Prof Luis Mur PhD
- BR21720 - Evolution and Molecular Systematics
- BR31420 - Bioinformatics and Functional Genomics
- BR33720 - Microbial Pathogenesis
- BR22310 - Infectious Diseases
- BR31420 - Bioinformatics and Functional Genomics
- BR33720 - Microbial Pathogenesis
- BR24610 - Advances in Human Biosciences
- BR22720 - Molecular Cell and Cancer Biology
- BR21720 - Evolution and Molecular Systematics
- BR33320 - Gene Expression and Developmental Genetics
In my Food Security Research I am interested in developing our understanding of the genetic & biochemical events associated with plant responses to stress & in identifying sources of tolerance/resistance. This work is based on the use of model plant species, Arabidopsis & Brachypodium distachyon & also crops, wheat (Triticum aestivum), oats (Avena sativa) tomato (Solanum esculentum) & barley (Hordeum vulgare).
My interests in clinical health focus on the respiratory tract & identifying drug leads from natural products. Lung cancer (LC) is the most prevalent cancer in the world with 1.3 million deaths recorded each year. Only 15% of patients live for five or more years after initial diagnosis, primarily due to late detection. Chronic obstructive pulmonary disease (COPD) is characterised by an increase in mucus production due to hyperplasia of goblet cells, & hypertrophy of mucus glands COPD is a leading cause of death, arising from acute exacerbations (sudden worsening of symptoms) which may be triggered by infection or environmental pollutants. My research in this area is focusing on the detection of metabolite biomarkers for LC & COPD & investigating possible links with the lung microbiome.
My research in bioactive natural products focus on identifying anti-microbial metabolites against such human pathogens as MSRA & Pseudomonas aeruginosa from invasive plant species & extremophile microbial strains.
I employ cutting edge genomic & post-genomic approaches but will use classical physiological, genetic, biochemical or microbiological approaches- as appropriate. I have numerous national & international collaborations which are supported by funding from the BBSRC, the EU, NSF (USA), DEFRA, Royal Society, Welsh Assembly, & AU Research Fund.
Corrigendum to Metabolomic-based biomarker discovery for non-invasive lung cancer screening: A case study [Biochimica et Biophysica Acta (BBA) – General subjects, vol. 1860 (2016), pp. 2682–2687]. Biochimica et Biophysica Acta (BBA) - General Subjects2017.
Project Report No. 557: Screening for 'costs of disease resistance'. Agriculture and Horticulture Development Board2016.
Ethylene, Nitric Oxide and Haemoglobins in Plant Tolerance to Flooding. In (eds) Abiotic Stresses in Crop Plants. CABI Publishing pp. 43-53.2015.
Genome-wide association study for crown rust (Puccinia coronata f. sp. avenae) and powdery mildew (Blumeria graminis f. sp. avenae) resistance in an oat (Avena sativa) collection of commercial varieties and landraces. Frontiers in Plant Science 6 1032015.
Senescence and programmed cell death. In (eds) Biochemistry and Molecular Biology of Plants. Wiley pp. 925-982.2015.
The development of tea blister caused by Exobasidium vexans in tea (Camellia sinensis) correlates with the reduced accumulation of some antimicrobial metabolites and the defence signals salicylic and jasmonic acids. Plant Pathology 64 (6) pp. 1471-1483.2015.
A metabolomic study in oats (Avena sativa) highlights a drought tolerance mechanism based on salicylate signalling pathways and the modulation of carbon, antioxidant and photo-oxidative metabolism. Plant, Cell and Environment2014.
Revealing the Molecular and Physiological Responses to Water Deficit in the Bioenergy Crop Miscanthus x giganteus. Plant Biology Europe - FESPB/EPSO 2014 Congress, Dublin, Ireland, 22/06/2014 - 26/06/2014. pp. 34. Other2014.
The effect of resistance to mildew infection on ruminal fermentation of Lolium perenne. In (ed) EGF at 50: The future of European grasslands. Proceedings of the 25th General Meeting of the European Grassland Federation, Aberystwyth, Wales, 7-11 September 2014. : Grassland Science in Europe. Proceedings of the 25th General Meeting of the European Grassland Federation, Aberystwyth, United Kingdom of Great Britain and Northern Ireland, 07/09/2014 - 11/09/2014. Prifysgol Aberystwyth | Aberystwyth University pp. 849.2014.
Comparison of cell wall composition across 15 ecotypes of Brachypodium distachyon originating from the eastern and western Mediterranean. 1st International Brachypodium Conference, Modena, Italy, 19/06/2013 - 21/06/2013.2013.
