Dr Michael Rose

PhD

Dr Michael Rose

Reader

Institute Director of Learning and Teaching

Contact Details

Profile

I am an animal scientist with a particular interest in dairy cows. I graduated in 1989 with a degree in Animal Science and followed this with a PhD in 1993, where I investigated the extent of the milk yield response of dairy cows to bovine somatotropin. Following this I worked in the National Institute of Grassland and Livestock Research, Tsukuba, Japan, for several years as a research officer, where I studied the metabolic endocrinology of dairy cows. I moved to Aberystwyth University in 2000. From 2016, I have acted as Director of Learning and Teaching for IBERS.

Additional Information

I have two dogs.

Teaching

Research

I am interested in the physiology of ruminants, but especially dairy cows. With colleagues, I have a project to investigate the immunity of the endometrium and the response to endometritis in dairy cows. Additionally, with other colleagues, I have a project to identify immune markers of mastitis susceptibility in early lactation in dairy cows. Thirdly, I am working with others to model the behaviour of dairy cows using GPS and other forms of precision agriculture.

Publications

Itoh, F, Obara, Y, Rose, MT & Fuse, H 1998, 'Heat influences on plasma insulin and glucagon in response to secretogogues in non-lactating dairy cows' Domestic Animal Endocrinology, vol 15, no. 6, pp. 499-510.
Itoh, F, Obara, Y, Rose, MT, Fuse, H & Hashimoto, H 1998, 'Insulin and glucagon secretion in lactating cows during heat exposure' Journal of Animal Science, vol 76, no. 8, pp. 2182-2189.
Itoh, F, Obara, Y, Fuse, H, Rose, MT, Osaka, I & Takahashi, H 1998, 'Effects of heat exposure on plasma insulin, glucagon and metabolites in response to nutrient injection in heifers' Comparative Biochemistry and Physiology - Part C: Pharmacology, Toxicology and Endocrinology, vol 119, no. 2, pp. 157-64. DOI: 10.1016/S0742-8413(97)00203-X
Rose, MT, Itoh, F, Matsumoto, M, Takahashi, Y & Obara, Y 1998, 'Insulin-independent glucose uptake in growth hormone treated dairy cows' Journal of Dairy Research, vol 65, no. 3, pp. 423-31.
Rose, MT, Itoh, F & Takahashi, Y 1998, 'Effect of glucose-dependent insulinotropic polypeptide on whole-body glucose utilization in sheep' Experimental Physiology, vol 83, no. 6, pp. 783-92.
Rose, MT, Obara, Y, Itoh, F, Hashimoto, H & Takahashi, Y 1997, 'Non-insulin- and insulin-mediated glucose uptake in dairy cows' Journal of Dairy Research, vol 64, no. 3, pp. 341-353. DOI: 10.1017/S0022029997002215
Rose, MT, Obara, Y, Itoh, F, Hashimoto, H & Takahashi, Y 1997, 'Growth hormone does not affect non-insulin-mediated glucose uptake in sheep' Experimental Physiology, vol 82, no. 4, pp. 749-760.
Rose, MT, Obara, Y, Fuse, H, Itoh, F, Ozawa, A, Takahashi, Y, Hodate, K & Ohashi, S 1996, 'Effect of growth hormone-releasing factor on the response to insulin of cows during early and late lactation' Journal of Dairy Science, vol 79, no. 10, pp. 1734-45. DOI: 10.3168/jds.S0022-0302(96)76540-2
Rose, MT, Van Houten, BHGW & Watts, EJ 2008, 'Cell signalling pathways controlling contraction of platelet-derived growth factor stimulated fibroblast populated collagen matrices as a model of wound contraction' Equine Veterinary Journal.
