Prof Luis Mur
- BR21720 - Evolution and Molecular Systematics
- BR31420 - Bioinformatics and Functional Genomics
- BR33720 - Microbial Pathogenesis
- BR22310 - Infectious Diseases
- BR31420 - Bioinformatics and Functional Genomics
- BR33720 - Microbial Pathogenesis
- BR24610 - Advances in Human Biosciences
- BR22720 - Molecular Cell and Cancer Biology
- BR21720 - Evolution and Molecular Systematics
- BR33320 - Gene Expression and Developmental Genetics
In my Food Security Research I am interested in developing our understanding of the genetic & biochemical events associated with plant responses to stress & in identifying sources of tolerance/resistance. This work is based on the use of model plant species, Arabidopsis & Brachypodium distachyon & also crops, wheat (Triticum aestivum), oats (Avena sativa) tomato (Solanum esculentum) & barley (Hordeum vulgare).
My interests in clinical health focus on the respiratory tract & identifying drug leads from natural products. Lung cancer (LC) is the most prevalent cancer in the world with 1.3 million deaths recorded each year. Only 15% of patients live for five or more years after initial diagnosis, primarily due to late detection. Chronic obstructive pulmonary disease (COPD) is characterised by an increase in mucus production due to hyperplasia of goblet cells, & hypertrophy of mucus glands COPD is a leading cause of death, arising from acute exacerbations (sudden worsening of symptoms) which may be triggered by infection or environmental pollutants. My research in this area is focusing on the detection of metabolite biomarkers for LC & COPD & investigating possible links with the lung microbiome.
My research in bioactive natural products focus on identifying anti-microbial metabolites against such human pathogens as MSRA & Pseudomonas aeruginosa from invasive plant species & extremophile microbial strains.
I employ cutting edge genomic & post-genomic approaches but will use classical physiological, genetic, biochemical or microbiological approaches- as appropriate. I have numerous national & international collaborations which are supported by funding from the BBSRC, the EU, NSF (USA), DEFRA, Royal Society, Welsh Assembly, & AU Research Fund.
ABA Suppresses Botrytis cinerea Elicited NO Production in Tomato to Influence H2O2 Generation and Increase Host Susceptibility. Frontiers in Plant Science 7 709 10.3389/fpls.2016.007092016.
Laser-Based Methods for Detection of Nitric Oxide in Plants. In K. Gupta (ed), Plant Nitric Oxide: Methods and Protocols. Methods in Molecular Biology, vol. 1242 Springer Nature pp. 113-126. 10.1007/978-1-4939-3600-7_102016.
Linking dynamic phenotyping with metabolite analysis to study natural variation in drought responses of Brachypodium distachyon. Frontiers in Plant Science 7 1751 10.3389/fpls.2016.017512016. (In press)
Metabolome-mediated biocryomorphic evolution promotes carbon fixation in Greenlandic cryoconite holes. Environmental Microbiology 10.1111/1462-2920.133492016.
Metabolomic-based biomarker discovery for non-invasive lung cancer screening: A case study. Biochimica et Biophysica Acta (BBA) - General Subjects 10.1016/j.bbagen.2016.07.0072016.
Metagenomic Sequencing of the Chronic Obstructive Pulmonary Disease Upper Bronchial Tract Microbiome Reveals Functional Changes Associated with Disease Severity. PLoS One 11 (2) 0149095 10.1371/journal.pone.01490952016.
Project Report No. 557: Screening for 'costs of disease resistance'. Agriculture and Horticulture Development Board2016.
Taxon interactions control the distributions of cryoconite bacteria colonizing a High Arctic ice cap. Molecular Ecology 25 (15) pp. 3752-3767. 10.1111/mec.137152016.
Terminator Operon Reporter: combining a transcription termination switch with reporter technology for improved gene synthesis and synthetic biology applications. Scientific Reports 6 26572 10.1038/srep265722016.
The metabolomic detection of lung cancer biomarkers in sputum. Lung Cancer 94 pp. 88-95. 10.1016/j.lungcan.2016.02.0062016.
