Dr Michael Rose PhD

Dr Michael Rose

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Profile

I am an animal scientist with a particular interest in dairy cows. I graduated in 1989 with a degree in Animal Science and followed this with a PhD in 1993, where I investigated the extent of the milk yield response of dairy cows to bovine somatotropin. Following this I worked in the National Institute of Grassland and Livestock Research, Tsukuba, Japan, for several years as a research officer, where I studied the metabolic endocrinology of dairy cows. I moved to Aberystwyth University in 2000. From 2016, I have acted as Director of Learning and Teaching for IBERS.

Additional Information

I have two dogs.

Teaching

Research

I am interested in the physiology of ruminants, but especially dairy cows. With colleagues, I have a project to investigate the immunity of the endometrium and the response to endometritis in dairy cows. Additionally, with other colleagues, I have a project to identify immune markers of mastitis susceptibility in early lactation in dairy cows. Thirdly, I am working with others to model the behaviour of dairy cows using GPS and other forms of precision agriculture.

Publications

2017

Wonfor, R., Natoli, M., Rose, M., Nash, D. 2017. Effects of preimplantation factor on interleukin-6 and prostaglandin F2a and E2 in the bovine endometrium. Theriogenology 102 pp. 174-182. 10.1016/j.theriogenology.2017.08.001

Watanabe, H., Rose, M., Kanayama, Y., Shirakawa, H., Aso, H. 2017. Energy Homeostasis by the Peripheral Serotonergic System. In K. F. Shad. (ed) Seratonin - A Chemical Messenger Between All Types of Living Cells. InTechOpen 10.5772/intechopen.68831

Crowley, E.J., King, J.J., Wilkinson, T., Worgan, H., Huson, K.M., Rose, M., McEwan, N. 2017. Comparison of the microbial population in rabbits and guinea pigs by next generation sequencing. PLoS One 12 (2) e0165779 10.1371/journal.pone.0165779 Cadair

2016

Hondo, T., Someya, S., Nagasawa, Y., Terada, S., Watanabe, H., Chen, X., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M., Nochi, T., Aso, H. 2016. Cyclophilin A is a new M cell marker of bovine intestinal epithelium. Cell and Tissue Research 364 (3) pp. 585-597. 10.1007/s00441-015-2342-1 Cadair

Williams, M., MacParthalain, N., Brewer, P., James, P., Rose, M. 2016. A novel behavioral model of the pasture-based dairy cow from GPS data using data mining and machine learning techniques. Journal of Dairy Science 99 (3) pp. 2063-2075. 10.3168/jds.2015-10254 Cadair

Watanabe, H., Nakano, T., Saito, R., Aksaka, D., Saito, K., Ogasawara, H., Minashima, T., Miyazawa, K., Kanaya, T., Takakura, I., Inoue, N., Ikeda, I., Chen, X., Miyake, M., kitazawa, h., Shirakawa, H., Sato, K., Tahara, K., Nagasawa, Y., Watanabe, K., Rose, M., Aso, H. 2016. Serotonin Improves High Fat Diet Induced Obesity in Mice. PLoS One 11 (1) e0147143 10.1371/journal.pone.0147143 Cadair

Clamp, R., Creevey, C., Natoli, M., Barnea, E.R., Nash, D., Rose, M. 2016. Interaction of preimplantation factor with the bovine global endometrial transcriptome. British Society of Animal Science Annual conference. Cadair

2015

Takanashi, S., Nochi, T., Abe, M., Itaya, N., Urakawa, M., Sato, K., Tao, Z., Uemura, S., Hayashi, T., Kiku, Y., kitazawa, h., Rose, M., Watanabe, K., Aso, H. 2015. Extracellular cyclophilin A possesses chemotaxic activity in cattle. Veterinary Research 46 (80) 10.1186/s13567-015-0212-1 Cadair

