Prof Peter Brophy

PhD

Prof Peter Brophy

Professor

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PhD on anthelmintic metabolism in parasitic worms. After holding a Medical Research Council research post at Aberystwyth completed further research training in biotechnology at the Leicester BioCentre. In 1992 was awarded a Wellcome Trust Fellowship based at Nottingham University exploring parasite defences against immune assault. A Senior Research Fellowship in the Leicester Pharmacy School (1994-97) provided opportunities in rational drug design and lead compound synthesis. Established the first proteomics laboratory dedicated to parasitic worm investigations during Readership posts at the Universities of Aberystwyth and Liverpool (1997-2007). In 2007 returned to Aberystwyth as a Professor in Parasitology. Has held a number of research contracts to address key problems in parasite control (anthelmintic resistance, vaccine, drug and biomarker discovery).

 

Teaching

Research

My current research interest is to resolve using functional genomics how liver and rumen fluke parasites interact with their respective host environments. To date, new parasite proteins have been discovered to support drug and vaccine development and diagnostics . I am also interested in developing new molecular tools to measure anthelmintic resistance in liver fluke and a protein biomarker panel has been identified to measure Triclabendazole (TCBZ) failure and resistance for new laboratory and penside  tests.

Publications

Davis, C, Winters, A, Milic, I, Devitt, A, Cookson, A, Brophy, P & Morphew, R 2020, 'Evidence of sequestration of triclabendazole and associated metabolites by extracellular vesicles of Fasciola hepatica', Scientific Reports, vol. 10, 13445. https://doi.org/10.1038/s41598-020-69970-4
Tyson, F, Dalesman, S, Brophy, P & Morphew, R 2020, 'Novel Equine Faecal Egg Diagnostics: Validation of the FECPAKG2', Animals, vol. 10, no. 8, 1254. https://doi.org/10.3390/ani10081254
Collett, C, Morphew, R, Timson, D, Phillips, H & Brophy, P 2020, 'Pilot Evaluation of Two Fasciola hepatica Biomarkers for Supporting Triclabendazole (TCBZ) Efficacy Diagnostics', Molecules, vol. 25, no. 15, 3477. https://doi.org/10.3390/molecules25153477
McCosker, P, Hussain, W, McVeigh, P, McCammick, E, Clarke, N, McKay, F, Robb, E, Brophy, P, Timson, D, Mousley, A, Marks, N & Maule, A 2020, 'RNA interference dynamics in juvenile Fasciola hepatica are altered during in vitro growth and development', International Journal for Parasitology: Drugs and Drug Resistance, vol. 14, pp. 46-55. https://doi.org/10.1016/j.ijpddr.2020.08.004
Pawluk, R, Stuart, R, Garcia de Leaniz, C, Cable, J, Morphew, R, Brophy, P & Consuegra, S 2019, 'Smell of Infection: a novel, non-invasive method for detection of fish excretory- secretory proteins', Journal of Proteome Research, vol. 18, no. 3, pp. 1371-1379. https://doi.org/10.1021/acs.jproteome.8b00953
More publications on the Research Portal