Dr Debbie Nash

PhD, PGCtHE, Senior Fellow of Higher Education Academy, Registered Animal Scientist

Dr Debbie Nash

Senior Lecturer

Contact Details

Profile

I gained my Ph.D. at The Royal Veterinary College, University of London in 2007. My research developed in vivo and in vitro models to enhance the study of the innate immune response to breeding-induced endometritis in mares which is a significant cause of infertility. During this time I gained a range of laboratory skills and was involved in four animal trials including taking sole lead of one. Consequently I am a personal Home Office licence holder and am competent in a range of reproductive and clinical procedures such as ultrasound of the reproductive tract, blood sampling and uterine biopsy.

I joined Aberystwyth University as a Lecturer in Equine and Animal Science in 2007. I lead undergraduate to MSc modulesI also supervise PhD and MPhil students. The projects I supervise tend to include developing an ex vivo tissue culture technique as a potential anti-inflammatory screening test, testing potential anti-inflammatory compounds. I've also dabbled in population genetics with collaboration of colleagues in our state-of-the-art genomics facility.

I am an active member of the British Society for Animal Science Programme Committee, taking responsibility for arranging the equine sessions on several occasions, as well as chairing sessions each year. In 2011 I was invited onto the consultative committee for setting up the Register of Animal Scientists and in 2012 was invited and elected to the BSAS Council. In addition, I am the founder, organiser and chair of the Colloquium for Equine Reproduction (http://users.aber.ac.uk/dmn/cfer/Homepage.html), which since its inaugural event in 2010, goes from strength to strength. A further event was held in 2011 and CFER was hosted within the BSAS annual conference in 2013 and in 2015.

Teaching

Research

Reproductive physiology (specifically uterine inflammatory disease of horses and cattle); native pony population genetics.

