Dr Candida Nibau

PhD

Dr Candida Nibau

Contact Details

Profile

I received my PhD at the University of Massachusetts, Amherst, USA, in 2005 on a thesis entitled 'The role of the Arabidopsis small GTPase Arac7 (ROP9) in hormone signaling', under supervision of Prof. Alice Cheung. In 2005 I moved to the UK for my first postdoctoral position to join the lab of Dr. Juliet Coates where I studied the role of Arabidillo proteins during lateral root formation in Arabidopsis. In October 2008 I moved to Aberystwyth University to join Dr. Glyn Jenkins' lab as a technician on the Barley Meiosis LoLa project. Since 2012 I have been working as a Post-doc in the lab of Prof. John Doonan.

Research

In order to survive in an ever changing environment, plants have to be able to monitor changes in the environment and adapt their development programs accordingly. I am interested in the signaling pathways triggered in the plant in response to external and endogenous stimuli and how these pathways affect plant growth and development.

During my PhD work I looked at the role of small G proteins as signal transducers to plant hormones that regulate many aspects of development. My post-doctoral work focused on some of the downstream molecules activated by specific developmental programs triggered during lateral root formation in Arabidopsis. In particular, I studied the role Arabidillo proteins during lateral root initiation and established that Arabidillo protein stability is regulated by proteasome-dependent degradation and this is important for its function during lateral root initiation. In the lab of Dr. Glyn Jenkins using cytogenetical techniques we developed a recombination map in barley. This allowed us to test the effect of different stimuli and the loss of specific meiotic proteins on the recombination process in barley.

My current project in Prof. Doonan's lab involves the study of cyclin-dependent kinases and how they affect male meiosis at higher temperatures. Male meiosis and recombination are very sensitive to temperature changes and this affects plant fitness and yield. Understanding the pathways behind temperature sensing and meiosis in plants will help to inform the breeding of crops better suited for an ever-changing climate.