Ethylene, Nitric Oxide and Haemoglobins in Plant Tolerance to Flooding. In U. Chakraborty, B. Chakraborty (eds), Abiotic Stresses in Crop Plants. CABI Publishing pp. 43-53.2015.
Genome-wide association study for crown rust (Puccinia coronata f. sp. avenae) and powdery mildew (Blumeria graminis f. sp. avenae) resistance in an oat (Avena sativa) collection of commercial varieties and landraces. Frontiers in Plant Science 6 103 10.3389/fpls.2015.001032015.
Modulation of Pb-induced stress in Prosopis shoots through an interconnected network of signaling molecules, phenolic compounds and amino acids. Plant Physiology and Biochemistry 99 pp. 11-20. 10.1016/j.plaphy.2015.12.0042015.
RapGene: a fast and accurate strategy for synthetic gene assembly in Escherichia coli. Scientific Reports 5 11302 10.1038/srep113022015.
Regulatory role of nitric oxide in plants. Russian Journal of Plant Physiology (Fiziologiya rastenii) 62 (4) pp. 427-440. 10.1134/S10214437150401352015.
The development of tea blister caused by Exobasidium vexans in tea (Camellia sinensis) correlates with the reduced accumulation of some antimicrobial metabolites and the defence signals salicylic and jasmonic acids. Plant Pathology 64 (6) pp. 1471-1483. 10.1111/ppa.123642015.
The human salivary microbiome exhibits temporal stability in bacterial diversity. FEMS Microbiology Ecology 91 (9) fiv091 10.1093/femsec/fiv0912015.
A metabolomic study in oats (Avena sativa) highlights a drought tolerance mechanism based on salicylate signalling pathways and the modulation of carbon, antioxidant and photo-oxidative metabolism. Plant, Cell and Environment 10.1111/pce.125012014.
Coupled cryoconite ecosystem structure–function relationships are revealed by comparing bacterial communities in alpine and Arctic glaciers. FEMS Microbiology Ecology 89 (2) pp. 222-237. 10.1111/1574-6941.122832014.
Effects of bovine colostrum supplementation on upper respiratory illness in active males. Brain, Behavior, and Immunity 39 pp. 194-203. 10.1016/j.bbi.2013.10.0322014.
Guarding the guard cells? New Phytologist 203 (2) pp. 349-351. 10.1111/nph.128822014.
Revealing the Molecular and Physiological Responses to Water Deficit in the Bioenergy Crop Miscanthus x giganteus. Plant Biology Europe - FESPB/EPSO 2014 Congress, Dublin, Ireland, 22/06/2014 - 26/06/2014. pp. 34. Other2014.
The effect of resistance to mildew infection on ruminal fermentation of Lolium perenne. In A. Hopkins (ed), EGF at 50: The future of European grasslands. Proceedings of the 25th General Meeting of the European Grassland Federation, Aberystwyth, Wales, 7-11 September 2014. : Grassland Science in Europe. Proceedings of the 25th General Meeting of the European Grassland Federation, Aberystwyth, United Kingdom of Great Britain and Northern Ireland, 07/09/2014 - 11/09/2014. Prifysgol Aberystwyth | Aberystwyth University pp. 849.2014.
Trichoderma asperelloides suppresses nitric oxide generation elicited by Fusarium oxysporum in Arabidopsis roots. Molecular Plant-Microbe Interactions 27 (4) pp. 307-314. 10.1094/MPMI-06-13-0160-R2014.
Update on the genomics and basic biology of Brachypodium: International Brachypodium Initiative (IBI). Trends in Plant Science 19 (7) pp. 414-418. 10.1016/j.tplants.2014.05.0022014.
An assessment of the biotechnological use of hemoglobin modulation in cereals. Physiologia Plantarum 10.1111/ppl.121152013.
Comparative Metabolite Fingerprinting of the Rumen System during Colonisation of Three Forage Grass (Lolium perenne L.) Varieties. PLoS One 8 (11) e82801 10.1371/journal.pone.00828012013.
Comparison of cell wall composition across 15 ecotypes of Brachypodium distachyon originating from the eastern and western Mediterranean. 1st International Brachypodium Conference, Modena, Italy, 19/06/2013 - 21/06/2013.2013.