Kanaya, T, Aso, H, Miyazawa, K, Kido, T, Minashima, T, Watanabe, K, Ohwada, S, Kitazawa, H, Rose, MT & Yamaguchi, T 2007, 'Staining patterns for actin and villin distinguish M cells in bovine follicle-associated epithelium' Research in Veterinary Science, vol 82, no. 2, pp. 141-149. DOI: 10.1016/j.rvsc.2006.05.009
Miyazawa, K, Kanaya, T, Tanaka, S, Takakura, I, Watanabe, K, Ohwada, S, Kitazawa, H, Rose, MT, Sakaguchi, S, Katamine, S, Yamaguchi, T & Aso, H 2007, 'Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice' Histochemistry and Cell Biology, vol 127, no. 3, pp. 291-301. DOI: 10.1007/s00418-006-0250-x
Rose, MT, Wolf, BT & Haresign, W 2007, 'Effect of the level of iodine in the diet of pregnant ewes on the concentration of immunoglobulin G in the plasma of neonatal lambs following the consumption of colostrum' British Journal of Nutrition, vol 97, no. 2, pp. 315-320. DOI: 10.1017/S0007114507337306
Yamasaki, T, Tahara, K, Takano, S, Inoue-Murayama, M, Rose, MT, Minashima, T, Aso, H & Ito, S 2006, 'Mechanism of plasma glutathione peroxidase production in bovine adipocytes' Cell and Tissue Research, vol 326, no. 1, pp. 139-147. DOI: 10.1007/s00441-006-0194-4
Miyazawa, K, Aso, H, Honda, M, Kido, T, Minashima, T, Kanaya, T, Watanabe, K, Ohwada, S, Rose, MT & Yamaguchi, T 2006, 'Identification of bovine dendritic cell phenotype from bovine peripheral blood' Research in Veterinary Science, vol 81, no. 1, pp. 40-45. DOI: 10.1016/j.rvsc.2005.09.003
Miyazawa, K, Aso, H, Kanaya, T, Kido, T, Minashima, T, Watanabe, K, Ohwada, S, Kitazawa, H, Rose, MT, Tahara, K, Yamasaki, T & Yamaguchi, T 2006, 'Apoptotic process of porcine intestinal M cells' Cell and Tissue Research, vol 323, no. 3, pp. 425-432. DOI: 10.1007/s00441-005-0086-z
McConochie, HR & Rose, MT 2006, 'The long road to a representative model of bovine lactation in dairy cows' Journal of Integrated Field Science, vol 3, pp. 67-72.
Sakamoto, K, Komatsu, T, Kobayashi, T, Rose, MT, Aso, H, Hagino, A & Obara, Y 2005, 'Growth hormone acts on the synthesis and secretion of alpha-casein in bovine mammary epithelial cells' Journal of Dairy Research, vol 72, no. 3, pp. 264-270. DOI: 10.1017/S0022029905000889
Rose, MT, Weekes, TEC & Rowlinson, P 2005, 'Correlation of blood and milk components with the milk yield response to bovine somatotropin in dairy cows' Domestic Animal Endocrinology, vol 28, no. 3, pp. 296-307. DOI: 10.1016/j.domaniend.2004.12.001
Rose, MT, Weekes, TEC & Rowlinson, P 2004, 'Individual variation in the milk yield response to bovine somatotropin in dairy cows' Journal of Dairy Science, vol 87, no. 7, pp. 2024-2031. DOI: 10.3168/jds.S0022-0302(04)70020-X
Tahara, K, Aso, H, Yamasaki, T, Rose, MT, Takasuga, A, Sugimoto, Y, Yamaguchi, T & Takano, S 2004, 'Cloning and expression of type XII collagen isoforms during bovine adipogenesis' Differentiation, vol 72, no. 4, pp. 113-122. DOI: 10.1111/j.1432-0436.2004.07204006.x
McConochie, HR, Rose, MT, Haresign, W & Davies, B 2004, 'Mammary specific function of a bovine mammary epithelial cell clone cultured on collagen I coated inserts' Journal of Animal and Feed Sciences, vol 13, no. Supplement 1, pp. 523-526.
