Prof David Whitworth BA (Oxon), PhD (Warwick), SFHEA, FIBMS

Prof David Whitworth

Professor

Department of Life Sciences

Contact Details

Profile

Dave is a Professor of Biochemistry at Aberystwyth and coordinates the Biochemistry degree scheme. He studied for a BA in Biochemistry at Balliol College, Oxford (1991-1995) before completing a PhD in bacterial genetics at the University of Warwick (1999). After two postdoctoral posts and a lectureship at Warwick, Dave moved to Aberystwyth in 2008. He has been a senior fellow of the Higher Education Academy since 2016 and served a term as member of Council for the Microbiology Society. Dave's research interests include bacterial genome evolution and functional genomics (particularly of predatory myxobacteria), and the pedagogy of skills and creativity.

Research

My research group focuses on predatory myxobacteria, such as Myxococcus xanthus, and how they have evolved to prey upon other microbes. We study natural myxobacteria isolates and their secreted vesicles/metabolites, using a variety of 'omic, biochemical and phenotypic techniques to identify genes conferring antimicrobial activity. We have recently become interested in applying myxobacteria as biological control agents in agriculture. Various projects are investigating how best to protect crop plants and edible insects from problematic fungal and bacterial pathogens using myxobacteria. 

Publications

Arakal, BS, Rowlands, RS, Maddocks, SE, Whitworth, DE, James, PE & Livingstone, PG 2025, 'Myxobacteria from soil can substantially reduce the bacterial load in a wound infection model', Journal of Applied Microbiology, vol. 136, no. 1, lxae315. 10.1093/jambio/lxae315
Li, Z, Zhu, H, Whitworth, DE & Stevens, DC 2024, 'Biology of myxobacteria', Frontiers in Microbiology, vol. 15, 1450345. 10.3389/fmicb.2024.1450345
Arakal, BS, Rowlands, RS, McCarthy, M, Whitworth, DE, Maddocks, SE, James, PE & Livingstone, PG 2024, 'Corallococcus senghenyddensis sp. nov., a myxobacterium with potent antimicrobial activity', Journal of Applied Microbiology, vol. 135, no. 5, lxae102. 10.1093/jambio/lxae102
Swetha, RG, Arakal, BS, Rajendran, S, Sekar, K, Whitworth, DE, Ramaiah, S, James, PE, Livingstone, PG & Anbarasu, A 2024, 'MyxoPortal: A database of myxobacterial genomic features', Database: The Journal of Biological Databases and Curation, vol. 2024, baae056. 10.1093/database/baae056
Radford, EJ & Whitworth, DE 2024, The genetic basis of predation by myxobacteria. in Advances in Microbial Physiology. vol. 85, Advances in Microbial Physiology, Elsevier, pp. 1-55. 10.1016/bs.ampbs.2024.04.001
More publications on the Research Portal