Dr Debbie Nash PhD, PGCtHE, Senior Fellow of Higher Education Academy, Registered Animal Scientist

Dr Debbie Nash

Senior Lecturer

Contact Details

Profile

I gained my Ph.D. at The Royal Veterinary College, University of London in 2007. My research developed in vivo and in vitro models to enhance the study of the innate immune response to breeding-induced endometritis in mares which is a significant cause of infertility. During this time I gained a range of laboratory skills and was involved in four animal trials including taking sole lead of one. Consequently I am a personal Home Office licence holder and am competent in a range of reproductive and clinical procedures such as ultrasound of the reproductive tract, blood sampling and uterine biopsy.

I joined Aberystwyth University as a Lecturer in Equine and Animal Science in 2007. I lead undergraduate to MSc modulesI also supervise PhD and MPhil students. The projects I supervise tend to include developing an ex vivo tissue culture technique as a potential anti-inflammatory screening test, testing potential anti-inflammatory compounds. I've also dabbled in population genetics with collaboration of colleagues in our state-of-the-art genomics facility.

I am an active member of the British Society for Animal Science Programme Committee, taking responsibility for arranging the equine sessions on several occasions, as well as chairing sessions each year. In 2011 I was invited onto the consultative committee for setting up the Register of Animal Scientists and in 2012 was invited and elected to the BSAS Council. In addition, I am the founder, organiser and chair of the Colloquium for Equine Reproduction (http://users.aber.ac.uk/dmn/cfer/Homepage.html), which since its inaugural event in 2010, goes from strength to strength. A further event was held in 2011 and CFER was hosted within the BSAS annual conference in 2013 and in 2015.

Teaching

Research

Reproductive physiology (specifically uterine inflammatory disease of horses and cattle); native pony population genetics.

Publications

2017

Wonfor, R., Natoli, M., Rose, M., Nash, D. 2017. Effects of preimplantation factor on interleukin-6 and prostaglandin F2a and E2 in the bovine endometrium. Theriogenology 102 pp. 174-182. 10.1016/j.theriogenology.2017.08.001

Wonfor, R., Natoli, M., Shah, I., Beckmann, M., Nash, R.J., Nash, D. 2017. Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell line. Journal of Ethnopharmacology 10.1016/j.jep.2017.08.006

2016

Clamp, R., Creevey, C., Natoli, M., Barnea, E.R., Nash, D., Rose, M. 2016. Interaction of preimplantation factor with the bovine global endometrial transcriptome. British Society of Animal Science Annual conference. Cadair

2015

Winton, C.L., Plant, Y., Hind, P., McMahon, R., Hegarty, M., McEwan, N., Davies-Morel, M., Powell, W., Nash, D. 2015. Comparative genetic diversity in a sample of pony breeds from the UK and North America: A case study in the conservation of global genetic resources. Ecology and Evolution 5 (16) pp. 3507-3522. 10.1002/ece3.1562 Cadair

Clamp, R., Natoli, M., Barnea, E.R., Nash, D., Rose, M. 2015. Effect of preimplantation factor in an in vitro model of bovine E. coli endometritis. Proceedings of the British Society of Animal Science. Cadair

Clamp, R., Natoli, M., Barnea, E.R., Rose, M., Nash, D. 2015. Effect of preimplantation factor in response to a LPS challenge on bovine endometrial IL-6 secretion and expression. International Conference on Biology and Pathology of Reproduction in Domestic Animals. Cadair

2014

Morrell, J., Georgakas, A., Lundeheim, N., Nash, D.M., Davies-Morel, M.C.G., Johannison, A. 2014. Effect of heterologous and homologous seminal plasma on stallion sperm quality. Theriogenology 82 pp. 176-183. 10.1016/j.theriogenology.2014.03.020 Cadair

Ross, A., Nash, D.M., Paddison, J. 2014. The validation of a novel protocol for the culture of equine endometrial epithelial and stromal cells. BSAS Annual Conference 2014, 29-30 April 2014. Cadair

Clamp, R.E., Paddison, J.S., Nash, D.M., Rose, M.T., Barnea, E. 2014. Effect of pre-implantation factor on the secretion of prostaglandin F2α and prostaglandin E2 from bovine endometrial tissue following a lipopolysaccharide challenge in vitro. BSAS Annual Conference 2014, 29-30 April 2014. Cadair

Ross, A., Paddison, J.S., Nash, D.M. 2014. Validation of a novel culture protocol for equine endometrial cells as a model to investigate uterine inflammation. UFAW Welfare Conference. Cadair

2013

Paddison, J.S., Nash, D.M., Barnea, E. 2013. Effect of Preimplanataion Factor (PIF) and lipopolysaccharide on inflammatory responses of equine endometrial explants in vitro. Endometritis as a cause of infertility in domestic animals: new diagnostic and therapeutic strategies. Cadair

Davies-Morel, M.C.G., Lawlor, O.M.F., Nash, D.M. 2013. Equine endometrial cytology and bacteriology: Effectiveness for predicting live foaling rates. Veterinary Journal 198 (1) pp. 206-211. 10.1016/j.tvjl.2013.08.002 Other Cadair

