Prof Karl Hoffmann PhD

Additional Information

PROJECT WEBPAGES:

       Flatworm Functional Genomics Initiative (FUGI): 

       www.sanger.ac.uk/science/collaboration/flatworm-functional-genomics-initiative-fugi

Teaching

Research

My research revolves around trying to answer this question: How can fundamental studies of developmental biology & gene regulation guide our search for next generation anthelmintic solutions?

Parasitic worms cause some of the most disfiguring, debilitating & chronic infectious diseases of human & animal populations across the globe. Reliance on limited drug classes to treat affected individuals & the lack of available vaccines to induce protective immunity suggests that current experimental approaches in identifying urgently needed anthelmintics have yet to deliver sustainable solutions.

Utilising both hypothesis-led & discovery driven research approaches my laboratory is developing new strategies for controlling parasitic helminths of biomedical importance. Our area of expertise is Schistosoma mansoni, one of the three main trematode species responsible for the neglected tropical disease Schistosomiasis. More than 200 million people suffer from this chronic & debilitating disease, with 90% of all worldwide cases found in poverty-stricken areas of sub-Saharan Africa where up to 300,000 individuals die each year. Praziquantel is currently used to treat schistosomiasis, but the need for repetitive treatment in endemic communities, concerns over the development of resistance & an unknown mechanism of action all have contributed to the active search for new chemotherapeutic agents or a prophylactic vaccine.

To identify next generation anthelmintics we look for solutions in the interrelated disciplines of helminth developmental biology, epigenetics & gene regulation. Our research includes individual-gene & (epi) genome-wide investigations, supported by experimental models of schistosome infection & objective analyses of helminth viability & phenotype. We envision that our integrated approach will enable progress to be made against an intractable disease affecting some of the most disadvantaged populations of the developing world.

Publications

2017

Egesa, M., Hoffmann, K., Hokke, C.H., Yazdanbakhsh, M., Cose, S. 2017. Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles. Trends in Parasitology 1671 10.1016/j.pt.2017.07.007

Nur-e-Alam, M., Yousaf, M., Ahmed, S., Al-Sheddi, E.S., Shah, I., Fazakerley, D., Bari, A., Ghabbour, H.A., Threadgill, M.D., Whatley, K., Hoffmann, K., Al-Rehaily, A.J. 2017. Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense. Journal of Natural Products 10.1021/acs.jnatprod.7b00188 Cadair

Adema, C.M., Hillier, L.W., Jones, C.S., Loker, E.S., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., do Amaral, L.R., Arican-Goktas, H.D., Assis, J.G., Baba, E.H., Baron, O.L., Bayne, C.J., Bickham-Wright, U., Biggar, K.K., Blouin, M., Bonning, B.C., Botka, C., Bridger, J.M., Buckley, K.M., Buddenborg, S.K., Lima Caldeira, R., Carleton, J., Carvalho, O.S., Castillo, M.G., Chalmers, I.W., Christensens, M., Clifton, S., Cosseau, C., Coustau, C., Cripps, R.M., Cuesta-Astroz, Y., Cummins, S.F., Di Stephano, L., Dinguirard, N., Duval, D., Emrich, S., Feschotte, C., Feyereisen, R., Fitzgerald, P., Fronick, C., Fulton, L., Galinier, R., Gava, S.G., Geusz, M., Geyer, K.K., Giraldo-Calderón, G.I., de Souza Gomes, M., Gordy, M.A., Gourbal, B., Grunau, C., Hanington, P.C., Hoffmann, K.F., Hughes, D., Humphries, J., Jackson, D.J., Jannotti-Passos, L.K., De Jesus Jeremias, W., Jobling, S., Kamel, B., Kapusta, A., Kaur, S., Koene, J.M., Kohn, A.B., Lawson, D., Lawton, S.P., Liang, D., Limpanont, Y., Liu, S., Lockyer, A.E., Lovato, T.L., Ludolf, F., Magrini, V., Mcmanus, D.P., Medina, M., Misra, M., Mitta, G., Mkoji, G.M., Montague, M.J., Montelongo, C., Moroz, L.L., Munoz-Torres, M.C., Niazi, U., Noble, L.R., Oliveira, F.S., Pais, F.S., Papenfuss, A.T., Peace, R., Pena, J.J., Pila, E.A., Quelais, T., Raney, B.J., Rast, J.P., Rollinson, D., Rosse, I.C., Rotgans, B., Routledge, E.J., Ryan, K.M., Scholte, L.L.S., Storey, K.B., Swain, M., Tennessen, J.A., Tomlinson, C., Trujillo, D.L., Volpi, E.V., Walker, A.J., Wang, T., Wannaporn, I., Warren, W.C., Wu, X., Yoshino, T.P., Yusuf, M., Zhang, S., Zhao, M., Wilson, R.K. 2017. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications 8 15451 (2017) pp. 15451. 10.1038/ncomms15451 Other Cadair

