Dr Russ Morphew

PhD

Dr Russ Morphew

Senior Lecturer

Institute Director of Marketing and Recruitment

Contact Details

Teaching

Module Coordinator
Lecturer
Tutor

Research

Current research is aimed at utilising modern high resolution proteomic technologies and mass spectrometry to investigate protein function and interactions. This work has focussed upon microbial-host interactions and the proteins that act upon this interface. In particular, how proteins can facilitate the invasion, establishment or colonisation of an organism within a host. Present research focuses upon the interaction of ruminant bacteria upon ingested forage using proteomics to uncover proteins involved in bacterial colonisation, plant protein degradation and the metabolic pathways involved. Also of interest are parasitic helminths of economic importance including the liver flukes Fasciola hepatica and F. gigantica, nematodes Haemonchus contortus and Teladorsagia circumcincta and the model nematode Caenorhabditis elegans. Recent research using high resolution proteomics has focussed upon vaccine discovery and the development and response to anthelmintic stress and metabolism. The main driver of future research is to increase our understanding of how proteins interact with other proteins within the same organism, between organisms, within a host or with a forage. How proteins interact with ligands such as anthelmintics and metabolites are also of interest, including how proteins function in the metabolism and action of anthelmintics and ultimately anthelmintic resistance.

Publications

Purification of native Sigma Class Glutathione Transferase from Fasciola hepaticaDuncan, J., Cutress, D., Morphew, R. & Brophy, P. 2018 In : Molecular and Biochemical Parasitology.
Worms at the Royal Welsh ShowTyson, F., Allen, T., Pennington, C., Brophy, P., Thomas, E. & Morphew, R. 2017 In : Veterinary Record.181, 14, p. 376-377
Saprotrophic proteomes of biotypes of the witches’ broom pathogen Moniliophthora perniciosaPierre, S., Griffith, G., Morphew, R., Mur, L. & Scott, I. 2017 In : Fungal Biology.121, 9, p. 743-75311 p.
Myxobacteria are able to prey broadly upon clinically-relevant pathogens, exhibiting a prey range which cannot be explained by phylogenyLivingstone, P., Morphew, R. & Whitworth, D. 2017 In : Frontiers in Microbiology.8, 1593
Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola SpeciesMorphew, R., Wilkinson, T., MacKintosh, N., Jahndel, V., Paterson, S., McVeigh, P., Abbas Abidi, S. M., Saifullah, K., Raman, M., Ravikumar , G., LaCourse, E. J., Maule, A. G. & Brophy, P. 2016 In : Journal of Proteome Research.15, 9, p. 3308-332114 p.
The effects of PPO activity on the proteome of ingested red clover and implications for improving the nutrition of grazing cattleHart, E., Onime, L. A., Davies, T., Morphew, R. & Kingston-Smith, A. 2016 In : Journal of Proteomics.141, p. 67-76
Calmodulin disruption impacts growth and motility in juvenile liver flukeMcCammick, E., McVeigh, P., McCusker, P., Timson, D., Morphew, R., Brophy, P., Marks, N., Mousley, A. & Maule, A. 2016 In : Parasites & Vectors.9, 13 p., 46
Identification of the rumen fluke Calicophoron daubneyi infecting cattle in WalesHuson, K. M., Brophy, P., Morphew, R. & MacKintosh, N. 2015 In : Advances in Animal Biosciences.6, Special Issue 02, p. 1831 p.
Time-dependent tegumental surface changes in juvenile Fasciola gigantica in response to triclabendazole treatment in goatAhammed Shareef, P. A., Brennan, G. P., McVeigh, P., Hannan Khan, M. A., Morphew, R. M., Mousley, A., Marks, N. J., Khalid Saifullah, M. K., Brophy, P. M., Maule, A. G. & Abidi, S. M. A. 2014 In : Acta Tropica.136, p. 108-11710 p.
