Chromosome Dynamics

Cod y Modiwl: BR21820
Teitl y Modiwl: Chromosome Dynamics
Blwyddyn Academaidd: 2026/2027
Semester: Semester 2
Cyd-gysylltydd y Modiwl: Dr Dylan Phillips
Rhestr Ddarllen: Gweld ar Aspire
Staff Eraill sy'n Cyfrannu: Dr Dylan Phillips; Dr Ruth Wonfor; Dr Joe Ironside; Dr Ifat Shah

Dulliau Asesu

Math o Asesiad	Manylion Asesiad	Cyfran
Asesiad Semester	Practical test: 2 Awr	50%
Arholiad Semester	Exam: 2 Awr	50%
Asesiad Ailsefyll	Supplementary practical test: 2 Awr	50%
Arholiad Ailsefyll	Exam: 2 Awr	50%

Canlyniadau Dysgu

Wedi cwblhau'r modiwl dylai'r myfyrwyr fedru:

Describe the structure, function and evolution of eukaryotic chromosomes, and identify the factors governing chromosome stability and driving karyotype diversity.
Outline the nature and effects on the phenotype of numerical and structural changes of chromosomes.
Discern how meiosis and recombination underpin genetic variation.
Construct, test statistically and interpret linkage maps.

Disgrifiad cryno

Chromosomes carry genes with great precision and fidelity between cell cycles, and from one generation to the next. This module explores how chromosomes have evolved to be proficient vehicles of inheritance, and how differences and changes in chromosome number and structure have important implications for speciation and the fitness of eukaryotic organisms. It also shows how chromosomes provide the environment for the expression and recombination of genes, and how chromosomes underpin sex determination and the evolution of breeding systems. Practical classes complement the lecture series, in which model organisms are used to demonstrate the principles and practice of genetic mapping.

Cynnwys

The course is divided into 4 interrelated sections:

1. Chromosome structure and evolution
Defining and comparing karyotypes by chromosome components. Drivers and models of chromosome evolution, sex determination and breeding systems, extrachromosomal inheritance and epigenetics.

2. Chromosome mutation
The nature of numerical and structural chromosome change and its relationship to fertility and aetiology of human genetic disorders.

3. Meiosis and Recombination
The cytology and molecular genetics of meiosis and recombination.

4. Practicals
Karyology, meiosis, recombination and linkage mapping in model organisms.

Sgiliau Modiwl

Math o Sgiliau	Manylion Sgiliau
Cyfathrebu	Listening and questioning skills are honed in lectures and practical classes.
Datblygu personol a chynllunio gyrfa	Discerning the central role of chromosomes in governing the phenotype is an important skill in terms of pursuing a career in clinical and biomedical science.
Datrys Problemau	Scientific method will be exercised by posing and testing hypotheses in the practical classes.
Gwaith Tim	The acquisition and analysis of class data in the practicals encourages an active role in group activities.
Gwella dysgu a pherfformiad ei hun	Progress and performance is monitored through feedback on practical assessments and a module review session to prepare for the examination.
Rhifedd	Data are obtained and analysed statistically in the practical classes.
Sgiliau pwnc penodol	Ability to discern the central role of the chromosome in the genetics and evolution of eukaryotes.
Sgiliau ymchwil	The practical classes will develop transferable lab skills in microscopy, microbiological techniques, and in following written protocols.
Technoleg Gwybodaeth	Internet search engines are used for directed wider reading.

Nodau

Mae'r modiwl hwn yn cydymffurfio a FfCChC Lefel 5