Prof John Draper
I currently manage the High Resolution Metabolomics Laboratory and am responsible for oversight of Enabling Technologies within IBERS including core facilities for Metabolomics, Next Generation Sequencing, Plant Phenomics and Bioinformatics.
From a technology perspective I am interested in the development of generic, high throughput phenotyping methodologies, based on global metabolite analysis (metabolomics) for use in a range of fields. My lab is concentrating on metabolite fingerprinting & profiling using high resolution mass spectrometry techniques.
I have established a range of collaborations with laboratories interested in the application of metabolomics technology in food & nutrition research & in plant pathology. We have developed high throughput methods (metabolite fingerprinting, data representation & data analysis) for compositional analysis & comparison of food raw materials. Alongside clinical/veterinary institutions & industry partners, we are currently researching methods for determining dietary exposure & individual responses to diet constituents in humans & domesticated animals from blood & urine analysis.
From a fundamental research perspective my team has pioneered the development of Brachypodium distachyon as a new model system for plant functional genomics. Together with local & international collaborators we played a key role in collecting & characterizing Brachypodium distachyon germplasm in terms of karyotype, comparative genomics, tissue culture behavior, transformation efficiency & pathogen interactions.
Currently I am developing a metabolomics platform for both metabolite identification & high throughput phenotyping in grasses & cereals based on the Brachypodium metabolome. A practical application of this research focuses on a study of metabolic reprogramming in B. distachyon, rice & barley during the biotrophic phases of interaction with rice blast. In collaboration with Nick Talbot (Univ. Exeter, UK) this project extends to an analysis of metabolome changes in Magnapo