Prof Luis Mur PhD
- BR21720 - Evolution and Molecular Systematics
- BR31420 - Bioinformatics and Functional Genomics
- BR33720 - Microbial Pathogenesis
- BR24610 - Advances in Human Biosciences
- BR33320 - Gene Expression and Developmental Genetics
- BR22310 - Infectious Diseases
- BR21720 - Evolution and Molecular Systematics
- BR33720 - Microbial Pathogenesis
- BR22720 - Molecular Cell and Cancer Biology
- BR31420 - Bioinformatics and Functional Genomics
In my Food Security Research I am interested in developing our understanding of the genetic & biochemical events associated with plant responses to stress & in identifying sources of tolerance/resistance. This work is based on the use of model plant species, Arabidopsis & Brachypodium distachyon & also crops, wheat (Triticum aestivum), oats (Avena sativa) tomato (Solanum esculentum) & barley (Hordeum vulgare).
My interests in clinical health focus on the respiratory tract & identifying drug leads from natural products. Lung cancer (LC) is the most prevalent cancer in the world with 1.3 million deaths recorded each year. Only 15% of patients live for five or more years after initial diagnosis, primarily due to late detection. Chronic obstructive pulmonary disease (COPD) is characterised by an increase in mucus production due to hyperplasia of goblet cells, & hypertrophy of mucus glands COPD is a leading cause of death, arising from acute exacerbations (sudden worsening of symptoms) which may be triggered by infection or environmental pollutants. My research in this area is focusing on the detection of metabolite biomarkers for LC & COPD & investigating possible links with the lung microbiome.
My research in bioactive natural products focus on identifying anti-microbial metabolites against such human pathogens as MSRA & Pseudomonas aeruginosa from invasive plant species & extremophile microbial strains.
I employ cutting edge genomic & post-genomic approaches but will use classical physiological, genetic, biochemical or microbiological approaches- as appropriate. I have numerous national & international collaborations which are supported by funding from the BBSRC, the EU, NSF (USA), DEFRA, Royal Society, Welsh Assembly, & AU Research Fund.
Favouring NO over H2O2 production will increase Pb tolerance in Prosopis farcta via altered primary metabolism. Ecotoxicology and Environmental Safety 142 pp. 293-302. 10.1016/j.ecoenv.2017.04.036 Cadair2017.
Marker-Assisted Selection for Durable Rust Resistance in a Widely Adopted Wheat Cultivar "Inqilab-91". International Journal of Agriculture and Biology 10.17957/IJAB/15.04052017 (In press).
Corrigendum to Metabolomic-based biomarker discovery for non-invasive lung cancer screening: A case study [Biochimica et Biophysica Acta (BBA) – General subjects, vol. 1860 (2016), pp. 2682–2687]. Biochimica et Biophysica Acta (BBA) - General Subjects 10.1016/j.bbagen.2017.02.015 Cadair2017.
Expression of FlHMA3, a vacuolar P1B2-ATPase from Festulolium loliaceum, correlates with response to cadmium stress. Plant Physiology and Biochemistry 112 pp. 270-277. 10.1016/j.plaphy.2017.01.013 Cadair2017.
Compromised Photosynthetic Electron Flow and H2O2 Generation Correlate with Genotype-Specific Stomatal Dysfunctions during Resistance against Powdery Mildew in Oats. Frontiers in Plant Science 7 1660 10.3389/fpls.2016.01660 Cadair2016.
Metabolomic-based biomarker discovery for non-invasive lung cancer screening: A case study. Biochimica et Biophysica Acta (BBA) - General Subjects 1860 (11 (Part B)) pp. 2682-2687. 10.1016/j.bbagen.2016.07.007 Cadair2016.
Terminator Operon Reporter: Combining a transcription termination switch with reporter technology for improved gene synthesis and synthetic biology applications. Scientific Reports 6 26572 10.1038/srep26572 Cadair2016.
Metagenomic Sequencing of the Chronic Obstructive Pulmonary Disease Upper Bronchial Tract Microbiome Reveals Functional Changes Associated with Disease Severity. PLoS One 11 (2) 0149095 10.1371/journal.pone.0149095 Cadair2016.
Project Report No. 557: Screening for 'costs of disease resistance'. Agriculture and Horticulture Development Board Cadair2016.
Laser-Based Methods for Detection of Nitric Oxide in Plants. In (ed) Plant Nitric Oxide: Methods and Protocols. Methods in Molecular Biology, vol. 1242 Springer Nature pp. 113-126. 10.1007/978-1-4939-3600-7_10 Cadair2016.
Modulation of Pb-induced stress in Prosopis shoots through an interconnected network of signaling molecules, phenolic compounds and amino acids. Plant Physiology and Biochemistry 99 pp. 11-20. 10.1016/j.plaphy.2015.12.004 Cadair2015.
The development of tea blister caused by Exobasidium vexans in tea (Camellia sinensis) correlates with the reduced accumulation of some antimicrobial metabolites and the defence signals salicylic and jasmonic acids. Plant Pathology 64 (6) pp. 1471-1483. 10.1111/ppa.12364 Cadair2015.
