Prof Joanne Hamilton

PhD

Prof Joanne Hamilton

Institute Director of Student Experience

Professor

Contact Details

Teaching

Research

My research focuses on the use of proteomic and molecular technologies to explore host- parasite interactions. My current interests are unravelling the complexities of innate immunity in a range of invertebrates and in exploring the mechanisms used by parasites to overcome the host immune system. Current projects include drug resistance mechanisms in model and parasitic nematodes; liver fluke biology; tsetse fly-trypanosome interactions; immunity in Giant African land snails; immunity in Biomphalaria sp. (an intermediate snail host involved in the transmission of schistosomiasis); schistosome biology and the role of the arthropod gut in the transmission of human pathogens.
I also have a major role in ensuring that University research becomes part of the school curriculum as Principal Investigator on the RCUK funded Schools University Partnership Initiative: SusNet Wales (Sustainability Network Wales).

SusNet Wales is a collaborative multi-disciplinary approach to delivering a "Module" in Sustainability and Social Responsibility developed, led and delivered by practising researchers within Aberystwyth University. It provides exposure to world class research to encourage young people to pursue relevant post-16 studies, establish research careers and become better informed global citizens.

Awards

  • Commendation Award House of Commons, Science Engineering and Technology for Britain.
  • BBSRC Schools Regional Champion (2011-2013)

Publications

Hamilton, J, Grattan, J & Hughes, P 2016, SusNet Wales: Blended Learning Environments for Raising Ambition, Aspirations and driving Social Mobility. An invited case study for Universities UK and the UK Government’s Social Mobility Advisory Group (commissioned by RCUK and the National Coordinating Centre for Public Engagement).
Hamilton, J, Davey, H & Rose, M 2016, Life Sciences Aberystwyth University: A Blended Higher Education Environment for Raising Ambition, Aspirations and driving Social Mobility. Response to Welsh Government’s Consultation on Foundation Degrees in Wales.
Hart, E, Brophy, P, Prescott, M, Bartley, DJ, Wolf, B & Hamilton, JV 2015, 'A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: Case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus' Veterinary Parasitology, vol 207, no. 3-4, pp. 266-275. DOI: 10.1016/j.vetpar.2014.12.003
Hart, EH, Morphew, RM, Bartley, DJ, Millares, P, Wolf, BT, Brophy, PM & Hamilton, JV 2012, 'The soluble proteome phenotypes of ivermectin resistant and ivermectin susceptible Haemonchus contortus females compared' Veterinary Parasitology, vol 190, no. 1-2, pp. 104-113. DOI: 10.1016/j.vetpar.2012.06.009
Moxon, JV, LaCourse, EJ, Wright, HA, Perally, S, Prescott, MC, Gillard, JL, Barrett, J, Hamilton, JV & Brophy, PM 2010, 'Proteomic analysis of embryonic Fasciola hepatica: Characterization and antigenic potential of a developmentally regulated heat shock protein' Veterinary Parasitology, vol 169, no. 1-2, pp. 62-75. DOI: 10.1016/j.vetpar.2009.12.031
Jones, LM, Staffa, K, Perally, S, LaCourse, EJ, Brophy, PM & Hamilton, JV 2010, 'Proteomic analyses of Caenorhabditis elegans dauer larvae and long-lived daf-2 mutants implicates a shared detoxification system in longevity assurance' Journal of Proteome Research, vol 9, no. 6, pp. 2871-2881. DOI: 10.1021/pr9009639
Moxon, JV, Flynn, R, Golden, O, Hamilton, JV, Mulcahy, G & Brophy, PM 2010, 'Immune responses directed at egg proteins during experimental infection with the liver fluke Fasciola hepatica' Parasite Immunology, vol 32, no. 2, pp. 111-124. DOI: 10.1111/j.1365-3024.2009.01171.x
Pierre, S, Mur, LAJ, Morphew, R, Hamilton, J, Scott, IM & Griffith, GW 2009, 'Proteomic analysis of the cacao pathogen Moniliophthora perniciosa' 16th International Cocoa Research Conference, Bali, Indonesia, 2009 - 2009, .
Schramm, G, Hamilton, JV, Balog, CIA, Wuhrer, M, Gronow, A, Beckmann, S, Wippersteg, V, Grevelding, CG, Goldmann, T, Weber, E, Brattig, NW, Deelder, AM, Dunne, DW, Hokke, CH, Haas, H & Doenhoff, MJ 2009, 'Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs' Molecular and Biochemical Parasitology, vol 166, no. 1, pp. 4-14. DOI: 10.1016/j.molbiopara.2009.02.003
Lehane, MJ, Aksoy, S, Gibson, W, Kerhornou, A, Berriman, M, Hamilton, JV, Soares, MB, Bonaldo, BF, Lehane, S & Hall, N 2008, 'Adult midgut expressed sequence tags from the tsetse fly Glossina morsitans morsitans and expression analysis of putative immune response genes' Genome Biology, vol 4, no. R63, R63. DOI: 10.1186/gb-2003-4-10-r63
Morgan, CT, LaCourse, EJ, Rushbrook, BJ, Greetham, D, Hamilton, JV, Barrett, J, Bailey, K & Brophy, PM 2006, 'Plasticity demonstrated in the proteome of a parasitic nematode within the intestine of different host strains' Proteomics, vol 6, no. 16, pp. 4633-4645. DOI: 10.1002/pmic.200600068
Barrett, J, Brophy, PM & Hamilton, JV 2005, 'Analysing proteomic data' International Journal for Parasitology, vol 35, no. 5, pp. 543-553. DOI: 10.1016/j.ijpara.2005.01.013
Hamilton, JV & Lehane, MJ 2005, 'Tsetse midgut immunity - DiGE-ESTing for clues into African sleeping sickness' Outlooks on Pest Management, vol 16, no. 1, pp. 19-22. DOI: 10.1564/16feb06
Doenhoff, MJ, Chiodini, PL & Hamilton, JV 2004, 'Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies?' Parasitology, vol 20, no. 1, pp. 35-39. DOI: 10.1016/j.pt.2003.10.019
Braig, HR, Lehane, MJ & Hamilton, JV 2003, 'Isolation of Enterobacter sakazakii from midgut of Stomoxys calcitrans' Emerging Infectious Diseases, vol 9, no. 10, pp. 1355-1356. DOI: 10.3201/eid0910.030218
Boulanger, N, Munks, RJL, Hamilton, JV, Vovelle, F, Brun, R, Lehane, MJ & Bulet, P 2002, 'Epithelial innate immunity - A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect Stomoxys calcitrans' Journal of Biological Chemistry, vol 277, pp. 49921-49926. DOI: 10.1074/jbc.M206296200
Hamilton, JV, Munks, RJL, Lehane, SM & Lehane, MJ 2002, 'Association of midgut defensin with a novel serine protease in the blood-sucking fly Stomoxys calcitrans' Insect Molecular Biology, vol 11, no. 3, pp. 197-205. DOI: 10.1046/j.1365-2583.2002.00325.x