Aso, H, Tahara, K, Yamasaki, T, Rose, MT, Kido, T, Minashima, T, Miyazawa, K, Hayashi, S, Sanosaka, M, Watanabe, K, Ohwada, S & Yamaguchi, T 2004, 'The profile of gene expression during bovine adipogenesis: Cloning and expression of type XII collagen isoforms' Journal of Animal and Feed Sciences, vol 13, no. Supp. 1, pp. 369-372.
Takenouchi, T, Miyashita, N, Ozutsumi, K, Rose, MT & Aso, H 2004, 'Role of caveolin-1 and cytoskeletal proteins, actin and vimentin, in adipogenesis of bovine intramuscular preadipocyte cells' Cell Biology International, vol 28, no. 8-9, pp. 615-23. DOI: 10.1016/j.cellbi.2004.05.003
Rose, MT, Aso, H, Yonekura, S, Komatsu, T, Hagino, A, Ozutsumi, K & Obara, Y 2002, 'In vitro differentiation of a cloned bovine mammary epithelial cell' Journal of Dairy Research, vol 69, no. 3, pp. 345-355. DOI: 10.1017/S0022029902005551
Itoh, F, Hodate, K, Koyama, S, Rose, MT, Matsumoto, M, Ozawa, A & Obara, Y 2001, 'Effects of heat exposure on adrenergic modulation of insulin and glucagon secretion in sheep' Endocrine Journal, vol 48, no. 2, pp. 193-198. DOI: 10.1507/endocrj.48.193
Hayashi, S, Aso, H, Watanabe, S, Nara, H, Rose, MT, Ohwada, S & Yamaguchi, T 2000, 'Sequence of IGF-I, IGF-II, and HGF expression in regenerating skeletal muscle' Histochemistry and Cell Biology, vol 122, no. 5, pp. 427-434. DOI: 10.1007/s00418-004-0704-y
Aso, H, Tamura, K, Rose, MT, Tomioka, Y, Mizugaki, M & Ishida, N 1999, 'Effect of alpha 1-acidic glycoprotein in the ascitic fluid of cancer patients on human NK cells: selective suppression of interferon-induced NK activation' Inflammation, vol 23, no. 2, pp. 117-29. DOI: 10.1023/A:1020236927814
Aso, H, Yoshite, O, Tomioka, Y, Rose, MT & Mizugaki, M 1999, 'A 63 kDa tumor necrosis factor inhibitor released from a human monocytic leukemia cell line, THP-1' Microbiology and Immunology, vol 43, no. 1, pp. 53-59.
Rose, MT 2012, 'Effect of growth factors on the migration of equine oral and limb fibroblasts using an in vitro scratch assay' Veterinary Journal, vol 193, no. 2, pp. 539-544. DOI: 10.1016/j.tvjl.2012.01.010
Rose, MT, Pearson, S & Cratchley, T 2012, 'Effect of iodine, selenium and cobalt rumen boluses given to dry dairy cows on the immunoglobulin and thyroid hormone status of calves' Animal Science Journal, vol 83, no. 7, pp. 543-548. DOI: 10.1111/j.1740-0929.2011.00991.x
Takakura, I, Miyazawa, K, Kanaya, T, Itani, W, Watanabe, K, Ohwada, S, Watanabe, H, Hondo, T, Rose, MT, Mori, T, Sakaguchi, S, Nishida, N, Katamine, S, Yamaguchi, T & Aso, H 2011, 'Orally administered prion protein is incorporated by M cells and spreads into lymphoid tissues with macrophages in prion protein knockout mice' American Journal of Pathology, vol 179, no. 3, pp. 1301-1309. DOI: 10.1016/j.ajpath.2011.05.058
Watanabe, H, Rose, MT & Aso, H 2011, 'Role of peripheral serotonin in glucose and lipid metabolism' Current Opinion in Lipidology, vol 22, no. 3, pp. 186-191. DOI: 10.1097/MOL.0b013e3283462273
Watts, EJ & Rose, MT 2011, 'Extracellular matrix expression by equine oral and limb fibroblasts in in vitro culture' Research in Veterinary Science, vol 92, no. 2, pp. 213-218. DOI: 10.1016/j.rvsc.2011.03.020
