Dr Ifat Parveen Shah

BSc, PhD, PGCTHE, MRSC

Dr Ifat Parveen Shah

Institute Director of International Teaching

Senior Lecturer

Contact Details

Profile

I received my PhD at the University of Bath (England, UK), in 2001 on a thesis entitled "Novel Hypoxia-Selective Prodrugs of Radiosensitisers and Chemosensitisers" under the supervision of Professor Mike D. Threadgill (Department of Pharmacy and Pharmacology) and Dr. William J. D. Whish (Department of Biology and Biochemistry). I joined IGER in 2002 as the post-doctoral researcher on a BBSRC-LINK project (Phytochemical library from British plants 2002-2004) with a pharmaceutical industrial partner (Molecular Nature Ltd.) on the isolation and identification of natural plant products. This enabled me to expand my skills into natural product chemistry, following my PhD studies in which I trained as a synthetic medicinal chemist focusing on design, synthesis and evaluation of drugs for cancer therapy. In 2004, I was made principal investigator on a metabolomics project to develop a pre-mortem diagnostic test for transmissible spongiform encepathalopathy (TSE) diseases in sheep and cattle.I have since also worked on a project concerned with utilising a metabolomics approach to improve animal health and performance. In April 2008, I joined the Biorenewables and Environmental Change division at IBERS.

Additional Information

  • KESS PhD Studentship (07/15) - Developing oats as a source of pharmaceutical, nutraceutical and cosmetic ingredients. Ifat Parveen Shah, Kevin Shingfield, Catherine Howarth, Cark Mansell (Industrial partner)
  • Life Science Research Network Wales - National Research Network (NRN) (10/15-09/19; ?60,000): PhD Studentship: Exploiting natural products from Hops (Humulus lupulus) to suppress tuberculosis. Luis Mur, Ifat Parveen, Prof. Les Baillie.
  • Newton-Bhabha Fund, 6-month Fellowship (2015; ?5,000): Comparative metabolic profiling of Phyllanthus emblica and transgenic Arabidopsis thaliana over expressing type III Polyketide synthase. Luis Mur, Ifat Parveen Shah.
  • TETFUND Split-Site PhD (Nigeria-UK; 2015-2017; ?40,000) - The targeting and identifying clinically active natural products from Moringa. Luis Mur, Ifat Parveen.
  • BBSRC ICASE (10/15-09/19; ?90,000): Endophytic Bacteria: Co-existence and Chemical Warfare. Kerrie Farrar, Ifat Parveen.
  • HVCfP Network Fund (06/15-12/16; ?50,000) - Exploiting Oat Genetic Resources to Elevate Bioactive Avenanthramide Content. Luis Mur and Ifat Parveen, Cathy Howarth
  • Access to Masters (ATM) European Social Fund (?13,400) (10/14-10/15) - Isolation, purification and structure elucidation of antimicrobial compounds from Japanese Knotweed. Ifat Parveen Shah and Luis Mur
  • Life Science Research Network Wales - National Research Network (NRN) (10/15-09/19; ?60,000): PhD Studentship: Identifying new antimicrobial drugs in microorganisms from extreme environments. Luis Mur, Ifat Parveen Shah, Arwyn Edwards.
  • Life Science Research Network Wales - National Research Network (NRN) (10/14-09/19; ?60,000): PhD Studentships: Targeting natural products to counter the challenge of MRSA. Luis Mur and Ifat Parveen Shah
  • BBSRC Sparking Impact Award (2014; ?16,000): Maximizing t

Teaching

Research

My research focusses on the following areas:

Green Biotechnology: High value chemicals to improve plant and human health. Antimicrobials from extremophiles. Rhizosphere and endophytic microbes to identify metabolites that promote plant growth or trigger plant defence.

Identification of chemical markers linked to key traits relevant for the biorefining industry: Chemicals in Miscanthus and oats, which are active against pests such as nematodes and pathogens and link these to specific QTLs.