Geyer, K., Niazi, U., Duval, D., Cosseau, C., Tomlinson, C., Chalmers, I., Swain, M., Cutress, D., Bickham-Wright, U., Munshi, S.E., Grunau, C., Yoshino, T.P., Hoffmann, K. 2017. The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni. PLoS Neglected Tropical Diseases 11 (5) e0005246 10.1371/journal.pntd.0005246 Cadair

2016

Cosseau, C., Wolkenhauer, O., Padalino, G., Geyer, K., Hoffmann, K., Grunau, C. 2016. (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach. Trends in Parasitology 33 (4) pp. 285-294. 10.1016/j.pt.2016.12.002 Cadair

Niazi, U., Geyer, K., Vickers, M., Hoffmann, K., Swain, M. 2016. DISMISS: MeDIP-seq: High-throughput sequencing. Other

Niazi, U., Geyer, K.K., Vickers, M.J., Hoffmann, K., Swain, M. 2016. DISMISS: detection of stranded methylation in MeDIP-Seq data. BMC Bioinformatics 17 295 10.1186/s12859-016-1158-7 Cadair

2015

Hoffmann, K. 2015. Sharing expertise/data/reagents. Accelerating R&D for Neglected Diseases through Global Collaborations: WIPO Re:Search Partnership Stories 2013-2015. 2ndth edn, BIO Ventures for Global Health, Seattle, USA pp. 23. Cadair

Nowacki, F.C., Swain, M.T., Klychnikov, O.I., Niazi, U., Ivens, A., Quintana, J.F., Hensbergen, P.J., Hokke, C.H., Buck, A.H., Hoffmann, K.F. 2015. Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni. Journal of Extracellular Vesicles 4 28665 10.3402/jev.v4.28665 Cadair

Chalmers, I.W., Fitzsimmons, C.M., Brown, M., Pierrot, C., Jones, F.M., Wawrzyniak, J.M., Fernandez-Fuentes, N., Tukahebwa, E.M., Dunne, D.W., Khalife, J., Hoffmann, K.F. 2015. Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment. PLoS Neglected Tropical Diseases 9 (7) pp. e0003920. 10.1371/journal.pntd.0003920 Cadair

Smit, C.H., van Diepen, A., Nguyen, D.L., Wuhrer, M., Hoffmann, K.F., Deelder, A.M., Hokke, C.H. 2015. Glycomic analysis of life stages of the human parasite Schistosoma mansoni reveals developmental expression profiles of functional and antigenic glycan motifs. Molecular and Cellular Proteomics 14 (7) pp. 1750-1769. 10.1074/mcp.M115.048280 Other Cadair

Reimers, N., Homann, A., Höschler, B., Langhans, K., Wilson, R.A., Pierrot, C., Khalife, J., Grevelding, C.G., Chalmers, I.W., Yazdanbakhsh, M., Hoffmann, K.F., Hokke, C.H., Haas, H., Schramm, G. 2015. Drug-Induced Exposure of Schistosoma mansoni Antigens SmCD59a and SmKK7. PLoS Neglected Tropical Diseases 9 (3) e0003593 10.1371/journal.pntd.0003593 Cadair