Watanabe, H., Chen, X., Shoji, N., Saito, R., Nakano, T., Saito, K., Sumiyoshi, K., Rose, M., Okada, N., Watanabe, K., Aso, H. 2015. Stimulatory effect of plasma samples from fattening cattle on adipogenesis-related gene expression in preadipocyte cells. Animal Science Journal 86 (7) pp. 698-706. 10.1111/asj.12344 Cadair

Clamp, R., Natoli, M., Barnea, E.R., Nash, D., Rose, M. 2015. Effect of preimplantation factor in an in vitro model of bovine E. coli endometritis. Proceedings of the British Society of Animal Science. Cadair

Clamp, R., Natoli, M., Barnea, E.R., Rose, M., Nash, D. 2015. Effect of preimplantation factor in response to a LPS challenge on bovine endometrial IL-6 secretion and expression. International Conference on Biology and Pathology of Reproduction in Domestic Animals. Cadair

2014

Takahashi, H., Sato, K., Yamaguchi, T., Miyake, M., Watanabe, H., Nagasawa, Y., Kitagawa, E., Terada, S., Urakawa, M., Rose, M.T., McMahon, C.D., Watanabe, K., Ohwada, S., Gotoh, T., Aso, H. 2014. Myostatin alters glucose transporter-4 (GLUT4) expression in bovine skeletal muscles and myoblasts isolated from. double-muscled (DM) and normal-muscled (NM) Japanese Shorthorn cattle. Domestic Animal Endocrinology 48 pp. 62-68. 10.1016/j.domaniend.2014.01.007 Cadair

Watanabe, H., Saito, R., Nakano, T., Takahashi, H., Takahashi, Y., Sumiyoshi, K., Sato, K., Chen, X., Okada, N., Iwasaki, S., Harjanti, D.W., Sekiguchi, N., Sano, H., Kitazawa, H., Rose, M.T., Ohwada, S., Watanabe, K., Aso, H.Vaudry, H. 2014. Effect of Peripheral 5-HT on Glucose and Lipid Metabolism in Wether Sheep. PLoS One 9 (2) e88058 10.1371/journal.pone.0088058 Other Cadair

Clamp, R.E., Paddison, J.S., Nash, D.M., Rose, M.T., Barnea, E. 2014. Effect of pre-implantation factor on the secretion of prostaglandin F2α and prostaglandin E2 from bovine endometrial tissue following a lipopolysaccharide challenge in vitro. BSAS Annual Conference 2014, 29-30 April 2014. Cadair

Yonekura, S., Hirota, S., Tokutake, Y., Rose, M.T., Katoh, K., Aso, H. 2014. Dexamethasone and Acetate Modulate Cytoplasmic Leptin in Bovine Preadipocytes. Asian-Australasian Journal of Animal Sciences 27 (4) pp. 567-573. 10.5713/ajas.2013.13559 Cadair

2013

Yonekura, S., Tokutake, Y., Hirota, T., Rose, M.T., Katoh, K., Aso, H. 2013. Proliferating bovine intramuscular preadipocyte cells synthesize leptin. Domestic Animal Endocrinology 45 (1) pp. 33-37. 10.1016/j.domaniend.2013.03.004 Cadair

Iwasaki, S., Miyake, M., Watanabe, H., Kitagawa, E., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M.T., Aso, H. 2013. Expression of Myostatin in Neural Cells of the Olfactory System. Molecular Neurobiology 47 (1) pp. 1-8. 10.1007/s12035-012-8342-1 Cadair

Clamp, R., Paddison, J., Rose, M., Nash, D., Barnea, E.R. 2013. Effect of pre-implantation factor on the secretion of prostaglandins from bovine endometrial tissue following a lipopolysaccharide challenge in vitro. Endometritis as a cause of infertility in domestic animals. Cadair

2012

Rose, M.T. 2012. Effect of growth factors on the migration of equine oral and limb fibroblasts using an in vitro scratch assay. Veterinary Journal 193 (2) pp. 539-544. 10.1016/j.tvjl.2012.01.010 Cadair

