Dr Russ Morphew

PhD

Dr Russ Morphew

Senior Lecturer

Institute Director of Marketing and Recruitment

Contact Details

Teaching

Research

Current research is aimed at utilising modern high resolution proteomic technologies and mass spectrometry to investigate protein function and interactions. This work has focussed upon microbial-host interactions and the proteins that act upon this interface. In particular, how proteins can facilitate the invasion, establishment or colonisation of an organism within a host. Present research focuses upon the interaction of ruminant bacteria upon ingested forage using proteomics to uncover proteins involved in bacterial colonisation, plant protein degradation and the metabolic pathways involved. Also of interest are parasitic helminths of economic importance including the liver flukes Fasciola hepatica and F. gigantica, nematodes Haemonchus contortus and Teladorsagia circumcincta and the model nematode Caenorhabditis elegans. Recent research using high resolution proteomics has focussed upon vaccine discovery and the development and response to anthelmintic stress and metabolism. The main driver of future research is to increase our understanding of how proteins interact with other proteins within the same organism, between organisms, within a host or with a forage. How proteins interact with ligands such as anthelmintics and metabolites are also of interest, including how proteins function in the metabolism and action of anthelmintics and ultimately anthelmintic resistance.

Publications

Purification of native Sigma Class Glutathione Transferase from Fasciola hepaticaDuncan, J., Cutress, D., Morphew, R. & Brophy, P. 2018 In : Molecular and Biochemical Parasitology.222, p. 45-506 p.
Worms at the Royal Welsh ShowTyson, F., Allen, T., Pennington, C., Brophy, P., Thomas, E. & Morphew, R. 2017 In : Veterinary Record.181, 14, p. 376-377
Saprotrophic proteomes of biotypes of the witches’ broom pathogen Moniliophthora perniciosaPierre, S., Griffith, G., Morphew, R., Mur, L. & Scott, I. 2017 In : Fungal Biology.121, 9, p. 743-75311 p.
Myxobacteria are able to prey broadly upon clinically-relevant pathogens, exhibiting a prey range which cannot be explained by phylogenyLivingstone, P., Morphew, R. & Whitworth, D. 2017 In : Frontiers in Microbiology.8, 1593
Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola SpeciesMorphew, R., Wilkinson, T., MacKintosh, N., Jahndel, V., Paterson, S., McVeigh, P., Abbas Abidi, S. M., Saifullah, K., Raman, M., Ravikumar , G., LaCourse, E. J., Maule, A. G. & Brophy, P. 2016 In : Journal of Proteome Research.15, 9, p. 3308-332114 p.
More publications on the Research Portal