Dr David Whitworth

PhD, FRSB, SFHEA

Dr David Whitworth

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Research

My research focuses on the myxobacterial predator Myxococcus xanthus and how it preys upon other microbes. We are studying natural myxobacterial isolates using a variety of genomic, proteomic and phenotypic techniques to identify the genes conferring antimicrobial activity. Particular topics of interest include the predatory vesicles shed by myxobacteria, and myxobacterial signalling pathways and how they alter behaviour in response to a changing environment. In particular, I am interested in the social and predatory myxobacteria, and how they use two-component signalling pathways to co-ordinate group behaviour.

Publications

Genome Sequencing and Comparative Transcriptomics Provide a Holistic View of 4-Nitrophenol Degradation and Concurrent Fatty Acid Catabolism by Rhodococcus sp. Strain BUPNP1Sengupta, K., Swain, M., Livingstone, P., Whitworth, D. & Saha, P., 2019 , In : Frontiers in Microbiology.9, 3209.
Genome Sequencing and Pan-Genome Analysis of 23 Corallococcus spp. Strains Reveal Unexpected Diversity, With Particular Plasticity of Predatory Gene SetsLivingstone, P., Morphew, R. & Whitworth, D., 2018 , In : Frontiers in Microbiology.9, 3187.
Genome Analysis, Metabolic Potential and Predatory Capabilities of Herpetosiphon llansteffanense sp. nov.Livingstone, P., Morphew, R., Cookson, A. & Whitworth, D., 2018 , In : Applied and Environmental Microbiology.
Interspecies conflict affects RNA expressionWhitworth, D., 2018 , In : FEMS Microbiology Letters.365, 10, fny096.
Transcriptional changes when Myxococcus xanthus preys on Escherichia coli suggest myxobacterial predators are consititutively toxic but regulate their feedingLivingstone, P., Millard, A., Swain, M. T. & Whitworth, D. E., 2018 , In : Microbial Genomics.4, 2, 152.
More publications on the Research Portal