Publications

Hughes, N, Askew, KL, Scotson, CP, Williams, KS, Sauze, C, Corke, F, Doonan, J & Nibau, C 2017, 'Non-destructive, high-content analysis of wheat grain traits using X-ray micro computed tomography' Plant Methods, vol 13, 76. DOI: 10.1186/s13007-017-0229-8
Bush, MS, Pierrat, O, Nibau, C, Mikitova, V, Zheng, T, Corke, FMK, Vlachonasios, K, Mayberry, LK, Browning, KS & Doonan, J 2016, 'eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and is Modulated by Phosphorylation' Plant Physiology, vol 172, no. 1, pp. 128-140. DOI: 10.1104/pp.16.00435
Doonan, J, Boyle, R, Han, J, Williams, KS, Alcalde Barrios, A, Strange, H, Corke, F, Nibau, C, Scotson, CP, Camargo-Rodriguez, A, Zwiggelaar, R, Sturrock, C & Mooney, S 2016, 'Image-based phenotyping to measure plant diversity and performance' Plant and Animal Genome Conference XXIV, San Diego, California, United States of America, 2016 - 2016, .
Phillips, D, Jenkins, G, Macaulay, M, Nibau, C, Wnetrzak, J, Fallding, DS, Colas, I, Oakey, H, Waugh, R & Ramsay, L 2015, 'The effect of temperature on the male and female recombination landscape of barley' New Phytologist, vol 208, no. 2, pp. 421-429. DOI: 10.1111/nph.13548
Gibbs, DJ, Voß, U, Harding, SA, Fannon, J, Moody, LA, Yamada, E, Swarup, K, Nibau, C, Bassel, GW, Choudhary, A, Lavenus, J, Bradshaw, SJ, Stekel, DJ, Bennett, MJ & Coates, JC 2014, 'AtMYB93 is a novel negative regulator of lateral root development in Arabidopsis' New Phytologist, vol 203, no. 4, pp. 1194-207. DOI: 10.1111/nph.12879
Zheng, T, Nibau, C, Phillips, DW, Jenkins, G, Armstrong, SJ & Doonan, JH 2014, 'CDKG1 protein kinase is essential for synapsis and male meiosis at high ambient temperature in Arabidopsis thaliana' Proceedings of the National Academy of Sciences of the United States of America, vol 111, no. 6, pp. 2182-2187. DOI: 10.1073/pnas.1318460111
Nibau, C, Tao, L, Levasseur, K, Wu, H-M & Cheung, AY 2013, 'The Arabidopsis small GTPase AtRAC7/ROP9 is a modulator of auxin and abscisic acid signalling' Journal of Experimental Botany, vol 64, no. 11, pp. 3425-3437. DOI: 10.1093/jxb/ert179
Phillips, DW, Wnetrzak, J, Nibau, CS, Barakate, A, Ramsay, L, Wright, F, Higgins, JD, Perry, RM & Jenkins, G 2013, 'Quantitative high resolution mapping of HvMLH3 foci in barley pachytene nuclei reveals a strong distal bias and weak interference' Journal of Experimental Botany, vol 64, no. 8, pp. 2139-2154. DOI: 10.1093/jxb/ert079
Yu, F, Qian, L, Nibau, CS, Duan, Q, Kita, D, Levasseur, K, Li, X, Lu, C, Li, H, Hou, C, Li, L, Buchanan, BB, Chen, L, Cheung, AY, Li, D & Luan, S 2012, 'FERONIA receptor kinase pathway suppresses abscisic acid signaling in Arabidopsis by activating ABI2 phosphatase' Proceedings of the National Academy of Sciences of the United States of America, vol 109, no. 36, pp. 14693-14698. DOI: 10.1073/pnas.1212547109
Phillips, DW, Nibau, CS, Wnetrzak, J & Jenkins, G 2012, 'High Resolution Analysis of Meiotic Chromosome Structure and Behaviour in Barley (Hordeum vulgare L.)' PLoS One, vol 7, no. 6. DOI: 10.1371/journal.pone.0039539
Nibau, C & Cheung, A 2011, 'New insights into the functional roles of CrRLKs in the control of plant cell growth and development' Plant Signaling and Behavior, vol 6, no. 5, pp. 655-659. DOI: 10.4161/psb.6.5.14951
Phillips, D, Nibau, C, Wnetrzak, J, Ramsay, L & Jenkins, G 2011, 'Assaying pairing and recombination in barley (Hordeum vulgare)' Paper presented at 3rd British Meiosis Meeting, Sheffield, United Kingdom of Great Britain and Northern Ireland, 2011, .
Nibau, C, Di Stilio, VS, Wu, H & Cheung, AY 2010, 'Arabidopsis and Tobacco SUPERMAN regulate hormone signalling and mediate cell proliferation and differentiation' Journal of Experimental Botany, vol 62, no. 3, pp. 949-961. DOI: 10.1093/jxb/erq325
Nibau, C, Gibbs, DJ, Bunting, KA, Moody, LA, Smiles, EJ, Tubby, JA, Bradshaw, SJ & Coate, JC 2010, 'ARABIDILLO proteins have a novel and conserved domain structure important for the regulation of their stability' Plant Molecular Biology, vol 75, no. 1-2, pp. 77-92. DOI: 10.1007/s11103-010-9709-1
Wnetrzak, J, Phillips, D, Nibau, C, Fallding, D, Jones, N & Jenkins, G 2010, 'Manipulation of meiotic recombination in barley (Hordeum vulgare)' PlantMicro-Wales Meeting, Aberystwyth, United Kingdom of Great Britain and Northern Ireland, 2010 - 2010, .
Phillips, D, Nibau, C, Ramsey, L, Waugh, R & Jenkins, G 2010, 'Development of a molecular cytogenetic recombination assay for barley' Cytogenetic and Genome Research, vol 129, no. 1-3, pp. 154-161. DOI: 10.1159/000314335
Phillips, D, Nibau, C, Fallding, D, Timofejeva, L, Jones, N & Jenkins, G 2009, 'Assaying recombination in barley (Hordeum vulgare)' Monogram Meeting, Bristol, United Kingdom of Great Britain and Northern Ireland, 2009, .