Edwards, J., Brown, M., Peak, E., Bartholomew, B., Nash, R.J., Hoffmann, K.F. 2015. The Diterpenoid 7-Keto-Sempervirol, Derived from Lycium chinense, Displays Anthelmintic Activity against both Schistosoma mansoni and Fasciola hepatica. PLoS Neglected Tropical Diseases 9 (3) e0003604 10.1371/journal.pntd.0003604 Cadair

2014

Hoffmann, K.F., Brindley, P.J., Berriman, M. 2014. Halting harmful helminths: Vaccines and new drugs are needed to combat parasitic worm infections. Science 346 (168) pp. 168-169. 10.1126/science.1261139 Cadair

Yoshino, T.P., Brown, M., Wu, X., Jackson, C.J., Ocadiz-Ruiz, R., Chalmers, I.W., Kolb, M., Hokke, C.H., Hoffmann, K.F. 2014. Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression. International Journal for Parasitology 44 (8) pp. 551-563. 10.1016/j.ijpara.2014.04.002 Cadair

Hai, Y., Edwards, J., Van Zandt, M.C., Hoffmann, K.F., Christianson, D.W. 2014. Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis. Biochemistry 53 (28) pp. 4671-4684. 10.1021/bi5004519 Cadair

2013

Geyer, K.K., Chalmers, I.W., MacKintosh, N.D., Hirst, J.E., Geoghegan, R., Badets, M., Brophy, P.M., Brehm, K., Hoffmann, K.F. 2013. Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes. BMC Genomics 14 462 10.1186/1471-2164-14-462 Cadair

Truscott, M., Evans, D.A., Gunn, M., Hoffmann, K.F. 2013. Schistosoma mansoni Hemozoin Modulates Alternative Activation of Macrophages via Specific Suppression of Retnla Expression and Secretion. Infection and Immunity 81 (1) pp. 133-142. 10.1128/IAI.00701-12 Cadair

2012

Geyer, K.K., Hoffmann, K.F. 2012. Epigenetics: a key regulator of platyhelminth developmental biology? International Journal for Parasitology 42 (3) pp. 221-224. 10.1016/j.ijpara.2012.02.003 Cadair

Brehm, K., Carlton, J.M., Hoffmann, K.F. 2012. Editorial: Parasite genomics and post-genomic activities: 21st century resources for the parasite immunologist. Parasite Immunology 34 (2-3) pp. 47-49. 10.1111/j.1365-3024.2011.01346.x Other Cadair

Chalmers, I.W., Hoffmann, K.F. 2012. Platyhelminth venom allergen-like (VAL) proteins: revealing structural diversity, class specific features and biological associations across the phylum. Parasitology 139 (10) pp. 1231-1245. 10.1017/S0031182012000704 Cadair

Fitzsimmons, C.M., Jones, F.M., Stearn, A., Chalmers, I.W., Hoffmann, K.F., Wawrzyniak, J., Wilson, S., Kabatereine, N.B., Dunne, D.W. 2012. The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses. PLoS Neglected Tropical Diseases 6 (4) e1593 10.1371/journal.pntd.0001593 Cadair

2011

Swain, M.T., Larkin, D.M., Caffrey, C.R., Davies, S.J., Loukas, A., Skelly, P.J., Hoffmann, K.F. 2011. Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery. Trends in Parasitology 27 (12) pp. 555-564. 10.1016/j.pt.2011.09.003 Cadair

Geyer, K.K., Rodríguez-López, C.M., Hoffmann, K.F., Chalmers, I.W., Munshi, S.E., Truscott, M., Heald, J.K., Wilkinson, M.J., Hoffmann, K.F. 2011. Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni. Nature Communications 2 424 10.1038/ncomms1433 Cadair

