- Dr Graham Stafford (Senior Lecturer - University of Sheffield)
|Delivery Type||Delivery length / details|
|Lecture||33 x 1 Hour Lectures|
|Practical||2 x 4 Hour Practicals|
|Practical||1 x 2 Hour Practical|
|Assessment Type||Assessment length / details||Proportion|
|Semester Assessment||Lab Report (1000 words)||20%|
|Semester Assessment||Worksheet of data handling questions to research and complete||40%|
|Semester Assessment||Protein Portfolio. A synthesis of the module material culminating in a piece of written work submitted online (approx. 2500 words).||40%|
|Supplementary Assessment||Students must take elements of assessment equivalent to those that led to failure of the module.||100%|
On successful completion of this module students should be able to:
1. Define how the amino acid sequence contributes to other levels of protein structure and the mechanism associated with protein folding.
2. Recount a variety of post-translational modifications of proteins and describe the processes which govern the targeting of proteins to specific organelles within the cell.
3. Explain how enzymes are assayed and how they can be isolated. Students should also be able to manipulate kinetic data to infer relevant parameters of enzymatic reactions.
4. Perform experimental protocols for the manipulation and characterisation of proteins and to report the results of such experimental investigations clearly and concisely.
5. Manipulate and utilise mathematical equations to enable the extraction of common protein biochemical parameters.
The module is designed to extend and reinforce aspects of proteins dealt with in the first year. It will incorporate current research into proteins, folding of nascent proteins, post-translational modifications, working with proteins and manipulating protein biochemical data. The module aims to provide students with a firm understanding of the relationship between protein structure and protein function and how to apply this knowledge.
The content will broadly cover:
Protein Structure; Enzymes and enzyme kinetics; Metal Co-factors and prosthetic groups, Protein folding; Protein Targeting; Experimenting and handling proteins; Protein biochemical data manipulation; Protein research.
|Skills Type||Skills details|
|Application of Number||A significant component of the module is taught through data-handling problems .|
|Communication||Effective written communication skills will be developed to produce work for a wider audience through a protein portfolio database.|
|Improving own Learning and Performance||Outside the formal contact hours, students will be expected to research materials, manage time and meet deadlines. The directed study elements will provide opportunity for students to explore their own learning styles and preferences and identify their needs and barriers to learning. Students will be able to review and monitor their progress and plan for improvement of personal performance.|
|Information Technology||Accessing the web for information sources and using databases to find primary literature, preparation of coursework. Students will also be assessed through an online test.|
|Personal Development and Career planning||This skill is not developed in this module .|
|Problem solving||This skill is a key component of the module, working out how to find, interpret, and summarise information and present it in an accessible format.|
|Research skills||This is a research based module that requires students to assimilate knowledge from academic literature.|
|Subject Specific Skills||Subject specific concepts relating to protein biochemistry and enzymology will be developed. Students will be able to demonstrate an understanding of integrated structure and function of proteins and evaluate pertinent protein properties. Students will also solve protein biochemical problems using numerical data and mathematical equations.|
|Team work||Students will work in pairs during the practical class.|
This module is at CQFW Level 5