Dr Iain Chalmers

PhD

Dr Iain Chalmers

Senior Lecturer

Department of Life Sciences

Contact Details

Profile

2013-present
Lecturer in Veterinary Biosciences, IBERS, Aberstwyth University, UK
2010-2013
EU-funded Post-Doctoral Research Associate, IBERS, Aberystwyth University, UK
2008-2009
Research Technician, IBERS, Aberystwyth University, UK
2002-2009
Wellcome Trust PhD programme, under supervision of Dr. Karl Hoffmann, Department of Pathology, University of Cambridge, UK
1998-2002
BSc (Hons.) Degree in Immunology, Edinburgh University, UK

Teaching

Research

My research focuses on the identification and characterisation of helminth proteins essential to the parasites survival in the host. The aim of this research is to discover novel vaccine candidates/drug targets and to also gain a deeper understanding of host/parasite interactions. Using bioinformatic approaches, my research also examines the evolution of gene families (such as the SmVAL family) across parasitic and non-parasitic species.

Publications

Davey, SD, Chalmers, IW, Fernandez-Fuentes, N, Swain, MT, Smith, D, Abbas Abidi, SM, Saifullah, MK, Raman, M, Ravikumar, G, McVeigh, P, Maule, AG, Brophy, PM & Morphew, RM 2022, 'In silico characterisation of the complete Ly6 protein family in Fasciola gigantica supported through transcriptomics of the newly-excysted juveniles', Molecular Omics, vol. 18, no. 1, pp. 45-56. 10.1039/D1MO00254F
Hulme, BJ, Geyer, KK, Forde-Thomas, JE, Padalino, G, Phillips, DW, Ittiprasert, W, Karinshak, SE, Mann, VH, Chalmers, IW, Brindley, PJ, Hokke, CH & Hoffmann, KF 2022, 'Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production', PLOS Pathogens, vol. 18, no. 1, e1009828. 10.1371/journal.ppat.1009828
Padalino, G, El-Sakkary, N, Liu, LJ, Liu, C, Harte, DSG, Barnes, RE, Sayers, E, Forde-Thomas, J, Whiteland, H, Bassetto, M, Ferla, S, Johnson, G, Jones, AT, Caffrey, CR, Chalmers, I, Brancale, A & Hoffmann, KF 2021, 'Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation', European Journal of Medicinal Chemistry, vol. 226, 113823, pp. 113823. 10.1016/j.ejmech.2021.113823, 10.1016/j.ejmech.2021.113823, 10.1016/j.ejmech.2021.113823
Perally, S, Geyer, KK, Farani, PSG, Chalmers, IW, Fernandez-Fuentes, N, Maskell, DR, Hulme, BJ, Forde-Thomas, J, Phillips, D, Farias, LP, Collins, JJ & Hoffmann, KF 2021, 'Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function', International Journal for Parasitology, vol. 51, no. 4, pp. 251-261. 10.1016/j.ijpara.2020.09.004
Padalino, G, Ferla, S, Brancale, A, Chalmers, I & Hoffmann, K 2019, 'Erratum to ‘Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni’ [IJP Drugs Drug Resist. 8 (2018) 559–570]', International Journal for Parasitology: Drugs and Drug Resistance, vol. 10, pp. 91. 10.1016/j.ijpddr.2019.07.001
More publications on the Research Portal