Peak, E., Hoffmann, K. 2011. Cross-disciplinary approaches for measuring parasitic helminth viability and phenotype. Anais da Academia Brasileira de Ciências 83 (2) pp. 649-662. 10.1590/S0001-37652011000200024 Cadair

Peak, E., Hoffmann, K.F. 2011. Dual fluorescence assay. Cadair

2010

Peak, E., Chalmers, I.W., Hoffmann, K.F. 2010. Development and Validation of a Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability. PLoS Neglected Tropical Diseases 4 (7) e759 10.1371/journal.pntd.0000759 Cadair

2009

Fitzpatrick, J.M., Peak, E., Perally, S., Chalmers, I.W., Barrett, J., Yoshino, T.P., Ivens, A.C., Hoffmann, K.F. 2009. Anti-schistosomal intervention targets identified by lifecycle transcriptomic analyses. PLoS Neglected Tropical Diseases 3 (11) e543. 10.1371/journal.pntd.0000543 Cadair

Fitzpatrick, J.M., Fuentes, J.M., Chalmers, I.W., Wynn, T.A., Modolell, M., Hoffmann, K.F., Hesse, M. 2009. Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity. International Journal for Parasitology 39 (3) pp. 267-279. 10.1016/j.ijpara.2008.06.015 Cadair

Geyer, K., Rodrigues Lopez, C.M., Wilkinson, M.J., Hoffmann, K.F. 2009. The Schistosoma mansoni genome is methylated. The Schistosome Molecular Toolbox Workshop. Cadair

Peak, E., Chalmers, I.W., Hoffmann, K.F. 2009. Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect Schistosoma viability. The Schistosome Molecular Toolbox Workshop. Cadair

Truscott, M., Hoffmann, K.F. 2009. Schistosoma mansoni haemozoin affects macrophage phenotype in a changing cytokine milieu. British Society for Parasitology. Cadair

2008

Lockyer, A.E., Spinks, J., Kane, R.A., Hoffmann, K.F., Fitzpatrick, J.M., Rollinson, D., Noble, L.R., Jones, C.S. 2008. Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni. BMC Genomics 9 634 10.1186/1471-2164-9-634 Cadair

Fitzpatrick, J.M., Protasio, A.V., McArdle, A.J., Williams, G.A., Johnston, D.A., Hoffmann, K.F. 2008. Use of Genomic DNA as an Indirect Reference for Identifying Gender-Associated Transcripts in Morphologically Identical, but Chromosomally Distinct, Schistosoma mansoni Cercariae. PLoS Neglected Tropical Diseases 2 (10) e323 10.1371/journal.pntd.0000323 Cadair Other

Chalmers, I.W., McArdle, A.J., Coulson, R.M.R., Wagner, M.A., Schmid, R., Hirai, H., Hoffmann, K.F. 2008. Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family. BMC Genomics 9 (89) 89 10.1186/1471-2164-9-89 Cadair Other

2007

Grevelding, C.G., Hoffmann, K.F. 2007. Schistosome genomics and beyond: News and views. Experimental Parasitology 117 (3) pp. 223-224. 10.1016/j.exppara.2007.09.001 Cadair

Hokke, C.H., Deelder, A.M., Hoffmann, K.F., Wuhrer, M. 2007. Glycomics-driven discoveries in schistosome research. Experimental Parasitology 117 (3) pp. 275-283. 10.1016/j.exppara.2007.06.003 Cadair

Hokke, C.H., Fitzpatrick, J.M., Hoffmann, K.F. 2007. Integrating transcriptome, proteome and glycome analyses of Schistosoma biology. Trends in Parasitology 23 (4) pp. 165-174. 10.1016/j.pt.2007.02.007 Cadair

2006

Fitzpatrick, J.M., Hoffmann, K.F. 2006. Dioecious Schistosoma mansoni express divergent gene repertoires regulated by pairing. International Journal for Parasitology 36 (10-11) pp. 1081-1089. 10.1016/j.ijpara.2006.06.007 Cadair