Hondo, T, Kanaya, T, Takakura, I, Watanabe, H, Takahashi, Y, Nagasawa, Y, Terada, S, Ohwada, S, Watanabe, K, Kitazawa, H, Rose, MT, Yamaguchi, T & Aso, H 2011, 'Cytokeratin 18 is a specific marker of bovine intestinal M cell' American Journal of Physiology - Gastrointestinal and Liver Physiology, vol 300, no. 3, pp. G442-G453. DOI: 10.1152/ajpgi.00345.2010
Miyazawa, K, Kanaya, T, Takakura, I, Tanaka, S, Hondo, T, Watanabe, H, Rose, MT, Kitazawa, H, Yamaguchi, T, Katamine, S, Nishida, N & Aso, H 2010, 'Transcytosis of murine-adapted Bovine Spongiform Encephalopathy agents in an in vitro bovine M cell model' Journal of Virology, vol 84, no. 23, pp. 12285-12291. DOI: 10.1128/JVI.00969-10
Watanabe, H, Akasaka, D, Ogasawara, H, Sato, K, Miyake, M, Saito, K, Takahashi, Y, Kanaya, T, Takakura, I, Hondo, T, Chao, G, Rose, MT, Ohwada, S, Watanabe, K, Yamaguchi, T & Aso, H 2010, 'Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover' Endocrinology, vol 151, no. 10, pp. 4776-4786. DOI: 10.1210/en.2009-1349
Watts, EJ & Rose, MT 2010, 'Platelet-derived growth factor acts via both the Rho-kinase and p38 signaling enzymes to stimulate contraction in an in vitro model of equine wound healing' Domestic Animal Endocrinology, vol 38, no. 4, pp. 253-259. DOI: 10.1016/j.domaniend.2009.11.004
Wolf, BT, Molloy, HRB, Trayte, MJ & Rose, MT 2010, 'Behaviour of growing lambs housed on straw or woodchip bedding materials and their preference for floor type' Applied Animal Behaviour Science, vol 124, no. 1-2, pp. 45-50. DOI: 10.1016/j.applanim.2010.01.011
Miyazawa, K, Hondo, T, Kanaya, T, Tanaka, S, Takakura, I, Itani, W, Rose, MT, Kitazawa, H, Yamaguchi, T & Aso, H 2010, 'Characterization of newly established bovine intestinal epithelial cell line' Histochemistry and Cell Biology, vol 133, no. 1, pp. 125-134. DOI: 10.1007/s00418-009-0648-3
Watts, EJ & Rose, MT 2009, 'Comparison of extracellular matric production in equine oral mucosal and dermal limb fibroblasts'.
Rose, MT, Weekes, TEC & Rowlinson, P 2009, 'Relationship between the milk yield response to short-term bovine somatotropin treatment and the lipolytic response to adrenaline in dairy cows' Domestic Animal Endocrinology, vol 36, no. 1, pp. 24-31. DOI: 10.1016/j.domaniend.2008.09.001
Watts, E & Rose, M 2009, 'Equine limb and oral fibroblasts in in vitro models of cell proliferation and wound contraction' pp. 19.
Nagai, Y, Aso, H, Ogasawara, H, Tanaka, S, Taketa, Y, Watanabe, K, Ohwada, S, Rose, MT, Kitazawa, H & Yamaguchi, T 2008, 'Anterior Pituitary Progenitor Cells Express Costimulatory Molecule 4Ig-B7-H31' Journal of Immunology, vol 181, no. 9, pp. 6073–6081.
Nagai, Y, Aso, H, Ogasawara, H, Tanaka, S, Taketa, Y, Watanabe, K, Ohwada, S, Rose, MT, Kitazawa, H & Yamaguchi, T 2008, 'Anterior pituitary progenitor cells express costimulatory molecule 4Ig-B7-H3' Journal of Immunology, vol 181, no. 9, pp. 6073-6081.
Kanaya, T, Miyazawa, K, Takakura, I, Itani, W, Watanabe, K, Ohwada, S, Kitazawa, H, Rose, MT, McConochie, HR, Okano, H, Yamaguchi, T & Aso, H 2008, 'Differentiation of a murine intestinal epithelial cell line (MIE) towards the M cell lineage' American Journal of Physiology - Gastrointestinal and Liver Physiology, vol 295, no. 2, pp. G273-G284. DOI: 10.1152/ajpgi.00378.2007
Rose, MT, Van Houten, BHGW & Watts, EJ 2008, 'Development of a laboratory model to test natural products for wound healing properties in horses', pp. 39-41, IBERS Knowledge-based Innovations, 1 8 01 July.
