Prof Luis Mur

PhD

Prof Luis Mur

Professor

IBERS

Contact Details

Teaching

Research

In my Food Security Research I am interested in developing our understanding of the genetic & biochemical events associated with plant responses to stress & in identifying sources of tolerance/resistance. This work is based on the use of model plant species, Arabidopsis & Brachypodium distachyon & also crops, wheat (Triticum aestivum), oats (Avena sativa) tomato (Solanum esculentum) & barley (Hordeum vulgare).

My interests in clinical health focus on the respiratory tract & identifying drug leads from natural products. Lung cancer (LC) is the most prevalent cancer in the world with 1.3 million deaths recorded each year. Only 15% of patients live for five or more years after initial diagnosis, primarily due to late detection. Chronic obstructive pulmonary disease (COPD) is characterised by an increase in mucus production due to hyperplasia of goblet cells, & hypertrophy of mucus glands COPD is a leading cause of death, arising from acute exacerbations (sudden worsening of symptoms) which may be triggered by infection or environmental pollutants. My research in this area is focusing on the detection of metabolite biomarkers for LC & COPD & investigating possible links with the lung microbiome.

My research in bioactive natural products focus on identifying anti-microbial metabolites against such human pathogens as MSRA & Pseudomonas aeruginosa from invasive plant species & extremophile microbial strains.

I employ cutting edge genomic & post-genomic approaches but will use classical physiological, genetic, biochemical or microbiological approaches- as appropriate. I have numerous national & international collaborations which are supported by funding from the BBSRC, the EU, NSF (USA), DEFRA, Royal Society, Welsh Assembly, & AU Research Fund.

Research Groups

  • One Health

Publications

Skalska, A, Wolny, E, Beckmann, M, Doonan, JH, Hasterok, R & Mur, LAJ 2021, 'Allotetraploidization in Brachypodium May Have Led to the Dominance of One Parent’s Metabolome in Germinating Seeds', Cells, vol. 10, no. 4, e828. https://doi.org/10.3390/cells10040828
Monteiro de Barros, MR, Davies-Morel, MCG, Mur, LAJ, Creevey, CJ, Alison, RH & Nash, DM 2021, 'Characterization of an Ex Vivo Equine Endometrial Tissue Culture Model Using Next-Generation RNA-Sequencing Technology', Animals, vol. 11, no. 7, e1995. https://doi.org/10.3390/ani11071995
Wolny, E, Skalska, A, Braszewska, A, Mur, LAJ & Hasterok, R 2021, 'Defining the cell wall, cell cycle and chromatin landmarks in the responses of brachypodium distachyon to salinity', International Journal of Molecular Sciences, vol. 22, no. 2, 949. https://doi.org/10.3390/ijms22020949
Kharbech, O, Massoud, MB, Chaoui, A, Mur, LAJ & Djebali, W 2021, 'Exogenous Nitric Oxide Confers Tolerance to Cr(VI) in Maize (Zea mays L.) Seedlings by Modulating Endogenous Oxido-Nitrosative Events', Journal of Plant Growth Regulation. https://doi.org/10.1007/s00344-021-10411-5
Skalska, A, Beckmann, M, Corke, F, Savas Tuna, G, Tuna, M, Doonan, JH, Hasterok, R & Mur, LAJ 2021, 'Metabolomic Variation Aligns with Two Geographically Distinct Subpopulations of Brachypodium Distachyon before and after Drought Stress', Cells, vol. 10, no. 3, 683. https://doi.org/10.3390/cells10030683
More publications on the Research Portal