Reimert, C.M., Fitzsimmons, C.M., Joseph, S., Mwatha, J.K., Jones, F.M., Kimani, G., Hoffmann, K.F., Booth, M., Kabatereine, N.B., Dunne, D.W., Vennervald, B.J. 2006. Eosinophil activity in Schistosoma mansoni infections in vivo and in vitro in relation to plasma cytokine profile pre- and posttreatment with praziquantel. Clinical and Vaccine Immunology 13 (5) pp. 584-593. 10.1128/CVI.13.5.584-593.2006 Cadair

Vermeire, J.J., Taft, A.S., Hoffmann, K.F., Fitzpatrick, J.M., Yoshino, T.P. 2006. Schistosoma mansoni: DNA microarray gene expression profiling during the miracidium-to-mother sporocyst transformation. Molecular and Biochemical Parasitology 147 (1) pp. 39-47. 10.1016/j.molbiopara.2006.01.006 Cadair

Wynn, T.A., Aliberti, J., Hoffmann, K.F., Jankovic, D., Feng, C.G., Kullberg, M.C., Sher, A. 2006. Experimental Models for the Analysis of IL-10 Function. In F. M. Marincola. (ed) Interleukin-10. Taylor & Francis Cadair Other

Fitzpatrick, J.M., Hirai, Y., Hirai, H., Hoffmann, K.F. 2006. Schistosome egg production is dependent upon the activities of two developmentally regulated tyrosinases. FASEB Journal 21 (3) pp. 823-835. 10.1096/fj.06-7314com Other Cadair

Wuhrer, M., Koeleman, C.A.M., Fitzpatrick, J.M., Hoffmann, K.F., Deelder, A.M., Hokke, C.H. 2006. Gender-specific expression of complex-type N-glycans in schistosomes. Glycobiology 16 (10) pp. 991-1006. 10.1093/glycob/cwl020 Cadair

2005

Fitzsimmons, C.M., Schramm, G., Jones, F.M., Chalmers, I.W., Hoffmann, K.F., Grevelding, C.G., Wuhrer, M., Hokke, C.H., Haas, H., Doenhoff, M.J., Dunne, D.W. 2005. Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs. Molecular and Biochemical Parasitology 144 (1) pp. 123-127. 10.1016/j.molbiopara.2005.08.003 Cadair

Fitzpatrick, J.M., Johnston, D.A., Williams, G.W., Williams, D.J., Freeman, T.C., Dunne, D.W., Hoffmann, K.F. 2005. An oligonucleotide microarray for transcriptome analysis of Schistosoma mansoni and its application/use to investigate gender-associated gene expression. Molecular and Biochemical Parasitology 141 (1) pp. 1-13. 10.1016/j.molbiopara.2005.01.007 Cadair

Fitzpatrick, J.M., Hoffmann, K.F. 2005. The Application of DNA Microarrays in the Functional Genomic Study of Schistosome/Host Biology. Schistosomiasis: World Class Parasites Volume 10. Springer Nature pp. 101-112. Cadair Other

2004

Fitzsimmons, C.M., Stewart, T.J., Hoffmann, K.F., Grogan, J.L., Yazdanbakhsh, M., Dunne, D.W. 2004. Human IgE response to the Schistosoma haematobium 22.6 kDa antigen. Parasite Immunology 26 (8-9) pp. 371-376. 10.1111/j.0141-9838.2004.00721.x Cadair

Fitzpatrick, J.M., Johansen, M.V., Johnston, D.A., Dunne, D.W., Hoffmann, K.F. 2004. Gender-associated gene expression in two related strains of Schistosoma japonicum. Molecular and Biochemical Parasitology 136 (2) pp. 191-209. 10.1016/j.molbiopara.2004.03.014 Cadair

Fitzsimmons, C.M., Joseph, S., Jones, F.M., Reimert, C.M., Hoffmann, K.F., Kazibwe, F., Kimani, G., Mwatha, J.K., Ouma, J.H., Tukahebwa, E.M., Kariuki, H.C., Vennervald, B.J., Kabatereine, N.B., Dunne, D.W. 2004. Chemotherapy for schistosomiasis in Ugandan fishermen: Treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin E. Infection and Immunity 72 (7) pp. 4023-4030. 10.1128/IAI.72.7.4023-4030.2004 Cadair