Wolf, BT & Rose, MT 2008, The effects of the use of straw or woodchip bedding materials on the behaviour of lambs. Report to Hybu Cig Cymru, Unknown Publisher.
Sanosaka, M, Minashima, T, Suzuki, K, Watanabe, K, Ohwada, S, Hagino, A, Rose, MT, Yamaguchi, T & Aso, H 2008, 'A combination of octanoate and oleate promotes in vitro differentiation of porcine intramuscular adipocytes' Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, vol 149, no. 2, pp. 285-292. DOI: 10.1016/j.cbpb.2007.09.019
Williams, ML, James, W & Rose, M 2017, 'Fixed-time data segmentation and behaviour classification of pasture-based cattle: Enhancing performance using a hidden Markov model' Computers and Electronics in Agriculture. DOI: 10.1016/j.compag.2017.11.010
Wonfor, R, Natoli, M, Rose, M & Nash, D 2017, 'Effects of preimplantation factor on interleukin-6 and prostaglandin F2a and E2 in the bovine endometrium' Theriogenology, vol 102, pp. 174-182. DOI: 10.1016/j.theriogenology.2017.08.001
Watanabe, H, Rose, M, Kanayama, Y, Shirakawa, H & Aso, H 2017, Energy Homeostasis by the Peripheral Serotonergic System. in KF Shad (ed.), Seratonin - A Chemical Messenger Between All Types of Living Cells. InTechOpen. DOI: 10.5772/intechopen.68831
Crowley, EJ, King, JJ, Wilkinson, T, Worgan, H, Huson, KM, Rose, M & McEwan, N 2017, 'Comparison of the microbial population in rabbits and guinea pigs by next generation sequencing' PLoS One, vol 12, no. 2, e0165779. DOI: 10.1371/journal.pone.0165779
Hondo, T, Someya, S, Nagasawa, Y, Terada, S, Watanabe, H, Chen, X, Watanabe, K, Ohwada, S, Kitazawa, H, Rose, M, Nochi, T & Aso, H 2016, 'Cyclophilin A is a new M cell marker of bovine intestinal epithelium' Cell and Tissue Research, vol 364, no. 3, pp. 585-597. DOI: 10.1007/s00441-015-2342-1
Williams, M, MacParthalain, N, Brewer, P, James, P & Rose, M 2016, 'A novel behavioral model of the pasture-based dairy cow from GPS data using data mining and machine learning techniques' Journal of Dairy Science, vol 99, no. 3, pp. 2063-2075. DOI: 10.3168/jds.2015-10254
Watanabe, H, Nakano, T, Saito, R, Aksaka, D, Saito, K, Ogasawara, H, Minashima, T, Miyazawa, K, Kanaya, T, Takakura, I, Inoue, N, Ikeda, I, Chen, X, Miyake, M, kitazawa, H, Shirakawa, H, Sato, K, Tahara, K, Nagasawa, Y, Watanabe, K, Rose, M & Aso, H 2016, 'Serotonin Improves High Fat Diet Induced Obesity in Mice' PLoS One, vol 11, no. 1, e0147143. DOI: 10.1371/journal.pone.0147143
Clamp, R, Creevey, C, Natoli, M, Barnea, ER, Nash, D & Rose, M 2016, 'Interaction of preimplantation factor with the bovine global endometrial transcriptome.' Paper presented at British Society of Animal Science Annual conference, Chester, United Kingdom of Great Britain and Northern Ireland, 2016 - 2016, .
Hamilton, J, Davey, H & Rose, M 2016, Life Sciences Aberystwyth University: A Blended Higher Education Environment for Raising Ambition, Aspirations and driving Social Mobility. Response to Welsh Government’s Consultation on Foundation Degrees in Wales.
Takanashi, S, Nochi, T, Abe, M, Itaya, N, Urakawa, M, Sato, K, Tao, Z, Uemura, S, Hayashi, T, Kiku, Y, kitazawa, H, Rose, M, Watanabe, K & Aso, H 2015, 'Extracellular cyclophilin A possesses chemotaxic activity in cattle' Veterinary Research, vol 46, no. 80. DOI: 10.1186/s13567-015-0212-1