Characterisation of cell wall chemistry: Synthesis of diferulates using novel synthetic routes in order to develop monoclonal antibodies characterisation of cell walls and synthesis of chromogenic substrates for identification and quantification of cell-wall enzymes.

Professional Memberships:

Secretary of the Royal Society Chemistry Mid-Wales Local Section Committee.

Collaborations:

  • Professor Michael D. Threadgill (Department of Pharmacy and Pharmacology, University of Bath).
  • Professor Mark Baird (School of Chemistry, Bangor University)
  • Dr. Mark Elliott (Cardiff School of Chemistry, Cardiff University)
  • Professor John Ralph (Department of Biochemistry, University of Wisconsin-Madison)

Publications

Wonfor, R, Natoli, M, Shah, I, Beckmann, M, Nash, RJ & Nash, D 2017, 'Anti-inflammatory properties of an extract of M. ilicifolia in the human intestinal epithelial Caco-2 cell line' Journal of Ethnopharmacology, vol 209, pp. 283-287. DOI: 10.1016/j.jep.2017.08.006
Nur-e-Alam, M, Yousaf, M, Ahmed, S, Al-Sheddi, ES, Shah, I, Fazakerley, D, Bari, A, Ghabbour, HA, Threadgill, MD, Whatley, K, Hoffmann, K & Al-Rehaily, AJ 2017, 'Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense' Journal of Natural Products. DOI: 10.1021/acs.jnatprod.7b00188
Shah, I, Donnison, I, Insole, J, Winters, A, Dalton, S, Woodman, T, Bosch, M & Threadgill, MD 2016, 'An efficient assay for ferulic acid esterase and para-coumaric acid esterases in plants at physiologically relevant activities' Cell Chemistry and Biology, vol 6, no. 5, pp. 300-311.
Mohammad, RH, Nur e-Alam, M, Lahman, M, Shah, I, Tizzard, GJ, Coles, SJ, Fowler, M, Drake, AF, Heyes, D & Thoss, V 2016, 'Isolation and characterisation of 13 pterosins and pterosides from bracken (Pteridium aquilinum (L.) Kuhn) rhizome' Phytochemistry, vol 128, pp. 82-94. DOI: 10.1016/j.phytochem.2016.05.001
Belanche Gracia, A, Jones, EL, Shah, I & Newbold, C 2016, 'A metagenomics approach to evaluate the impact of dietary supplementation with Ascophyllum nodosum or Laminaria digitata on rumen function in Rusitec fermenters' Frontiers in Microbiology, vol 7, 299. DOI: 10.3389/fmicb.2016.00299
Parveen, I, Wilson, T, Threadgill, MD, Luyten, J, Roberts, RE, Robson, PR, Hauck, BD, Donnison, IS & Winters, AL 2014, 'Screening for potential co-products in a Miscanthus sinensis mapping family by liquid chromatography with mass spectrometry detection' Phytochemistry, vol 105, pp. 186-196. DOI: 10.1016/j.phytochem.2014.05.003
Parveen Shah, I, Wilson, T, Donnison, IS, Cookson, AR, Hauck, BD & Threadgill, MD 2013, 'Potential sources of high value chemicals from leaves, stems and flowers of Miscanthus sinensis 'Goliath' and Miscanthus sacchariflorus' Phytochemistry, vol 92, pp. 160-167. DOI: 10.1016/j.phytochem.2013.04.004
Parveen, I, Threadgill, MD, Hauck, BD, Donnison, IS & Winters, AL 2011, 'Isolation, identification and quantitation of hydroxycinnamic acid conjugates, potential platform chemicals, in the leaves and stems of Miscanthus x giganteus using LC-ESI-MS(n)' Phytochemistry, vol 72, no. 18, pp. 2376-2384. DOI: 10.1016/j.phytochem.2011.08.015
