Dr Narcis Fernandez-Fuentes
Narcis Fernandez-Fuentes is a Reader in Genomics/Bioinformatics. He received his M.Sc. degree in Biotechnology from the Universitat Autonoma de Barcelona, Spain, in 2001, and his PhD in Computational Biology from the same university in 2004.
During his PhD he was Marie Curie Training Fellow at the Structural Genomic Group in EMBL-EBI, Hinxton; Cambridge, U.K. where he worked with Prof. Liisa Holm; from Oct. 2002 to Apr. 2003 he worked with Prof. Michael J.E. Sternberg, Imperial College of London, U.K., supported by an EMBO and a FEBS short term fellowships and finally, between Oct. 2003 and Mar. 2004 he was visiting fellow at Dr. Fiser's Lab., Albert Einstein College of Medicine, NY, supported by Boehringer Ingelheim Fonds.
From 2004 to 2007 he was Research Associate at Dr. Andras Fiser Laboratory at Albert Einstein College of Medicine. From 2007 to 2011 he was a Lecturer funded by the RCUK Academic Fellow scheme at the Leeds Institute of Molecular Medicine were he established the Computational Biology Group within the Experimental Therapeutics Section.
In January 2012 he joined Aberystwyth University as Reader in Genomics/Bioinformatics.
Bioinformatics and Structural Bioinformatics. Protein design. Structure-based analysis of protein-protein interactions. Databases and bioinformatics tools. SNPs modelling.
Our research interests relate to a number of areas within Bioinformatics. We have a long-standing interest in protein structure prediction and structure-to-function relationship. We work in the study of biomolecular interactions, modeling of protein complexes in genome-wide interactomes, modulation of protein-protein interactions and structure-based protein design. We are also interested in computational design of peptides for the modulation of protein interactions as potential therapeutic agents or diagnostic tools. In the area of Plant Bioinformatics, we are developing bioinformatics-based approaches to complement guide and improve plant-breeding programmes and to understand the underlying biological mechanisms liked to the response to abiotic stresses. We are also interested in the modelling of genetic variation, e.g. SNPs, and the assessment of functional impact at protein level. Finally, we work in close collaboration with experimental labs in a synergistic manner by applying or developing novel tools to address different research questions.
On the mechanisms of protein interactions: predicting their affinity from unbound tertiary structures. Bioinformatics2017.
The GH51 α-l-arabinofuranosidase from Paenibacillus sp. THS1 is multifunctional, hydrolyzing main-chain and side-chain glycosidic bonds in heteroxylans. Biotechnology for Biofuels 9 140 10.1186/s13068-016-0550-x Cadair2016.
Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment. PLoS Neglected Tropical Diseases 9 (7) pp. e0003920. 10.1371/journal.pntd.0003920 Cadair2015.
A modular perspective of protein structures: application to fragment based loop modeling. In (ed) Protein Supersecondary Structures. Methods in Molecular Biology, vol. 932 Springer Nature pp. 141-158. 10.1007/978-1-62703-065-6_9 Cadair2013.
Computational Tools and Databases for the Study and Characterization of Protein Interactions. In (eds) Protein-Protein Interactions - Computational and Experimental Tools. Biochemistry, Genetics and Molecular Biology Chapter 19th edn, InTechOpen pp. 379-404. 10.5772/37268 Cadair2012.
Homozygous FOXE3 mutations cause non-syndromic, bilateral, total sclerocornea, aphakia, microphthalmia and optic disc coloboma. Molecular Vision 16 pp. 1162-8. Cadair2010.
Including Functional Annotations and Extending the Collection of Structural Classifications of Protein Loops (ArchDB). Bioinformatics and Biology Insights 1 pp. 77-90. Cadair2007.
Exchanging murine and human immunoglobulin constant chains affects the kinetics and thermodynamics of antigen binding and chimeric antibody autoreactivity. PLoS One 2 (12) pp. e1310. 10.1371/journal.pone.0001310 Cadair2007.
The immunoglobulin heavy chain constant region affects kinetic and thermodynamic parameters of antibody variable region interactions with antigen. Journal of Biological Chemistry 282 (18) pp. 13917-27. 10.1074/jbc.M700661200 Cadair2007.
Insights into the mechanism of microtubule stabilization by Taxol. Proceedings of the National Academy of Sciences of the United States of America 103 (27) pp. 10166-73. 10.1073/pnas.0603704103 Cadair2006.
Prediction of the conformation and geometry of loops in globular proteins: testing ArchDB, a structural classification of loops. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 60 (4) pp. 746-757. 10.1002/prot.20516 Cadair2005.