Prof Mike Young

Prof Mike Young

Emeritus Professor

Contact Details

Research

Our laboratory studies post-exponential phase gene expression in several Gram-positive bacteria, including Bacillus and Clostridium. Recent work on dormancy in Micrococcus luteus led to the discovery of the Rpf family of bacterial growth factors found throughout the actinobacteria (e.g. mycobacteria, streptomycetes). We are currently exploring the mechanism of actions of these secreted bacterial growth factors and their potential applications for TB protection and therapy.

Publications

A Tool for Multiple Targeted Genome Deletions that Is Precise, Scar-Free, and Suitable for Automation.Aubrey, W., Riley, M., Young, M., King, R. D., Oliver, S. G. & Clare, A. 2015 In : PLoS One.10, 12, 0142494
Surviving the heat: Heterogeneity of response in Saccharomyces cerevisiae provides insight into thermal damage to the membraneGuyot, S., Gervais, P., Young, M., Winckler, P., Dumont, J. & Davey, H. 2015 In : Environmental Microbiology.17, 8, p. 2982-2992
Cyclic Amp-Dependent Resuscitation of Dormant Mycobacteria by Exogenous Free Fatty AcidsShleeva, M., Goncharenko, A., Kudykina, Y., Young, D., Young, M., Kaprelyants, A. & Tailleux, L. (ed.) 2013 In : PLoS One.8, 12, e82914
PD5: a general purpose library for primer design softwareRiley, M. C., Aubrey, W., Young, M. & Clare, A. 2013 In : PLoS One.8, 11, p. n/a e80156
Zero Forcing, Linear and Quantum Controllability for Systems Evolving on NetworksBurgarth, D., D'Alessandro, D., Hogben, L., Severini, S. & Young, M. 2013 In : IEEE Transactions on Automatic Control.58, 9, p. 2349-23546 p.
Yeast-based automated high-throughput screens to identify anti-parasitic lead compoundsBilsland, E., Sparkes, A. C., Williams, K. S., Moss, H. J., de Clare, M., Pir, P., Rowland, J., Aubrey, W., Pateman, R., Young, M., Carrington, M., King, R. D. & Oliver, S. G. 2013 In : Open Biology.3, 2, 14 p., 120158
Multiple orphan histidine kinases interact directly with Spo0A to control the initiation of endospore formation in Clostridium acetobutylicumHeap, J. P., Young, D. I., Dago, A. E., Minton, N. P., Hoch, J. A., Young, M. & Steiner, E. 2011 In : Molecular Microbiology.80, 3, p. 641-65414 p.
Possible interactions between bacterial diversity, microbial activity and supraglacial hydrology of cryoconite holes in SvalbardEdwards, A., Anesio, A. M., Edwards Rassner, S. M., Sattler, B., Hubbard, B. P., Perkins, W. T., Young, M. & Griffith, G. W. 2011 In : ISME Journal.5, 1, p. 150-16011 p.
Genome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacteriumYoung, M., Artsatbanov, V., Beller, H. R., Chandra, G., Chater, K. F., Dover, L. G., Goh, E-B., Kahan, T., Kaprelyants, A. S., Kyrpides, N., Lapidus, A., Lowry, S. R., Lykidis, A., Mahillon, J., Markowitz, V., Mavromatis, K., Mukamolova, G. V., Oren, A., Rokem, J. S., Smith, M. C. M., Young, D. I. & Greenblatt, C. L. 2010 In : Journal of Bacteriology.192, 3, p. 841-86020 p.
Structural changes and cellular localization of resuscitation promoting factor in environmental isolates of Micrococcus luteusKoltunov, V., Greenblatt, C. L., Goncharenko, A. V., Demina, G. R., Klein, B. Y., Young, M. & Kaprelyants, A. S. 2010 In : Microbial Ecology.59, 2, p. 296-31015 p.
An Integrated Laboratory Robotic System for Autonomous Discovery of Gene FunctionSparkes, A. C., King, R. D., Aubrey, W., Benway, M., Byrne, E. L., Clare, A. J., Liakata, M., Markham, M., Whelan, K. E., Young, M. & Rowland, J. 2010 In : Journal of The Association for Laboratory Automation.15, 1, p. 33-408 p.
