Dr David Whitworth

PhD, FRSB, SFHEA

Dr David Whitworth

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Research

My research focuses on the myxobacterial predator Myxococcus xanthus and how it preys upon other microbes. We are studying natural myxobacterial isolates using a variety of genomic, proteomic and phenotypic techniques to identify the genes conferring antimicrobial activity. Particular topics of interest include the predatory vesicles shed by myxobacteria, and myxobacterial signalling pathways and how they alter behaviour in response to a changing environment. In particular, I am interested in the social and predatory myxobacteria, and how they use two-component signalling pathways to co-ordinate group behaviour.

Publications

Chambers, J, Sparks, N, Sydney, N, Livingstone, PG, Cookson, AR & Whitworth, DE 2021, 'Corrigendum to: “Comparative genomics and pan-genomics of the Myxococcaceae, including a description of five novel species: Myxococcus eversor sp. nov., Myxococcus llanfairpwllgwyngyllgogerychwyrndrobwllllantysiliogogogochensis sp. nov., Myxococcus vastator sp. nov., Pyxidicoccus caerfyrddinensis sp. nov. and Pyxidicoccus trucidator sp. nov.” [Genome Biol. Evol. 12(12) (2020) 2289-2302] ', Genome Biology and Evolution, vol. 13, no. 4. https://doi.org/10.1093/gbe/evab040
Ortet, P, Fochesato, S, Bitbol, A-F, Whitworth, DE, Lalaouna, D, Santaella, C, Heulin, T, Achouak, W & Barakat, M 2021, 'Evolutionary history expands the range of signaling interactions in hybrid multikinase networks', Scientific Reports, vol. 11, no. 1, pp. 11763. https://doi.org/10.1038/s41598-021-91260-w
Sydney, N, Swain, MT, So, JMT, Hoiczyk, E, Tucker, NP & Whitworth, DE 2021, 'The Genetics of Prey Susceptibility to Myxobacterial Predation: A Review, including an Investigation into Pseudomonas aeruginosa Mutations Affecting Predation by Myxococcus xanthus', Microbial Physiology. https://doi.org/10.1159/000515546
Whitworth, DE & Zwarycz, A 2020, 'A genomic survey of signalling in the myxococcaceae', Microorganisms, vol. 8, no. 11, 1739. https://doi.org/10.3390/microorganisms8111739
Whitworth, DE & Swain, MT 2020, 'A survey of non-coding RNAs in the social and predatory myxobacterium Myxococcus xanthus DK1622', Molecular Omics, vol. 16, no. 5, pp. 492-502. https://doi.org/10.1039/d0mo00068j
More publications on the Research Portal