Rose, M.T., Pearson, S., Cratchley, T. 2012. Effect of iodine, selenium and cobalt rumen boluses given to dry dairy cows on the immunoglobulin and thyroid hormone status of calves. Animal Science Journal 83 (7) pp. 543-548. 10.1111/j.1740-0929.2011.00991.x Cadair

2011

Takakura, I., Miyazawa, K., Kanaya, T., Itani, W., Watanabe, K., Ohwada, S., Watanabe, H., Hondo, T., Rose, M.T., Mori, T., Sakaguchi, S., Nishida, N., Katamine, S., Yamaguchi, T., Aso, H. 2011. Orally administered prion protein is incorporated by M cells and spreads into lymphoid tissues with macrophages in prion protein knockout mice. American Journal of Pathology 179 (3) pp. 1301-1309. 10.1016/j.ajpath.2011.05.058 Cadair

Watanabe, H., Rose, M.T., Aso, H. 2011. Role of peripheral serotonin in glucose and lipid metabolism. Current Opinion in Lipidology 22 (3) pp. 186-191. 10.1097/MOL.0b013e3283462273 Cadair

Watts, E.J., Rose, M.T. 2011. Extracellular matrix expression by equine oral and limb fibroblasts in in vitro culture. Research in Veterinary Science 92 (2) pp. 213-218. 10.1016/j.rvsc.2011.03.020 Cadair

Hondo, T., Kanaya, T., Takakura, I., Watanabe, H., Takahashi, Y., Nagasawa, Y., Terada, S., Ohwada, S., Watanabe, K., Kitazawa, H., Rose, M.T., Yamaguchi, T., Aso, H. 2011. Cytokeratin 18 is a specific marker of bovine intestinal M cell. American Journal of Physiology - Gastrointestinal and Liver Physiology 300 (3) pp. G442-G453. 10.1152/ajpgi.00345.2010 Cadair

2010

Miyazawa, K., Kanaya, T., Takakura, I., Tanaka, S., Hondo, T., Watanabe, H., Rose, M.T., Kitazawa, H., Yamaguchi, T., Katamine, S., Nishida, N., Aso, H. 2010. Transcytosis of murine-adapted Bovine Spongiform Encephalopathy agents in an in vitro bovine M cell model. Journal of Virology 84 (23) pp. 12285-12291. 10.1128/JVI.00969-10 Cadair

Watanabe, H., Akasaka, D., Ogasawara, H., Sato, K., Miyake, M., Saito, K., Takahashi, Y., Kanaya, T., Takakura, I., Hondo, T., Chao, G., Rose, M.T., Ohwada, S., Watanabe, K., Yamaguchi, T., Aso, H. 2010. Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover. Endocrinology 151 (10) pp. 4776-4786. 10.1210/en.2009-1349 Cadair

Watts, E.J., Rose, M.T. 2010. Platelet-derived growth factor acts via both the Rho-kinase and p38 signaling enzymes to stimulate contraction in an in vitro model of equine wound healing. Domestic Animal Endocrinology 38 (4) pp. 253-259. 10.1016/j.domaniend.2009.11.004 Cadair

Wolf, B.T., Molloy, H.R.B., Trayte, M.J., Rose, M.T. 2010. Behaviour of growing lambs housed on straw or woodchip bedding materials and their preference for floor type. Applied Animal Behaviour Science 124 (1-2) pp. 45-50. 10.1016/j.applanim.2010.01.011 Cadair

Miyazawa, K., Hondo, T., Kanaya, T., Tanaka, S., Takakura, I., Itani, W., Rose, M.T., Kitazawa, H., Yamaguchi, T., Aso, H. 2010. Characterization of newly established bovine intestinal epithelial cell line. Histochemistry and Cell Biology 133 (1) pp. 125-134. 10.1007/s00418-009-0648-3 Cadair

