Dr Iain Chalmers PhD

Dr Iain Chalmers

Lecturer in Veterinary Biosciences

Contact Details

Profile

2013-present
Lecturer in Veterinary Biosciences, IBERS, Aberstwyth University, UK
2010-2013
EU-funded Post-Doctoral Research Associate, IBERS, Aberystwyth University, UK
2008-2009
Research Technician, IBERS, Aberystwyth University, UK
2002-2009
Wellcome Trust PhD programme, under supervision of Dr. Karl Hoffmann, Department of Pathology, University of Cambridge, UK
1998-2002
BSc (Hons.) Degree in Immunology, Edinburgh University, UK

Teaching

Research

My research focuses on the identification and characterisation of helminth proteins essential to the parasites survival in the host. The aim of this research is to discover novel vaccine candidates/drug targets and to also gain a deeper understanding of host/parasite interactions. Using bioinformatic approaches, my research also examines the evolution of gene families (such as the SmVAL family) across parasitic and non-parasitic species.

Publications

2017

Adema, C.M., Hillier, L.W., Jones, C.S., Loker, E.S., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., do Amaral, L.R., Arican-Goktas, H.D., Assis, J.G., Baba, E.H., Baron, O.L., Bayne, C.J., Bickham-Wright, U., Biggar, K.K., Blouin, M., Bonning, B.C., Botka, C., Bridger, J.M., Buckley, K.M., Buddenborg, S.K., Lima Caldeira, R., Carleton, J., Carvalho, O.S., Castillo, M.G., Chalmers, I.W., Christensens, M., Clifton, S., Cosseau, C., Coustau, C., Cripps, R.M., Cuesta-Astroz, Y., Cummins, S.F., Di Stephano, L., Dinguirard, N., Duval, D., Emrich, S., Feschotte, C., Feyereisen, R., Fitzgerald, P., Fronick, C., Fulton, L., Galinier, R., Gava, S.G., Geusz, M., Geyer, K.K., Giraldo-Calderón, G.I., de Souza Gomes, M., Gordy, M.A., Gourbal, B., Grunau, C., Hanington, P.C., Hoffmann, K.F., Hughes, D., Humphries, J., Jackson, D.J., Jannotti-Passos, L.K., De Jesus Jeremias, W., Jobling, S., Kamel, B., Kapusta, A., Kaur, S., Koene, J.M., Kohn, A.B., Lawson, D., Lawton, S.P., Liang, D., Limpanont, Y., Liu, S., Lockyer, A.E., Lovato, T.L., Ludolf, F., Magrini, V., Mcmanus, D.P., Medina, M., Misra, M., Mitta, G., Mkoji, G.M., Montague, M.J., Montelongo, C., Moroz, L.L., Munoz-Torres, M.C., Niazi, U., Noble, L.R., Oliveira, F.S., Pais, F.S., Papenfuss, A.T., Peace, R., Pena, J.J., Pila, E.A., Quelais, T., Raney, B.J., Rast, J.P., Rollinson, D., Rosse, I.C., Rotgans, B., Routledge, E.J., Ryan, K.M., Scholte, L.L.S., Storey, K.B., Swain, M., Tennessen, J.A., Tomlinson, C., Trujillo, D.L., Volpi, E.V., Walker, A.J., Wang, T., Wannaporn, I., Warren, W.C., Wu, X., Yoshino, T.P., Yusuf, M., Zhang, S., Zhao, M., Wilson, R.K. 2017. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications 8 15451 (2017) pp. 15451. 10.1038/ncomms15451 Other Cadair

Geyer, K., Niazi, U., Duval, D., Cosseau, C., Tomlinson, C., Chalmers, I., Swain, M., Cutress, D., Bickham-Wright, U., Munshi, S.E., Grunau, C., Yoshino, T.P., Hoffmann, K. 2017. The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni. PLoS Neglected Tropical Diseases 11 (5) e0005246 10.1371/journal.pntd.0005246 Cadair

2015

Chalmers, I.W., Fitzsimmons, C.M., Brown, M., Pierrot, C., Jones, F.M., Wawrzyniak, J.M., Fernandez-Fuentes, N., Tukahebwa, E.M., Dunne, D.W., Khalife, J., Hoffmann, K.F. 2015. Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment. PLoS Neglected Tropical Diseases 9 (7) pp. e0003920. 10.1371/journal.pntd.0003920 Cadair