Exploiting Brachypodium to Identify Cell Wall-Specific Responses to Drought. 1st International Brachypodium Conference, Modena, Italy, 19/06/2013 - 21/06/2013. pp. S4.4.2013.
Exploring the mechanisms behind the effects of chronic bovine colostrum supplementation on risk of upper respiratory tract infection. 11th International Society of Exercise and Immunology symposium, Newcastle, Australia, 09/09/2013 - 12/09/2013.2013.
Genetic Diversity and Population Structure Among Oat Cultivars and Landraces. Plant Molecular Biology Reporter 31 (6) pp. 1305-1314. 10.1007/s11105-013-0598-82013.
Integrating nitric oxide into salicylic acid and jasmonic acid/ ethylene plant defense pathways. Frontiers in Plant Science 4 215 10.3389/fpls.2013.002152013.
Nitric oxide in plants an assessment of the current state of knowledge. AoB PLANTS 5 pls052 10.1093/aobpla/pls0522013.
Physiological and growth responses to water deficit in the bioenergy crop Miscanthus x giganteus. Frontiers in Plant Science 4 pp. 468. 10.3389/fpls.2013.004682013.
Spectroscopic monitoring of NO traces in plants and human breath: applications and perspectives. Applied Physics B: Lasers and Optics 110 (2) pp. 203-211. Other2013.
Stomatal lock-up following pathogenic challenge: source or symptom of costs of resistance in crops? Plant Pathology 62 (S1) pp. 72-82. 10.1111/ppa.121742013.
Striking a balance:does nitrate uptake and metabolism regulate both NO generation and scavenging? Frontiers in Plant Science 4 288 10.3389/fpls.2013.002882013.
The form of nitrogen nutrition affects resistance against Pseudomonas syringae pv. phaseolicola in tobacco. Journal of Experimental Botany 64 (2) pp. 553-568. 10.1093/jxb/ers3482013.
A novel function for a redox-related LEA protein (SAG21/AtLEA5) in root development and biotic stress responses. Plant, Cell and Environment 35 (2) pp. 418-429. 10.1111/j.1365-3040.2011.02394.x2012.
Commentary - NO and ROS homeostasis in mitochondria: a central role for alternative oxidase. New Phytologist 195 (1) pp. 1-3. 10.1111/j.1469-8137.2012.04189.x2012.
Evidence of a role for foliar salicylic acid in regulating the rate of post-ingestive protein breakdown in ruminants and contributing to landscape pollution. Journal of Experimental Botany 63 (8) pp. 3243-3255. 10.1093/jxb/ers0482012.
Evolution and taxonomic split of the model grass Brachypodium distachyon. Annals of Botany 109 (2) pp. 385-405. 10.1093/aob/mcr2942012.
Haemoglobin modulates NO emission and hyponasty under hypoxia-related stress in Arabidopsis thaliana. Journal of Experimental Botany 63 (15) pp. 5581-5591. 10.1093/jxb/ers2102012.
Latent soil effects of grazing and ammonium deposition on Deschampsia flexuosa tillers inserted and grown in heather moorland soil. Environmental and Experimental Botany 81 pp. 72-78. 10.1016/j.envexpbot.2012.02.0062012.
Nitric oxide counters ethylene effects on ripening fruits. Plant Signaling and Behavior 7 (4) pp. 476-483. 10.4161/psb.195232012.
Separating the inseparable: The metabolomic analysis of plant-pathogen interactions. In N. Hardy, R. Hall (eds), Plant Metabolomics : Methods and Protocols. Methods in Molecular Biology2012.
Targeting sources of drought tolerance within an Avena spp. collection through multivariate approaches. Planta 236 (5) pp. 1529-1545. 10.1007/s00425-012-1709-82012.
Brachypodium as a model for studying traits relevant for the development of bioenergy grasses. 1st European Brachypodium Workshop, Versailles, France, 19/10/2011 - 21/10/2011. pp. Abstract No: P2.9.2011.
