Gwybodaeth Modiwlau

Module Identifier
BS34520
Module Title
FUNCTIONAL GENOMICS
Academic Year
2011/2012
Co-ordinator
Semester
Semester 1
Pre-Requisite
BS12910
Pre-Requisite
BS23720
Pre-Requisite
BS22720
Other Staff

Course Delivery

Delivery Type Delivery length / details
Lecture 28 x 1 hour lectures
Practical 7 x 2 hour computer workshops
 

Assessment

Assessment Type Assessment length / details Proportion
Semester Exam 2 Hours   Essays and data interpretation  40%
Semester Assessment 60%
Supplementary Exam 2 Hours   2 hour written examination (essays and data interpretation  40%
Supplementary Assessment Resubmission of failed coursework or alternative  60%

Learning Outcomes

On completion of this applied module, students should be able to:



  • demonstrate an appreciation of the international scale of co-ordinated effort required to assemble the biological resources for analysis of gene function.
  • communicate a theoretical experience of using genomics and related databases to analyse gene and genome inter-relationships.
  • describe the current methodologies for prediction of the structural relationships of proteins.
  • evaluate the value and constraints associated with the study of model systems for functional genomics.
  • demonstrate an understanding of the basic technological principles of transcriptome, proteome and metabolome analysis.
  • discuss the range of computational methods being used to interpret functional genomics data.
  • discuss the concepts of high throughput screening and forced evolution methodologies in modern biology.
  • appreciate current research strategies for gene discovery and determining gene function (functional genomics) and biological data analysis and interpretation (bioinformatics) .
  • describe the role that genomics and bioinformatics has to play in modern medicine and fundamental research.
  • demonstrate skills and knowledge of the concepts underlying database access, sequence analysis, protein classification and functional assignment.
  • appreciate the range of computational methods being used to interpret functional genomics data.
  • show awareness of the current status of the human genome project and its context in society.

Content

The lectures and workshops cover the following topics:


  • An Introduction to Functional genomics
  • The Human Genome Project
  • Investigation of genetic diseases
  • Development of genomics resources
  • Genome mapping strategies
  • Model systems for functional genomics
  • Introduction to 'Omic technologies
  • Methodologies for predicting gene function
  • Post genomics technologies
  • Protein-protein interactions
  • Advanced protein modelling and secondary structure prediction
  • HighThroughput Screening
  • Systems Biology
  • Advanced Bioinformatics methods
  • Data interpretation methods
  • Specific examples of the application of genomics and bioinformatics to ongoing research at Aberystwyth

Brief description

This module is an integrated series of lectures, seminars and workshops covering the modern discipline of Functional Genomics. Functional Genomics has been defined as 'The development and application of global (genome-wide or system-wide) experimental approaches to assess gene function by making use of the information and reagents provided by genome sequencing and mapping' (Hietor, P. and Boguski, M. (1997) Science 278:601). Functional genomics employs novel technologies for genome-wide analysis supported by IT. This involves experimental and computational methods. High throughput experimental technologies based on measuring gene expression, protein structure and protein interactions are being used to generate large datasets to aid understanding of gene function. Powerful information systems are required for the efficient management and integration of the experimental data. The results emerging from these analyses will inform new predictive strategies to identify new and useful genes and potential drug targets, understand gene behaviour, and develop novel therapeutic products.

Aims

The module provides an introduction to post-genomics technologies and practical training in bioinformatics methods.

Reading List

General Text
Campbell, A. Malcolm. Discovering genomics, proteomics, and bioinformatics /A. Malcolm Campbell, Laurie J. Heyer. Primo search Gibson, Greg. A primer of genome science /Greg Gibson, Spencer V. Muse. http://www.loc.gov/catdir/toc/ecip052/2004024285.html Lesk, Arthur M. Introduction to bioinformatics /Arthur M. Lesk. Primo search Mount, David W. Bioinformatics :sequence and genome analysis /David W. Mount. Primo search

Notes

This module is at CQFW Level 6