Reimers, N., Homann, A., Höschler, B., Langhans, K., Wilson, R.A., Pierrot, C., Khalife, J., Grevelding, C.G., Chalmers, I.W., Yazdanbakhsh, M., Hoffmann, K.F., Hokke, C.H., Haas, H., Schramm, G. 2015. Drug-Induced Exposure of Schistosoma mansoni Antigens SmCD59a and SmKK7. PLoS Neglected Tropical Diseases 9 (3) e0003593 10.1371/journal.pntd.0003593 Cadair

Farnell, E.J., Tyagi, N., Ryan, S., Chalmers, I.W., Pinot de Moira, A., Jones, F.M., Wawrzyniak, J., Fitzsimmons, C.M., Tukahebwa, E.M., Furnham, N., Maizels, R.M., Dunne, D.W. 2015. Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection. Frontiers in Immunology 6 pp. 26. 10.3389/fimmu.2015.00026 Cadair

2014

Yoshino, T.P., Brown, M., Wu, X., Jackson, C.J., Ocadiz-Ruiz, R., Chalmers, I.W., Kolb, M., Hokke, C.H., Hoffmann, K.F. 2014. Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression. International Journal for Parasitology 44 (8) pp. 551-563. 10.1016/j.ijpara.2014.04.002 Cadair

2013

Geyer, K.K., Chalmers, I.W., MacKintosh, N.D., Hirst, J.E., Geoghegan, R., Badets, M., Brophy, P.M., Brehm, K., Hoffmann, K.F. 2013. Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes. BMC Genomics 14 462 10.1186/1471-2164-14-462 Cadair

2012

Chalmers, I.W., Hoffmann, K.F. 2012. Platyhelminth venom allergen-like (VAL) proteins: revealing structural diversity, class specific features and biological associations across the phylum. Parasitology 139 (10) pp. 1231-1245. 10.1017/S0031182012000704 Cadair

Fitzsimmons, C.M., Jones, F.M., Stearn, A., Chalmers, I.W., Hoffmann, K.F., Wawrzyniak, J., Wilson, S., Kabatereine, N.B., Dunne, D.W. 2012. The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses. PLoS Neglected Tropical Diseases 6 (4) e1593 10.1371/journal.pntd.0001593 Cadair

2011

Geyer, K.K., Rodríguez-López, C.M., Hoffmann, K.F., Chalmers, I.W., Munshi, S.E., Truscott, M., Heald, J.K., Wilkinson, M.J., Hoffmann, K.F. 2011. Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni. Nature Communications 2 424 10.1038/ncomms1433 Cadair

2010

Peak, E., Chalmers, I.W., Hoffmann, K.F. 2010. Development and Validation of a Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability. PLoS Neglected Tropical Diseases 4 (7) e759 10.1371/journal.pntd.0000759 Cadair

2009

Fitzpatrick, J.M., Peak, E., Perally, S., Chalmers, I.W., Barrett, J., Yoshino, T.P., Ivens, A.C., Hoffmann, K.F. 2009. Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses. PLoS Neglected Tropical Diseases 3 (11) e543. 10.1371/journal.pntd.0000543 Cadair

Fitzpatrick, J.M., Fuentes, J.M., Chalmers, I.W., Wynn, T.A., Modolell, M., Hoffmann, K.F., Hesse, M. 2009. Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity. International Journal for Parasitology 39 (3) pp. 267-279. 10.1016/j.ijpara.2008.06.015 Cadair

Peak, E., Chalmers, I.W., Hoffmann, K.F. 2009. Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect Schistosoma viability. The Schistosome Molecular Toolbox Workshop. Cadair

2008

Chalmers, I.W., McArdle, A.J., Coulson, R.M.R., Wagner, M.A., Schmid, R., Hirai, H., Hoffmann, K.F. 2008. Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family. BMC Genomics 9 (89) 89 10.1186/1471-2164-9-89 Cadair Other

2005

Fitzsimmons, C.M., Schramm, G., Jones, F.M., Chalmers, I.W., Hoffmann, K.F., Grevelding, C.G., Wuhrer, M., Hokke, C.H., Haas, H., Doenhoff, M.J., Dunne, D.W. 2005. Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs. Molecular and Biochemical Parasitology 144 (1) pp. 123-127. 10.1016/j.molbiopara.2005.08.003 Cadair