Prof Luis Mur

PhD

Prof Luis Mur

Professor

Contact Details

Teaching

Research

In my Food Security Research I am interested in developing our understanding of the genetic & biochemical events associated with plant responses to stress & in identifying sources of tolerance/resistance. This work is based on the use of model plant species, Arabidopsis & Brachypodium distachyon & also crops, wheat (Triticum aestivum), oats (Avena sativa) tomato (Solanum esculentum) & barley (Hordeum vulgare).

My interests in clinical health focus on the respiratory tract & identifying drug leads from natural products. Lung cancer (LC) is the most prevalent cancer in the world with 1.3 million deaths recorded each year. Only 15% of patients live for five or more years after initial diagnosis, primarily due to late detection. Chronic obstructive pulmonary disease (COPD) is characterised by an increase in mucus production due to hyperplasia of goblet cells, & hypertrophy of mucus glands COPD is a leading cause of death, arising from acute exacerbations (sudden worsening of symptoms) which may be triggered by infection or environmental pollutants. My research in this area is focusing on the detection of metabolite biomarkers for LC & COPD & investigating possible links with the lung microbiome.

My research in bioactive natural products focus on identifying anti-microbial metabolites against such human pathogens as MSRA & Pseudomonas aeruginosa from invasive plant species & extremophile microbial strains.

I employ cutting edge genomic & post-genomic approaches but will use classical physiological, genetic, biochemical or microbiological approaches- as appropriate. I have numerous national & international collaborations which are supported by funding from the BBSRC, the EU, NSF (USA), DEFRA, Royal Society, Welsh Assembly, & AU Research Fund.

Publications

Transcriptional and Metabolomic Analyses Indicate that Cell Wall Properties are Associated with Drought Tolerance in Brachypodium distachyonLenk, I., Fisher, L., Vickers, M., Akinyemi, A., Didion, T., Swain, M., Sig Jensen, C., Mur, L. & Bosch, M., 2019 , In : International Journal of Molecular Sciences.20, 7, 1758.
Defining Metabolic Rewiring in Lung Squamous Cell CarcinomaPaes De Araujo, R., Bertoni, N., Seneda, A. L., Felix, T., Carvalho, M., Lewis, K. E., Hasimoto, É. N., Beckmann, M., Drigo, S. A., Reis, P. P. & Mur, L., 2019 , In : Metabolites.9, 3, 47.
Exploring the Roles of Aquaporins in Plant-Microbe InteractionsWang, R., Wang, M., Chen, K., Wang, S., Mur, L. & Guo, S., 2018 , In : Cells.7, 12, 267.
OsTSD2-mediated cell wall modification affects ion homeostasis and salt toleranceFang, C., Li, K., Wu, Y., Wang, D., Zhou, J., Liu, X., Li, Y., Jin, C., Liu, X., Mur, L. & Luo, J., 2018 , In : Plant, Cell and Environment.
Lung cancer: a new frontier for microbiome research and clinical translationMur, L., Huws, S., Cameron, S., Lewis, P. D. & Lewis, K. E., 2018 , In : ecancermedicalscience.12, 866.
More publications on the Research Portal