2009

Watts, E.J., Rose, M.T. 2009. Comparison of extracellular matric production in equine oral mucosal and dermal limb fibroblasts. Cadair

Rose, M.T., Weekes, T.E.C., Rowlinson, P. 2009. Relationship between the milk yield response to short-term bovine somatotropin treatment and the lipolytic response to adrenaline in dairy cows. Domestic Animal Endocrinology 36 (1) pp. 24-31. 10.1016/j.domaniend.2008.09.001 Cadair

Watts, E., Rose, M. 2009. Equine limb and oral fibroblasts in in vitro models of cell proliferation and wound contraction. Other Cadair

2008

Nagai, Y., Aso, H., Ogasawara, H., Tanaka, S., Taketa, Y., Watanabe, K., Ohwada, S., Rose, M.T., Kitazawa, H., Yamaguchi, T. 2008. Anterior Pituitary Progenitor Cells Express Costimulatory Molecule 4Ig-B7-H31. Journal of Immunology 181 (9) pp. 6073–6081. Cadair Other

Nagai, Y., Aso, H., Ogasawara, H., Tanaka, S., Taketa, Y., Watanabe, K., Ohwada, S., Rose, M.T., Kitazawa, H., Yamaguchi, T. 2008. Anterior pituitary progenitor cells express costimulatory molecule 4Ig-B7-H3. Journal of Immunology 181 (9) pp. 6073-6081. Cadair Other

Kanaya, T., Miyazawa, K., Takakura, I., Itani, W., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M.T., McConochie, H.R., Okano, H., Yamaguchi, T., Aso, H. 2008. Differentiation of a murine intestinal epithelial cell line (MIE) towards the M cell lineage. American Journal of Physiology - Gastrointestinal and Liver Physiology 295 (2) pp. G273-G284. 10.1152/ajpgi.00378.2007 Cadair Other

Rose, M.T., Van Houten, B.H.G.W., Watts, E.J. 2008. Development of a laboratory model to test natural products for wound healing properties in horses. Other Cadair

Wolf, B.T., Rose, M.T. 2008. The effects of the use of straw or woodchip bedding materials on the behaviour of lambs. Report to Hybu Cig Cymru Unknown Publisher Cadair

Sanosaka, M., Minashima, T., Suzuki, K., Watanabe, K., Ohwada, S., Hagino, A., Rose, M.T., Yamaguchi, T., Aso, H. 2008. A combination of octanoate and oleate promotes in vitro differentiation of porcine intramuscular adipocytes. Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology 149 (2) pp. 285-292. 10.1016/j.cbpb.2007.09.019 Cadair

Rose, M.T., Van Houten, B.H.G.W., Watts, E.J. 2008. Cell signalling pathways controlling contraction of platelet-derived growth factor stimulated fibroblast populated collagen matrices as a model of wound contraction. Equine Veterinary Journal 47th BEVA Congress: BEVA Congress 2008. Cadair

2007

Miyazawa, K., Kanaya, T., Tanaka, S., Takakura, I., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M.T., Sakaguchi, S., Katamine, S., Yamaguchi, T., Aso, H. 2007. Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice. Histochemistry and Cell Biology 127 (3) pp. 291-301. 10.1007/s00418-006-0250-x Cadair

Rose, M.T., Wolf, B.T., Haresign, W. 2007. Effect of the level of iodine in the diet of pregnant ewes on the concentration of immunoglobulin G in the plasma of neonatal lambs following the consumption of colostrum. British Journal of Nutrition 97 (2) pp. 315-320. 10.1017/S0007114507337306 Cadair

Kanaya, T., Aso, H., Miyazawa, K., Kido, T., Minashima, T., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M.T., Yamaguchi, T. 2007. Staining patterns for actin and villin distinguish M cells in bovine follicle-associated epithelium. Research in Veterinary Science 82 (2) pp. 141-149. 10.1016/j.rvsc.2006.05.009 Cadair