Brachypodium as a model for the grasses: Today and the future. Plant Physiology 157 (1) pp. 3-13. 10.1104/pp.111.1795312011.
Exploiting the Brachypodium Tool Box in cereal and grass research. New Phytologist 191 (2) pp. 334-347. 10.1111/j.1469-8137.2011.03748.x2011.
Metabolomic approaches indicate that cell wall modifications play a major role in ethylene-mediated resistance against Botrytis cinerea. Plant Journal 67 (5) pp. 852-868. 10.1111/j.1365-313X.2011.04639.x2011.
Methods of nitric oxide detection in plants: A commentary. Plant Science 181 (5) pp. 509-519. 10.1016/j.plantsci.2011.04.0032011.
Morphological classification of plant cell deaths. Cell Death and Differentiation 18 (8) pp. 1241-1246. 10.1038/cdd.2011.362011.
Nitric oxide, nitrate reductase and UV-B tolerance. Tree Physiology 31 (8) pp. 795-797. 10.1093/treephys/tpr0802011.
Plant hemoglobins: important playersat the crossroads between oxygen and nitric oxide. FEBS Letters 585 (24) pp. 3843-3849. 10.1016/j.febslet.2011.10.0362011.
Using Fourier Transform Infra-Red (FTIR) on sputum to develop a predictive model to differentiate lung cancer from healthy controls. American Journal of Respiratory and Critical Care Medicine 183 pp. Paper A6098.2011.
Accumulation of chlorophyll catabolites photosensitizes the hypersensitive response elicited by Pseudomonas syringae in Arabidopsis. New Phytologist 188 (1) pp. 161-174. 10.1111/j.1469-8137.2010.03377.x2010.
Blumeria graminis interactions with barley conditioned by different single R genes demonstrate a temporal and spatial relationship between stomatal dysfunction and cell death. Phytopathology 100 (1) pp. 21-32. 10.1094/PHYTO-100-1-0021 Cadair2010.
Fourier transform infra-red (FTIR) spectroscopy on sputum from lung cancer patients, healthy controls and a high-risk cohort. British Thoracic Society Winter Meeting 2010. British Thoracic Society Winter Meeting 2010, London, United Kingdom of Great Britain and Northern Ireland, 01/01/2010 - 03/01/2010. pp. A19-A20. 10.1136/thx.2010.150912.38 Cadair2010.
Identification of genes involved in the floral transition at the shoot apical meristem of Lolium perenne L. by use of suppression subtractive hybridisation. Plant Growth Regulation 59 (3) pp. 215-225. 10.1007/s10725-009-9407-7 Cadair2009.
Proteomic analysis of the cacao pathogen Moniliophthora perniciosa. 16th International Cocoa Research Conference, Bali, Indonesia, 16/11/2009 - 21/11/2009.2009.
Proteomic approaches to characterise the role of ethylene in tomato plants attached by Botrytis cinerea. Plant Sciences Wales, School of Biosciences, United Kingdom of Great Britain and Northern Ireland, 22/01/2009 - 23/01/2009. pp. p24.2009.
The phytohormone salicylic acid influences autolysis in ruminantingested plant cells. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology 153 (2 (Supplement)) S160 10.1016/j.cbpa.2009.04.323 Cadair2009.
Development of genetic and genomic research resources for Brachypodium distachyon, a new model system for grass crop research. Crop Science 48 (Supplement 1) pp. S69-S84. 10.2135/cropsci2007.06.0332tpg Cadair2008.
Fourier transform infrared spectroscopy and metabolic profiling in lung cancer. Winter Meeting of the British-Thoracic-Society. Winter Meeting of the British-Thoracic-Society, London, United Kingdom of Great Britain and Northern Ireland, 03/12/2008 - 05/12/2008. pp. A60-A61. Cadair2008.
Nitric oxide generation in Vicia faba phloem cells reveals them to be sensitive detectors as well as possible systemic transducers of stress. New Phytologist 178 (3) pp. 634-646. 10.1111/j.1469-8137.2008.02388.x Cadair2008.
