Prof Mike Young
- Email: firstname.lastname@example.org
- Office: Cledwyn Building
Our laboratory studies post-exponential phase gene expression in several Gram-positive bacteria, including Bacillus and Clostridium. Recent work on dormancy in Micrococcus luteus led to the discovery of the Rpf family of bacterial growth factors found throughout the actinobacteria (e.g. mycobacteria, streptomycetes). We are currently exploring the mechanism of actions of these secreted bacterial growth factors and their potential applications for TB protection and therapy.
Surviving the heat: Heterogeneity of response in Saccharomyces cerevisiae provides insight into thermal damage to the membrane. Environmental Microbiology 17 (8) pp. 2982-2992. 10.1111/1462-2920.12866 Other Cadair2015.
Multiple orphan histidine kinases interact directly with Spo0A to control the initiation of endospore formation in Clostridium acetobutylicum. Molecular Microbiology 80 (3) pp. 641-654. 10.1111/j.1365-2958.2011.07608.x Cadair2011.
Structural changes and cellular localization of resuscitation promoting factor in environmental isolates of Micrococcus luteus. Microbial Ecology 59 (2) pp. 296-310. 10.1007/s00248-009-9573-1 Cadair Other2010.
The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in situ. Molecular Microbiology 67 (3) pp. 672-684. 10.1111/j.1365-2958.2007.06078.x Cadair Other2008.
The role of resuscitation promoting factors in the virulence of Mycobacterium tuberculosis. Cadair2007.
Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation. Molecular Microbiology 59 (1) pp. 54-98. 10.1111/j.1365-2958.2005.04930.x Cadair2006.
Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro. Infection and Immunity 73 (5) pp. 3038-3043. 10.1128/IAI.73.5.3038-3043.2005 Cadair2005.
Differentiation of Micromonospora isolates from a coastal sediment in Wales on the basis of Fourier transform infrared spectroscopy, 16S rRNA sequence analysis, and the amplified fragment length polymorphism technique. Applied and Environmental Microbiology 70 (11) pp. 6619-6627. 10.1128/AEM.70.11.6619-6627.2004 Cadair2004.
Formation of 'non-culturable' cells of Mycobacterium smegmatis in stationary phase in response to growth under sub-optimal conditions and their Rpf-mediated resuscitation. Microbiology pp. 1687-1697. 10.1099/mic.0.26893-0 Cadair2004.
Degeneration of solventogenic Clostridium strains monitored by Fourier transform infrared spectroscopy of bacterial cells. Journal of Industrial Microbiology and Biotechnology 27 (5) pp. 314-321. 10.1038/sj.jim.7000146 Cadair2001.
Clostridium beijerinckii and Clostridium difficile detoxify methylglyoxal by a novel mechanism involving glycerol dehydrogenase. Applied and Environmental Microbiology 67 (5) pp. 2004-2010. 10.1128/AEM.67.5.2004-2010.2001 Cadair2001.