Prof David Whitworth


Prof David Whitworth


Department of Life Sciences

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My research focuses on the myxobacterial predator Myxococcus xanthus and how it preys upon other microbes. We are studying natural myxobacterial isolates using a variety of genomic, proteomic and phenotypic techniques to identify the genes conferring antimicrobial activity. Particular topics of interest include the predatory vesicles shed by myxobacteria, and myxobacterial signalling pathways and how they alter behaviour in response to a changing environment. 


Khalid, A, Cookson, AR, Whitworth, DE, Beeton, ML, Robins, LI & Maddocks, SE 2023, 'A Synthetic Polymicrobial Community Biofilm Model Demonstrates Spatial Partitioning, Tolerance to Antimicrobial Treatment, Reduced Metabolism, and Small Colony Variants Typical of Chronic Wound Biofilms', Pathogens, vol. 12, no. 1, 118. 10.3390/pathogens12010118
Arakal, BS, Whitworth, DE, James, PE, Rowlands, R, Madhusoodanan, NPT, Baijoo, MR & Livingstone, PG 2023, 'In Silico and In Vitro Analyses Reveal Promising Antimicrobial Peptides from Myxobacteria', Probiotics and Antimicrobial Proteins, vol. 15, no. 1, pp. 202-214. 10.1007/s12602-022-10036-4
Hahnke, RL, Müller, R, Whitworth, D, Wink, J & Garcia, R 2023, 'International Committee on Systematics of Prokaryotes: Subcommittee on the taxonomy of Myxobacteria (Myxococcota). Minutes of the closed online meeting, 21 September 2022', International Journal of Systematic and Evolutionary Microbiology, vol. 73, no. 5. 10.1099/ijsem.0.005846
Zwarycz, AS & Whitworth, DE 2023, 'Myxobacterial Predation: A Standardised Lawn Predation Assay Highlights Strains with Unusually Efficient Predatory Activity', Microorganisms, vol. 11, no. 2, 398. 10.3390/microorganisms11020398
Zwarycz, AS, Page, T, Nikolova, G, Radford, EJ & Whitworth, DE 2023, 'Predatory Strategies of Myxococcus xanthus: Prey Susceptibility to OMVs and Moonlighting Enzymes', Microorganisms, vol. 11, no. 4, 874. 10.3390/microorganisms11040874
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