Parveen, I, Threadgill, MD, Hauck, BD, Donnison, I & Winters, AL 2011, 'Isolation, identification and quantitation of hydroxycinnamic acid conjugates, potential platform chemicals, in the leaves and stems of Miscanthus × giganteus using LC–ESI-MSn' Phytochemistry, vol 72, no. 18, pp. 2376-2384. DOI: 10.1016/j.phytochem.2011.08.015,
Moorby, JM, Fraser, MD, Parveen, I, Lee, MRF & Wold, J-P 2010, 'Comparison of 2 high-throughput spectral techniques to predict differences in diet composition of grazing sheep and cattle' Journal of Animal Science, vol 88, no. 5, pp. 1905-1913. DOI: 10.2527/jas.2009-1944
Parveen, I, Moorby, JM, Fraser, MD, Erban, A & Kopka, J 2010, 'Relationship between grazing lamb growth rate and blood plasma analytes as profiled by gas chromatography with time-of-flight mass spectrometry (GC-TOF/MS)' Journal of Agricultural and Food Chemistry, vol 58, no. 2, pp. 913-917. DOI: 10.1021/jf902116m
Parveen, I, Threadgill, MD, Moorby, JM & Winters, AL 2010, 'Oxidative phenols in forage crops containing polyphenol oxidase enzymes' Journal of Agricultural and Food Chemistry, vol 58, no. 3, pp. 1371-1382. DOI: 10.1021/jf9024294
Hauck, BD, Parveen, I, Gallagher, JA, Donnison, IS & Winters, A 2010, 'Accumulation of soluble phenolic compounds in the forage grass species, cocksfoot (Dactylis glomerata L).' XXVth International Conference on Polyphenols, Montpellier, France, 2010 - 2010, pp. T2.03.
Parveen, I, Donnison, IS, Threadgill, MD, Hauck, BD & Winters, AL 2010, 'Isolation, identification and quantification of hydroxycinnamic acid conjugates in leaf and stem tissue of Miscanthus sacchariflorus and sinensis and their potential as platform chemicals' Gordon Research Conference, 'Green Chemistry', Davidson College, Davison, North Carolina, Davidson, United States of America, 2010 - 2010, .
Parveen, I, Threadgill, MD, Hauck, BD, Donnison, IS & Winters, AL 2010, 'Isolation, identification and quantification of hydroxycinnamic acid conjugates in leaf and stem tissue of Miscanthus x giganteus and their potential as platform chemicals' XXVth International Conference on Polyphenols, Montpellier, France, 2010 - 2010, pp. T5.62.
Parveen, I, Threadgill, MD, Hauck, BD, Donnison, IS & Winters, AL 2009, 'Rapid identification of hydroxycinnamate esters in Miscanthus giganteus and Miscanthus goliath as substrates for polyphenol oxidase using ESI-MS/MS' Planta Medica, vol 75, no. 9, pp. 900. DOI: 10.1055/s-0029-1234318
Parveen, I, Winters, A, Threadgill, MD, Hauck, BD & Morris, P 2008, 'Extraction, structural characterisation and evaluation of hydroxycinnamate esters of orchard grass (Dactylis glomerata) as substrates for polyphenol oxidase' Phytochemistry, vol 69, no. 16, pp. 2799-2806. DOI: 10.1016/j.phytochem.2008.08.019
Parveen, I, Morris, P, Winters, AL, Hauck, BD & Threadgill, MD 2008, 'Extraction, structural characterisation and evaluation of hydroxycinnamate esters of orchard grass (Dactylis glomerata) as substrates for polyphonel oxidase' Planta Medica, vol 74, pp. T1.51. DOI: 10.1055/s-0028-1084432
Parveen, I, Moorby, JM, Hirst, WM, Morris, SM & Fraser, MD 2008, 'Profiling of plasma and faeces by FT-IR to differentiate between heathland plant diets offered to zero-grazed sheep' Animal Feed Science and Technology, vol 144, no. 1-2, pp. 65-81. DOI: 10.1016/j.anifeedsci.2007.10.002