Pathogen-derived nitric oxide influences formation of the appressorium infection structure in the phytopathogenic fungus Blumeria graminis. Research in Microbiology 159 (6) pp. 476-480. 10.1016/j.resmic.2008.04.001 Cadair2008.
Using Fourier transform infrared (FTIR) spectroscopy to evaluate metabolic markers in sputum in patients with and without lung cancer. 6th Annual BTOG Meeting 2008, Dublin, Iceland, 23/01/2008 - 25/01/2008. pp. S11-S11. 10.1016/S0169-5002(08)70033-32008.
Enemy at the Gates: Interaction-Specific Stomatal Responses to Pathogenic Challenge. Plant Signaling and Behavior 2 (4) pp. 275-277. 10.4161/psb.2.4.41532007.
Metabolomic approaches to understand ethylene mediated defenses in Arabidopsis thaliana against Botrytis cinerea. In A. Ramina, C. Chang, J. Giovannoni, H. Klee, P. Perata, E. Woltering (eds), Advances in Plant Ethylene Research. Springer Nature, Dordrecht pp. 359-368. 10.1007/978-1-4020-6014-4_772007.
NO provides mainly avr-dependent inputs into cell death mechanisms associated with the hypersensitive response in tobacco. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology 146 (4) pp. S256. 10.1016/j.cbpa.2007.01.644 Cadair2007.
Throwing new light on the hypersensitive response. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology 146 (4) C2.9 Abstracts of the Annual Main Meeting of the Society for Experimental Biology, Glasgow, United Kingdom of Great Britain and Northern Ireland, 31/03/2007 - 04/04/2007. 10.1016/j.cbpa.2007.01.4452007.
Metabolomic approaches reveal that phosphatidic and phosphatidyl glycerol phospholipids are major discriminatory non-polar metabolites in responses by Brachypodium distachyon to challenge by Magnaporthe grisea. Plant Journal pp. 351-368. 10.1111/j.1365-313X.2006.02692.x Cadair2006.
Stomatal lock-open, a consequence of epidermal cell death, follows transient suppression of stomatal opening in barley attacked by Blumeria graminis. Journal of Experimental Botany pp. 2211-2226. Cadair Other2006.
In planta measurements of oxidative bursts elicited by avirulent and virulent bacterial pathogens suggests that H2O2 is insufficient to elicit cell death in tobacco. Plant, Cell and Environment pp. 548-561. 10.1111/j.1365-3040.2005.01301.x Cadair2005.
Laser photoacoustic detection allows in planta detection of nitric oxide in tobacco following challenge with avirulent and virulent pseudomonas syringae pathovars. Plant Physiology pp. 1247-1258. 10.1104/pp.104.055772 Other Cadair2005.
Nitric oxide contributes both to papilla-based resistance and the hypersensitive response in barley attacked by Blumeria graminis f. sp.hordei. Molecular Plant Pathology 6 (1) pp. 65-78. 10.1111/j.1364-3703.2004.00266.x Cadair2005.
The outcomes of concentration-specific interactions between salicylate and jasmonate signaling include synergy, antagonism, and oxidative stress leading to cell death. Plant Physiology 140 (1) pp. 249-262. 10.1104/pp.105.072348 Other Cadair2005.
Characterization of a proteinase inhibitor from Brachypodium distachyon suggests the conservation of defence signalling pathways between dicotyledonous plants and grasses. Molecular Plant Pathology 5 (4) pp. 267-280. 10.1111/j.1364-3703.2004.00225.x Cadair2004.
Magnaporthe grisea interactions with the model grass Brachypodium distachyon closely resemble those with rice (Oryza sativa). Molecular Plant Pathology. Wiley pp. 253-265. 10.1111/j.1364-3703.2004.00224.x Cadair2004.
Prospects for functional genomics in a new model grass. In D. Leister (ed), Plant Functional Genomics. Taylor & Francis2004.
Salicylic acid dependent signaling promotes basal thermotolerance but is not essential for acquired thermotolerance in Arabidopsis thaliana. Plant Journal 38 (3) pp. 432-447. 10.1111/j.1365-313X.2004.02054.x Other Cadair2004.