Towards Robot Scientists for autonomous scientific discoverySparkes, A. C., Aubrey, W., Byrne, E. L., Clare, A. J., Khan, M., Liakata, M., Markham, M., Rowland, J., Soldatova, L. N., Whelan, K. E., Young, M. & King, R. D. 2010 In : Automated Experimentation.2, 1, p. 1759-44992741 p.
Letters - Make way for robot scientistsByrne, E. L., Liakata, M., Whelan, K. E., Oliver, S. G., Rowland, J. J., Aubrey, W., Soldatova, L. N., Sparkes, A. C., Young, M., Markham, M., Clare, A. J., Pir, P. & King, R. D. 2009 In : Science.325, 5943, p. p945
The Robot Scientist AdamKing, R. D., Rowland, J. J., Aubrey, W., Liakata, M., Markham, M., Soldatova, L. N., Whelan, K. E., Clare, A. J., Young, M., Sparkes, A. C., Oliver, S. & Pir, P. 2009 In : Computer.42, 8, p. 46-549 p.
Evolution of plant senescenceThomas, H., Huang, L., Young, M. & Ougham, H. J. 2009 In : BMC Evolutionary Biology.9, 163, 163
Life with little oxygen: lessons from microbesWhitworth, D. E., Young, M., McEwan, N. R., Newbold, C. J., Smith, S. P. (ed.) & Spikes, K. J. (ed.) 2009 IBERS Knowledge-based Innovations, 2, p. 19-224 p.
The Automation of ScienceKing, R. D., Rowland, J. J., Oliver, S. G., Young, M., Aubrey, W., Byrne, E. L., Liakata, M., Markham, M., Pir, P., Soldatova, L. N., Sparkes, A. C., Whelan, K. E. & Clare, A. J. 2009 In : Science.324, 5923, p. 85-895 p.
Resuscitation-promoting factors are expressed in Mycobacterium tuberculosis-infected human tissueDavies, A. P., Dhillon, A. P., Young, M., Henderson, B., McHugh, T. D. & Gillespie, S. H. 2008 In : Tuberculosis.88, 5, p. 462-4687 p.
The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in situKaprelyants, A. S., Kana, B. D., Young, M., Sung, N., Gordhan, B. G., Downing, K. J., Machowski, E., Tsenova, L., Vostroktunova, G. & Kaplan, G. 2008 In : Molecular Microbiology.67, 3, p. 672-68413 p.
The role of resuscitation promoting factors in the virulence of Mycobacterium tuberculosisMachowski, E., Gordhan, B. G., Sung, N., Downing, K. J., Tsenova, L., Matsoso, L., Kaplan, G., Young, M., Kana, B. D. & Mizrahi, V. 2007
Proteins of the Rpf (resuscitation promoting factor) family are peptidoglycan hydrolasesTelkov, M. V., Demina, G. R., Voloshin, S. A., Salina, E. G., Dudik, T. V., Stekhanova, T. N., Mukamolova, G. V., Kazaryan, K. A., Goncharenko, A. V., Young, M. & Kaprelyants, A. S. 2006 In : Биохимия.71, 4, p. 414-4229 p.
Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitationMukamolova, G. V., Murzin, A. G., Salina, E. G., Demina, G. R., Kell, D. B., Kaprelyants, A. S. & Young, M. 2006 In : Molecular Microbiology.59, 1, p. 84-9815 p.
Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitroDowning, K. J., Mischenko, V. V., Shleeva, M. O., Young, D. I., Young, M., Kaprelyants, A. S., Apt, A. S. & Mizrahi, V. 2005 In : Infection and Immunity.73, 5, p. 3038-30436 p.
A novel firmicute protein family related to the actinobacterial resuscitation-promoting factors by non-orthologous domain displacementRavagnani, A., Finan, C. L. & Young, M. 2005 In : BMC Genomics.6, p. 39-5213 p.
Gene cloning in ClostridiaYoung, M., Davis, I., Minton, N. P. & Carter, G. 2005 in: Handbook on Clostridia. (Eds)Duerre. Duerre, P. (ed.). Taylor & Francis, p. 37-5216 p.
Mycobacterial dormancy and its relation to persistenceMukamolova, G. V., Kaprelyants, A. S. & Young, M. 2005 Parish. Parish, T. (ed.). Taylor & Francis, p. 265-32056 p.