Watanabe, H, Chen, X, Shoji, N, Saito, R, Nakano, T, Saito, K, Sumiyoshi, K, Rose, M, Okada, N, Watanabe, K & Aso, H 2015, 'Stimulatory effect of plasma samples from fattening cattle on adipogenesis-related gene expression in preadipocyte cells' Animal Science Journal, vol 86, no. 7, pp. 698-706. DOI: 10.1111/asj.12344
Clamp, R, Natoli, M, Barnea, ER, Nash, D & Rose, M 2015, 'Effect of preimplantation factor in an in vitro model of bovine E. coli endometritis.' Paper presented at Proceedings of the British Society of Animal Science, Chester, United Kingdom of Great Britain and Northern Ireland, 2015 - 2015, .
Clamp, R, Natoli, M, Barnea, ER, Rose, M & Nash, D 2015, 'Effect of preimplantation factor in response to a LPS challenge on bovine endometrial IL-6 secretion and expression' Paper presented at International Conference on Biology and Pathology of Reproduction in Domestic Animals, Gdansk, Poland, 2015 - 2015, .
Takahashi, H, Sato, K, Yamaguchi, T, Miyake, M, Watanabe, H, Nagasawa, Y, Kitagawa, E, Terada, S, Urakawa, M, Rose, MT, McMahon, CD, Watanabe, K, Ohwada, S, Gotoh, T & Aso, H 2014, 'Myostatin alters glucose transporter-4 (GLUT4) expression in bovine skeletal muscles and myoblasts isolated from. double-muscled (DM) and normal-muscled (NM) Japanese Shorthorn cattle.' Domestic Animal Endocrinology, vol 48, pp. 62-68. DOI: 10.1016/j.domaniend.2014.01.007
Watanabe, H, Saito, R, Nakano, T, Takahashi, H, Takahashi, Y, Sumiyoshi, K, Sato, K, Chen, X, Okada, N, Iwasaki, S, Harjanti, DW, Sekiguchi, N, Sano, H, Kitazawa, H, Rose, MT, Ohwada, S, Watanabe, K, Aso, H & Vaudry, H (ed.) 2014, 'Effect of Peripheral 5-HT on Glucose and Lipid Metabolism in Wether Sheep' PLoS One, vol 9, no. 2, e88058. DOI: 10.1371/journal.pone.0088058
Clamp, RE, Paddison, JS, Nash, DM, Rose, MT & Barnea, E 2014, 'Effect of pre-implantation factor on the secretion of prostaglandin F2α and prostaglandin E2 from bovine endometrial tissue following a lipopolysaccharide challenge in vitro.' Paper presented at BSAS Annual Conference 2014, 29-30 April 2014, Nottingham, United Kingdom of Great Britain and Northern Ireland, 2014 - 2014, pp. 207.
Yonekura, S, Hirota, S, Tokutake, Y, Rose, MT, Katoh, K & Aso, H 2014, 'Dexamethasone and Acetate Modulate Cytoplasmic Leptin in Bovine Preadipocytes' Asian-Australasian Journal of Animal Sciences, vol 27, no. 4, pp. 567-573. DOI: 10.5713/ajas.2013.13559
Yonekura, S, Tokutake, Y, Hirota, T, Rose, MT, Katoh, K & Aso, H 2013, 'Proliferating bovine intramuscular preadipocyte cells synthesize leptin' Domestic Animal Endocrinology, vol 45, no. 1, pp. 33-37. DOI: 10.1016/j.domaniend.2013.03.004
Iwasaki, S, Miyake, M, Watanabe, H, Kitagawa, E, Watanabe, K, Ohwada, S, Kitazawa, H, Rose, MT & Aso, H 2013, 'Expression of Myostatin in Neural Cells of the Olfactory System' Molecular Neurobiology, vol 47, no. 1, pp. 1-8. DOI: 10.1007/s12035-012-8342-1
Clamp, R, Paddison, J, Rose, M, Nash, D & Barnea, ER 2013, 'Effect of pre-implantation factor on the secretion of prostaglandins from bovine endometrial tissue following a lipopolysaccharide challenge in vitro' Paper presented at Endometritis as a cause of infertility in domestic animals, Olsztyn, Poland, 2013 - 2013, .