Prof Mike Young

Prof Mike Young

Emeritus Professor

Contact Details

Research

Our laboratory studies post-exponential phase gene expression in several Gram-positive bacteria, including Bacillus and Clostridium. Recent work on dormancy in Micrococcus luteus led to the discovery of the Rpf family of bacterial growth factors found throughout the actinobacteria (e.g. mycobacteria, streptomycetes). We are currently exploring the mechanism of actions of these secreted bacterial growth factors and their potential applications for TB protection and therapy.

Publications

Telkov, MV, Demina, GR, Voloshin, SA, Salina, EG, Dudik, TV, Stekhanova, TN, Mukamolova, GV, Kazaryan, KA, Goncharenko, AV, Young, M & Kaprelyants, AS 2006, 'Proteins of the Rpf (resuscitation promoting factor) family are peptidoglycan hydrolases' Биохимия, vol 71, no. 4, pp. 414-422. DOI: 10.1134/S0006297906040092
Mukamolova, GV, Murzin, AG, Salina, EG, Demina, GR, Kell, DB, Kaprelyants, AS & Young, M 2006, 'Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation' Molecular Microbiology, vol 59, no. 1, pp. 84-98. DOI: 10.1111/j.1365-2958.2005.04930.x
Downing, KJ, Mischenko, VV, Shleeva, MO, Young, DI, Young, M, Kaprelyants, AS, Apt, AS & Mizrahi, V 2005, 'Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro' Infection and Immunity, vol 73, no. 5, pp. 3038-3043. DOI: 10.1128/IAI.73.5.3038-3043.2005
Ravagnani, A, Finan, CL & Young, M 2005, 'A novel firmicute protein family related to the actinobacterial resuscitation-promoting factors by non-orthologous domain displacement' BMC Genomics, vol 6, pp. 39-52. DOI: 10.1186/1471-2164-6-39
Young, M, Davis, I, Minton, NP & Carter, G 2005, Gene cloning in Clostridia. in P Duerre (ed.), in: Handbook on Clostridia. (Eds)Duerre. Taylor & Francis, pp. 37-52.
Mukamolova, GV, Kaprelyants, AS & Young, M 2005, Mycobacterial dormancy and its relation to persistence. in T Parish (ed.), Parish. Taylor & Francis, pp. 265-320.
Young, M, Goodacre, R, Kassama, Y, Zhao, HJ & Kell, DB 2004, 'Differentiation of Micromonospora isolates from a coastal sediment in Wales on the basis of Fourier transform infrared spectroscopy, 16S rRNA sequence analysis, and the amplified fragment length polymorphism technique' Applied and Environmental Microbiology, vol 70, no. 11, pp. 6619-6627. DOI: 10.1128/AEM.70.11.6619-6627.2004
Downing, KJ, McAdam, RA, Kelly, F, Young, M, Betts, JC & Young, DI 2004, 'Global expression profiling of strains harbouring null mutations reveals that the five rpf-like genes of Mycobacterium tuberculosis show functional redundancy' Tuberculosis, pp. 3-4.
Goodacre, R, Mukamolova, GV, Young, M, Kaprelyants, AS, Zhao, HJ, Kell, DB & Finan, CL 2004, Resuscitation of 'uncultured' microorganisms. in T A (ed.), In. American Society for Microbiology, pp. 100-108.
Williams, HD, Shleeva, M, Mukamolova, GV & Young, M 2004, 'Formation of 'non-culturable' cells of Mycobacterium smegmatis in stationary phase in response to growth under sub-optimal conditions and their Rpf-mediated resuscitation' Microbiology, pp. 1687-1697. DOI: 10.1099/mic.0.26893-0
Mukamolova, GV, Kaprelyants, AS, Kell, DB & Young, M 2003, Adoption of the transiently non-culturable state - a bacterial survival strategy? in RK Poole (ed.), Advances in Microbial Physiology. vol. 47, Elsevier, pp. 65-129. DOI: 10.1016/S0065-2911(03)47002-1
Kaprelyants, AS, Mukamolova, GV, Young, M, Turapov, OA, Telkov, M, Kazarian, K & Kell, DB 2002, 'The rpf gene of Micrococcus luteus encodes an essential secreted growth factor' Molecular Microbiology, pp. 611-621. DOI: 10.1046/j.1365-2958.2002.03183.x
