|Delivery Type||Delivery length / details|
|Lecture||48 hours and 2 hours with invited speakers|
|Practical||2 x 3 hour practicals|
|Other||2 x 3 hour revision sessions|
|Assessment Type||Assessment length / details||Proportion|
|Semester Assessment||Workshop 1 report.||13%|
|Semester Assessment||Workshop 2 report.||13%|
|Semester Assessment||Cancer case study. Group work.||24%|
|Semester Exam||2 Hours Theory paper.||50%|
|Supplementary Assessment||Students must take elements of assessment equivalent to those that led to failure of the module.||50%|
|Supplementary Exam||2 Hours Students must take elements of assessment equivalent to those that led to failure of the module.||50%|
On successful completion of this module students should be able to:
1. Discuss key signalling mechanisms and their importance in the life of the cell.
2. Discuss the regulation of gene expression and its importance in the life of the cell.
3. Discuss the cell cycle, aging and cell death and relate these to development and cancer.
4. Discuss the molecular biology of cancer and its relationship to clinical oncology.
5. Working as a group, create a resource discussing the clinical and molecular biological aspects of a specific cancer.
6. Analyse raw developmental data and produce a summary and draw conclusions.
7. Critically interpret published data and analyse key published experiments.
In the section on the development of the early embryo we will examine how signals and differential gene expression are important for determining the basic body pattern of embryos as diverse as those of a fly and a human, determining the fates of individual cells in the embryo, and regulating the movements of cells required to form a complex organism.
Cell fate (differentiation) and movement are two key factors in the development of cancer and, in the final part of the module, we will examine how problems with signaling and differential gene expression can lead to cancer and show how many of the process that are features of early development are also crucial for the growth and spread of cancer. How this understanding impacts on treatments and outcomes will also be discussed,
Plant molecular cell biology will also be discussed focusing on special aspects of signaling and gene expression. The experimental and commercial manipulation of these will be addressed.
Two lectures will be set aside to allow staff to discuss relevant topical subjects. This will vary from year to year depending on recent research. It may involve IBERS staff talking about their own research work or be based on events in the media.
Workshops will use data interpretation exercises to reinforce and expand on the taught material. In addition students will work in groups to develop websites based on cancer molecular biology topics.
The module will also feature a 2 hour session involving an invited speaker who will talk about her or his work in a field related to the topic and discuss career paths with students.
The importance of cell signaling and its impact on differential gene expression will serve as an introduction to the module (building on the material in BR10310). This introductory section will also examine the regulation of cell migration and programmed cell death. These basic principles will then be put into context by examining the role they play in early embryo development, aging and cancer formation and treatment and plant cell biology.
|Skills Type||Skills details|
|Application of Number||Analysis of data, calculation of basic descriptive stats and production of appropriate graphical representations.|
|Communication||Production of succinct and professional reports within strict word limits and to a pre-set format. Production of professional, accessible web resources.|
|Improving own Learning and Performance|
|Information Technology||Production of a professional and accessible cancer topic website.|
|Personal Development and Career planning||Opportunity to hear about a career related to the topic and question an invited speaker about career paths.|
|Problem solving||Critical analysis of published data and approaches to resolution of conflicts in the literature. Developing and testing hypotheses.|
|Subject Specific Skills|
|Team work||Working together as a team, keeping minutes, organizing regular meetings, identifying and using the strengths of each member.|
Reading ListEssential Reading
Lodish, Harvey et. al. (2007) Molecular Cell Biology 6th Edition W. H. Freeman Primo search Neal, Anthony J. et al. (2008) Clinical Oncology, Basic Principles and Practice 4th Edition Hodder Arnold Primo search
This module is at CQFW Level 5