Senescence and programmed cell death. In (eds) Biochemistry and Molecular Biology of Plants. Wiley pp. 925-982. Cadair2015.
Genome-wide association study for crown rust (Puccinia coronata f. sp. avenae) and powdery mildew (Blumeria graminis f. sp. avenae) resistance in an oat (Avena sativa) collection of commercial varieties and landraces. Frontiers in Plant Science 6 103 10.3389/fpls.2015.00103 Cadair2015.
Ethylene, Nitric Oxide and Haemoglobins in Plant Tolerance to Flooding. In (eds) Abiotic Stresses in Crop Plants. CABI Publishing pp. 43-53. Cadair2015.
The effect of resistance to mildew infection on ruminal fermentation of Lolium perenne. In (ed) EGF at 50: The future of European grasslands. Proceedings of the 25th General Meeting of the European Grassland Federation, Aberystwyth, Wales, 7-11 September 2014. : Grassland Science in Europe. Proceedings of the 25th General Meeting of the European Grassland Federation. Prifysgol Aberystwyth | Aberystwyth University pp. 849. Cadair2014.
Coupled cryoconite ecosystem structure–function relationships are revealed by comparing bacterial communities in alpine and Arctic glaciers. FEMS Microbiology Ecology 89 (2) pp. 222-237. 10.1111/1574-6941.12283 Cadair2014.
Trichoderma asperelloides suppresses nitric oxide generation elicited by Fusarium oxysporum in Arabidopsis roots. Molecular Plant-Microbe Interactions 27 (4) pp. 307-314. 10.1094/MPMI-06-13-0160-R Cadair2014.
A metabolomic study in oats (Avena sativa) highlights a drought tolerance mechanism based on salicylate signalling pathways and the modulation of carbon, antioxidant and photo-oxidative metabolism. Plant, Cell and Environment 10.1111/pce.12501 Cadair2014.
Comparison of cell wall composition across 15 ecotypes of Brachypodium distachyon originating from the eastern and western Mediterranean. 1st International Brachypodium Conference. Cadair2013.
Exploiting Brachypodium to Identify Cell Wall-Specific Responses to Drought. 1st International Brachypodium Conference. Cadair2013.
Exploring the mechanisms behind the effects of chronic bovine colostrum supplementation on risk of upper respiratory tract infection. 11th International Society of Exercise and Immunology symposium. Cadair2013.
Latent soil effects of grazing and ammonium deposition on Deschampsia flexuosa tillers inserted and grown in heather moorland soil. Environmental and Experimental Botany 81 pp. 72-78. 10.1016/j.envexpbot.2012.02.006 Cadair2012.
Evidence of a role for foliar salicylic acid in regulating the rate of post-ingestive protein breakdown in ruminants and contributing to landscape pollution. Journal of Experimental Botany 63 (8) pp. 3243-3255. 10.1093/jxb/ers048 Cadair2012.
A novel function for a redox-related LEA protein (SAG21/AtLEA5) in root development and biotic stress responses. Plant, Cell and Environment 35 (2) pp. 418-429. 10.1111/j.1365-3040.2011.02394.x Cadair2012.
Separating the inseparable: The metabolomic analysis of plant-pathogen interactions. In (eds) Plant Metabolomics : Methods and Protocols. Methods in Molecular Biology Cadair2012.
Metabolomic approaches indicate that cell wall modifications play a major role in ethylene-mediated resistance against Botrytis cinerea. Plant Journal 67 (5) pp. 852-868. 10.1111/j.1365-313X.2011.04639.x Cadair2011.
Brachypodium as a model for studying traits relevant for the development of bioenergy grasses. 1st European Brachypodium Workshop. Cadair2011.
Using Fourier Transform Infra-Red (FTIR) on sputum to develop a predictive model to differentiate lung cancer from healthy controls. American Journal of Respiratory and Critical Care Medicine 183 pp. Paper A6098. Cadair2011.
Accumulation of chlorophyll catabolites photosensitizes the hypersensitive response elicited by Pseudomonas syringae in Arabidopsis. New Phytologist 188 (1) pp. 161-174. 10.1111/j.1469-8137.2010.03377.x Cadair2010.
Blumeria graminis interactions with barley conditioned by different single R genes demonstrate a temporal and spatial relationship between stomatal dysfunction and cell death. Phytopathology 100 (1) pp. 21-32. 10.1094/PHYTO-100-1-0021 Cadair2010.
Fourier transform infra-red (FTIR) spectroscopy on sputum from lung cancer patients, healthy controls and a high-risk cohort. British Thoracic Society Winter Meeting 2010. British Thoracic Society Winter Meeting 2010. pp. A19-A20. 10.1136/thx.2010.150912.38 Cadair2010.
Proteomic analysis of the cacao pathogen Moniliophthora perniciosa. 16th International Cocoa Research Conference. Cadair2009.
