Dr David Whitworth

PhD, FRSB, SFHEA

Dr David Whitworth

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Research

My research focuses on the myxobacterial predator Myxococcus xanthus and how it preys upon other microbes. We are studying natural myxobacterial isolates using a variety of genomic, proteomic and phenotypic techniques to identify the genes conferring antimicrobial activity. Particular topics of interest include the predatory vesicles shed by myxobacteria, and myxobacterial signalling pathways and how they alter behaviour in response to a changing environment. In particular, I am interested in the social and predatory myxobacteria, and how they use two-component signalling pathways to co-ordinate group behaviour.

Publications

Livingstone, PG, Ingleby, O, Girdwood, S, Cookson, AR, Morphew, RM & Whitworth, DE 2020, 'Predatory Organisms with Untapped Biosynthetic Potential: Descriptions of Novel Corallococcus Species C. aberystwythensis sp. nov., C. carmarthensis sp. nov., C. exercitus sp. nov., C. interemptor sp. nov., C. llansteffanensis sp. nov., C. praedator sp. nov., C. sicarius sp. nov., and C. terminator sp. nov', Applied and Environmental Microbiology, vol. 86, no. 2, e01931-19. https://doi.org/10.1128/AEM.01931-19
Furness, E, Whitworth, DE & Zwarycz, A 2020, Predatory interactions between myxobacteria and their prey. in The Ecology of Predation at the Microscale. Springer Nature, pp. 1-36. https://doi.org/10.1007/978-3-030-45599-6_1
Zwarycz, AS, Livingstone, PG & Whitworth, DE 2020, 'Within-species variation in OMV cargo proteins: The Myxococcus xanthus OMV pan-proteome', Molecular omics, vol. 16, no. 4, pp. 387-397. https://doi.org/10.1039/d0mo00027b
Stamou, GP, . Monokrousos, N, Gwynn-Jones, D, Whitworth, D & Paptheodorou, EM 2019, 'A polyphasic approach for assessing eco-system connectivity demonstrates that perturbation remodels network architecture in soil microcosms', Microbial Ecology. https://doi.org/10.1007/s00248-019-01367-x
Sengupta, K, Swain, M, Livingstone, P, Whitworth, D & Saha, P 2019, 'Genome Sequencing and Comparative Transcriptomics Provide a Holistic View of 4-Nitrophenol Degradation and Concurrent Fatty Acid Catabolism by Rhodococcus sp. Strain BUPNP1', Frontiers in Microbiology, vol. 9, 3209. https://doi.org/10.3389/fmicb.2018.03209
More publications on the Research Portal