Exploiting Brachypodium to Identify Cell Wall-Specific Responses to Drought. 1st International Brachypodium Conference, Modena, Italy, 19/06/2013 - 21/06/2013. pp. S4.4.2013.
Exploring the mechanisms behind the effects of chronic bovine colostrum supplementation on risk of upper respiratory tract infection. 11th International Society of Exercise and Immunology symposium, Newcastle, Australia, 09/09/2013 - 12/09/2013.2013.
Spectroscopic monitoring of NO traces in plants and human breath: applications and perspectives. Applied Physics B: Lasers and Optics 110 (2) pp. 203-211. Other2013.
Evidence of a role for foliar salicylic acid in regulating the rate of post-ingestive protein breakdown in ruminants and contributing to landscape pollution. Journal of Experimental Botany 63 (8) pp. 3243-3255.2012.
Haemoglobin modulates salicylate and jasmonate/ethylene-mediated resistance mechanisms against pathogens. Journal of Experimental Botany 63 (12) pp. 4375-4387. Other2012.
Separating the inseparable: The metabolomic analysis of plant-pathogen interactions. In (eds) Plant Metabolomics : Methods and Protocols. Methods in Molecular Biology2012.
Are stomatal responses the key to understanding the cost of fungal disease resistance in plants? Journal of the Science of Food and Agriculture 91 (9) pp. 1538-1540. Cadair2011.
Brachypodium as a model for studying traits relevant for the development of bioenergy grasses. 1st European Brachypodium Workshop, Versailles, France, 19/10/2011 - 21/10/2011. pp. Abstract No: P2.9.2011.
Evaluation of FTIR Spectroscopy as a diagnostic tool for lung cancer using sputum. BMC Cancer 10 (640) 640 Cadair2011.
Using Fourier Transform Infra-Red (FTIR) on sputum to develop a predictive model to differentiate lung cancer from healthy controls. American Journal of Respiratory and Critical Care Medicine 183 pp. Paper A6098.2011.
Blumeria graminis interactions with barley conditioned by different single R genes demonstrate a temporal and spatial relationship between stomatal dysfunction and cell death. Phytopathology 100 (1) pp. 21-32. Cadair2010.
Dual metabolomics: A novel approach to understanding plant-pathogen interactions. Phytochemistry 71 (5-6) pp. 590-597. Cadair2010.
Fourier transform infra-red (FTIR) spectroscopy on sputum from lung cancer patients, healthy controls and a high-risk cohort. British Thoracic Society Winter Meeting 2010. British Thoracic Society Winter Meeting 2010, London, United Kingdom of Great Britain and Northern Ireland, 01/01/2010 - 03/01/2010. pp. A19-A20. Cadair2010.
NO way to treat a cold. New Phytologist 189 (2) pp. 360-363. Cadair2010.
Aspirin, salicylates and cancer. The Lancet 373 (9671) pp. 1301-1309. Cadair2009.
Identification of coincident QTL for days to heading, spike length and spikelets per spike in Lolium perenne L. Euphytica 166 (1) pp. 61-70. Cadair2009.
Identification of genes involved in the floral transition at the shoot apical meristem of Lolium perenne L. by use of suppression subtractive hybridisation. Plant Growth Regulation 59 (3) pp. 215-225. Cadair2009.
Jasmonates interact with salicylic acid to confer basal thermotolerance in Arabidopsis thaliana. New Phytologist 182 (1) pp. 175-187. Cadair2009.
Proteomic analysis of the cacao pathogen Moniliophthora perniciosa. 16th International Cocoa Research Conference, Bali, Indonesia, 16/11/2009 - 21/11/2009.2009.
Proteomic approaches to characterise the role of ethylene in tomato plants attached by Botrytis cinerea. Plant Sciences Wales, School of Biosciences, United Kingdom of Great Britain and Northern Ireland, 22/01/2009 - 23/01/2009. pp. p24.2009.
The phytohormone salicylic acid influences autolysis in ruminantingested plant cells. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology 153 (2 (Supplement)) S160 Cadair2009.
Biphasic ethylene production during the hypersensitive response in Arabidopsis: A window into defence priming mechanisms? Plant Signaling and Behavior 4 (7) pp. 610-613. Cadair2008.
Development of genetic and genomic research resources for Brachypodium distachyon, a new model system for grass crop research. Crop Science 48 (Supplement 1) pp. S69-S84. Cadair2008.
Fourier transform infrared spectroscopy and metabolic profiling in lung cancer. Winter Meeting of the British-Thoracic-Society. Winter Meeting of the British-Thoracic-Society, London, United Kingdom of Great Britain and Northern Ireland, 03/12/2008 - 05/12/2008. pp. A60-A61. Cadair2008.