2006

Yamasaki, T., Tahara, K., Takano, S., Inoue-Murayama, M., Rose, M.T., Minashima, T., Aso, H., Ito, S. 2006. Mechanism of plasma glutathione peroxidase production in bovine adipocytes. Cell and Tissue Research 326 (1) pp. 139-147. 10.1007/s00441-006-0194-4 Cadair

Miyazawa, K., Aso, H., Honda, M., Kido, T., Minashima, T., Kanaya, T., Watanabe, K., Ohwada, S., Rose, M.T., Yamaguchi, T. 2006. Identification of bovine dendritic cell phenotype from bovine peripheral blood. Research in Veterinary Science 81 (1) pp. 40-45. 10.1016/j.rvsc.2005.09.003 Cadair

Miyazawa, K., Aso, H., Kanaya, T., Kido, T., Minashima, T., Watanabe, K., Ohwada, S., Kitazawa, H., Rose, M.T., Tahara, K., Yamasaki, T., Yamaguchi, T. 2006. Apoptotic process of porcine intestinal M cells. Cell and Tissue Research 323 (3) pp. 425-432. 10.1007/s00441-005-0086-z Cadair

McConochie, H.R., Rose, M.T. 2006. The long road to a representative model of bovine lactation in dairy cows. Journal of Integrated Field Science 3 pp. 67-72. Cadair Other

2005

Sakamoto, K., Komatsu, T., Kobayashi, T., Rose, M.T., Aso, H., Hagino, A., Obara, Y. 2005. Growth hormone acts on the synthesis and secretion of alpha-casein in bovine mammary epithelial cells. Journal of Dairy Research 72 (3) pp. 264-270. 10.1017/S0022029905000889 Cadair

Rose, M.T., Weekes, T.E.C., Rowlinson, P. 2005. Correlation of blood and milk components with the milk yield response to bovine somatotropin in dairy cows. Domestic Animal Endocrinology 28 (3) pp. 296-307. 10.1016/j.domaniend.2004.12.001 Cadair

2004

Rose, M.T., Weekes, T.E.C., Rowlinson, P. 2004. Individual variation in the milk yield response to bovine somatotropin in dairy cows. Journal of Dairy Science 87 (7) pp. 2024-2031. 10.3168/jds.S0022-0302(04)70020-X Cadair

Tahara, K., Aso, H., Yamasaki, T., Rose, M.T., Takasuga, A., Sugimoto, Y., Yamaguchi, T., Takano, S. 2004. Cloning and expression of type XII collagen isoforms during bovine adipogenesis. Differentiation 72 (4) pp. 113-122. 10.1111/j.1432-0436.2004.07204006.x Cadair

McConochie, H., Rose, M., Haresign, W., Davies, B. 2004. Mammary specific function of a bovine mammary epithelial cell clone cultured on collagen I coated inserts. Journal of Animal and Feed Sciences 13 (Supplement 1) 10th International Symposium on Ruminant Pysiology. pp. 523-526. Cadair

Aso, H., Tahara, K., Yamasaki, T., Rose, M.T., Kido, T., Minashima, T., Miyazawa, K., Hayashi, S., Sanosaka, M., Watanabe, K., Ohwada, S., Yamaguchi, T. 2004. The profile of gene expression during bovine adipogenesis: Cloning and expression of type XII collagen isoforms. Journal of Animal and Feed Sciences 13 (Supp. 1) pp. 369-372. Cadair Other

Takenouchi, T., Miyashita, N., Ozutsumi, K., Rose, M.T., Aso, H. 2004. Role of caveolin-1 and cytoskeletal proteins, actin and vimentin, in adipogenesis of bovine intramuscular preadipocyte cells. Cell Biology International 28 (8-9) pp. 615-23. 10.1016/j.cellbi.2004.05.003 Cadair