Parveen, I, Winters, AL, Hauck, BD & Morris, P 2008, 'Identification of substrates of polyphenol oxidase enzyme from cocksfoot species using NMR and LCMS techniques' A young scientists symposium, Garganano, Lake Garda, Italy, 2007 - 2007, .
Winters, AL, Gill, S, Parveen, I, Sullivan, ML & Webb, KJ 2008, 'Role of red clover polyphenol oxidase in pathogen resistance' 24th International Conference on Polyphenols, Salamanca, 2008 - 2008, pp. T3.28.
Parveen, I, Moorby, J, Fraser, M, Allison, G & Kopka, J 2007, 'Application of gas chromatography-mass spectrometry metabolite profiling techniques to the analysis of heathland plant diets of sheep' Journal of Agricultural and Food Chemistry, vol 55, no. 4, pp. 1129-1138. DOI: 10.1021/jf062995w
Parveen, I, Moorby, JM, Fraser, MD, Allison, GG & Kopka, J 2006, 'Application of GCMS-TOF metabolite profiling techniques to the analysis of heathland plant diets of sheep' Paper presented at 8th British Grassland Society Research Conference, Cirencester, United Kingdom of Great Britain and Northern Ireland, 2006 - 2006, pp. 103-104.
Winters, AL, Bryant, DN, Gallagher, JA, Lee, MRF, Minchin, FR, Parveen, I, Theodorou, MK & Morris, P 2006, 'Biochemistry and molecular biology of polyphenol oxidases in grasses' Paper presented at XXIII International Conference on Polyphenols, Winnipeg, Manitoba, Canada, 2006 - 2006, pp. 303-304.
Parveen, I, Moorby, JM, Hirst, WM, Morris, SM & Fraser, MD 2006, Profiling of plasma and faeces by FT-IR to differentiate between heathland plant diets offered to zero-grazed sheep. in 8th British Grassland Society Research Conference, 'Grassland as a Multifunctional Resource. British Grassland Society, pp. 101-102, 8th British Grassland Society Research Conference, Cirencester, United Kingdom of Great Britain and Northern Ireland, 2006.
Parveen, I, Moorby, JM, Allison, GG & Jackman, R 2005, 'The use of non-prion biomarkers for the diagnosis of bovine spongiform encephalopathy and scrapie in the live animal' Veterinary Research, vol 36, no. 5-6, pp. 665-683. DOI: 10.1051/vetres:2005028
Hill, K, Gescher, AJ, Perkins, S, Parveen, I, Threadgill, MD, Williams, ML, Sharma, RA, Verschoyle, RD & Steward, WP 2002, 'Chemopreventive efficacy and pharmacokinetics of curcumin in the Min/+ mouse, a model of familial adenomatous polyposis' Cancer Epidemiology, Biomarkers and Prevention, vol 11, no. 6, pp. 535-540.
Threadgill, MD, Ferrer, S, Naughton, DP & Parveen, I 2002, 'N- and O-alkylation of isoquinolin-1-ones in the Mitsunobu reaction: Development of potential drug delivery systems' Journal of the Chemical Society, Perkin Transactions 1, pp. 335-340. DOI: 10.1039/b109776h
Shah, I & Threadgill, MD 2000, 'Labelled compounds of interest as antitumour agents-VII1. [2H]- and [14C]-curcumin' Journal of Labelled Compounds and Radiopharmaceuticals, vol 43, no. 9, pp. 883-889. DOI: 10.1002/1099-1344(200008)43:9<883::AID-JLCR372>3.0.CO;2-4
Shah, I, Naughton, DP, Whish, WJD & Threadgill, MD 1999, '2-Nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: reductively triggered release of the parp inhibitor 5-bromoisoquinolinone' Bioorganic and Medicinal Chemistry Letters, vol 9, no. 14, pp. 2031-2036. DOI: 10.1016/S0960-894X(99)00306-6