Prof Peter Brophy

PhD

Prof Peter Brophy

Professor

IBERS

Contact Details

Profile

PhD on understanding how parasitic flatworms metabolise anthelmintics.  After a Medical Research Council postdoctoral post at Aberystwyth in parasite biochemistry gained experience in biotechnology at the Leicester BioCentre. In 1992 was awarded a Wellcome Trust Fellowship based at Nottingham University exploring parasite defences against immune assault. A Senior Research Fellowship at the Leicester Pharmacy School (1994-97) provided opportunities in target based drug design and lead compound synthesis. Established proteomics laboratories dedicated to parasite-host interactions during readership posts at the Universities of Aberystwyth and Liverpool. Returned to Aberystwyth as a Professor in Parasitology in 2007. Has held a number of research contracts to address key problems in parasite control (vaccine, drug and diagnostic discovery).

Teaching

Research

My current research interest is to resolve using functional genomics how liver and rumen fluke parasites interact with their respective host environments. To date, new parasite proteins have been discovered to support drug and vaccine development and diagnostics . I am also interested in developing new molecular tools to measure anthelmintic resistance in liver fluke and a protein biomarker panel has been identified to measure Triclabendazole (TCBZ) failure and resistance for new laboratory and penside  tests.

Research Groups

  • Parasitology and Helminth Control

Publications

Huson, KM, Morphew, R, Winters, A, Cookson, A, Hauck, B & Brophy, P 2021, 'In vitro screening as an anthelmintic discovery pipeline for Calicophoron daubneyi: Nutritive media and rumen environment-based approaches', Parasitology Research. https://doi.org/10.1007/s00436-021-07066-2
Stuart, R, Zwaanswijk, S, MacKintosh, N, Wititkornkul, B, Brophy, P & Morphew, R 2021, 'The soluble glutathione transferase superfamily: Role of Mu class in triclabendazole sulphoxide challenge in Fasciola hepatica', Parasitology Research, vol. 120, pp. 979–991. https://doi.org/10.1007/s00436-021-07055-5
Davis, C, Winters, A, Milic, I, Devitt, A, Cookson, A, Brophy, P & Morphew, R 2020, 'Evidence of sequestration of triclabendazole and associated metabolites by extracellular vesicles of Fasciola hepatica', Scientific Reports, vol. 10, 13445. https://doi.org/10.1038/s41598-020-69970-4
Tyson, F, Dalesman, S, Brophy, P & Morphew, R 2020, 'Novel Equine Faecal Egg Diagnostics: Validation of the FECPAKG2', Animals, vol. 10, no. 8, 1254. https://doi.org/10.3390/ani10081254
Collett, C, Morphew, R, Timson, D, Phillips, H & Brophy, P 2020, 'Pilot Evaluation of Two Fasciola hepatica Biomarkers for Supporting Triclabendazole (TCBZ) Efficacy Diagnostics', Molecules, vol. 25, no. 15, 3477. https://doi.org/10.3390/molecules25153477
More publications on the Research Portal