Publications

Wonfor, R, Natoli, M, Rose, M & Nash, D 2017, 'Effects of preimplantation factor on interleukin-6 and prostaglandin F2a and E2 in the bovine endometrium' Theriogenology, vol 102, pp. 174-182. DOI: 10.1016/j.theriogenology.2017.08.001
Wonfor, R, Natoli, M, Shah, I, Beckmann, M, Nash, RJ & Nash, D 2017, 'Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell line' Journal of Ethnopharmacology, vol 209, pp. 283-287. DOI: 10.1016/j.jep.2017.08.006
Clamp, R, Creevey, C, Natoli, M, Barnea, ER, Nash, D & Rose, M 2016, 'Interaction of preimplantation factor with the bovine global endometrial transcriptome.' Paper presented at British Society of Animal Science Annual conference, Chester, United Kingdom of Great Britain and Northern Ireland, 2016 - 2016, .
Winton, CL, Plant, Y, Hind, P, McMahon, R, Hegarty, M, McEwan, N, Davies-Morel, M, Powell, W & Nash, D 2015, 'Comparative genetic diversity in a sample of pony breeds from the UK and North America: A case study in the conservation of global genetic resources' Ecology and Evolution, vol 5, no. 16, pp. 3507-3522. DOI: 10.1002/ece3.1562
Clamp, R, Natoli, M, Barnea, ER, Nash, D & Rose, M 2015, 'Effect of preimplantation factor in an in vitro model of bovine E. coli endometritis.' Paper presented at Proceedings of the British Society of Animal Science, Chester, United Kingdom of Great Britain and Northern Ireland, 2015 - 2015, .
Clamp, R, Natoli, M, Barnea, ER, Rose, M & Nash, D 2015, 'Effect of preimplantation factor in response to a LPS challenge on bovine endometrial IL-6 secretion and expression' Paper presented at International Conference on Biology and Pathology of Reproduction in Domestic Animals, Gdansk, Poland, 2015 - 2015, .
Morrell, J, Georgakas, A, Lundeheim, N, Nash, DM, Davies-Morel, MCG & Johannison, A 2014, 'Effect of heterologous and homologous seminal plasma on stallion sperm quality.' Theriogenology, vol 82, pp. 176-183. DOI: 10.1016/j.theriogenology.2014.03.020
Ross, A, Nash, DM & Paddison, J 2014, 'The validation of a novel protocol for the culture of equine endometrial epithelial and stromal cells.' Paper presented at BSAS Annual Conference 2014, 29-30 April 2014, Nottingham, United Kingdom of Great Britain and Northern Ireland, 2014 - 2014, pp. 58.
Clamp, RE, Paddison, JS, Nash, DM, Rose, MT & Barnea, E 2014, 'Effect of pre-implantation factor on the secretion of prostaglandin F2α and prostaglandin E2 from bovine endometrial tissue following a lipopolysaccharide challenge in vitro.' Paper presented at BSAS Annual Conference 2014, 29-30 April 2014, Nottingham, United Kingdom of Great Britain and Northern Ireland, 2014 - 2014, pp. 207.
Ross, A, Paddison, JS & Nash, DM 2014, 'Validation of a novel culture protocol for equine endometrial cells as a model to investigate uterine inflammation.' UFAW Welfare Conference, York, United Kingdom of Great Britain and Northern Ireland, 2014, pp. 72.
Paddison, JS, Nash, DM & Barnea, E 2013, 'Effect of Preimplanataion Factor (PIF) and lipopolysaccharide on inflammatory responses of equine endometrial explants in vitro' Paper presented at Endometritis as a cause of infertility in domestic animals: new diagnostic and therapeutic strategies, Olsztyn, Poland, 2013 - 2013, .
Davies-Morel, MCG, Lawlor, OMF & Nash, DM 2013, 'Equine endometrial cytology and bacteriology: Effectiveness for predicting live foaling rates' Veterinary Journal, vol 198, no. 1, pp. 206-211. DOI: 10.1016/j.tvjl.2013.08.002
Winton, CL, Hegarty, MJ, McMahon, R, Slavov, GT, McEwan, NR, Davies-Morel, MCG, Morgan, CT, Powell, W & Nash, DM 2013, 'Genetic diversity and phylogenetic analysis of the native mountain ponies of Britain and Ireland reveal a novel rare population' Ecology and Evolution, vol 3, no. 4, pp. 934–947. DOI: 10.1002/ece3.507
Paddison, JS, Nash, DM & Barnea, E 2013, 'PreImplantation Factor (PIF) displays developmental-related evolving immune anti-inflammatory response of equine endometrial explants in vitro' pp. 4.
Clamp, R, Paddison, J, Rose, M, Nash, D & Barnea, ER 2013, 'Effect of pre-implantation factor on the secretion of prostaglandins from bovine endometrial tissue following a lipopolysaccharide challenge in vitro' Paper presented at Endometritis as a cause of infertility in domestic animals, Olsztyn, Poland, 2013 - 2013, .
Winton, CL, Hegarty, MJ, Slavov, GT, McEwan, NR, Davies-Morel, MCG, Potter, C, Powell, W & Nash, DM 2012, 'Phylogeographic relationships between native pony populations of Britain and Ireland'.
Reader, R, Parrott, C, Hegarty, M, McEwan, NR, Davies-Morel, M, Powell, W & Nash, DM 2011, 'An investigation of the role of Insulin-Like Growth Factor 1 (IGF-1) in determining adult height of the horse' BSAS, Nottingham, United Kingdom of Great Britain and Northern Ireland, 2011 - 2011, pp. 175-175.
Birch, R, Edwards, J, Worgan, HJ, Macias, B, Stevens, PR, Newbold, CJ & Nash, DM 2011, 'A preliminary characterisation of the ecology of gut anaerobic fungal populations in horses' pp. 176.
Winton, CL, Hegarty, MJ, McEwan, NR, Davies-Morel, MCG, Powell, W & Nash, DM 2011, 'Characterisation of phylogeographic relationships between native pony populations of Britain and Ireland.' Ecological Genetics Group, United Kingdom of Great Britain and Northern Ireland, 2011 - 2011, .
Nash, DM, Sheldon, IM, Herath, S & Lane, EA 2010, 'Endometrial explant culture to study the response of equine endometrium to insemination' Reproduction in Domestic Animals, vol 45, no. 4, pp. 670-676. DOI: 10.1111/j.1439-0531.2008.01328.x
Nash, DM, Sheldon, IM, Herath, S & Lane, EA 2010, 'Markers of the uterine innate immune response of the mare' Animal Reproduction Science, vol 119, no. 1-2, pp. 31-39. DOI: 10.1016/j.anireprosci.2009.11.008
Dickason, A, Nash, DM, Chaffe, OH & McEwan, NR 2010, 'Quantitative comparison of pressure distribution exerted by different numnahs beneath the saddle of a ridden horse' pp. p106.
Rapkin, EH, Guire, R, Davies-Morel, MCG & Nash, DM 2009, 'The effect of an endurance exercise upon kinematic parameters of the jump stride of the hind limb during take-off when jumping a cross country fence' 8th International conference on Equine Exercise Physiology, 'Science and Safaris', Cape Town, South Africa, 2010 - 2010, .
Williams, EJ, Sibley, K, Miller, AN, Lane, EA, Fishwick, J, Nash, DM, Herath, S, England, GCW, Dobson, H & Sheldon, IM 2008, 'The effect of Escherichia coli lipopolysaccharide and tumour necrosis factor alpha on ovarian function' American Journal of Reproductive Immunology, vol 60, no. 5, pp. 462-473. DOI: 10.1111/j.1600-0897.2008.00645.x
Penaluna, L, Herath, S, Sheldon, IM & Nash, DM 2008, 'Optimisation of an Equine Endometrial Cell Culture' The 12th Annual conference of the European Society for Domestic Animal Reproduction, Utrecht, Netherlands, 2008 - 2008, pp. 82. DOI: 10.1111/j.1439-0531.2008.01256.x
Cuervo-Arango, J, Worgan, H, Macías, B & Nash, DM 2008, 'Endometrial Toll-like Receptor 4 (TLR4) and Interleukin-8 (IL-8) Expression in Mares Resistant (RM) or Susceptible (SM) to Endometritis' The 12th Annual conference of the European Society for Domestic Animal Reproduction, Utrecht, Netherlands, 2008 - 2008, pp. 75. DOI: 10.1111/j.1439-0531.2008.01256.x
Sheldon, IM, Williams, EJ, Miller, ANA, Nash, DM & Herath, S 2008, 'Uterine diseases in cattle after parturition' Veterinary Journal, vol 176, no. 1, pp. 115-121. DOI: 10.1016/j.tvjl.2007.12.031
Nash, DM, Lane, EA, Herath, S & Sheldon, IM 2008, 'Endometrial explant culture for characterizing equine endometritis' American Journal of Reproductive Immunology, vol 59, no. 2, pp. 105-117. DOI: 10.1111/j.1600-0897.2007.00548.x
Lane, EA & Nash, DM 2008, 'Characteristics of follicular development and oestrus following prostaglandin administration in mares' Paper presented at The 12th Annual conference of the European Society for Domestic Animal Reproduction, Utrecht, Netherlands, 2008 - 2008, pp. 50. DOI: 10.1111/j.1439-0531.2008.01256.x