Differentiation of Micromonospora isolates from a coastal sediment in Wales on the basis of Fourier transform infrared spectroscopy, 16S rRNA sequence analysis, and the amplified fragment length polymorphism techniqueYoung, M., Goodacre, R., Kassama, Y., Zhao, H. J. & Kell, D. B. 2004 In : Applied and Environmental Microbiology.70, 11, p. 6619-66279 p.
Global expression profiling of strains harbouring null mutations reveals that the five rpf-like genes of Mycobacterium tuberculosis show functional redundancyDowning, K. J., McAdam, R. A., Kelly, F., Young, M., Betts, J. C. & Young, D. I. 2004 In : Tuberculosis.p. 3-42 p.
Resuscitation of 'uncultured' microorganismsGoodacre, R., Mukamolova, G. V., Young, M., Kaprelyants, A. S., Zhao, H. J., Kell, D. B. & Finan, C. L. 2004 In. A, T. (ed.). American Society for Microbiology, p. 100-1089 p.
Formation of 'non-culturable' cells of Mycobacterium smegmatis in stationary phase in response to growth under sub-optimal conditions and their Rpf-mediated resuscitationWilliams, H. D., Shleeva, M., Mukamolova, G. V. & Young, M. 2004 In : Microbiology.p. 1687-169711 p.
Adoption of the transiently non-culturable state - a bacterial survival strategy?Mukamolova, G. V., Kaprelyants, A. S., Kell, D. B. & Young, M. 2003 Advances in Microbial Physiology. Poole, R. K. (ed.). Elsevier, Vol. 47, p. 65-12965 p.
The rpf gene of Micrococcus luteus encodes an essential secreted growth factorKaprelyants, A. S., Mukamolova, G. V., Young, M., Turapov, O. A., Telkov, M., Kazarian, K. & Kell, D. B. 2002 In : Molecular Microbiology.p. 611-62111 p.
A family of autocrine growth factors in Mycobacterium tuberculosisKaprelyants, A. S., Mukamolova, G. V., Young, M., Turapov, O. A., Young, D. I. & Kell, D. B. 2002 In : Molecular Microbiology.46, 3, p. 623-63513 p.
Cloning, sequencing and heterologous expression of the gene for lupanine hydroxylase, a quinocytochrome c from a Pseudomonas sp.Young, M., Rogozinski, J., Marriott, S. A., Kaderbhai, M. A. & Hopper, D. J. 2002 In : Biochemical Journal.367, p. 483-4897 p.
Changes in muscularity with growth and its relationship with other carcass traits in three terminal sire breeds of sheepWarkup, C. C., Jones, H. E., Young, M. J., Wolf, B. T. & Lewis, R. M. 2002 In : Animal Science.74, 2, p. 265-27511 p.
Formation and resuscitation of 'non-culturable' cells of Rhodococcus rhodochrous and Mycobacterium tuberculosis in prolonged stationary phaseMukamolova, G. V., Telkov, M. V., Bagramyan, K., Young, M., Shleeva, M. O., Kaprelyants, A. S. & Kell, D. B. 2002 In : Microbiology.p. 1581-159111 p.
The use of X-ray computer tomography for measuring the muscularity of live sheepYoung, M. J., Lewis, R. M., Jones, H. E. & Wolf, B. T. 2002 In : Animal Science.p. 387-39913 p.
Degeneration of solventogenic Clostridium strains monitored by Fourier transform infrared spectroscopy of bacterial cellsGapes, J. R., Schuster, K. C., Goodacre, R. & Young, M. 2001 In : Journal of Industrial Microbiology and Biotechnology.27, 5, p. 314-3218 p.
Clostridium beijerinckii and Clostridium difficile detoxify methylglyoxal by a novel mechanism involving glycerol dehydrogenaseYoung, M., Kashket, S., Kashket, E. R. & Liyanage, H. 2001 In : Applied and Environmental Microbiology.67, 5, p. 2004-20107 p.
Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridiaRavagnani, A., Jennert, K. C. B., Steiner, E., Grünberg, R., Jefferies, J. R., Wilkinson, S. R., Young, D., Tidswell, E. C., Brown, D. P., Youngman, P., Morris, J. G. & Young, M. 2000 In : Molecular Microbiology.37, 5, p. 1172-1185