Kaprelyants, AS, Mukamolova, GV, Young, M, Turapov, OA, Young, DI & Kell, DB 2002, 'A family of autocrine growth factors in Mycobacterium tuberculosis' Molecular Microbiology, vol 46, no. 3, pp. 623-635. DOI: 10.1046/j.1365-2958.2002.03184.x
Young, M, Rogozinski, J, Marriott, SA, Kaderbhai, MA & Hopper, DJ 2002, 'Cloning, sequencing and heterologous expression of the gene for lupanine hydroxylase, a quinocytochrome c from a Pseudomonas sp.' Biochemical Journal, vol 367, pp. 483-489. DOI: 10.1042/BJ20020729
Warkup, CC, Jones, HE, Young, MJ, Wolf, BT & Lewis, RM 2002, 'Changes in muscularity with growth and its relationship with other carcass traits in three terminal sire breeds of sheep' Animal Science, vol 74, no. 2, pp. 265-275.
Mukamolova, GV, Telkov, MV, Bagramyan, K, Young, M, Shleeva, MO, Kaprelyants, AS & Kell, DB 2002, 'Formation and resuscitation of 'non-culturable' cells of Rhodococcus rhodochrous and Mycobacterium tuberculosis in prolonged stationary phase' Microbiology, pp. 1581-1591.
Young, MJ, Lewis, RM, Jones, HE & Wolf, BT 2002, 'The use of X-ray computer tomography for measuring the muscularity of live sheep' Animal Science, pp. 387-399.
Gapes, JR, Schuster, KC, Goodacre, R & Young, M 2001, 'Degeneration of solventogenic Clostridium strains monitored by Fourier transform infrared spectroscopy of bacterial cells' Journal of Industrial Microbiology and Biotechnology, vol 27, no. 5, pp. 314-321. DOI: 10.1038/sj.jim.7000146
Young, M, Kashket, S, Kashket, ER & Liyanage, H 2001, 'Clostridium beijerinckii and Clostridium difficile detoxify methylglyoxal by a novel mechanism involving glycerol dehydrogenase' Applied and Environmental Microbiology, vol 67, no. 5, pp. 2004-2010. DOI: 10.1128/AEM.67.5.2004-2010.2001
Ravagnani, A, Jennert, KCB, Steiner, E, Grünberg, R, Jefferies, JR, Wilkinson, SR, Young, D, Tidswell, EC, Brown, DP, Youngman, P, Morris, JG & Young, M 2000, 'Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridia' Molecular Microbiology, vol 37, no. 5, pp. 1172-1185. DOI: 10.1046/j.1365-2958.2000.02071.x
Aubrey, W, Riley, M, Young, M, King, RD, Oliver, SG & Clare, A 2015, 'A Tool for Multiple Targeted Genome Deletions that Is Precise, Scar-Free, and Suitable for Automation.' PLoS One, vol 10, no. 12, 0142494. DOI: 10.1371/journal.pone.0142494
Guyot, S, Gervais, P, Young, M, Winckler, P, Dumont, J & Davey, H 2015, 'Surviving the heat: Heterogeneity of response in Saccharomyces cerevisiae provides insight into thermal damage to the membrane' Environmental Microbiology, vol 17, no. 8, pp. 2982-2992. DOI: 10.1111/1462-2920.12866
Shleeva, M, Goncharenko, A, Kudykina, Y, Young, D, Young, M, Kaprelyants, A & Tailleux, L (ed.) 2013, 'Cyclic Amp-Dependent Resuscitation of Dormant Mycobacteria by Exogenous Free Fatty Acids' PLoS One, vol 8, no. 12, e82914. DOI: 10.1371/journal.pone.0082914
Riley, MC, Aubrey, W, Young, M & Clare, A 2013, 'PD5: a general purpose library for primer design software' PLoS One, vol 8, no. 11, e80156, pp. n/a. DOI: 10.1371/journal.pone.0080156
Burgarth, D, D'Alessandro, D, Hogben, L, Severini, S & Young, M 2013, 'Zero Forcing, Linear and Quantum Controllability for Systems Evolving on Networks' IEEE Transactions on Automatic Control, vol 58, no. 9, pp. 2349-2354. DOI: 10.1109/TAC.2013.2250075
Bilsland, E, Sparkes, AC, Williams, KS, Moss, HJ, de Clare, M, Pir, P, Rowland, J, Aubrey, W, Pateman, R, Young, M, Carrington, M, King, RD & Oliver, SG 2013, 'Yeast-based automated high-throughput screens to identify anti-parasitic lead compounds' Open Biology, vol 3, no. 2, 120158. DOI: 10.1098/rsob.120158
Heap, JP, Young, DI, Dago, AE, Minton, NP, Hoch, JA, Young, M & Steiner, E 2011, 'Multiple orphan histidine kinases interact directly with Spo0A to control the initiation of endospore formation in Clostridium acetobutylicum' Molecular Microbiology, vol 80, no. 3, pp. 641-654. DOI: 10.1111/j.1365-2958.2011.07608.x