Identification of genes involved in the floral transition at the shoot apical meristem of Lolium perenne L. by use of suppression subtractive hybridisation. Plant Growth Regulation 59 (3) pp. 215-225. 10.1007/s10725-009-9407-7 Cadair2009.
The phytohormone salicylic acid influences autolysis in ruminantingested plant cells. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology 153 (2 (Supplement)) S160 10.1016/j.cbpa.2009.04.323 Cadair2009.
Proteomic approaches to characterise the role of ethylene in tomato plants attached by Botrytis cinerea. Plant Sciences Wales. Cadair2009.
Fourier transform infrared spectroscopy and metabolic profiling in lung cancer. Winter Meeting of the British-Thoracic-Society. Winter Meeting of the British-Thoracic-Society. pp. A60-A61. Cadair2008.
Nitric oxide generation in Vicia faba phloem cells reveals them to be sensitive detectors as well as possible systemic transducers of stress. New Phytologist 178 (3) pp. 634-646. 10.1111/j.1469-8137.2008.02388.x Cadair2008.
Pathogen-derived nitric oxide influences formation of the appressorium infection structure in the phytopathogenic fungus Blumeria graminis. Research in Microbiology 159 (6) pp. 476-480. 10.1016/j.resmic.2008.04.001 Cadair2008.
Using Fourier transform infrared (FTIR) spectroscopy to evaluate metabolic markers in sputum in patients with and without lung cancer. 6th Annual BTOG Meeting 2008. 10.1016/S0169-5002(08)70033-3 Cadair2008.
Development of genetic and genomic research resources for Brachypodium distachyon, a new model system for grass crop research. Crop Science 48 (Supplement 1) pp. S69-S84. 10.2135/cropsci2007.06.0332tpg Cadair2008.
NO provides mainly avr-dependent inputs into cell death mechanisms associated with the hypersensitive response in tobacco. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology 146 (4) pp. S256. 10.1016/j.cbpa.2007.01.644 Cadair2007.
Throwing new light on the hypersensitive response. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology 146 (4) C2.9 Abstracts of the Annual Main Meeting of the Society for Experimental Biology. 10.1016/j.cbpa.2007.01.445 Cadair2007.
Metabolomic approaches to understand ethylene mediated defenses in Arabidopsis thaliana against Botrytis cinerea. In (eds) Advances in Plant Ethylene Research. Springer Nature, Dordrecht pp. 359-368. 10.1007/978-1-4020-6014-4_77 Cadair2007.
Metabolomic approaches reveal that phosphatidic and phosphatidyl glycerol phospholipids are major discriminatory non-polar metabolites in responses by Brachypodium distachyon to challenge by Magnaporthe grisea. Plant Journal pp. 351-368. 10.1111/j.1365-313X.2006.02692.x Cadair2006.
Stomatal lock-open, a consequence of epidermal cell death, follows transient suppression of stomatal opening in barley attacked by Blumeria graminis. Journal of Experimental Botany pp. 2211-2226. Cadair Other2006.
The outcomes of concentration-specific interactions between salicylate and jasmonate signaling include synergy, antagonism, and oxidative stress leading to cell death. Plant Physiology 140 (1) pp. 249-262. 10.1104/pp.105.072348 Other Cadair2005.
Laser photoacoustic detection allows in planta detection of nitric oxide in tobacco following challenge with avirulent and virulent pseudomonas syringae pathovars. Plant Physiology pp. 1247-1258. 10.1104/pp.104.055772 Other Cadair2005.
In planta measurements of oxidative bursts elicited by avirulent and virulent bacterial pathogens suggests that H2O2 is insufficient to elicit cell death in tobacco. Plant, Cell and Environment pp. 548-561. 10.1111/j.1365-3040.2005.01301.x Cadair2005.
Nitric oxide contributes both to papilla-based resistance and the hypersensitive response in barley attacked by Blumeria graminis f. sp.hordei. Molecular Plant Pathology 6 (1) pp. 65-78. 10.1111/j.1364-3703.2004.00266.x Cadair2005.
Prospects for functional genomics in a new model grass. In (ed) Plant Functional Genomics. Taylor & Francis Cadair2004.
Characterization of a proteinase inhibitor from Brachypodium distachyon suggests the conservation of defence signalling pathways between dicotyledonous plants and grasses. Molecular Plant Pathology 5 (4) pp. 267-280. 10.1111/j.1364-3703.2004.00225.x Cadair2004.
Salicylic acid dependent signaling promotes basal thermotolerance but is not essential for acquired thermotolerance in Arabidopsis thaliana. Plant Journal 38 (3) pp. 432-447. 10.1111/j.1365-313X.2004.02054.x Other Cadair2004.
Magnaporthe grisea interactions with the model grass Brachypodium distachyon closely resemble those with rice (Oryza sativa). Molecular Plant Pathology. Wiley pp. 253-265. 10.1111/j.1364-3703.2004.00224.x Cadair2004.
Powdery mildew, cereal cells and sustainable crop production. 11th International Cereal Rust and Powdery Mildew Conference. Cadair2004.