|Delivery Type||Delivery length / details|
|Lecture||28 x 1h lectures|
|Practical||2 x 3h practicals (duplicated)|
|Assessment Type||Assessment length / details||Proportion|
|Semester Assessment||Practical Exercise: consisting of 2 practical write ups to be handed in one week after each practical session, weeks 4, 5 and 6.||30%|
|Semester Exam||3 Hours One 3-hour theory paper||70%|
|Supplementary Assessment||3 Hours (plus re-submission of failed coursework or an alternative) One 3-hour theory paper.||100%|
On completion of the module the student
- will have an awareness of the diversity of parasites (as expressed in their structure, physiology, life cycles and development) and their potential to cause disease and economic loss
- be aware of attempts and strategies to control parasites
- will have an insight into recent developments in parasite molecular biology.
Sites of parasitism will be illustrated by a consideration of the vertebrate gut and how parasites are adapted for life in this specialized environment. There is a complex interaction between parasites and the immune systems of their hosts. Parasites have evolved a range of evasion strategies, including absorption of host antigen, antigenic variation, immuno-suppression and use of immunologically privileged sites. Immune evasion will be illustrated with examples from vertebrate and invertebrate hosts. Chemotherapy is still the most cost effective way of treating parasitic disease, but drug resistance is an increasing problem.
Parasites show a wide range of biochemical adaptations, many related to the micro-aerobic nature of their environment and the changes that occur during their life cycle. Biochemical differences between parasites and their hosts provide targets for rational chemotherapy, whilst differences between parasites and their free-living relatives can give an insight into the biochemical basis of parasitism. The organization of parasite genomes and some of the unique mechanisms of mRNA editing found in parasites will also be covered.
The discovery, development and mode of action of modern antiparasite drugs will be described, as will the mechanisms responsible for the evolution of drug resistance. The helminth nervous system is structurally simple, but biochemically complex and is an important target for anthelmintics.
The many problems involved in making a realistic assessment of the cost of parasitism or of measuring the impact of parasites on their natural hosts, will be discussed. Frequent attempts have been made to control parasites of humans, domesticated livestock and crops; the outcome of some of these control strategies will be evaluated. A summary of the current ideas on the evolution of parasites, the impact of parasites on the evolution of their hosts and of the concept of host-parasite specificity will be presented and discussed. The structure of parasites will be described in relation to the insight these studies provide into parasite survival both within the host and during the free-living stages. Life cycles, development and modes of transmission will include accounts of the importance of direct transmission, the role of vectors and intermediate hosts, zoonoses and reproductive potential (Ro). Patterns in the distribution of parasites will be described and the mechanisms responsible for generating those patterns evaluated. This will lead to a consideration of mathematical models and their use in predicting parasitic disease.
The module will include a seminar discussion on a recent research publication that will form the basis of a compulsory question in the written examination.
A full synopsis of the lecture course, including past papers and additional references is available on http:/www.aber.ac.uk/parasitology
Reading ListRecommended Text
Cox, F.E.G. (1993) Modern Parasitology 2nd Oxford. Primo search Smyth, J.D. (1994) Introduction to Animal Parasitology (with a chapter on Immunoparasitology written by D. Wakelin) Cambridge University Press. Primo search
This module is at CQFW Level 6