption of whole grain sourdough rye bread' Molecular Nutrition and Food Research, vol 57, no. 10, pp. 1859-1873. DOI: 10.1002/mnfr.201200777
Beckmann, M, Lloyd, A, Halder, S, Fave, G, Seal, C, Brandt, K, Mathers, JC & Draper, J 2013, 'Dietary exposure biomarker-lead discovery based on Metabolomics analysis of urine samples' Proceedings of the Nutrition Society, vol 72, no. 3, pp. 352-361. DOI: 10.1017/S0029665113001237
Tumilty, L, Davison, G, Beckmann, M & Thatcher, R 2013, 'Acute oral administration of a tyrosine and phenylalanine-free amino acid mixture reduces exercise capacity in the heat' European Journal of Applied Physiology, vol 113, no. 6, pp. 1511-1522. DOI: 10.1007/s00421-012-2577-4
Draper, J, Lloyd, AJ, Goodacre, R & Beckmann, M 2013, 'Flow infusion electrospray ionisation mass spectrometry for high throughput, non-targeted metabolite fingerprinting: A Review' Metabolomics, vol 9, no. 1 Supplement, pp. S4–S29. DOI: 10.1007/s11306-012-0449-x
Lloyd, AJ, Beckmann, M, Haldar, S, Seal, C, Brandt , K & Draper, J 2013, 'Data-driven strategy for the discovery of potential urinary biomarkers of habitual dietary exposure' American Journal of Clinical Nutrition, vol 97 , no. 2 , pp. 377-389. DOI: 10.3945/ajcn.112.048033
Graupels, F, Sarioglu, H, Beckmann, M, Hause, B, Spannagl, M, Draper, J, Lindermayr, C & Durner, J 2012, 'Deciphering systemic wound responses of the pumpkin extrafascicular phloem by metabolomics and stable isotope-coded protein labeling (ICPL).' Plant Physiology, vol 160, no. 4, pp. 2285-99. DOI: 10.​1104/​pp.​112.​205336