Nitric oxide generation in Vicia faba phloem cells reveals them to be sensitive detectors as well as possible systemic transducers of stress. New Phytologist 178 (3) pp. 634-646. Cadair2008.
Nitric oxide interacts with salicylate to regulate biphasic ethylene production during the hypersensitive response. Plant Physiology 148 (3) pp. 1537-1546. Cadair2008.
Pathogen-derived nitric oxide influences formation of the appressorium infection structure in the phytopathogenic fungus Blumeria graminis. Research in Microbiology 159 (6) pp. 476-480. Cadair2008.
Using Fourier transform infrared (FTIR) spectroscopy to evaluate metabolic markers in sputum in patients with and without lung cancer. 6th Annual BTOG Meeting 2008, Dublin, Iceland, 23/01/2008 - 25/01/2008. pp. S11-S11.2008.
NO provides mainly avr-dependent inputs into cell death mechanisms associated with the hypersensitive response in tobacco. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology 146 (4) pp. S256. Cadair2007.
Post-ingestion induction of plant cell death: Regulation and implications. pp. 200-. Cadair2007.
The application of MANOVA to analyse Arabidopsis thaliana metabolomic data from factorially designed experiments. Metabolomics pp. 517-530. Cadair2007.
The hypersensitive response; the centenary is upon us but how much do we know? Journal of Experimental Botany 59 (3) pp. 501-520. Cadair2007.
Throwing new light on the hypersensitive response. Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology 146 (4) C2.9 Abstracts of the Annual Main Meeting of the Society for Experimental Biology, Glasgow, United Kingdom of Great Britain and Northern Ireland, 31/03/2007 - 04/04/2007.2007.
Metabolomic approaches reveal that phosphatidic and phosphatidyl glycerol phospholipids are major discriminatory non-polar metabolites in responses by Brachypodium distachyon to challenge by Magnaporthe grisea. Plant Journal pp. 351-368. Cadair2006.
Stomatal lock-open, a consequence of epidermal cell death, follows transient suppression of stomatal opening in barley attacked by Blumeria graminis. Journal of Experimental Botany pp. 2211-2226. Cadair Other2006.
Harpin modulates the accumulation of salicylic acid by Arabidopsis cells via apoplastic alkalization. Journal of Experimental Botany pp. 3129-3136. Cadair2005.
In planta measurements of oxidative bursts elicited by avirulent and virulent bacterial pathogens suggests that H2O2 is insufficient to elicit cell death in tobacco. Plant, Cell and Environment pp. 548-561. Cadair2005.
Laser photoacoustic detection allows in planta detection of nitric oxide in tobacco following challenge with avirulent and virulent pseudomonas syringae pathovars. Plant Physiology pp. 1247-1258. Other Cadair2005.
NO way to live: the various roles of nitric oxide in plant-pathogen interactions. Journal of Experimental Botany pp. 489-505. Cadair2005.
Nitric oxide contributes both to papilla-based resistance and the hypersensitive response in barley attacked by Blumeria graminis f. sp.hordei. Molecular Plant Pathology 6 (1) pp. 65-78. Cadair2005.
The outcomes of concentration-specific interactions between salicylate and jasmonate signaling include synergy, antagonism, and oxidative stress leading to cell death. Plant Physiology 140 (1) pp. 249-262. Other Cadair2005.
A mutation in the Cap Binding Protein 20 gene confers drought tolerance to Arabidopsis. Plant Molecular Biology pp. 679-686. Cadair2004.
Characterization of a proteinase inhibitor from Brachypodium distachyon suggests the conservation of defence signalling pathways between dicotyledonous plants and grasses. Molecular Plant Pathology 5 (4) pp. 267-280. Cadair2004.
Magnaporthe grisea interactions with the model grass Brachypodium distachyon closely resemble those with rice (Oryza sativa). Molecular Plant Pathology. Wiley pp. 253-265. Cadair2004.
Powdery mildew, cereal cells and sustainable crop production. 11th International Cereal Rust and Powdery Mildew Conference, Norwich, United Kingdom of Great Britain and Northern Ireland, 23/08/2004 - 27/08/2004.2004.
Prospects for functional genomics in a new model grass. In (ed) Plant Functional Genomics. Taylor & Francis2004.
Ethylene regulates monomeric GTP-binding protein gene expression and activity in Arabidopsis. Plant Physiology 131 (4) pp. 1705-1717. Cadair2003.
Protein kinases in plants in the transduction of abiotic and biotic signals. Russian Journal of Plant Physiology (Fiziologiya rastenii) 49 (1) pp. 107-119. Cadair2002.
Ethylene signal perception and transduction: multiple paradigms? Biological Reviews 76 (1) pp. 103-108. Cadair2001.