Prof Joanne Hamilton PhD

Prof Joanne Hamilton

Professor

Contact Details

Teaching

Module Coordinator
Tutor
Lecturer

PhD Students

Miss Rebekah Stuart (second Supervisor). IBERS funded.

Example of PhD Project

Arthropods as environmental reservoirs of potential human pathogens
Cronobacter sakazakii (formerly known as Enterobacter sakazakii) is a foodborne pathogen that causes meningitis, sepsis, or necrotizing enterocolitis in newborns, particularly affecting premature or other immunocompromised infants. Morbidity & mortality associated with C. sakazakii infection in neonates varies considerably, & mortality rates as high as 80% have been recorded. Although most documented cases involve infants, reports also describe adult infections. Whilst this organism has been susceptible to antibiotics in the past, there is concern regarding antibiotic resistance in C. sakazakii. C. sakazakii was isolated from the guts of larvae of the stable fly, Stomoxys calcitrans, demonstrating, for the first time, an environmental reservoir for C. sakazakii & raising the possibility that environmental contamination by insects may be important in the spread of this opportunistic organism (Hamilton, Lehane & Braig, 2003). This PhD project will investigate the role of arthropods as environmental reservoirs of human pathogens using a combination of entomological, molecular & bioinformatics approaches.

Joanne V. Hamilton, Michael J. Lehane, & Henk R. Braig. Isolation of Enterobacter sakazakii from Midgut of Stomoxys calcitrans. Emerg Infect Dis. 2003 Oct.

If you are interested in pursuing postgraduate research with me please contact me .

Research

My research focuses on the use of proteomic and molecular technologies to explore host- parasite interactions. My current interests are unravelling the complexities of innate immunity in a range of invertebrates and in exploring the mechanisms used by parasites to overcome the host immune system. Current projects include drug resistance mechanisms in model and parasitic nematodes; liver fluke biology; tsetse fly-trypanosome interactions; immunity in Giant African land snails; immunity in Biomphalaria sp. (an intermediate snail host involved in the transmission of schistosomiasis); schistosome biology and the role of the arthropod gut in the transmission of human pathogens.
I also have a major role in ensuring that University research becomes part of the school curriculum as Principal Investigator on the RCUK funded Schools University Partnership Initiative: SusNet Wales (Sustainability Network Wales).

SusNet Wales is a collaborative multi-disciplinary approach to delivering a "Module" in Sustainability and Social Responsibility developed, led and delivered by practising researchers within Aberystwyth University. It provides exposure to world class research to encourage young people to pursue relevant post-16 studies, establish research careers and become better informed global citizens.

Awards

  • Commendation Award House of Commons, Science Engineering and Technology for Britain.
  • BBSRC Schools Regional Champion (2011-2013)

Publications

2015

Hart, E., Brophy, P., Prescott, M., Bartley, D.J., Wolf, B., Hamilton, J.V. 2015. A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: Case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus. Veterinary Parasitology 207 (3-4) pp. 266-275. 10.1016/j.vetpar.2014.12.003 Cadair

2012

Hart, E.H., Morphew, R.M., Bartley, D.J., Millares, P., Wolf, B.T., Brophy, P.M., Hamilton, J.V. 2012. The soluble proteome phenotypes of ivermectin resistant and ivermectin susceptible Haemonchus contortus females compared. Veterinary Parasitology 190 (1-2) pp. 104-113. 10.1016/j.vetpar.2012.06.009 Cadair

2010

Moxon, J.V., LaCourse, E.J., Wright, H.A., Perally, S., Prescott, M.C., Gillard, J.L., Barrett, J., Hamilton, J.V., Brophy, P.M. 2010. Proteomic analysis of embryonic Fasciola hepatica: Characterization and antigenic potential of a developmentally regulated heat shock protein. Veterinary Parasitology 169 (1-2) pp. 62-75. 10.1016/j.vetpar.2009.12.031 Cadair