Edwards, A, Anesio, AM, Edwards Rassner, SM, Sattler, B, Hubbard, BP, Perkins, WT, Young, M & Griffith, GW 2011, 'Possible interactions between bacterial diversity, microbial activity and supraglacial hydrology of cryoconite holes in Svalbard' ISME Journal, vol 5, no. 1, pp. 150-160. DOI: 10.1038/ismej.2010.100
Young, M, Artsatbanov, V, Beller, HR, Chandra, G, Chater, KF, Dover, LG, Goh, E-B, Kahan, T, Kaprelyants, AS, Kyrpides, N, Lapidus, A, Lowry, SR, Lykidis, A, Mahillon, J, Markowitz, V, Mavromatis, K, Mukamolova, GV, Oren, A, Rokem, JS, Smith, MCM, Young, DI & Greenblatt, CL 2010, 'Genome sequence of the Fleming strain of Micrococcus luteus, a simple free-living actinobacterium' Journal of Bacteriology, vol 192, no. 3, pp. 841-860. DOI: 10.1128/JB.01254-09
Koltunov, V, Greenblatt, CL, Goncharenko, AV, Demina, GR, Klein, BY, Young, M & Kaprelyants, AS 2010, 'Structural changes and cellular localization of resuscitation promoting factor in environmental isolates of Micrococcus luteus' Microbial Ecology, vol 59, no. 2, pp. 296-310. DOI: 10.1007/s00248-009-9573-1
Sparkes, AC, King, RD, Aubrey, W, Benway, M, Byrne, EL, Clare, AJ, Liakata, M, Markham, M, Whelan, KE, Young, M & Rowland, J 2010, 'An Integrated Laboratory Robotic System for Autonomous Discovery of Gene Function' Journal of The Association for Laboratory Automation, vol 15, no. 1, pp. 33-40. DOI: 10.1016/j.jala.2009.10.001
Sparkes, AC, Aubrey, W, Byrne, EL, Clare, AJ, Khan, M, Liakata, M, Markham, M, Rowland, J, Soldatova, LN, Whelan, KE, Young, M & King, RD 2010, 'Towards Robot Scientists for autonomous scientific discovery' Automated Experimentation, vol 2, no. 1, pp. 1759-4499. DOI: 10.1186/1759-4499-2-1
Byrne, EL, Liakata, M, Whelan, KE, Oliver, SG, Rowland, JJ, Aubrey, W, Soldatova, LN, Sparkes, AC, Young, M, Markham, M, Clare, AJ, Pir, P & King, RD 2009, 'Letters - Make way for robot scientists' Science, vol 325, no. 5943, pp. p945. DOI: 10.1126/science.325_945a
King, RD, Rowland, JJ, Aubrey, W, Liakata, M, Markham, M, Soldatova, LN, Whelan, KE, Clare, AJ, Young, M, Sparkes, AC, Oliver, S & Pir, P 2009, 'The Robot Scientist Adam' Computer, vol 42, no. 8, pp. 46-54. DOI: 10.1109/MC.2009.270
Thomas, H, Huang, L, Young, M & Ougham, HJ 2009, 'Evolution of plant senescence' BMC Evolutionary Biology, vol 9, no. 163, 163. DOI: 10.1186/1471-2148-9-163
Whitworth, DE, Young, M, McEwan, NR, Newbold, CJ, Smith, SP (ed.) & Spikes, KJ (ed.) 2009, 'Life with little oxygen: lessons from microbes', pp. 19-22, IBERS Knowledge-based Innovations, 2 01 July.
King, RD, Rowland, JJ, Oliver, SG, Young, M, Aubrey, W, Byrne, EL, Liakata, M, Markham, M, Pir, P, Soldatova, LN, Sparkes, AC, Whelan, KE & Clare, AJ 2009, 'The Automation of Science' Science, vol 324, no. 5923, pp. 85-89. DOI: 10.1126/science.1165620
McHugh, TD, Davies, AP, Young, M, Gillespie, SH, Dhillon, AP & Henderson, B 2008, 'Resuscitation-promoting factors are expressed in Mycobacterium tuberculosis-infected human tissue' Tuberculosis, vol 88, no. 5, pp. 462-468.
Kaprelyants, AS, Kana, BD, Young, M, Sung, N, Gordhan, BG, Downing, KJ, Machowski, E, Tsenova, L, Vostroktunova, G & Kaplan, G 2008, 'The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in situ' Molecular Microbiology, vol 67, no. 3, pp. 672-684. DOI: 10.1111/j.1365-2958.2007.06078.x
Machowski, E, Gordhan, BG, Sung, N, Downing, KJ, Tsenova, L, Matsoso, L, Kaplan, G, Young, M, Kana, BD & Mizrahi, V 2007, 'The role of resuscitation promoting factors in the virulence of Mycobacterium tuberculosis'.