Prof Peter Brophy

PhD

Prof Peter Brophy

Professor

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Profile

PhD on understanding how parasitic flatworms metabolise anthelmintics.  After a Medical Research Council postdoctoral post at Aberystwyth in parasite biochemistry gained experience in biotechnology at the Leicester BioCentre. In 1992 was awarded a Wellcome Trust Fellowship based at Nottingham University exploring parasite defences against immune assault. A Senior Research Fellowship at the Leicester Pharmacy School (1994-97) provided opportunities in target based drug design and lead compound synthesis. Established proteomics laboratories dedicated to parasite-host interactions during readership posts at the Universities of Aberystwyth and Liverpool. Returned to Aberystwyth as a Professor in Parasitology in 2007. Has held a number of research contracts to address key problems in parasite control (vaccine, drug and diagnostic discovery).

Teaching

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Research

My current research interest is to resolve using functional genomics how liver and rumen fluke parasites interact with their respective host environments. To date, new parasite proteins have been discovered to support drug and vaccine development and diagnostics . I am also interested in developing new molecular tools to measure anthelmintic resistance in liver fluke and a protein biomarker panel has been identified to measure Triclabendazole (TCBZ) failure and resistance for new laboratory and penside  tests.

Research Groups

  • Parasitology and Helminth Control

Publications

Reigate, C, Williams, HW, Denwood, M, Morphew, R, Thomas, E & Brophy, P 2021, 'Evaluation of two Fasciola hepatica faecal egg counting protocols in sheep and cattle', Veterinary Parasitology, vol. 294, 109435. https://doi.org/10.1016/j.vetpar.2021.109435
Wititkornkul, B, Hulme, BJ, Tomes, JJ, Allen, NR, Davis, CN, Davey, SD, Cookson, AR, Phillips, HC, Hegarty, MJ, Swain, MT, Brophy, PM, Wonfor, RE & Morphew, RM 2021, 'Evidence of Immune Modulators in the Secretome of the Equine Tapeworm Anoplocephala perfoliata', Pathogens, vol. 10, no. 7, e912. https://doi.org/10.3390/pathogens10070912
Williams, E, Brophy, P, Williams, HW, Davies, N & Jones, R 2021, 'Gastrointestinal nematode control practices in ewes: Identification of factors associated with application of control methods known to influence anthelmintic resistance development', Veterinary Parasitology: Regional Studies and Reports, vol. 24, 100562. https://doi.org/10.1016/j.vprsr.2021.100562
Huson, KM, Morphew, R, Winters, A, Cookson, A, Hauck, B & Brophy, P 2021, 'In vitro screening as an anthelmintic discovery pipeline for Calicophoron daubneyi: Nutritive media and rumen environment-based approaches', Parasitology Research, vol. 120, no. 4, pp. 1351-1362. https://doi.org/10.1007/s00436-021-07066-2
Allen, N, Taylor-Mew, AR, Wilkinson, T, Huws, S, Phillips, H, Morphew, R & Brophy, P 2021, 'Modulation of Rumen Microbes Through Extracellular Vesicle Released by the Rumen Fluke Calicophoron daubneyi', Frontiers in Cellular and Infection Microbiology, vol. 11, 661830. https://doi.org/10.3389/fcimb.2021.661830
More publications on the Research Portal