Winton, C.L., Hegarty, M.J., McMahon, R., Slavov, G.T., McEwan, N.R., Davies-Morel, M.C.G., Morgan, C.T., Powell, W., Nash, D.M. 2013. Genetic diversity and phylogenetic analysis of the native mountain ponies of Britain and Ireland reveal a novel rare population. Ecology and Evolution 3 (4) pp. 934–947. 10.1002/ece3.507 Cadair

Paddison, J.S., Nash, D.M., Barnea, E. 2013. PreImplantation Factor (PIF) displays developmental-related evolving immune anti-inflammatory response of equine endometrial explants in vitro. Cadair

Clamp, R., Paddison, J., Rose, M., Nash, D., Barnea, E.R. 2013. Effect of pre-implantation factor on the secretion of prostaglandins from bovine endometrial tissue following a lipopolysaccharide challenge in vitro. Endometritis as a cause of infertility in domestic animals. Cadair

2012

Winton, C.L., Hegarty, M.J., Slavov, G.T., McEwan, N.R., Davies-Morel, M.C.G., Potter, C., Powell, W., Nash, D.M. 2012. Phylogeographic relationships between native pony populations of Britain and Ireland. Cadair

2011

Reader, R., Parrott, C., Hegarty, M., McEwan, N.R., Davies-Morel, M., Powell, W., Nash, D.M. 2011. An investigation of the role of Insulin-Like Growth Factor 1 (IGF-1) in determining adult height of the horse. BSAS. Cadair

Birch, R., Edwards, J., Worgan, H.J., Macias, B., Stevens, P.R., Newbold, C.J., Nash, D.M. 2011. A preliminary characterisation of the ecology of gut anaerobic fungal populations in horses. Cadair

Winton, C.L., Hegarty, M.J., McEwan, N.R., Davies-Morel, M.C.G., Powell, W., Nash, D.M. 2011. Characterisation of phylogeographic relationships between native pony populations of Britain and Ireland. Ecological Genetics Group. Cadair

2010

Nash, D.M., Sheldon, I.M., Herath, S., Lane, E.A. 2010. Markers of the uterine innate immune response of the mare. Animal Reproduction Science 119 (1-2) pp. 31-39. 10.1016/j.anireprosci.2009.11.008 Cadair

Dickason, A., Nash, D.M., Chaffe, O.H., McEwan, N.R. 2010. Quantitative comparison of pressure distribution exerted by different numnahs beneath the saddle of a ridden horse. Cadair Other

Nash, D.M., Sheldon, I.M., Herath, S., Lane, E.A. 2010. Endometrial explant culture to study the response of equine endometrium to insemination. Reproduction in Domestic Animals 45 (4) pp. 670-676. 10.1111/j.1439-0531.2008.01328.x Cadair

2009

Rapkin, E.H., Guire, R., Davies-Morel, M.C.G., Nash, D.M. 2009. The effect of an endurance exercise upon kinematic parameters of the jump stride of the hind limb during take-off when jumping a cross country fence. 8th International conference on Equine Exercise Physiology, 'Science and Safaris', Cape Town. Cadair

2008

Williams, E.J., Sibley, K., Miller, A.N., Lane, E.A., Fishwick, J., Nash, D.M., Herath, S., England, G.C.W., Dobson, H., Sheldon, I.M. 2008. The effect of Escherichia coli lipopolysaccharide and tumour necrosis factor alpha on ovarian function. American Journal of Reproductive Immunology 60 (5) pp. 462-473. 10.1111/j.1600-0897.2008.00645.x Cadair

Penaluna, L., Herath, S., Sheldon, I.M., Nash, D.M. 2008. Optimisation of an Equine Endometrial Cell Culture. The 12th Annual conference of the European Society for Domestic Animal Reproduction. 10.1111/j.1439-0531.2008.01256.x Cadair Other

Cuervo-Arango, J., Worgan, H., Macías, B., Nash, D.M. 2008. Endometrial Toll-like Receptor 4 (TLR4) and Interleukin-8 (IL-8) Expression in Mares Resistant (RM) or Susceptible (SM) to Endometritis. The 12th Annual conference of the European Society for Domestic Animal Reproduction. 10.1111/j.1439-0531.2008.01256.x Cadair Other

Sheldon, I.M., Williams, E.J., Miller, A.N.A., Nash, D.M., Herath, S. 2008. Uterine diseases in cattle after parturition. Veterinary Journal 176 (1) pp. 115-121. 10.1016/j.tvjl.2007.12.031 Cadair

Nash, D.M., Lane, E.A., Herath, S., Sheldon, I.M. 2008. Endometrial explant culture for characterizing equine endometritis. American Journal of Reproductive Immunology 59 (2) pp. 105-117. 10.1111/j.1600-0897.2007.00548.x Cadair Other

Lane, E.A., Nash, D.M. 2008. Characteristics of follicular development and oestrus following prostaglandin administration in mares. The 12th Annual conference of the European Society for Domestic Animal Reproduction. 10.1111/j.1439-0531.2008.01256.x Cadair Other