Jones, L.M., Staffa, K., Perally, S., LaCourse, E.J., Brophy, P.M., Hamilton, J.V. 2010. Proteomic analyses of Caenorhabditis elegans dauer larvae and long-lived daf-2 mutants implicates a shared detoxification system in longevity assurance. Journal of Proteome Research 9 (6) pp. 2871-2881. 10.1021/pr9009639 Cadair

Moxon, J.V., Flynn, R., Golden, O., Hamilton, J.V., Mulcahy, G., Brophy, P.M. 2010. Immune responses directed at egg proteins during experimental infection with the liver fluke Fasciola hepatica. Parasite Immunology 32 (2) pp. 111-124. 10.1111/j.1365-3024.2009.01171.x Cadair

2009

Pierre, S., Mur, L.A.J., Morphew, R., Hamilton, J., Scott, I.M., Griffith, G.W. 2009. Proteomic analysis of the cacao pathogen Moniliophthora perniciosa. 16th International Cocoa Research Conference. Cadair

Schramm, G., Hamilton, J.V., Balog, C.I.A., Wuhrer, M., Gronow, A., Beckmann, S., Wippersteg, V., Grevelding, C.G., Goldmann, T., Weber, E., Brattig, N.W., Deelder, A.M., Dunne, D.W., Hokke, C.H., Haas, H., Doenhoff, M.J. 2009. Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs. Molecular and Biochemical Parasitology 166 (1) pp. 4-14. 10.1016/j.molbiopara.2009.02.003 Cadair

2008

Lehane, M.J., Aksoy, S., Gibson, W., Kerhornou, A., Berriman, M., Hamilton, J.V., Soares, M.B., Bonaldo, B.F., Lehane, S., Hall, N. 2008. Adult midgut expressed sequence tags from the tsetse fly Glossina morsitans morsitans and expression analysis of putative immune response genes. Genome Biology 4 (R63) R63 10.1186/gb-2003-4-10-r63 Other Cadair

2006

Morgan, C.T., LaCourse, E.J., Rushbrook, B.J., Greetham, D., Hamilton, J.V., Barrett, J., Bailey, K., Brophy, P.M. 2006. Plasticity demonstrated in the proteome of a parasitic nematode within the intestine of different host strains. Proteomics 6 (16) pp. 4633-4645. 10.1002/pmic.200600068 Other Cadair

2005

Barrett, J., Brophy, P.M., Hamilton, J.V. 2005. Analysing proteomic data. International Journal for Parasitology 35 (5) pp. 543-553. 10.1016/j.ijpara.2005.01.013 Cadair

Hamilton, J.V., Lehane, M.J. 2005. Tsetse midgut immunity - DiGE-ESTing for clues into African sleeping sickness. Outlooks on Pest Management 16 (1) pp. 19-22. 10.1564/16feb06 Cadair

2004

Doenhoff, M.J., Chiodini, P.L., Hamilton, J.V. 2004. Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies? Parasitology 20 (1) pp. 35-39. 10.1016/j.pt.2003.10.019 Cadair

2003

Braig, H.R., Lehane, M.J., Hamilton, J.V. 2003. Isolation of Enterobacter sakazakii from midgut of Stomoxys calcitrans. Emerging Infectious Diseases 9 (10) pp. 1355-1356. 10.3201/eid0910.030218 Cadair Other

2002

Boulanger, N., Munks, R.J.L., Hamilton, J.V., Vovelle, F., Brun, R., Lehane, M.J., Bulet, P. 2002. Epithelial innate immunity - A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect Stomoxys calcitrans. Journal of Biological Chemistry 277 pp. 49921-49926. 10.1074/jbc.M206296200 Other Cadair

Hamilton, J.V., Munks, R.J.L., Lehane, S.M., Lehane, M.J. 2002. Association of midgut defensin with a novel serine protease in the blood-sucking fly Stomoxys calcitrans. Insect Molecular Biology 11 (3) pp. 197-205. 10.1046/j.1365-2583.2002.00325.x Cadair