Prof Luis Mur

PhD

Prof Luis Mur

Professor

IBERS

Contact Details

Teaching

Research

In my Food Security Research I am interested in developing our understanding of the genetic & biochemical events associated with plant responses to stress & in identifying sources of tolerance/resistance. This work is based on the use of model plant species, Arabidopsis & Brachypodium distachyon & also crops, wheat (Triticum aestivum), oats (Avena sativa) tomato (Solanum esculentum) & barley (Hordeum vulgare).

My interests in clinical health focus on the respiratory tract & identifying drug leads from natural products. Lung cancer (LC) is the most prevalent cancer in the world with 1.3 million deaths recorded each year. Only 15% of patients live for five or more years after initial diagnosis, primarily due to late detection. Chronic obstructive pulmonary disease (COPD) is characterised by an increase in mucus production due to hyperplasia of goblet cells, & hypertrophy of mucus glands COPD is a leading cause of death, arising from acute exacerbations (sudden worsening of symptoms) which may be triggered by infection or environmental pollutants. My research in this area is focusing on the detection of metabolite biomarkers for LC & COPD & investigating possible links with the lung microbiome.

My research in bioactive natural products focus on identifying anti-microbial metabolites against such human pathogens as MSRA & Pseudomonas aeruginosa from invasive plant species & extremophile microbial strains.

I employ cutting edge genomic & post-genomic approaches but will use classical physiological, genetic, biochemical or microbiological approaches- as appropriate. I have numerous national & international collaborations which are supported by funding from the BBSRC, the EU, NSF (USA), DEFRA, Royal Society, Welsh Assembly, & AU Research Fund.

Research Groups

  • One Health

Publications

Wolny, E, Skalska, A, Braszewska, A, Mur, LAJ & Hasterok, R 2021, 'Defining the cell wall, cell cycle and chromatin landmarks in the responses of brachypodium distachyon to salinity', International Journal of Molecular Sciences, vol. 22, no. 2, 949. https://doi.org/10.3390/ijms22020949
Baptista, R, Bhowmick, S, Shen, J & Mur, LAJ 2021, 'Molecular Docking Suggests the Targets of Anti-Mycobacterial Natural Products', Molecules, vol. 26, no. 2, 475. https://doi.org/10.3390/molecules26020475
Wang, X, Chen, J, Ge, J, Huang, M, Cai, J, Zhou, Q, Dai, T, Mur, LAJ & Jiang, D 2021, 'The different root apex zones contribute to drought priming induced tolerance to a reoccurring drought stress in wheat', Crop Journal. https://doi.org/10.1016/j.cj.2020.11.008
Seneda, AL, Lapa, RML, Felix, TF, Minutentag, IW, Campos, CF, Oliveira, RAD, Oliveira, CC, Hasimoto, ÉN, Cataneo, DC, Cataneo, AJM, De Faveri, J, Drigo, SA, Mur, LAJ & Reis, PP 2021, 'Typical Lung Carcinoids with Metastasis: Potential Role of MicroRNAs in the Regulation of Adaptive Immunity Associated with Disease: a Case Study', Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, vol. 55, no. S2, pp. 1-12. https://doi.org/10.33594/000000320
Skalska, A, Stritt, C, Wyler, M, Williams, HW, Vickers, M, Han, J, Tuna, M, Savas Tuna, G, Susek, K, Swain, M, Wóycicki, RK, Chaudhary, S, Corke, F, Doonan, JH, Roulin, AC, Hasterok, R & Mur, LAJ 2020, 'Genetic and Methylome Variation in Turkish Brachypodium Distachyon Accessions Differentiate Two Geographically Distinct Subpopulations', International Journal of Molecular Sciences, vol. 21, no. 18, 6700. https://doi.org/10.3390/ijms21186700
More publications on the Research Portal