Hoffmann, K.F., Fitzpatrick, J.M. 2004. Gene Expression Studies Using Self-Fabricated Parasite cDNA Microarrays. In S. E. Melville. (ed) Parasite Genomics Protocols. 270th edn, Springer Nature pp. 219-236. Cadair Other

Wynn, T.A., Hesse, M., Sandler, N.G., Kaviratne, M., Hoffmann, K.F., Chiaramonte, M.G., Reiman, R., Cheever, A.W., Sypek, J.P., Mentink-Kane, M.M. 2004. P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon gamma and the IL-13 decoy receptor. Hepatology 39 (3) pp. 676-687. 10.1002/hep.20102 Cadair

2003

Hoffmann, K.F., Dunne, D.W. 2003. Characterization of the Schistosoma transcriptome opens up the world of helminth genomics. Genome Biology 5 203 10.1186/gb-2003-5-1-203 Cadair

2002

Hoffmann, K.F., Johnston, D.A., Dunne, D.W. 2002. Identification of Schistosoma mansoni gender-associated gene transcripts by cDNA microarray profiling. Genome Biology 3 (8) pp. RESEARCH0041. 10.1186/gb-2002-3-8-research0041 Cadair

Schopf, L.R., Hoffmann, K.F., Cheever, A.W., Urban, J.F., Wynn, T.A. 2002. IL-10 is critical for host resistance and survival during gastrointestinal helminth infection. Journal of Immunology 168 (5) pp. 2383-2392. Other Cadair

2001

Park, M.K., Hoffmann, K.F., Cheever, A.W., Amichay, D., Wynn, T.A., Farber, J.M. 2001. Patterns of chemokine expression in models of Schistosoma mansoni inflammation and infection reveal relationships between type 1 and type 2 responses and chemokines in vivo. Infection and Immunity 69 (11) pp. 6755-6768. 10.1128/IAI.69.11.6755-6768.2001 Cadair

Hoffmann, K.F., McCarty, T.C., Segal, D.H., Chiaramonte, M., Hesse, M., Davis, E.M., Cheever, A.W., Meltzer, P.S., Morse, H.C., Wynn, T.A. 2001. Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type-1 and type-2 cytokine-mediated inflammatory reactions. FASEB Journal 15 (13) pp. 2545-25477. 10.1096/fj.01-0306fje Cadair

2000

Cheever, A.W., Hoffmann, K.F., Wynn, T.A. 2000. Immunopathology of schistosomiasis mansoni in mice and men. Immunology Today 21 (9) pp. 465-466. 10.1016/S0167-5699(00)01626-1 Cadair

Hoffmann, K.F., Cheever, A.W., Wynn, T.A. 2000. IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. Journal of Immunology 164 (12) pp. 6406-6416. Other Cadair

1999

Hoffmann, K.F., James, S.L., Cheever, A.W., Wynn, T.A. 1999. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. Journal of Immunology 163 (2) pp. 927-938. Other Cadair

1998

Hoffmann, K.F., Caspar, P., Cheever, A.W., Wynn, T.A. 1998. IFN-gamma, IL-12, and TNF-alpha are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12. Journal of Immunology 161 (8) pp. 4201-4210. Cadair

1997

Hoffmann, K.F., Strand, M. 1997. Molecular characterization of a 20.8-kDa Schistosoma mansoni antigen. Sequence similarity to tegumental associated antigens and dynein light chains. Journal of Biological Chemistry 272 (23) pp. 14509-14515. Cadair

1996

Hoffmann, K.F., Strand, M. 1996. Molecular identification of a Schistosoma mansoni tegumental protein with similarity to cytoplasmic dynein light chains. Journal of Biological Chemistry 271 (42) pp. 26117-26123. 10.1074/jbc.271.42.26117 Cadair