In vitro biomarker discovery in the parasitic flatworm Fasciola hepatica for monitoring chemotherapeutic treatmentMorphew, R. M., MacKintosh, N. D., Hart, E. H., Prescott, M., LaCourse, E. J. & Brophy, P. M. 2014 In : EuPA Open Proteomics.3, p. 85-9915 p.
RNAi dynamics in juvenile Fasciola spp. liver flukes reveals the persistence of gene silencing in vitroMcVeigh, P., McCammick, E., McCusker, P., Morphew, R. M., Mousley, A., Abidi, A., Saifullah, K. M., Muthusamy, R., Gopalakrishnan, R., Spithill, T. W., Dalton, J. P., Brophy, P. M., Marks, N. J. & Maule, A. G. 2014 In : PLoS Neglected Tropical Diseases.8, 9, 0003185
Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica resleased by Nonident P40Morphew, R. M., Hamilton, C. M., Wright, H. A., Dowling, D. J., O'Neill, S. M. & Brophy, P. M. 2013 In : Veterinary Parasitology.191, 3-4, p. 379–385
The soluble proteome phenotypes of ivermectin resistant and ivermectin susceptible Haemonchus contortus females comparedHart, E. H., Morphew, R. M., Bartley, D. J., Millares, P., Wolf, B. T., Brophy, P. M. & Hamilton, J. V. 2012 In : Veterinary Parasitology.190, 1-2, p. 104-11310 p.
Anthelmintic metabolism in parasitic helminths: proteomic insightsBrophy, P. M., Mackintosh, N. & Morphew, R. M. 2012 In : Parasitology.139, 9, p. 1205-121713 p.
The Sigma Class glutathione transferase from the liver fluke Fasciola hepaticaLaCourse, E. J., Perally, S., Morphew, R. M., Moxon, J. V., Prescott, M. C., Dowling, D. J., O'Neill, S. M., Kipar, A., Hetzel, U., Hoey, E., Zafra, R., Buffoni, L., Arévalo, J. P. & Brophy, P. M. 2012 In : PLoS Neglected Tropical Diseases.6, 5, p. n/a e1666
Proteomics and in silico approaches to extend understanding of the glutathione transferase superfamily of the tropical liver fluke Fasciola giganticaMorphew, R. M., Eccleston, N., Wilkinson, T. J., McGarry, J., Perally, S., Prescott, M., Ward, D., Williams, D., Paterson, S., Raman, M., Ravikumar, G., Khalid Saifullah, M., Abbas Abidi, S. M., McVeigh, P., Maule, A. G., Brophy, P. M. & LaCourse, E. J. 2012 In : Journal of Proteome Research.11, 12, p. 5876–588914 p.
Towards delineating functions within the fasciola secreted cathepsin L protease family by integrating in vivo based sub-proteomics and phylogeneticsMorphew, R. M., Wright, H. A., LaCourse, E. J., Porter, J., Barrett, J., Woods, D. J. & Brophy, P. M. 2011 In : PLoS Neglected Tropical Diseases.5, 1, e-937
Proteomic analysis of the cacao pathogen Moniliophthora perniciosaPierre, S., Mur, L. A. J., Morphew, R., Hamilton, J., Scott, I. M. & Griffith, G. W. 2009
The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and functionHamilton, C. M., Dowling, D. J., Loscher, C. E., Morphew, R. M., Brophy, P. M. & O'Neill, S. M. 2009 In : Infection and Immunity.77, 6, p. 2488-249811 p.
Comparative proteomics of excretory-secretory proteins released by the liver fluke Fasciola hepatica in sheep host bile and during in vitro culture ex hostMorphew, R. M., Wright, H. A., LaCourse, E. J., Woods, D. J. & Brophy, P. M. 2007 In : Molecular and Cellular Proteomics.6, p. 963-97210 p.
Proteomic analysis of glutathione transferases from the liver fluke parasite, Fasciola hepaticaChemale, G., Morphew, R. M., Moxon, J. V., Morassuti, A. L., LaCourse, E. J., Barrett, J., Johnston, D. A. & Brophy, P. M. 2006 In : Proteomics.6, 23, p. 6263-627311 p.
Flatworm parasite proteomicsMorphew, R. M., Barrett, J. & Brophy, P. M. 2006 in. N, J. (ed.). CABI Publishing, p. 327-