2002

Rose, M.T., Aso, H., Yonekura, S., Komatsu, T., Hagino, A., Ozutsumi, K., Obara, Y. 2002. In vitro differentiation of a cloned bovine mammary epithelial cell. Journal of Dairy Research 69 (3) pp. 345-355. 10.1017/S0022029902005551 Cadair

2001

Itoh, F., Hodate, K., Koyama, S., Rose, M.T., Matsumoto, M., Ozawa, A., Obara, Y. 2001. Effects of heat exposure on adrenergic modulation of insulin and glucagon secretion in sheep. Endocrine Journal 48 (2) pp. 193-198. 10.1507/endocrj.48.193 Cadair Other

2000

Hayashi, S., Aso, H., Watanabe, S., Nara, H., Rose, M.T., Ohwada, S., Yamaguchi, T. 2000. Sequence of IGF-I, IGF-II, and HGF expression in regenerating skeletal muscle. Histochemistry and Cell Biology 122 (5) pp. 427-434. 10.1007/s00418-004-0704-y Cadair

1999

Aso, H., Tamura, K., Rose, M.T., Tomioka, Y., Mizugaki, M., Ishida, N. 1999. Effect of alpha 1-acidic glycoprotein in the ascitic fluid of cancer patients on human NK cells: selective suppression of interferon-induced NK activation. Inflammation 23 (2) pp. 117-29. 10.1023/A:1020236927814 Cadair

Aso, H., Yoshite, O., Tomioka, Y., Rose, M.T., Mizugaki, M. 1999. A 63 kDa tumor necrosis factor inhibitor released from a human monocytic leukemia cell line, THP-1. Microbiology and Immunology 43 (1) pp. 53-59. Cadair

1998

Itoh, F., Obara, Y., Rose, M.T., Fuse, H. 1998. Heat influences on plasma insulin and glucagon in response to secretogogues in non-lactating dairy cows. Domestic Animal Endocrinology 15 (6) pp. 499-510. Other Cadair

Itoh, F., Obara, Y., Rose, M.T., Fuse, H., Hashimoto, H. 1998. Insulin and glucagon secretion in lactating cows during heat exposure. Journal of Animal Science 76 (8) pp. 2182-2189. Other Cadair

Itoh, F., Obara, Y., Fuse, H., Rose, M.T., Osaka, I., Takahashi, H. 1998. Effects of heat exposure on plasma insulin, glucagon and metabolites in response to nutrient injection in heifers. Comparative Biochemistry and Physiology - Part C: Pharmacology, Toxicology and Endocrinology 119 (2) pp. 157-64. 10.1016/S0742-8413(97)00203-X Cadair

Rose, M.T., Itoh, F., Matsumoto, M., Takahashi, Y., Obara, Y. 1998. Insulin-independent glucose uptake in growth hormone treated dairy cows. Journal of Dairy Research 65 (3) pp. 423-31. Cadair

Rose, M.T., Itoh, F., Takahashi, Y. 1998. Effect of glucose-dependent insulinotropic polypeptide on whole-body glucose utilization in sheep. Experimental Physiology 83 (6) pp. 783-92. Cadair

1997

Rose, M.T., Obara, Y., Itoh, F., Hashimoto, H., Takahashi, Y. 1997. Non-insulin- and insulin-mediated glucose uptake in dairy cows. Journal of Dairy Research 64 (3) pp. 341-353. 10.1017/S0022029997002215 Cadair

Rose, M.T., Obara, Y., Itoh, F., Hashimoto, H., Takahashi, Y. 1997. Growth hormone does not affect non-insulin-mediated glucose uptake in sheep. Experimental Physiology 82 (4) pp. 749-760. Other Cadair

1996

Rose, M.T., Obara, Y., Fuse, H., Itoh, F., Ozawa, A., Takahashi, Y., Hodate, K., Ohashi, S. 1996. Effect of growth hormone-releasing factor on the response to insulin of cows during early and late lactation. Journal of Dairy Science 79 (10) pp. 1734-45. 10.3168/jds.S0022-0302(96)76540-2 Cadair